7 research outputs found
Overcoming Impostor Syndrome
- Publication venue
- UND Scholarly Commons
- Publication date
- 12/11/2020
- Field of study
ALA Core\u27s AvramCamp is designed to be a safe and inclusive day-long workshop for people of marginalized genders, including women, non-binary folks, and trans men, to come together and discuss challenges these groups commonly face while working in the library technology field. Each AvramCamp begins with a workshop to talk about Impostor Syndrome: what it is, how to recognize it, and strategies to overcome those feelings of being a fake or a fraud. Participants are encouraged to engage with the facilitators, creating a lively and honest discussion around an often private and sensitive topic
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
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- Böhringer Stefan
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- Caulfield Mark
- Cavalieri Margherita
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- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
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- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
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- Cho Yoon Shin
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- Chouraki Vincent
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- Cimponeriu Dan
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- Steinthorsdottir Valgerdur
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- Wilsgaard Tom
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- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
- Author
- Aaron Folsom
- Aaron Isaacs
- Abbas Dehghan
- Adebowale Adeyemo
- Adrienne Tin
- Afshin Parsa
- Aida Karina Dieffenbach
- Alan B. Weder
- Alan B. Zonderman
- Alan F. Wright
- Alan Go
- Alan R. Shuldiner
- Alanna C. Morrison
- Albert Hofman
- Albert V. Smith
- Albert W. Dreisbach
- Alena Stancakova
- Alex N. Parker
- Alexander Teumer
- Alexandre F. R. Stewart
- Alistair Hall
- Amy J. Swift
- Anders Hamsten
- Andre Franke
- Andre G. Uitterlinden
- Andreas Meinitzer
- Andreas Tomaschitz
- Andreas Ziegler
- Andres Metspalu
- Andrew A. Hicks
- Andrew D. Johnson
- Andrew Plump
- Andrew Singleton
- Andrew Taylor
- Andrew Wong
- Angela Doering
- Angelo Scuteri
- Anika Grosshennig
- Anja Medack
- Anke Tonjes
- Anna F. Dominiczak
- Anna Köttgen
- Anna Maria Corsi
- Anna-Liisa Hartikainen
- Anne U. Jackson
- Annette Peters
- Annika Rosengren
- Anthony J. Balmforth
- Antonietta Robino
- Antonio Lupo
- Anuj Goel
- Aravinda Chakravarti
- Arne Schillert
- Arnika K. Wagner
- Aroon D. Hingorani
- Asif Rasheed
- Atsushi Takahashi
- Aude Saint-Pierre
- Audrey Y. Chu
- Augustine Kong
- Augusto D. Pichard
- Ayo Doumatey
- Ayse Demirkan
- Bamidele Tayo
- Barbara Kollerits
- Barbara Ludwig
- Barry I. Freedman
- Belen Ponte
- Ben A. Oostra
