Impact of Metallic Nanoparticles on the Nutritional Values of Spirulina

Spirulina has high nutritional values and anti-oxidative properties. It is a staple diet due to its easy cultivation and greater nutritional values in biological macromolecules (proteins, lipids, and carbohydrates), pigments (chlorophyll, carotenoids, phycobiliproteins) vitamins, minerals, phenolic compounds, and amino acids. Spirulina also has been used as a nutraceutical to treat numerous diseases and disorders due to its promising therapeutic values. However, extensive anthropogenic activities cause the discharge of metals and metallic nanoparticles into the environment that might cause toxicity to marine and freshwater microalgae due to bioaccumulation. The presence of metals in the environment beyond the normal range does not only affect the growth but also the nutritional values of microalgae. The nutritional properties and usage of Spirulina along with the harmful effects of metals and metallic nanoparticles on Spirulina are highlighted and summarized in this paper

THERAPEUTIC APPLICATIONS OF Spirulina AGAINST HUMAN PATHOGENIC VIRUSES

Viruses can spread worldwide and the early detection of emerging infectious diseases and outbreaks in humans and animals is important for effective surveillance and prevention. Viruses such as human immunodeficiency virus (HIV), swine flu, and influenza virus are some of the viruses that spread diseases worldwide. However, the non-availability of effective antiviral drugs and the drug-resistance among the virus and host have become the major problems in controlling viral infections. The natural products from microalgae can be an alternative therapeutic agent to control viral infections in humans. Spirulina is a well-known cyanobacterium that has been consumed by humans as a food supplement for more than centuries without side-effects. Spirulina possesses high nutritional values and provides numerous health benefits to the consumers. Spirulina can be an alternative natural therapeutic agent for numerous virus infections as it contains several bioactive compounds with proven antiviral effect on enveloped viruses (Herpes simplex virus, measles virus, mumps virus) and non-enveloped viruses (astrovirus, rotavirus) by preventing the spread of the virus in the host cells. Spirulina also serves as a natural supplement that strengthens the immune system. This review focuses on the antiviral properties and immunostimulant effects of Spirulina as a potential therapeutic supplement on human health

Sensitivity of Proteus vulgaris to zinc oxide nanoparticles

Zinc oxide nanoparticle (ZnO NP) has become a popular choice in nanomedicine and in the treatment of infections. The present study investigated the sensitivity of Proteus vulgaris to ZnO NPs. The bacteriostatic and bactericidal effects on P. vulgaris were determined by using turbidity and colony count methods. The oxidative stress induced by the treatment of ZnO NPs was evaluated by investigating the level of intracellular reactive oxygen species (ROS) along with lipid peroxidation (LP) analysis. The results showed the highest bacterial growth inhibition of 76.21±1.91 and 87.49±3.29% determined using the turbidity and colony count methods, respectively. The highest oxidative stress effects were observed in P. vulgaris exposed to 100 μg/mL of ZnO NPs for 24 h as shown by 510.90±108.53% increase in ROS production and 328.77±44.36% increase in LP level. The Fourier transform infrared spectroscopy (FTIR) spectrum illustrated the possible involvement of functional groups such as amine, alkane, acid and alkene from the bacterial cell wall in allowing the surface attachment of nanoparticles on the bacterial cells. Hence, the present study clearly demonstrated the sensitivity of P. vulgaris to ZnO NPs