Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men - Fig 2

Cumulative mortality from other causes than prostate cancer (A) and cumulative mortality from prostate cancer (B), in men with a prostate cancer diagnosis (n = 2259) according to strata of 25(OH)D concentration. Adjusted for age, month of blood sampling, examination, physical activity, BMI, smoking and education. Death from prostate cancer (n = 381) and death from all other causes (n = 228) was set as competing events in panel A and B, respectively.</p

DataSheet_1_Cardiovascular outcomes after curative prostate cancer treatment: A population-based cohort study.docx

ObjectiveTo investigate differences in cardiovascular disease (CVD) morbidity and mortality after radical prostatectomy or definitive radiotherapy with or without androgen deprivation therapy (ADT).Materials and methodsWe used population-based data from the Cancer Registry of Norway, the Norwegian Patient Registry and the Norwegian Cause of Death Registry including 19 289 men ≤80 years diagnosed with non-metastatic prostate cancer during 2010-2019. Patients were treated with radical prostatectomy or definitive radiotherapy. We used competing risk models to compare morbidity from overall CVD, acute myocardial infarction (AMI), cerebral infarction, thromboembolism, and CVD-specific mortality for the overall cohort and stratified by prognostic risk groups.ResultsAfter a median follow-up time of 5.4 years (IQR 4.6 years), there were no differences in adjusted rates of AMI, cerebral infarction, and CVD-specific death between radical prostatectomy and definitive radiotherapy in any of the prognostic risk groups. Rates of overall CVD (0.82; 95% CI 0.76-0.89) and thromboembolism (0.30; 95% CI 0.20-0.44) were lower for definitive radiotherapy than radical prostatectomy during the first year of follow-up. After this overall CVD rates (1.19; 95% CI 1.11-1.28) were consistently higher across all risk groups in patients treated with definitive radiotherapy, but there were no differences regarding thromboembolism.ConclusionsDuring the first years after treatment, no differences were found in rates of AMI, cerebral infarction, and CVD-specific death between radiotherapy and radical prostatectomy in any of the prognostic risk groups. This suggests that ADT use in combination with radiotherapy may not increase the risks of these outcomes in a curative setting. The increased overall CVD rate for definitive radiotherapy after the first year indicates a possible relationship between definitive radiotherapy and other CVDs than AMI and cerebral infarction.</p

Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men - Fig 1

<p>Hazard ratios (solid lines) with 95% confidence intervals (dashed lines) for all-cause mortality across the distribution of 25(OH)D in (A) men with prostate cancer and in (B) men without prostate cancer. Adjusted for age, month of blood sampling, examination, physical activity, BMI, smoking and education. 25(OH)D was included as restricted cubic splines with five knots.</p

Hazard Ratios (HR) with 95% confidence intervals for total mortality (red line) and incident prostate cancer (blue line) by category of s-25(OH)D.

<p>Separate analyses were performed for the two endpoints. 25(OH)D 50–69 nmol/l is the reference category. In the total mortality analysis, adjustment was made for age, case status, month of blood sampling, examination, physical activity, BMI, smoking and education. In the prostate cancer incidence analysis adjustment was made for age, month of blood sampling, examination and education.</p

Hazard ratio (HR) and 95% confidence intervals (95% CI) for total mortality by concentration of s-25(OH)D.

<p>Hazard ratio (HR) and 95% confidence intervals (95% CI) for total mortality by concentration of s-25(OH)D.</p

Characteristics of the study population at baseline by s-25(OH)D concentration.

Characteristics of the study population at baseline by s-25(OH)D concentration.</p

Hazard ratio (HR) and 95% confidence interval (95% CI) for cause specifics deaths in patients with prostate cancer.

<p>Hazard ratio (HR) and 95% confidence interval (95% CI) for cause specifics deaths in patients with prostate cancer.</p

Supplementary Tables 1 and 2 from Biomarkers Related to One-Carbon Metabolism as Potential Risk Factors for Distal Colorectal Adenomas

Supplementary Tables 1 and 2 from Biomarkers Related to One-Carbon Metabolism as Potential Risk Factors for Distal Colorectal Adenoma

Characteristics of individuals within quintile levels of glucose.

<p>Characteristics of individuals within quintile levels of glucose.</p

Birthweight and all-cause mortality after childhood and adolescent leukemia: a cohort of children with leukemia from Denmark, Norway, Sweden, and Washington State

Background: High birthweight may predispose children to acute lymphoid leukemia, whereas low birthweight is associated with childhood morbidity and mortality. Low and high birthweight have been inconsistently associated with mortality in children with leukemia. Material and methods: In a cohort of childhood and adolescent leukemia (0–19 years) patients from registries in Denmark, Norway, Sweden, and Washington State in the United States (1967–2015), five-year all-cause mortality was assessed by birthweight and other measures of fetal growth using the cumulative incidence function and Cox regression with adjustment for sex, diagnosis year, country, the presence of Down’s syndrome or other malformations, and type of leukemia. Results: Among 7148 children and adolescents with leukemia (55% male), 4.6% were low (1–2 years old; 1.0 (95% CI: 0.6, 1.5) for 3–8 years old; 1.0 (95% CI: 0.6, 1.8) for 9–13 years old; and 1.2 (95% CI: 0.7, 2.1) for 14–19 years old, and were similar for size for gestational age and Ponderal index. In analyses restricted to children born full term (37–41 weeks of gestation), results were only slightly attenuated but risk was markedly increased for infants aged ≤1 year (HR for low birthweight = 3.2, 95% CI: 1.2, 8.8). Conclusion: This cohort study does not suggest that low birthweight or SGA is associated with increased five-year all-cause mortality risk among children with any type of childhood leukemia or acute lymphoblastic leukemia, specifically, beyond infancy.</p