- Benedicte Stengel
- Benjamin F. Voight
- Benjamin J. Wright
- Bernhard K. Krämer
- Bernhard O. Böhm
- Bernhard Paulweber
- Bernhard R. Winkelmann
- Bo Hedblad
- Bok-Ghee Han
- Braxton D. Mitchell
- Brenda W. Penninx
- Brendan M. Buckley
- Bruce M. Psaty
- Bruno H. Stricker
- Candace Guiducci
- Carl D. Langefeld
- Carl G. P. Platou
- Carlos Iribarren
- Carmen A. Peralta
- Carole Proust
- Caroline Hayward
- Caroline S. Fox
- Carsten A. Böger
- Catherine Helmer
- Charles N. Rotimi
- Charles S. Janipalli
- Chien-Hsiun Chen
- Chittaranjan S. Yajnik
- Christa Meisinger
- Christian Fuchsberger
- Christian Gieger
- Christian Hengstenberg
- Christian M. Shaffer
- Christian Müller
- Christina Loley
- Christina Willenborg
- Christoph Bickel
- Christoph Sinning
- Christopher J. O’Donnell
- Christopher Newton-Cheh
- Christopher P. Nelson
- Christopher W. Knouff
- Cinzia Sala
- Claire Perret
- Colin A. McKenzie
- Cornelia M. van Duijn
- Cristian Pattaro
- Cristiano Fava
- Cuno S. P. M. Uiterwaal
- D. G. Vinay
- Dabeeru C. Rao
- Daehee Kang
- Dag S. Thelle
- Dan E. Arking
- Daniel Ackermann
- Daniel I. Chasman
- Daniel J. Rader
- Daniel Levy
- Daniel Shriner
- Daniel Taliun
- Daniela Ruggiero
- Daniela Toniolo
- Daniele Cusi
- Danish Saleheen
- Darina Czamara
- David Altshuler
- David Couper
- David Ellinghaus
- David Hadley
- David P. Strachan
- David S. Siscovick
- Dawn M. Waterworth
- Debbie A. Lawlor
- Dena Hernandez
- Devin Absher
- Diana Kuh
- Diana Zelenika
- Diederick E. Grobbee
- Dongfeng Gu
- Donna K. Arnett
- Dorairajan Prabhakaran
- Douglas Ruderfer
- E-Shyong Tai
- Edward G. Lakatta
- Elena Rochtchina
- Elin Org
- Elizabeth G. Holliday
- Elizabeth J. Atkinson
- Emelia Benjamin
- Eran Halperin
- Eric Boerwinkle
- Eric J. G. Sijbrands
- Erik Ingelsson
- Erika Salvi
- Erkki Vartiainen
- Ervin R. Fox
- Erwin P. Bottinger
- Eva Albrecht
- Eva Brand
- Ewa Zukowska-Szczechowska
- F. Gerald R. Fowkes
- Fadi J. Charchar
- Federico Murgia
- Feng Zhang
- Fernando Rivadeneira
- Florian Ernst
- Florian Kronenberg
- Francesco U. S. Mattace-Raso
- Francis S. Collins
- Francois Cambien
- Frank B. Hu
- Fredrik Nyberg
- Fulvio Ricceri
- Fumihiko Takeuchi
- Fuu-Jen Tsai
- Gang Shi
- Gary C. Curhan
- Gary F. Mitchell
- Gavin Lucas
- Georg Homuth
- George A. Wells
- George B. Ehret
- George Davey Smith
- Gerjan J. Navis
- Germaine C. Verwoert
- Gian-Andri Thun
- Gina Hilton
- Giorgio Pistis
- Giovanni Gambaro
- Giovanni Malerba
- Giriraj R. Chandak
- Giuseppe Matullo
- Goncalo R. Abecasis
- Grant W. Montgomery
- Guangju Zhai
- Gudmar Thorleifsson
- Gudmundur Thorgeirsson
- Gudny Eiriksdottir
- Gudrun Veldre
- Gunnar Jacobs
- Guo Li
- H-Erich Wichmann
- Haidong Zhu
- Hakon H. Hakonarson
- Halit Ongen
- Hans J. Rupprecht
- Hao Mei
- Harald Dobnig
- Harald Grallert
- Harold Snieder
- Harry Campbell
- Heather M. Stringham
- Helena Schmidt
- Henri Wallaschofski
- Henry Völzke
- Heribert Schunkert
