Autonomous Systems as Legal Agents: Directly by the Recognition of Personhood or Indirectly by the Alchemy of Algorithmic Entities

The clinical manifestations of platelet dense (δ) granule defects are easy bruising, as well as epistaxis and bleeding after delivery, tooth extractions and surgical procedures. The observed symptoms may be explained either by a decreased number of granules or by a defect in the uptake/release of granule contents. We have developed a method to study platelet dense granule storage and release. The uptake of the fluorescent marker, mepacrine, into the platelet dense granule was measured using flow cytometry. The platelet population was identified by the size and binding of a phycoerythrin-conjugated antibody against GPIb. Cells within the discrimination frame were analysed for green (mepacrine) fluorescence. Both resting platelets and platelets previously stimulated with collagen and the thrombin receptor agonist peptide SFLLRN was analysed for mepacrine uptake. By subtracting the value for mepacrine uptake after stimulation from the value for uptake without stimulation for each individual, the platelet dense granule release capacity could be estimated. Whole blood samples from 22 healthy individuals were analysed. Mepacrine incubation without previous stimulation gave mean fluorescence intensity (MFI) values of 83±6 (mean ± 1 SD, range 69–91). The difference in MFI between resting and stimulated platelets was 28±7 (range 17–40). Six members of a family, of whom one had a known δ-storage pool disease, were analysed. The two members (mother and son) who had prolonged bleeding times also had MFI values disparate from the normal population in this analysis. The values of one daughter with mild bleeding problems but a normal bleeding time were in the lower part of the reference interval

Domain-wall coercivity in ferromagnetic systems with nonuniform local magnetic field

Domain-wall (DW) coercive field, H-CW, which characterizes pinning of DW's in soft magnetic materials, decreases strongly with increasing value of gradient, G, of the effective local DW-position-restoring magnetic field. Particular shapes of the dependence, H-CW(G), can be calculated from the mean energy dissipation of the DW moving over the particular profile of the DW pinning field, H-p. In this paper, H-CW(G) is calculated from a wall-pinning field, H-p, which is expressed as a stochastic function of the DW coordinate, x(DW). The wall-pinning field, H-p, is described as a Wiener-Levy stochastic process modified by two correlation lengths in such a way that H-p is stationary for large DW displacements and dH(p) /dx(DW) is well defined for small DW displacements. The computed H-CW(G) is close to a hyperbolic decrease, but it approaches finite values if G-->O and it decreases in a much steeper way than alpha 1/G for high values of G, which agrees with the experimental observations. Experimentally, the dependence H-CW(G) was measured on close-packed arrays of cylindrical bubble domains in two thin films of magnetic garnets, where the local field gradient, G, was controlled within the range 10(9)-10(10) A/m(2) by changing distances between neighboring DW's. The DW coercive field, H-CW, extrapolated from the measured values for G-->O was close to 80 A/m for both samples, while H-CW(G approximate to 10(10) A/m(2)) was several times smaller. Fitting the calculated H-CW(G) dependence to the experimental data, we obtained values of the Wiener-Levy correlation lengths well comparable to the DW width parameters

Disease Complementarities and the Evaluation of Public Health Interventions

This paper provides a theoretical and empirical investigation of the positive complementarities between disease-specific policies introduced by competing risks of mortality. The incentive to invest in prevention against one cause of death depends positively on the level of survival from other causes. This means that a specific public health intervention has benefits other than the direct medical reduction in mortality: it affects the incentives to fight other diseases so the overall reduction in mortality will, in general, be larger than that predicted by the direct medical effects. We discuss evidence of these cross-disease effects by using data on neo-natal tetanus vaccination through the Expanded Programme on Immunization of the World Health Organization.

Spectrum of Andreev Bound States in a Molecule Embedded Inside a Microwave-Excited Superconducting Junction

Non-dissipative Josephson current through nanoscale superconducting constrictions is carried by spectroscopically sharp energy states, so-called Andreev bound states. Although theoretically predicted almost 40 years ago, no direct spectroscopic evidence of these Andreev bound states exists to date. We propose a novel type of spectroscopy based on embedding a superconducting constriction, formed by a single-level molecule junction, in a microwave QED cavity environment. In the electron-dressed cavity spectrum we find a polariton excitation at twice the Andreev bound state energy, and a superconducting-phase dependent ac Stark shift of the cavity frequency. Dispersive measurement of this frequency shift can be used for Andreev bound state spectroscopy.Comment: Published version; 4+ pages, 3 figure

Myopic loss aversion under ambiguity and gender effects

Experimental evidence suggests that the frequency with which individuals get feedback information on their investments has an effect on their risk-taking behavior. In particular, when they are given information sufficiently often, they take less risks compared with a situation in which they are informed less frequently. We find that this result still holds when subjects do not know the probabilities of the lotteries they are betting upon. We also detect significant gender effects, in that the frequency with which information is disclosed mostly affects male betting behavior, and that males become more risk-seeking after experiencing a loss

Charge Hall effect driven by spin-dependent chemical potential gradients and Onsager relations in mesoscopic systems

We study theoretically the spin-Hall effect as well as its reciprocal phenomenon (a transverse charge current driven by a spin-dependent chemical potential gradient) in electron and hole finite size mesoscopic systems. The Landauer-Buttiker-Keldysh formalism is used to model samples with mobilities and Rashba coupling strengths which are experimentally accessible and to demonstrate the appearance of measurable charge currents induced by the spin-dependent chemical potential gradient in the reciprocal spin-Hall effect. We also demonstrate that within the mesoscopic coherent transport regime the Onsager relations are fulfilled for the disorder averaged conductances for electron and hole mesoscopic systems.Comment: 5 pages, 6 figures, typos correcte

Phase Modulated Thermal Conductance of Josephson Weak Links

We present a theory for quasiparticle heat transport through superconducting weak links. The thermal conductance depends on the phase difference ($\phi$) of the superconducting leads. Branch conversion processes, low-energy Andreev bound states near the contact and the suppression of the local density of states near the gap edge are related to phase-sensitive transport processes. Theoretical results for the influence of junction transparency, temperature and disorder, on the phase modulation of the conductance are reported. For high-transmission weak links, $D\to 1$, the formation of an Andreev bound state at $\epsilon_{\text{\tiny b}}=\Delta\cos(\phi/2)$ leads to suppression of the density of states for the continuum excitations that transport heat, and thus, to a reduction in the conductance for $\phi\simeq\pi$. For low-transmission ($D\ll 1$) barriers resonant scattering at energies $\epsilon\simeq(1+D/2)\Delta$ leads to an increase in the thermal conductance as $T$ drops below $T_c$ (for phase differences near $\phi=\pi$).Comment: 4 pages, 3 figures Expanded discussion of boundary conditions for Ricatti amplitude