Uticaj različitih načina gajenja paprike na debljinu perikarpa ploda

It has long been known that the quality of pepper has a big impact variety, environmental conditions and applied agricultural technology. The aim of this study was to determine the influence they have different ways of growing peppers on pericarp thickness, which is the main indicator of quality. To come up with an answer I see the set that included growing peppers from seedlings bare vessels, container seedlings and direct sowing. All these varieties were grown in the open field and in the greenhouse with a plastic film mulching, straw and with the use of Agri. The results of three years of research indicate that in the production of pepper seedlings obtained from the container with the thickest fruits pericarp.Odavno je poznato da na kvalitet paprike veliki uticaj ima sorta, ekološki uslovi i primenjena agrotehnika. Cilj ovog istraživanja bio je da utvrdi koliki uticaj imaju različiti načini gajenja paprike na debljinu perikarpa, koji je osnovni pokazatelj kvaliteta. Da bi došli do odgovora postavljen ja ogled koji je uključivao gajenja paprike iz rasada golih žila, kontejnerskog rasada i direktnom setvom. Sve ove varijante gajene su na otvorenom polju i u plasteniku uz nastiranje sa folijom, slamom i uz upotrebu agrila. Rezultati trogodišnjeg istraživanja ukazuju da se pri proizvodnji paprike iz kontejnerskog rasada dobijaju plodovi sa najdebljim perikarpom

Histamine index and clinical expression of rheumatoid arthritis activity

Background/Aim: Many arguments prove the pathophysiologic role of histamine in the process of remodeling and joint destruction in rheumatoid arthritis. The aim of our study was to find out if there was a relation between histamine concentration in synovial fluid and blood with clinical expression of disease activity. Methods: Histamine concentration in synovial fluid and blood was determinated in 19 patients with rheumatoid arthritis. Histamine concentration measurement was based on the Shore's fluorometric method. Histamine index (HI) was evaluated as a ratio between histamine concentration in synovial fluid and blood. Disease activity score, DAS 28 (3), with three variables (erythrocyte sedimentation rate, the number of swelled joints and the number of tender joints) was also evaluated. Results: Our results showed that there was no significant difference in concentration of histamine in synovial fluid and blood related to disease activity. However, there was a significiant difference in the histamine index which was increased proportionally with disease activity. Conclusion: Our study indicates that histamine index could be useful in estimation of rheumatoid arthritis activity

Glucagon Effects on Ischemic Vasodilatation in the Isolated Rat Heart

The myocardial reperfusion following ischemia leads to the ischemic vasodilation by affecting the release of various vasoactive substances, such as free radicals, NO, and histamine. In addition, some evidences suggest that glucagon itself may alter the release of those substances. In this study, we investigated the ischemic vasodilation of the isolated rat heart, as well as the concentrations of NO, TBARS, and histamine in the coronary venous effluent either in the presence or in the absence of glucagon. Our results showed that in the presence of glucagon, there was a faster restoration of coronary perfusion pressure during ischemic vasodilation compared to the absence of glucagon (124 ± 5.6 versus 81 ± 5.2 s) with no apparent changes in TBARS concentration. The glucagon's administration leads to the decreased release of histamine by approximately 35%. Biphasic release of NO in the presence of glucagon initially showed augmentation by 60%, followed by the significant attenuation of 45%

Histamine Blood Concentration in Ischemic Heart Disease Patients

The aim of this study was to investigate histamine blood concentration in subjects suffering from different types of ischemic heart diseases during the period of eight days. Our results showed that the histamine blood level was associated with different types of ischemic heart diseases. The blood histamine level in all investigated patients was significantly higher when compared to control subjects (44.87 ± 1.09 ng mL−1), indicating the increase of histamine release in patients suffering from coronary diseases. In patients suffering from ACS-UA and ACS-STEMI, the second day peak of histamine level occurs (90.85 ± 6.34 ng mL−1 and 121.7 ± 6.34 ng mL−1, resp.) probably as the reperfusion event. Furthermore, our data suggest that histamine can be additional parameter of myocardial ischemia along with cardiac specific enzymes and may prove to be an excellent single prognostic marker for multitude of ischemic heart diseases