- Hermann Brenner
- Heyo K. Kroemer
- Hilma Holm
- Hirotsugu Ueshima
- Holly Kramer
- Honghuang Lin
- Hua Tang
- Hubert Scharnagl
- Hugh Watkins
- Hyung-Lae Kim
- I. Mateo Leach
- Ian Ford
- Ian H. de Boer
- Ian N. M. Day
- Ida Yii-Der Chen
- Idris Guessous
- Iftikhar Kullo
- Igor Rudan
- Ilja M. Nolte
- Ines Barroso
- Inga Prokopenko
- Ingrid Borecki
- Inke R. König
- Ioanna Tzoulaki
- Iris M. Heid
- Ivana Kolcic
- Ivana Persico
- J. H. Young
- J. Wouter Jukema
- Jaakko Tuomilehto
- Jaana Laitinen
- Jaap W. Deckers
- Jackie A. Cooper
- Jacqueline C. M. Witteman
- Jacques S. Beckmann
- James E. Hixson
- James F. Meschia
- James F. Wilson
- James Scott
- James T. Willerson
- Jan A. Staessen
- Jan Stritzke
- Janine F. Felix
- Janja Nahrstedt
- Janos Terzic
- Jasmin Divers
- Jaspal S. Kooner
- Jayashri Aragam
- Jean-Charles Lambert
- Jean-Michel Gaspoz
- Jeanette Erdmann
- Jeanette M. Stafford
- Jeffrey R. Gulcher
- Jeffrey R. O’Connell
- Jemma C. Hopewell
- Jennifer A. Smith
- Jennifer L. Bragg-Gresham
- Jer-Yuarn Wu
- Jerome I. Rotter
- Jessica D. Faul
- Jiang He
- Jianjun Liu
- Jian’an Luan
- Jie Jin Wang
- Jie Yao
- Jing Hua Zhao
- Jingzhong Ding
- Joanne Murabito
- Joban S. Sehmi
- Joe Devaney
- Joel N. Hirschhorn
- Johanna Kuusisto
- Johanne Tremblay
- Johannes H. Smit
- Johannes Haerting
- John Attia
- John B. Whitfield
- John C. Chambers
- John Chalmers
- John Danesh
- John F. Peden
- John M. Connell
- John P. Beilby
- John R. Thompson
- John S. Gottdiener
- Jong-Young Lee
- Jorma Viikari
- Josef Coresh
- Joseph M. Lindsay
- Joshua C. Bis
- Joshua C. Denny
- Joshua Knowles
- Juan P. Casas
- Judith A Hoffman Bolton
- Juha Karjalainen
- Jutta Palmen
- Jyotika K. Fernandes
- Jürgen Grässler
- K. Radha Mani
- Karen L. Mohlke
- Kari Stefansson
- Karin Halina Greiser
- Karl Andersen
- Karl J. Lackner
- Karl Werdan
- Karl Winkler
- Karlhans Endlich
- Katalin Susztak
- Katja Butterbach
- Kay-Tee Khaw
- Kazuhiko Yamamoto
- Keith L. Keene
- Kelly Volcik
- Kenneth M. Kent
- Kenneth M. Rice
- Kent D. Taylor
- Kerri L. Wiggins
- Khanh-Dung Hoang Nguyen
- Kiran Musunuru
- Klaus Stark
- Kristian Hveem
- Kristin Marciante
- Kurt Lohman
- L. Adrienne Cupples
- Lars Lind
- Laura J. Scott
- Laura Portas
- Laura R. Loehr
- Laurence Tiret
- Leena Peltonen
- Leif Groop
- Lenore J. Launer
- Leo-Pekka Lyytikäinen
- Leslie J. Raffel
- Li Chen
- Li-Ching Chang
- Liming Qu
- Linda S. Adair
- Loic Yengo
- Lori L. Bonnycastle
- Louise V. Wain
- Lowell Satler
- Lude Franke
- Luigi Ferrucci
- Lyle J. Palmer
- Lynda M. Rose
- Lynne E. Wagenknecht
- Lyudmyla Kedenko
- M. Arfan Ikram
- M. J. Kranthi Kumar
- Maciej Tomaszewski
- Madhumathi Rao
- Maija Garnaas
- Maja Barbalic
- Maksim Struchalin
- Man Li
- Manuela Uda
- Marco Orru
- Marcus Dörr
- Marcus E. Kleber
- Marcus Fischer
- Margaret M. Redfield
- Margherita Cavalieri
- Margot Haun
- Margus Viigimaa
- Maria Blettner
