Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT- 2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the The Catalan Government DURSI grant 2009SGR1489

La reutilización de los espacios funerarios de la tumba QH33 durante el Reino Nuevo y la Baja Época

La presente tesis doctoral es un estudio de carácter histórico acerca del uso secundario en diferentes periodos de la tumba QH33 de la necrópolis de Qubbet el-Hawa. Se describe de manera individualizada y exhaustiva la tumba en cuestión, desde un punto de vista técnico y arquitectónico. También se explica la funcionalidad de los diferentes espacios de la tumba. En un primer apartado se tratan las reutilizaciones acontecidas en la necrópolis de Qubbet el-Hawa en los periodos de ocupación detectados, es decir, finales del Segundo Periodo Intermedio, Reino Nuevo y Baja Época. Después viene un apartado dedicado al robo de tumbas, con una introducción previa antes de abordar la situación ocurrida en QH33. Finalmente se incluye un apartado que trata los rituales funerarios documentados, la categorización y tipologías extraídas del ajuar hallado, así como titulaturas, genealogías y prosopografía de los individuos enterrados conocidos, procedente de la tumba QH33. Todo el material procedente de esta tumba así como la información generada en este trabajo es inédita ya que dicha tumba nunca fue publicada.The present thesis is a historical study about the secondary use in different periods of the tomb QH33 in the necropolis of Qubbet el-Hawa. The grave in question is described individually and exhaustively, from a technical and architectural point of view. It also explains the functionality of the different spaces of the tomb. The first section deals with the re-uses that occurred in the necropolis of Qubbet el-Hawa in the periods of reoccupation detected, that is, the end of the Second Intermediate Period, the New Kingdom and the Late Period. Then comes a section dedicated to the robbery of graves, with a previous introduction before addressing the situation that occurred in QH33. Finally, a section is included that deals with the documented funerary rituals, the categorization and typologies extracted from the funerary equipment found, as well as titles, genealogies and prosopography of the known buried individuals, coming from the grave QH33. All the material from this tomb and the information generated in this work is unprecedented since the tomb was never published.Tesis Univ. Jaén. Departamento de Antropología, Geografía e Historia. Leída el 26 de julio de 2019

Proyecto Qubbet El-Hawa: Las tumbas nº 33 y 34h. Tercera Campaña 2010.

En el presente artículo se exponen los resultados preliminares de los trabajos multidisciplinares llevados a cabo en la necrópolis de Qubbet el-Hawa (Asuán) durante el año 2010. En este sentido, se detallan los trabajos arqueológicos llevados a cabo en las tumbas 33 y 34 (ambas datadas en la Dinastía XII) y algunos estudios específicos resultantes de ellos. Se describen los primeros resultados de las labores de conservación realizados en la tumba 34h (Junes).Preliminary results of the multidisciplinary works carried out in the necropolis of Qubbet el-Hawa (Aswan) during 2010 season are detailed in the present paper. A brief account of major archaeological results from the works carried out in tombs nº 33 and 34 (both dated to the 12th Dynasty) are detailed together with specific studies derived from them. First results of the conservation measures in tomb 34h (Khunes) are described

Clinical characterization and outcomes of 85 patients with neurosarcoidosis.

To analyze the frequency and clinical phenotype of neurosarcoidosis (NS) in one of the largest nationwide cohorts of patients with sarcoidosis reported from southern Europe. NS was evaluated according to the Diagnostic Criteria for Central Nervous System and Peripheral Nervous System Sarcoidosis recently proposed by Stern et al. Pathologic confirmation of granulomatous disease was used to subclassify NS into definite (confirmation in neurological tissue), probable (confirmation in extraneurological tissue) and possible (no histopathological confirmation of the disease). Of the 1532 patients included in the cohort, 85 (5.5%) fulfilled the Stern criteria for NS (49 women, mean age at diagnosis of NS of 47.6 years, 91% White). These patients developed 103 neurological conditions involving the brain (38%), cranial nerves (36%), the meninges (3%), the spinal cord (10%) and the peripheral nerves (14%); no patient had concomitant central and peripheral nerve involvements. In 59 (69%) patients, neurological involvement preceded or was present at the time of diagnosis of the disease. According to the classification proposed by Stern et al., 11 (13%) were classified as a definite NS, 61 (72%) as a probable NS and the remaining 13 (15%) as a possible NS. In comparison with the systemic phenotype of patients without NS, patients with CNS involvement presented a lower frequency of thoracic involvement (82% vs 93%, q = 0.018), a higher frequency of ocular (27% vs 10%, q

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective