267 research outputs found
Persistent hyperprolactinemia and bilateral galactocele in a male infant: case report
Galactocele is a benign breast lesion, usually occurring in nursing women. This lesion is a rare cause of breast enlargement in
children. In this paper we describe the case of an infant with hyperprolactinemia (which persisted throughout 15 years of clinical
observation) and bilateral galactocele.We speculate that a congenital midline defect in our patient might have impaired the normal
dopaminergic inhibitory tone on pituitary lactotroph cells, thus leading to an increased prolactin secretion by the pituitary gland;
this, in turn, might have favored the development of the galactocele
Persistent Hyperprolactinemia and Bilateral Galactocele in a Male Infant
Galactocele is a benign breast lesion, usually occurring in nursing women.
This lesion is a rare cause of breast enlargement in children. In this paper we describe
the case of an infant with hyperprolactinemia (which persisted throughout 15 years of
clinical observation) and bilateral galactocele. We speculate that a congenital midline defect in our patient might have impaired the normal dopaminergic inhibitory tone on pituitary lactotroph cells, thus leading to an increased prolactin secretion by the pituitary gland; this, in turn, might have favored the development of the galactocele
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Delays in completion and results reporting of clinical trials under the Paediatric Regulation in the European Union: A cohort study
Background: Few medicines have been approved for children, leading to rates of off-label prescribing reported to be as high as 90%. In 2007, the European Union adopted the Paediatric Regulation, which mandates that pharmaceutical companies conduct paediatric studies for all new medicines, unless granted a waiver. We aimed to evaluate the availability of paediatric trial results from studies required under the Paediatric Regulation for new medicines authorised in the EU. Methods and findings The European Medicines Agency (EMA) public database of paediatric investigation plans was searched for new medicines centrally authorised in the EU between 1 January 2010 and 31 December 2014 with at least 1 required paediatric study. For our study cohort of paediatric clinical trials required for these medicines, we used internal EMA databases and publicly available trial registries to determine changes to the planned completion date or study design, rates of trial completion, time to trial completion, and results reporting (peer-reviewed publication or posting on trial registry). Cox proportional hazards regression models were constructed to examine factors associated with study completion. A total of 326 paediatric clinical trials were required for 122 novel medicines authorised by the EMA between 2010 and 2014. In all, 76% (247/326) of paediatric studies were not planned to be completed until after the initial marketing authorisation. The planned completion dates for 50% (162/326) were further postponed by a median of 2.2 years. Overall, 38% (124/326) of paediatric studies were completed as of 30 November 2017. The rate of trial completion for paediatric studies planned to be completed after initial marketing authorisation was 23% (56/247), versus 86% (68/79) for trials planned to be completed before authorisation (adjusted hazard ratio 0.11; 95% CI 0.06–0.19). Among completed studies, the results were reported in a public registry or in the peer-reviewed literature for 85% (105/124) at a median of 1.1 years after study completion, and 60% (74/124) were published in a peer-reviewed journal. Limitations of this study include the potential lack of generalisability to medicines not authorised by the EMA and the possibility for more of these trials to be completed or published in the future. Conclusions: The completion of many paediatric studies required under the Paediatric Regulation has been delayed. Paediatric studies planned to be completed after marketing authorisation were associated with a lower likelihood of eventual completion, highlighting the need to examine the implementation of current policies in ensuring timely availability of important paediatric information
The Effect of Obesity Management on Body Image in Patients Seeking Treatment at Medical Centers
treatment-
seeking patients with obesity. We aimed to investigate
the effects of obesity management on body image in patients
with obesity attending Italian medical centers for
weight loss programs.
Research Methods and Procedures: A total of 473 obese
patients seeking treatment in 13 Italian medical centers
(80% females; age, 45.9 standard deviation 11.0 years;
BMI, 36.8 5.7 kg/m2) were evaluated at baseline and after
a 6-month weight loss treatment. Body uneasiness, psychiatric
distress, and binge eating were tested by Body Uneasiness
Test (BUT, Part A), Symptom CheckList-90 (SCL-
90), and Binge Eating Scale (BES), respectively.
Results: At 6-month follow-up, the percentage weight loss
was significantly higher in men (9.0 6.3%) than in
women (6.8 7.3%; p 0.010). Both men and women had
a significant improvement in BUT Global Severity Index
and in all of the BUT subscales with the exception of the
Compulsive Self-Monitoring subscale. Linear regression
analysis selected baseline psychological and behavioral
measures (global score of BUT and SCL-90) and improved
psychiatric distress and binge eating as independent predictors
of changes in basal body dissatisfaction in females,
whereas in males, changes were associated only with baseline
BUT-Global Severity Index score, binge eating, and its
treatment-associated improvement. Pre-treatment BMI and
BMI changes did not enter the regression.