- Maria Soler Artigas
- Marie Metzger
- Marilyn C. Cornelis
- Marina Ciullo
- Mario A. Morken
- Mario Pirastu
- Maris Laan
- Mariza de Andrade
- Marjo-Riitta Jarvelin
- Mark A. McEvoy
- Mark Hlatky
- Mark J. Caulfield
- Mark Lathrop
- Mark Seielstad
- Mark Woodward
- Marketa Sjögren
- Markku Laakso
- Markus Perola
- Martin Adam
- Martin D. Tobin
- Martin Farrall
- Martin G. Larson
- Mary F. Feitosa
- Mary Susan Burnett
- Masato Isono
- Massimiliano Cocca
- Massimo Mangino
- Mathias Gorski
- Matthew Denniff
- Matthew N. Cooper
- Matthias Nauck
- Matthias Olden
- Max C. Walker
- Medea Imboden
- Meena Kumari
- Megan E. Rudock
- Melanie Waldenberger
- Melissa Garcia
- Menno Pruijm
- Meredith Foster
- Michael Boehnke
- Michael G. Marmot
- Michael M. Hoffmann
- Michael Nalls
- Michael Preuss
- Michael Stumvoll
- Michele K. Evans
- Michele M. Sale
- Michiaki Kubo
- Michiel L. Bots
- Mika Kivimaki
- Mika Kähönen
- Min Jin Go
- Ming-Huei Chen
- Mingyao Li
- Mladen Boban
- Morris J. Brown
- Muhammad Islam
- Muredach P Reilly
- Murielle Bochud
- Myriam Alexander
- Myriam Rheinberger
- N. Charlotte Onland-Moret
- Nabila Bouatia-Naji
- Najaf Amin
- Nanette I. Steinle
- Nanette R. Lee
- Naoharu Iwai
- Naoyuki Kamatani
- Narisu Narisu
- Neil Risch
- Nele Friedrich
- Nicholas G. Martin
- Nicholas J. Wareham
- Nicholas L. Smith
- Nicholette D. Palmer
- Nick Hastie
- Nick R. G. Shrine
- Nicole L. Glazer
- Nicole Probst-Hensch
- Nicole Soranzo
- Niek Verweij
- Nilesh J. Samani
- Nish Chaturvedi
- Noel Burtt
- Norbert Watzinger
- Norihiro Kato
- Norman Klopp
- null null
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- null null
- Olga Jarinova
- Olivier Devuyst
- Olle Melander
- Olli Raitakari
- Omri Gottesman
- Oscar H. Franco
- Ozren Polasek
- Paavo Zitting
- Pankaj Arora
- Pankaj Sharma
- Panos Deloukas
- Paolo Gasparini
- Paolo Vineis
- Patricia B. Munroe
- Patricia P. Chang
- Patrick Diemert
- Patrick Linsel-Nitschke
- Paul Elliott
- Paul F. O’Reilly
- Paul M. Ridker
- Paul Mitchell
- Paul Muntner
- Paul R. Burton
- Pavel Hamet
- Peng Chen
- Peter E. H. Schwarz
- Peter H. Whincup
- Peter J. van der Most
- Peter Kovacs
- Peter Nilsson
- Peter P. Pramstaller
- Peter S. Braund
- Peter Vollenweider
- Petra Bruse
- Philip Howard
- Philipp S. Wild
- Philippa J. Talmud
- Philippe Froguel
- Pierre Meneton
- Pilar Galan
- Pim van der Harst
- Pio d’Adamo
- Qiong Yang
- Rainer Rettig
- Ramachandran S. Vasan
- Rebecca Hardy
- Reedik Mägi
- Reijo Laaksonen
- Reiner Biffar
- Reinhold Schmidt
- Renate Schnabel
- Richard J. Rodeheffer
- Richard Myers
- Richard N. Bergman
- Richard S. Cooper
- Richard W. Morris
- RickTwee-Hee Ong
- Rita P. S. Middelberg
- Robert Clarke
- Robert J. Carroll
- Robert Roberts
- Robert W. Lawrence
- Robert Wilensky
- Robert Zweiker
- Roberto Elosua
- Rodney J. Scott
- Ron Waksman
- Ronit Katz
- Rory Collins
- Rossella Sorice
- Ruth J. F. Loos
- Ruth McPherson
