Observation of a nanophase segregation in LiCl aqueous solutions from Transient Grating Experiments

Transient Grating experiments performed on supercooled LiCl, RH2O solutions with R>6 reveal the existence of a strong, short time, extra signal which superposes to the normal signal observed for the R=6 solution and other glass forming systems. This extra signal shows up below 190 K, its shape and the associated timescale depend only on temperature, while its intensity increases with R. We show that the origin of this signal is a phase separation between clusters with a low solute concentration and the remaining, more concentrated, solution. Our analysis demonstrates that these clusters have a nanometer size and a composition which are rather temperature independent, while increasing R simply increases the number of these clusters.Comment: 19 pages+ 8 figures+ 2 table

Disinvestment in healthcare: An overview of HTA agencies and organizations activities at European level

Background: In an era of a growing economic pressure for all health systems, the interest for "disinvestment" in healthcare increased. In this context, evidence based approaches such as Health Technology Assessment (HTA) are needed both to invest and to disinvest in health technologies. In order to investigate the extent of application of HTA in this field, methodological projects/frameworks, case studies, dissemination initiatives on disinvestment released by HTA agencies and organizations located in Europe were searched. Methods: In July 2015, the websites of HTA agencies and organizations belonging to the European network for HTA (EUnetHTA) and the International Network of Agencies for HTA (INAHTA) were accessed and searched through the use of the term "disinvestment". Retrieved deliverables were considered eligible if they reported methodological projects/frameworks, case studies and dissemination initiatives focused on disinvestment in healthcare. Results: 62 HTA agencies/organizations were accessed and eight methodological projects/frameworks, one case study and one dissemination initiative were found starting from 2007. With respect to methodological projects/frameworks, two were delivered in Austria, one in Italy, two in Spain and three in U.K. As for the case study and the dissemination initiative, both came from U.K. The majority of deliverables were aimed at making an overview of existing disinvestment approaches and at identifying challenges in their introduction. Conclusions: Today, in a healthcare context characterized by resource scarcity and increasing service demand, "disinvestment" from low-value services and reinvestment in high-value ones is a key strategy that may be supported by HTA. The lack of evaluation of technologies in use, in particular at the end of their lifecycle, may be due to the scant availability of frameworks and guidelines for identification and assessment of obsolete technologies that was shown by our work. Although several projects were carried out in different countries, most remain constrained to the field of research. Disinvestment is a relatively new concept in HTA that could pose challenges also from a methodological point of view. To tackle these challenges, it is necessary to construct experiences at international level with the aim to develop new methodological approaches to produce and grow evidence on disinvestment policies and practices

Analysis of short-term blood pressure variability in pheochromocytoma/paraganglioma patients

Data on short-term blood pressure variability (BPV), which is a well-established cardiovascular prognostic tool, in pheochromocytoma and paraganglioma (PPGL) patients is still lack and conflicting. We retrospectively evaluated 23 PPGL patients referred to our unit from 2010 to 2019 to analyze 24 h ambulatory blood pressure monitoring (24-h ABPM)-derived markers of short-term BPV, before and after surgical treatment. PPGL diagnosis was assessed according to guidelines and confirmed by histologic examination. The 24-h ABPM-derived markers of short-term BPV included: circadian pressure rhythm; standard deviation (SD) and weighted SD (wSD) of 24-h, daytime, and night-time systolic and diastolic blood pressure (BP); average real variability (ARV) of 24-h, daytime, and night-time systolic and diastolic BP. 7 males and 16 females of 53 ± 18 years old were evaluated. After surgical resection of PPGL we found a significant decrease in 24-h systolic BP ARV (8.8 ± 1.6 vs. 7.6 ± 1.3 mmHg, p < 0.001), in 24-h diastolic BP ARV (7.5 ± 1.6 vs. 6.9 ± 1.4 mmHg, p = 0.031), and in wSD of 24-h diastolic BP (9.7 ± 2.0 vs 8.8 ± 2.1 mmHg, p = 0.050) comparing to baseline measurements. Moreover, baseline 24-h urinary metanephrines significantly correlated with wSD of both 24-h systolic and diastolic BP. Our study highlights as PPGL patients, after proper treatment, show a significant decrease in some short-term BPV markers, which might represent a further cardiovascular risk factor

