822 research outputs found
Time variations in the deep underground muon flux
More than 35 million high-energy muons collected with the MACRO detector at
the underground Gran Sasso Laboratory have been used to search for flux
variations of different nature. Two kinds of studies were carried out: a search
for the occurrence of clusters of events and a search for periodic variations.
Different analysis methods, including the Scan Statistics test and the
Lomb-Scargle spectral analysis have been applied to the data.Comment: 7 pages, 5 figures, accepted by EP
Applications of polymerized metal tetra-amino phthalocyanines towards hydrogen peroxide detection
This work reports the use of metallo tetra-amino phthalocyanines (MTAPc, M = Co and Mn) polymer thin films on gold and glassy carbon electrode surfaces for the detection and monitoring of hydrogen peroxide (H2O2). The polymer-modified electrodes were characterized using electrochemical and microscopic-based methods. Atomic force microscopy (AFM) was used to study the bare and polymer-modified ITO surfaces. The electrocatalytic reduction of H2O2 with glassy carbon polymer-modified electrodes gave higher current densities compared to their gold counterparts. The electroanalytical properties of H2O2 were obtained using a real-time calibration curve of the amperometric determination in pH 7.4 aqueous solution. The limits of detection (LoD) of the polymer-modified electrodes towards electroreduction of H2O2 were of the order of 10–7 M, with high sensitivity ranging from 6.0–15.4 mA.mM-1.cm-2
CHEK2 1100 delC mutation in Russian ovarian cancer patients
BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers
Accounting students' IT applicaton skills over a 10-year period
This paper reports on the changing nature of a range of information technology (IT) application skills that students declare on entering an accounting degree over the period from 1996 to 2006. Accounting educators need to be aware of the IT skills students bring with them to university because of the implications this has for learning and teaching within the discipline and the importance of both general and specific IT skills within the practice and craft of accounting. Additionally, IT skills constitute a significant element within the portfolio of employability skills that are increasingly demanded by employers and emphasized within the overall Higher Education (HE) agenda. The analysis of students' reported IT application skills on entry to university, across a range of the most relevant areas of IT use in accounting, suggest that their skills have continued to improve over time. However, there are significant differential patterns of change through the years and within cohorts. The paper addresses the generalizability of these findings and discusses the implications of these factors for accounting educators, including the importance of recognising the differences that are potentially masked by the general increase in skills; the need for further research into the changing nature, and implications, of the gender gap in entrants' IT application skills; and the low levels of entrants' spreadsheet and database skills that are a cause for concern
Prospects for the measurement of muon-neutrino disappearance at the FNAL-Booster
Neutrino physics is nowadays receiving more and more attention as a possible
source of information for the long-standing problem of new physics beyond the
Standard Model. The recent measurement of the mixing angle in the
standard mixing oscillation scenario encourages us to pursue the still missing
results on leptonic CP violation and absolute neutrino masses. However,
puzzling measurements exist that deserve an exhaustive evaluation. The NESSiE
Collaboration has been setup to undertake conclusive experiments to clarify the
muon-neutrino disappearance measurements at small , which will be able to
put severe constraints to models with more than the three-standard neutrinos,
or even to robustly measure the presence of a new kind of neutrino oscillation
for the first time. To this aim the use of the current FNAL-Booster neutrino
beam for a Short-Baseline experiment has been carefully evaluated. This
proposal refers to the use of magnetic spectrometers at two different sites,
Near and Far. Their positions have been extensively studied, together with the
possible performances of two OPERA-like spectrometers. The proposal is
constrained by availability of existing hardware and a time-schedule compatible
with the CERN project for a new more performant neutrino beam, which will
nicely extend the physics results achievable at the Booster. The possible FNAL
experiment will allow to clarify the current disappearance tension
with appearance and disappearance at the eV mass scale. Instead, a new
CERN neutrino beam would allow a further span in the parameter space together
with a refined control of systematics and, more relevant, the measurement of
the antineutrino sector, by upgrading the spectrometer with detectors currently
under R&D study.Comment: 76 pages, 52 figure
Prospect for Charge Current Neutrino Interactions Measurements at the CERN-PS
Tensions in several phenomenological models grew with experimental results on
neutrino/antineutrino oscillations at Short-Baseline (SBL) and with the recent,
carefully recomputed, antineutrino fluxes from nuclear reactors. At a
refurbished SBL CERN-PS facility an experiment aimed to address the open issues
has been proposed [1], based on the technology of imaging in ultra-pure
cryogenic Liquid Argon (LAr). Motivated by this scenario a detailed study of
the physics case was performed. We tackled specific physics models and we