- S. -J. Cathy Fann
- Samer Najjar
- Sanaz Sedaghat
- Sanjay Kinra
- Santhi K. Ganesh
- Santosh Dahgam
- Sarah H. Wild
- Satoshi Umemura
- Sekar Kathiresan
- Serge Hercberg
- Serkalem Demissie-Banjaw
- Sharon L. R. Kardia
- Sheila Ulivi
- Shih-Jen Hwang
- Shiro Maeda
- Shufeng Chen
- Siim Sõber
- Simon Heath
- Simonetta Guarrera
- Smita R. Kulkarni
- Solveig Gretarsdottir
- Sonny Dandona
- Stacey B. Gabriel
- Stefan Blankenberg
- Stefan Coassin
- Stefan Enroth
- Stefan Kloiber
- Stefan Pilz
- Stefan R. Bornstein
- Stefan Schreiber
- Stefan-Martin Brand
- Stefania Bandinelli
- Stella Trompet
- Stephan B. Felix
- Stephan J. L. Bakker
- Stephen E. Epstein
- Stephen Fortmann
- Stephen G. Ball
- Stephen J. Hancock
- Stephen T. Turner
- Steve E. Humphries
- Steven C. Hunt
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- Su-Chi Lim
- Sudha Seshadri
- Sue Shaw-Hawkins
- Susan R. Heckbert
- Susana Eyheramendy
- Sven Bergmann
- Sylvia E. Rosas
- Sylvia Stracke
- Takayoshi Ohkubo
- Talin Haritunians
- Tamara B. Harris
- Tanja B. Grammer
- Tanja Zeller
- Tatiana Kuznetsova
- Tatijana Zemunik
- Tatjana Stojakovic
- Tatsuhiko Tsunoda
- Tazeen H. Jafar
- Terho Lehtimäki
- Terrence Forrester
- Terri L. Young
- Tetsuro Miki
- Themistocles L. Assimes
- Thomas F. Münzel
- Thomas H. Mosley
- Thomas Illig
- Thomas J. Wang
- Thomas Lumley
- Thomas Meitinger
- Thomas Quertermous
- Thor Aspelund
- Thorsten Reffelmann
- Tien-Yin Wong
- Tiit Nikopensius
- Tim D. Spector
- Timothy M. Frayling
- Tin Aung
- Toby Johnson
- Tom R. Gaunt
- Tomohiro Katsuya
- Tomonori Okamura
- Tonu Esko
- Toshihiro Tanaka
- Toshiko Tanaka
- Toshio Ogihara
- Tunde Salako
- Tune H. Pers
- Ulf Gyllensten
- Unnur Thorsteinsdottir
- Uwe Völker
- Valur Emilsson
- Vasyl Pihur
- Veikko Salomaa
- Veronique Vitart
- Vikal Tripathy
- Ville Aalto
- Vilmundur Gudnason
- Vincent Chouraki
- Vincent Mooser
- Viviane Nicaud
- Vladan Mijatovic
- W. H. Linda Kao
- Walter Palmas
- Wayne D. Rosamond
- Wei-Min Chen
- Weihua Zhang
- Wendy L. McArdle
- Wiek H. van Gilst
- Wilfried Renner
- Will T. Longstreth
- William Matthai
- Wilmar Igl
- Winfried März
- Wolfgang Koenig
- Wolfgang Lieb
- Wolfram Goessling
- Xiaofeng Zhu
- Xiaoling Wang
- Xiuqing Guo
- Xueling Sim
- Yali Li
- Yan V. Sun
- Yanbin Dong
- Yasuharu Tabara
- Yen-Pei C. Chang
- Yi-An Ko
- Yik-Ying Teo
- Ying A. Wang
- Ying Wu
- Yingchang Lu
- Yong Li
- Yongmei Liu
- Yoon Shin Cho
- Yoshikuni Kita
- Young Jin Kim
- Yuan-Tsong Chen
- Yukinori Okada
- Yuri Milaneschi
- Yurii Aulchenko
- Yusuke Nakamura
- Yvonne T. van der Schouw
- Zouhair Aherrahrou
- Åsa Johansson
- Publication venue
- Springer Nature America, Inc
- Publication date
- 27/10/2015
- Field of study
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways
Genetic studies of body mass index yield new insights for obesity biology
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- Abecasis G. R.