Discussion: Obesity treatment, even with a modest degree
of weight loss, is associated with a significant improvement
of body image, in both females and males. This effect
depends mainly on psychological factors, not on the amount
of weight loss
Biostimulant Action of Dissolved Humic Substances From a Conventionally and an Organically Managed Soil on Nitrate Acquisition in Maize Plants
Conversion of conventional farming (CF) to organic farming (OF) is claimed to allow a sustainable management of soil resources, but information on changes induced on dissolved organic matter (DOM) are scarce. Among DOM components, dissolved humic substances (DHS) were shown to possess stimulatory effects on plant growth. DHS were isolated from CF and OF soil leacheates collected from soil monolith columns: first in November (bare soils) and then in April and June (bare and planted soils). DHS caused an enhancement of nitrate uptake rates in maize roots and modulated several genes involved in nitrogen acquisition. The DHS from OF soil exerted a stronger biostimulant action on the nitrate uptake system, but the first assimilatory step of nitrate was mainly activated by DHS derived from CF soil. To validate the physiological response of plants to DHS exposure, real-time RT-PCR analyses were performed on those genes most involved in nitrate acquisition, such as ZmNRT2.1, ZmNRT2.2, ZmMHA2 (coding for two high-affinity nitrate transporters and a PM H+-proton pump), ZmNADH:NR, ZmNADPH:NR, and ZmNiR (coding for nitrate reductases and nitrite reductase). All tested DHS fractions induced the upregulation of nitrate reductase (NR), and in particular the OF2 DHS stimulated the expression of both tested transcripts encoding for two NR isoforms. Characteristics of DHS varied during the experiment in both OF and CF soils: a decrease of high molecular weight fractions in the OF soil, a general increase in the carboxylic groups content, as well as diverse structural modifications in OF vs. CF soils were observed. These changes were accelerated in planted soils. Similarity of chemical properties of DHS with the more easily obtainable water-soluble humic substance extracted from peat (WEHS) and the correspondence of their biostimulant actions confirm the validity of studies which employ WEHS as an easily available source of DHS to investigate biostimulant actions on agricultural crops
The role of ICTs and public-private cooperation for cultural heritage tourism. The case of Smart Marca / Il ruolo delle ICT e della cooperazione pubblico-privati per il turismo culturale. Il caso di Smart Marca
This paper analyzes the opportunities related to public-private cooperation for the implementation of information communication technologies (ICTs) to promote cultural heritage tourism. After a literature review on the role of cooperation between private and public sectors and the most relevant information communication technologies (ICTs) for the promotion of cultural heritage, the analysis moves to travel apps, by illustrating features, main trends and some applications of this technology to cultural heritage and tourism. In the second part, the connection between tourism, cultural heritage and digital technologies is analyzed through the description of Smart Marca app, which, starting from the cooperation between local public and private entities, exploited ICTs to promote cultural tourism in Fermo area (Marche Region, Italy).  Il contributo analizza le potenzialità della cooperazione pubblico-privata nella progettazione e realizzazione di nuove tecnologie dell’informazione (ICT) per la promozione del turismo del patrimonio culturale. Dopo una rassegna della letteratura dedicata al ruolo della collaborazione tra pubblico e privato e delle ICT per la promozione del patrimonio culturale e lo sviluppo turistico di un territorio, l’articolo focalizza l’attenzione sulle applicazioni mobili di viaggio, illustrandone trend e caratteristiche, nonché alcuni esempi di applicazione di questa tecnologia al patrimonio culturale e al turismo. Nella seconda parte, la connessione tra turismo, patrimonio culturale e ICT viene analizzata attraverso la descrizione dell’app Smart Marca, che, a partire dalla cooperazione tra enti pubblici e attori privati, ha utilizzato le nuove tecnologie per promuovere il turismo culturale nel territorio fermano (Regione Marche, Italia)
Artificial Intelligence-suggested Predictive Model of Survival in Patients Treated With Stereotactic Radiotherapy for Early Lung Cancer