optimized the neutrino beam through a full simulation. Experimental aspects not
fully covered by the LAr detection, i.e. the measurements of the lepton charge
on event-by-event basis and their energy over a wide range, were also
investigated. Indeed the muon leptons from Charged Current (CC) (anti-)neutrino
interactions play an important role in disentangling different phenomenological
scenarios provided their charge state is determined. Also, the study of muon
appearance/disappearance can benefit of the large statistics of CC muon events
from the primary neutrino beam. Results of our study are reported in detail in
this proposal. We aim to design, construct and install two Spectrometers at
"NEAR" and "FAR" sites of the SBL CERN-PS, compatible with the already proposed
LAr detectors. Profiting of the large mass of the two Spectrometers their
stand-alone performances have also been exploited.Comment: 70 pages, 38 figures. Proposal submitted to SPS-C, CER
An optically stimulated superconducting-like phase in K3C60 far above equilibrium Tc
The control of non-equilibrium phenomena in complex solids is an important
research frontier, encompassing new effects like light induced
superconductivity. Here, we show that coherent optical excitation of molecular
vibrations in the organic conductor K3C60 can induce a non-equilibrium state
with the optical properties of a superconductor. A transient gap in the real
part of the optical conductivity and a low-frequency divergence of the
imaginary part are measured for base temperatures far above equilibrium Tc=20
K. These findings underscore the role of coherent light fields in inducing
emergent order.Comment: 40 pages, 23 figure
BRCA1 4153delA founder mutation in Russian ovarian cancer patients
The BRCA1 4153delA allele is frequently referred to as the Russian founder mutation, as it was initially detected in several cancer families from Moscow. Our earlier studies have demonstrated 1% occurrence of BRCA1 4153delA heterozygosity in familial and/or early-onset and/or bilateral Russian breast cancer (BC) patients. Since literature data suggest that the 4153delA variant is more associated with ovarian cancer (OC) than with BC, we expected to reveal a highly elevated frequency of this genotype in Russian ovarian cancer series. However, real-time allele-specific PCR genotyping has detected only two BRCA1 4153delA carriers out of 177 unselected OC patients (1.1%). Both these carriers were early-onset and had serous carcinomas of grade 3. Thus, our study supports neither the Russian origin of BRCA1 4153delA mutation, nor its selectivity towards ovarian versus breast cancer predisposition
A novel flexible field-aligned coordinate system for tokamak edge plasma simulation
Tokamak plasmas are confined by a magnetic field that limits the particle and heat transport perpendicular to the field. Parallel to the field the ionised particles can move freely, so to obtain confinement the field lines are “closed” (ie.form closed surfaces of constant poloidal flux) in the core of a tokamak. Towards, the edge, however, the field lines intersect physical surfaces, leading to interaction between neutral and ionised particles, and the potential melting of the material surface. Simulation of this interaction is important for predicting the performance and lifetime of future tokamak devices such as ITER. Field-aligned coordinates are commonly used in the simulation of tokamak plasmas due to the geometry and magnetic topology of the system. However, these coordinates are limited in the geometry they allow in the poloidal plane due to orthogonality requirements. A novel 3D coordinate system is proposed herein that relaxes this constraint so that any arbitrary, smoothly varying geometry can be matched in the poloidal plane while maintaining a field-aligned coordinate. This system is implemented in BOUT++ and tested for accuracy using the method of manufactured solutions. A MAST edge cross-section is simulated using a fluid plasma model and the results show expected behaviour for density, temperature, and velocity. Finally, simulations of an isolated divertor leg are conducted with and without neutrals to demonstrate the ion-neutral interaction near the divertor plate and the corresponding beneficial decrease in plasma temperature
Molecular activated recombination in divertor simulation plasma on GAMMA 10/PDX
In the tandem mirror GAMMA 10/PDX, molecular activated recombination (MAR) leading to plasma detachment has been observed by additional hydrogen gas injection to the divertor simulation plasma (i.e. end loss plasma) which is exposed to the V-shaped target in the divertor simulation experimental module (D-module). The temperature near the corner of the V-shaped target decreased from ∼23 eV to ∼2 eV as the neutral pressure in the D-module increased. A clear density rollover was observed at ∼2 Pa. A position of the density maximum moves to upstream of the plasma with increase in the neutral pressure and the density near the corner of the target decreases to detach the plasma from the target. After the occurrence of the density rollover, the Balmer β intensity decreases as with the density but the Balmer α intensity continues to increase, indicating the dissociative attachment process in MAR is more dominant than the ion conversion process although the rate coefficient of the former process is lower than that of the latter one, which is calculated by using a collisional radiative model. This would be caused by the MAR process related to triatomic hydrogen molecules which significantly contributed to the detachment process
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