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- Xie C.
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- Yao J.
- Yee J.
- Yengo L.
- Yerges-Armstrong L. M.
- Young A.
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- Young L.
- Zaboli G.
- Zalloua P. A.
- Zanen P.
- Zelenika D.
- Zemunik T.
- Zerbini G.
- Zgaga L.
- Zhai G.
- Zhang F.
- Zhang Q.
- Zhang W.
- Zhao J. H.
- Zhao W.
- Zheng W.
- Zhu H.
- Zhu X.
- Zhuang W. V.
- Ziegler A.
- Zillikens M. C.
- Zimmermann M. E.
- Zitting P.
- Zondervan K. T.
- Zonzin P.
- Zukowska-Szczechowska E.
- Zygmunt M.
- Ärnlöv J.
- Österholm A. M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10 -8 ), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis
Veränderungen, die außerhalb des milchproduzierenden/-ableitenden Systems entstehen
- Author
- A Barth
- A Bruwer
- A Böger
- A Coarasa-Cerdán
- A Fletcher
- A Gerlach
- A Hackl
- A Heinig
- A Stacey-Clear
- A Taghian
- A Vargas
- A Wijnmaalen
- AB Ackerman
- AB Redfern
- AE Giuliano
- AE Giuliano
- AH Chevinsky
- AH Pollack
- AJ Leibman
- AJ Sherman
- AL Belton
- AM Kligman
- AM Neville
- AM Pluchinotta
- AN Wilkes
- AP Gallimore
- AT Sandisen
- B Byrd
- B Eisner
- B Fisher
- B Katzer
- B Katzer
- BA Donaldson
- BB Nielson
- BD Coley
- BD Toombs
- BF Coughlin
- BG Silverman
- BM Egbert
- C Anderson
- C Diederich
- C Glanzmann
- C Gries
- C Kujat
- C Singer
- C Thiels
- C Toker
- C Yuehan
- CA Britton
- CD Haagensen
- CD Haagensen
- CD Korbin
- CDM Fletcher
- CG Cederlund
- CI Caskey
- CJ Markopoulos
- CL Harlow
- CL Shapiro
- CM Powell
- CM Wilson
- CN Schremmer
- CR Varin
- CW Elston
- CW Piccoli
- CW Wiliams
- CY Ahn
- D Hamele-Bena
- D Kirsby
- D Krag
- D Makanjuola
- DB Jones
- DB Kopans
- DB Kopans
- DD Dershaw
- DD Dershaw
- DD Paulus
- DD Paulus
- DE Barker
- DE March
- DL Camara de
- DL Monticciolo
- DM Ikeda
- DM Millar
- DV Habif
- E Kessler
- E Makai
- E Samuel
- E Schwarz
- EA Sickles
- EF Conant
- EJ Cornford
- EJ Domanskis
- EL Rosen
- EL Schmitt
- ES Wargotz
- ES Wargotz
- ES Wargotz
- F Ortiz-Monasterio
- F Osmers
- F Wegener
- F Zandrino
- FA Pameijer
- FA Tavassoli
- FE Gump
- FI Jackson
- FJ Hernandez
- FJ Shuler
- FK Beller
- FM Enzinger
- FM Hall
- FO Huhn
- FP Weber
- G Cardenosa
- G Heede
- G Hermann
- G Herrmann
- G Liszka
- G Liszka
- G Ott
- G Pettinato
- G Pettinato
- G Svane
- G Viale
- GA Beyer
- GA Timberlake
- GF Maillard
- GL Dunnington
- GM Rothman
- GW Carlson
- GW Eklund
- GW Geelhoed
- H Bryant
- H Charache
- H Cremer
- H Daschner
- H Eichner
- H Eichner
- H Hamperl
- H Hamperl
- H Hirmand
- H Ingleby
- H Kalbfleisch
- H Lüchtrath
- H Minagi
- H Noack
- H Pambakian
- H Stein
- HA Christian
- HC Burrell
- HD Böttcher
- HE Reynolds
- HG Strauß
- HH Mertens
- HJ Hahn