Late-onset systemicus lupus erithematosus

© 2014, Serbian Medical Society . All rights reserved. There is an assumption that the late-onset systemic lupus erythematosus (SLE), with the beginning after the age of 50, has a different clinical course, with an insidious start and non-specific first manifestations. The incidence of late-onset SLE is 12-20% of all patients with SLE. Atypical presentation, nonspecific initial clinical manifestations and smaller incidence of SLE in elderly population may contribute to the delayed diagnosis. It could be concluded that despite the less major organ involvement (nephritis, central nervous system), and more benign course of disease, late-onset SLE has poorer prognosis, because of the higher frequency of co-morbid conditions and higher organ damage, due to the aging and longer exposition to typical vascular risk factors. The prognosis depends not only on the disease per se, but on the clinical context in which it occurs. Strategies to reduce the occurrence of cardiovascular disease, osteoporosis, pathological fractures, infections and other forms of damage should be aggressively implemented particularly in the late-onset patients, and they have to be closely followed because they are more susceptible to damage in long-term follow-up

Management of antiphospholipid syndrome in adults: The european league against rheumatism (EULAR) recommendations

© 2019, Serbian Medical Society. All rights reserved. Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid (aPL) antibodies. The European League Against Rheumatism, EULAR, has published a set of recommendations for the management of antiphospholipid syndrome in adults, based on the systematic literature reviews (SLRs) results and expert opinions. Low dose aspirin (LDA) is recommended for asymptomatic aPL carriers, patients with systemic lupus erythematosus without prior thrombotic or obstetric APS, and nonpregnant women with a history of obstetric APS only, all with high-risk aPL profiles. Patients with APS and the first unprovoked venous thrombosis should receive long-term treatment with vitamin K antagonists (VKA) with a target international normalised ratio (INR) of 2–3. In patients with APS with the first arterial thrombosis, treatment with VKA with INR 2–3 or INR 3–4 is recommended, considering the individual’s bleeding/ thrombosis risk. For patients with recurrent arterial or venous thrombosis despite adequate treatment, addition of LDA, increase of INR target to 3–4 or switch to low molecular weight heparin may be considered. In women with prior obstetric APS, combination treatment with LDA and prophylactic dosage heparin during pregnancy is recommended. In patients with recurrent pregnancy complications, increase of heparin to therapeutic dose, addition of hydroxychloroquine or addition of low-dose prednisolone in the first trimester may be considered. These recommendations aim to guide treatment in adults with APS

Psoriasis eruptions-like side effects after the use of etanercept-case report

© 2019, Serbian Medical Society. All rights reserved. The use of tumor necrosis factor antagonists (anti-TNF) has become a usual practice to treat various inflammatory diseases. Although indicated for the treatment of psoriasis, anti-TNF may paradoxically trigger a psoriasiform condition. We present a case of a female patient who, during the use of etanercept for rheumatoid arthritis, developed psoriasis. After histopathological confirmation and consultation, the dermatologist concluded that psoriasis was a paradoxical effect of anti-TNF inhibitors. Anti-TNF inhibitor is replaced with other biological drug-tocilizumab. After the change of the drug, psoriasis eruptions were completely resolved. The paradoxical form of psoriasis after the use of anti-TNF inhibitor requires a change of the drug with other mechanism of action