On the Coherent State Path Integral for Linear Systems

We present a computation of the coherent state path integral for a generic linear system using ``functional methods'' (as opposed to discrete time approaches). The Gaussian phase space path integral is formally given by a determinant built from a first-order differential operator with coherent state boundary conditions. We show how this determinant can be expressed in terms of the symplectic transformation generated by the (in general, time-dependent) quadratic Hamiltonian for the system. We briefly discuss the conditions under which the coherent state path integral for a linear system actually exists. A necessary -- but not sufficient -- condition for existence of the path integral is that the symplectic transformation generated by the Hamiltonian is (unitarily) implementable on the Fock space for the system.Comment: 15 pages, plain Te

Stochastic model of hysteresis

The methods of the probability theory have been used in order to build up a new model of hysteresis. It turns out that the reversal points of the control parameter (e. g., the magnetic field) are Markov points which determine the stochastic evolution of the process. It has been shown that the branches of the hysteresis loop are converging to fixed limit curves when the number of cyclic back-and-forth variations of the control parameter between two consecutive reversal points is large enough. This convergence to limit curves gives a clear explanation of the accommodation process. The accommodated minor loops show the return-point memory property but this property is obviously absent in the case of non-accommodated minor loops which are not congruent and generally not closed. In contrast to the traditional Preisach model the reversal point susceptibilities are non-zero finite values. The stochastic model can provide a good approximation of the Raylaigh quadratic law when the external parameter varies between two sufficiently small values.Comment: 13 pages, 14 figure

EPR before EPR: a 1930 Einstein-Bohr thought experiment revisited

In 1930 Einstein argued against consistency of the time-energy uncertainty relation by discussing a thought experiment involving a measurement of mass of the box which emitted a photon. Bohr seemingly triumphed over Einstein by arguing that the Einstein's own general theory of relativity saves the consistency of quantum mechanics. We revisit this thought experiment from a modern point of view at a level suitable for undergraduate readership and find that neither Einstein nor Bohr was right. Instead, this thought experiment should be thought of as an early example of a system demonstrating nonlocal "EPR" quantum correlations, five years before the famous Einstein-Podolsky-Rosen paper.Comment: 11 pages, revised, accepted for publication in Eur. J. Phy

Electrical plasmon detection in graphene waveguides

We present a simple device architecture that allows all-electrical detection of plasmons in a graphene waveguide. The key principle of our electrical plasmon detection scheme is the non-linear nature of the hydrodynamic equations of motion that describe transport in graphene at room temperature and in a wide range of carrier densities. These non-linearities yield a dc voltage in response to the oscillating field of a propagating plasmon. For illustrative purposes, we calculate the dc voltage arising from the propagation of the lowest-energy modes in a fully analytical fashion. Our device architecture for all-electrical plasmon detection paves the way for the integration of graphene plasmonic waveguides in electronic circuits.Comment: 9 pages, 3 figure

Development of Hydrogen Peroxide Monopropellant Rocktes

Alta S.p.A. (Italy) and DELTACAT Ltd. (United Kingdom) are conducting a study, funded by the European Space Agency, into the development of hydrogen peroxide monopropellant thrusters using advanced catalytic beds. The present paper focuses on the design of two different demonstration thrusters with nominal ratings of 5 N and 25 N. Design requirements and specifications are presented, followed by the main results of a concept study, which was conducted to define the approximate dimensions needed. Some details about the specific design of the two prototypes and the choice of the main components are provided, with particular regard to the sensors and transducers to be used during the experimentation. Different catalytic bed configurations, including pure silver gauzes and pellets coated with manganese oxide or platinum, are going to be tested in the prototype thrusters, in order to find the optimum one for further industrial development. A dedicated test bench, designed and r..

Study of MicroPattern Gaseous detectors with novel nanodiamond based photocathodes for single photon detection in EIC RICH

Identification of high momentum hadrons at the future EIC is crucial, gaseous RICH detectors are therefore viable option. Compact collider setups impose to construct RICHes with small radiator length, hence significantly limiting the number of detected photons. More photons can be detected in the far UV region, using a windowless RICH approach. QE of CsI degrades under strong irradiation and air contamination. Nanodiamond based photocathodes (PCs) are being developed as an alternative to CsI. Recent development of layers of hydrogenated nanodiamond powders as an alternative photosensitive material and their performance, when coupled to the THick Gaseous Electron Multipliers (THGEM)-based detectors, are the objects of an ongoing R\&D. We report about the initial phase of our studies.Comment: 3 pages, 5 figures, RICH2018 conference proceedin