- HJ Schmidt-Hermes
- HJ Son
- HK Deininger
- I Andersson
- J Bernhards
- J Gershon-Cohen
- J Lammer
- J Mester
- J Müller-Quernheim
- J Ordi
- J Patel
- J Smahel
- J Teubner
- J Yahalom
- JA Hale
- JD Gorman
- JE Berkowitz
- JE Meyer
- JE Tomaszewski
- JG Azzopardi
- JG Lorigan
- JH Langkowski
- JH Scholefield
- JK Baum
- JL Puente
- JM Buatti
- JM Destouet
- JM Jordan
- JM Kemmeren
- JM Radhi
- JR Bernstein
- JR Castelló
- JR Harris
- JR Zack
- JS Greenberg
- JS Mitnick
- JS Suen
- JW Berg
- JW Odom
- JWT Muller
- K Bork
- K Dowlatshahi
- K Döinghaus
- K Goerke
- K Hergan
- K Hergan
- K Holzegel
- K Lendvai-Virágh
- K Lendvai-Virágh
- K Ludwig
- K Usuki
- K Wilhelm
- KA Hultborn
- KF Koschnick
- KH Fye
- KH Perzin
- KK Lindfors
- KL Cook
- KM McMasters
- KP Hunfeld
- KP Hunfeld
- KP Hunfeld
- KTK Chen
- KTK Chen
- L Apesteguía
- L Barnes
- L Bieringer
- L Kalisher
- L Leger
- L Liberman
- L Liberman
- L Mastro Del
- L Molnar
- L Ozzello
- L Tabàr
- LA Brinton
- LA Venta
- LE Albertyn
- LG Bohman
- LI Alpert
- LI Everson
- LK Marchant
- LL Liberman
- LL Tuthill
- LW Bassett
- LW Bassett
- M Ali
- M Bircoll
- M Bodó
- M Bünning
- M Copeland
- M Friedrich
- M Friedrich
- M Hartstein
- M Helmer
- M Julien
- M Lanyi
- M Lanyi
- M Lefkowitz
- M Morgen
- M Nayar
- M Oimomi
- M Pamilo
- M Petit
- M Rebner
- M Rothmann
- M Sklair-Levy
- M Zwaan
- M Zwaan
- MA Cohen
- MA Helvie
- MA Polger
- MAR Moreira
- MB Amin
- MB McSweeney
- ME Kehoe
- ME Murray
- ME Reitz
- MF Vuitch
- MH Mondor
- MJ Homer
- MJ Kints van
- MJ Ross
- MK Shetty
- MM Kemeny
- MP Foschini
- MP Stokkel
- MS Soo
- MS Soo
- MS Soo
- MS Soo
- MW Greenberg
- MW Jones
- N Barros de
- N Bjurstam
- N Ellerbroek
- N Fiessinger
- NA Courcoutsakis
- NC Mambo
- NG Soler
- NP Smith
- OG Robinson
- P Citoler
- P Hajek
- P Pohl
- P Springer
- P Veronesi
- PB Rosen
- PD Waterworth
- PDC Broks
- PE Nylander
- PH Wiernik
- PI Liu
- PJ DiPiro
- PJ Kragel
- PL Fitzgibbons
- PL Fitzgibbons
- PM Camuto
- PM Royen
- PP Rosen
- PP Rosen
- PP Rosen
- PP Rosen
- PR Studdy
- R Bässler
- R Bässler
- R Bässler
- R Bässler
- R Bässler
- R Eulenburg
- R Freitas De
- R Gersuny
- R Glauner
- R Hooley
- R Leborgne
- R Leborgne
- R Leborgne
- R Moncada
- R Mulcare
- R Novak
- R Walsh
- R Zucali
- RA Beres
- RB Crosbie
- RB Duda
- RB Noone
- RC Haggitt
- RE Ibrahim
- RI Egan
- RL Ellis
- RM Donnell
- RM Treeck
- RO Hickman
- RS Boova
- RS Pascual
- RW Parsons
- S Bergonzi
- S Bianchi
- S Catania
- S Jaffer
- S Kurul
- S Laifer
- S Pilnik
- S Rühm
- SA North
- SA Silver
- SC Harvey
- SG Pollard
- SH Heywang-Köbrunner
- SI Hajdu
- SK Suneja
- SL Hancock
- SL Leal
- SM Smith
- SN Georgiannos
- SP Davies
- SP Roux
- SS Linden
- ST Jewett
- SY Chung
- T Becker
- T Cholnoky De
- T Decho
- T Decho