Difficulties in the diagnosis of inclusion body myositis case report

© 2019, University of Kragujevac, Faculty of Science. All rights reserved. Inclusion body myositis belongs to the group of idiopathic inflammatory myopathies. Two processes, one autoimmune and the other degenerative, appear to occur in parallel. There are two forms of inclusion body myositis, hereditary and sporadic. Case report: 47-year-old woman with muscle weakness and atrophy of the distal and proximal muscles, and involvement of quadriceps and deep finger flexors was admitted for neuromuscular evaluation. These changes have been started gradually and insidiously over three years. Electromyography findings were nonspecific and for this reason in the beginning of the disease it was misdiagnosed as demyelization peripheral neuropathy. Muscle biopsy, with the presence of characteristic structures such as rimmed vacuoles and amyloid deposits definitely confirmed the diagnosis of inclusion body myositis. Conclusion: There are several difficulties in the diagnosis of inclusion body myositis as nonspecific EMG findings and overreliance on electrophysiology and lack of the cardinal histological features in muscle biopsy. Although this disease is rare and incurable, making the correct diagnosis is crucial to directing the patient to physical therapy for weakness and occupational therapy to improve a patient’s ability in activities of daily living

Granulomatosis with polyangitis (Wegener’s) and central nervous system involvement: Case report

Introduction Granulomatosis with polyangitis (Wegener’s) is an antineutrophil cytoplasmic antibody (PR3-ANCA)-associated vasculitis, which commonly involves the upper and lower respiratory tracts and kidneys. Central nervous system involvement is reported in less than 11%, and rarely present at onset. Case Outline We report the case of a 41-year-old male patient with a high disease activity, large organ involvement, as well as central nervous system manifestations presented at onset. Treatment with intravenous pulse methylprednisolone, followed by the pulsed doses of cyclophosphamide was induced. After 6 months of cyclophosphamide pulse therapy a remission was achieved. Next, azathioprine was used for maintenance during the next 18 months. There were no disease flares during 24-month follow-up. Conclusion Granulomatosis with polyangitis (Wegener’s) with large organ involvement, affecting the central nervous system structures require a rapid diagnosis and intensive medication treatment in order to prevent or reduce irreversible damage. Our experience confirms the findings reported in the literature that the severe forms of the disease are associated with increased probability of achieving remission, which reflects increased responsiveness of such patients to immunosuppressant therapy

Correlations between clinical parameters and health related quality of life in postmenopausal osteoporotic women

© 2016, University of Kragujevac, Faculty of Science. All rights reserved. e purpose of this study was to assess the correlation between health-related quality of life (HRQoL) and clinically relevant osteodensitometric and biochemical parameters in postmenopausal osteoporotic women. Bone mineral density (BMD) and T scores of the lumbar vertebrae and femoral neck were assessed in 100 osteoporotic women (56 without previous fractures and 44 with previous fractures) using dual x-ray absorptiometry. e Fracture Risk Assessment Tool (FRAX) index for major osteoporotic and hip fractures was calculated based on demographic data and hip BMD. Venous blood samples were taken from each subject for biochemical analysis (serum calcium, phosphorus, alkaline phosphatase and vitamin D levels). HRQoL was assessed using the QUALEFFO-41 questionnaire (domains: Health perception, Pain, and Physical, Social and Mental function). Basic participant characteristics (age, menopause length, body mass index, smoking habits, hereditary tendency towards fracture, fracture history) correlated with some of the QUALEFFO-41 domains, but the correlation coefficients were low (r<0.3), except in the case of the correlation between Pain and fracture history (r=0.638). Of the six variables included in the multiple regression model, fracture history was shown to be the most significant predictor with respect to the following three QUALEFFO-41 domains: Pain (b=20.511), Social function (b=2.548) and Health perception (b=3.185). Correlation analysis showed that after adjustment for basic characteristics, BMD and T score of the femoral neck and Pain (r=0.331 and r=0.449, respectively), Social function (r=0.422 and r=0.419) and Health perception (r=0.434 for T score of the femoral neck) exhibited the strongest correlations. Vitamin D was negatively correlated with Mental function, while the other biochemical parameters exhibited variable correlations with the QUALEFFO- 41 domains (r 0.2-0.5). Our study confirmed the previously established relationship between BMD of the femoral neck and HRQoL in patients with osteoporosis and demonstrated correlations between various blood bone metabolism parameters and HRQoL that have not been previously investigated