Background/aim: Overall survival (OS)-predictive models to clinically stratify patients with stage I Non-Small Cell Lung Cancer (NSCLC) undergoing stereotactic body radiation therapy (SBRT) are still unavailable. The aim of this work was to build a predictive model of OS in this setting. Patients and methods: Clinical variables of patients treated in three Institutions with SBRT for stage I NSCLC were retrospectively collected into a reference cohort A (107 patients) and 2 comparative cohorts B1 (32 patients) and B2 (38 patients). A predictive model was built using Cox regression (CR) and artificial neural networks (ANN) on reference cohort A and then tested on comparative cohorts. Results: Cohort B1 patients were older and with worse chronic obstructive pulmonary disease (COPD) than cohort A. Cohort B2 patients were heavier smokers but had lower Charlson Comorbidity Index (CCI). At CR analysis for cohort A, only ECOG Performance Status 0-1 and absence of previous neoplasms correlated with better OS. The model was enhanced combining ANN and CR findings. The reference cohort was divided into prognostic Group 1 (0-2 score) and Group 2 (3-9 score) to assess model's predictions on OS: grouping was close to statistical significance (p=0.081). One and 2-year OS resulted higher for Group 1, lower for Group 2. In comparative cohorts, the model successfully predicted two groups of patients with divergent OS trends: higher for Group 1 and lower for Group 2. Conclusion: The produced model is a relevant tool to clinically stratify SBRT candidates into prognostic groups, even when applied to different cohorts. ANN are a valuable resource, providing useful data to build a prognostic model that deserves to be validated prospectively
Star-Related Lipid Transfer Protein 10 (STARD10): A Novel Key Player in Alcohol-Induced Breast Cancer Progression
Background: Ethanol abuse promotes breast cancer development, metastasis and recurrence stimulating mammary tumorigenesis by mechanisms that remain unclear. Normally, 35% of breast cancer is Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2)-positive that predisposes to poor prognosis and relapse, while ethanol drinking leads to invasion of their ERBB2 positive cells triggering the phosphorylation status of mitogen-activated protein kinase. StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. Interestingly, STARD10 has been described to be highly expressed in 35–40% of ERBB2-positive breast cancers. In this study, we demonstrate that ethanol administration promotes STARD10 and ERBB2 expression that is significantly associated with increased cell malignancy and aggressiveness.
Material and methods: We investigated the effect of ethanol on STARD10-ERBB2 cross-talk in breast cancer cells, MMTV-neu transgenic mice and in clinical ERBB2-positive breast cancer specimens with Western Blotting and Real-time PCR. We also examined the effects of their knockdown and overexpression on transient transfected breast cancer cells using promoter activity, MTT, cell migration, calcium and membrane fluidity assays in vitro.
Results: Ethanol administration induces STARD10 and ERBB2 expression in vitro and in vivo. ERBB2 overexpression causes an increase in STARD10 expression, while overexpression of ERBB2’s downstream targets, p65, c-MYC, c-FOS or c-JUN induces STARD10 promoter activity, correlative of enhanced ERBB2 function. Ethanol and STARD10-mediated cellular membrane fluidity and intracellular calcium concentration impact ERBB2 signaling pathway as evaluated by enhanced p65 nuclear translocation and binding to both ERBB2 and STARD10 promoters.
Conclusion: Our finding proved that STARD10 and ERBB2 positively regulate each other’s expression and function. Taken together, our data demonstrate that ethanol can modulate ERBB2’s function in breast cancer via a novel interplay with STARD10
REducing INFectiOns thRough Cardiac device Envelope: insight from real world data. The REINFORCE Project
Background: Infections resulting from cardiac implantable electronic device (CIED) implantation are severely impacting on patients' and on health care systems. The use of TYRXTM absorbable antibiotic-eluting envelope has proven to decrease major CIED infections within 12 months of CIED surgery. Aims: to evaluate the impact of the envelope use on infection-related clinical events in a real-world contemporary patient population. Methods: Data on patients undergoing CIED surgery were collected prospectively by participating centers of the One Hospital ClinicalService project. Patients were divided into two groups according to whether TYRXTM absorbable antibiotic-eluting envelope was used or not. Results: Out of 1819 patients, 872 (47.9%) were implanted with an absorbable antibiotic-eluting envelope and included in the Envelope group and 947 (52.1%) patients who did not receive an envelope were included in the Control group. Compared to control, patients in the Envelope group had higher thrombo-embolic or hemorrhagic risk, higher BMI, lower LVEF and more comorbidities. During a mean follow-up of 1.4 years, the incidence of infection-related events was significantly higher in the control compared to the Envelope group (2.4% vs 0.8%, p = 0.007). The 5-year cumulative incidence of infection-related events was 8.1% in the control and 2.1% in the Envelope group (HR: 0.34, 95%CI: 0.14-0.80, p = 0.010). Conclusions: In our analysis, the use of an absorbable antibiotic-eluting envelope in the general CIED population was associated with a lower risk of systemic and pocket infection
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