- T Diaz-Bustamente
- T Koide
- T Kühn
- T Lendvai
- T Leonhardt
- T Löwhagen
- TCB Dehn
- TJ Barloon
- TL Péntek
- TR Carter
- TT Alagaratnam
- TT Huang
- TW Pettinger
- U Fischer
- U Göbel
- UN Riede
- UN Riede
- V Barth
- V Misgeld
- V Pfeifer
- VP Jackson
- W Bain
- W Bartlett
- W Golder
- W Hoeffken
- W Hoeffken
- W Künzel
- W Peters
- W Peters
- W Simon
- W Undeutsch
- W Westinghouse-Logan
- WA Berg
- WA Berg
- WD Schönegg
- WM Hanna
- WS Johnson
- WS Symmers
- WT Yang
- WT Yang
- WT Yang
- WV Bogomoletz
- Y Inoue
- Y Nagashima
- Y Rosen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2003
- Field of study
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- Author
- Aalto Ville
- Abecasis Goncalo R
- Absher Devin
- Ackermann Daniel
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Aherrahrou Zouhair
- Albrecht Eva
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Andersen Karl
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- Uitterlinden André G.
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- Werdan Karl
- Whincup Peter H
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- Wichmann H-Erich
- Wiggins Kerri L
- Wild Philipp S
- Wild Sarah H
- Wilensky Robert
- Willenborg Christina
- Willerson James T
- Wilson James F
- Winkelmann Bernhard R
- Winkler Karl
- Witteman Jacqueline CM
- Wong Andrew
- Wong Tien-Yin
- Woodward Mark
- Wright Alan F.
- Wright Benjamin J
- Wu Jer-Yuarn
- Wu Ying
- Yajnik Chittaranjan S
- Yamamoto Kazuhiko
- Yang Qiong
- Yao Jie
- Yengo Loic
- Young JH
- Young Terri L
- Zelenika Diana
- Zeller Tanja
- Zemunik Tatijana
- Zhai Guangju
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Ziegler Andreas
- Zitting Paavo
- Zonderman Alan B.
- Zukowska-Szczechowska Ewa
- Zweiker Robert
- Publication venue
- 'Nature Research Society'
- Publication date
- 01/01/2016
- Field of study
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways
Genetic studies of body mass index yield new insights for obesity biology
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- Abecasis GR
- Abecasis Gonçalo R.
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- Wojczynski Mary K.
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- Workalemahu Tsegaselassie
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- Zhang Qunyuan
- Zhang Weihua
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- Zhao Jing Hua
- Zhao Wei
- Zheng W
- Zheng Wei
- Zhu H
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- Zhuang WV
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- Ziegler A
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- Zillikens M. Carola
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- Ärnlöv J
- Ärnlöv Johan
- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p