Manual de desarrollo de aplicaciones teleinformáticas de un sistema domótico

El manual se halla estructurado de la siguiente manera: el capítulo 1 se refiere al Diseño de la arquitectura de software y a la implementación de los componentes de la arquitectura de software. En el capítulo 2, se describe la guía de usuario de la aplicaciones teleinformáticas para el sistema domótico. Previamente, se presenta la justificación, objetivos y la metodología de desarrollo del software del sistema domóticoThe manual is structured as follows: Chapter 1 refers to Software architecture design and implementation of software architecture components. Chapter 2 describes the user guide for telematics applications for the home automation system. Previously, the justification, objectives and methodology of software development of the home automation systemDiseño de la Arquitectura se software – Implementación de los componentes de la Arquitectura de software – Nodo de aplicaciones de alto nivel – Nodo Acceso al sistema – Módulo de reconocimiento facial – Guía de usuario de las aplicaciones para el sistema domótico – Descripción de los componentes de software que conforman el sistema domótico155 página

[Epidemiological profile of rheumatoid arthritis]

Abstract Background: Rheumatoid arthritis affects approximately between 0.3 and 1.2% of the world population. In Latin America, different studies have estimated a prevalence between 0.2 and 0.5% in the population over 16 years of age. Objective: To identify the epidemiological profile of rheumatoid arthritis. Material and methods: Descriptive cross-sectional design carried out in an urban population of a social security institution in Mexico. The information of the clinical file of 373 patients was studied. The epidemiological profile included the sociodemographic dimension, family history, health, clinical, therapeutic, biochemical, extra-articular manifestations and complications. Statistical analysis percentages, means, confidence intervals for percentages and confidence intervals for averages were calculated. Results: The wrists were the most affected joints with 44.6% (95% CI: 39.5-49.6%). The extra-articular manifestation with the highest prevalence was asthenia with 9.9% (95% CI: 6.9-12.9%); predominant diagnosis according to ICD-10 was seropositive rheumatoid arthritis with 59.8% (95% CI: 54.8-64.8%), and the rheumatoid factor was highly positive in 78.3% (95% CI: 74.1-82.5%); predominant treatment was with combined therapy at diagnosis in 97.6% (95% CI: 96.0-99.1%). The duration of treatment was > 10 years in 34.1% (95% CI: 29.2-38.8%). Conclusion: This work has described the epidemiological profile of the patient with rheumatoid arthritis in different dimensions. Resumen Introducción: la artritis reumatoide afecta aproximadamente entre 0.3 y 1.2% de la población mundial. En Latinoamérica diferentes estudios han estimado una prevalencia entre 0.2 y 0.5% en población mayor de 16 años de edad. Objetivo: identificar el perfil epidemiológico de la artritis reumatoide. Material y métodos: diseño transversal descriptivo llevado a cabo en población urbana de una institución de seguridad social en México. Se estudió la información del expediente clínico de 373 pacientes. El perfil epidemiológico incluyó la dimensión sociodemográfica, antecedentes heredofamiliares, de salud, clínicos, terapéuticos, bioquímicos, de manifestaciones extraarticulares y de complicaciones. Se calcularon porcentajes, promedios, e intervalos de confianza para porcentajes y promedios. Resultados: las muñecas fueron las articulaciones más afectadas con 44.6% (IC 95%: 39.5-49.6%). La manifestación extraarticular con más alta prevalencia fue la astenia con 9.9% (IC 95%: 6.9-12.9%); el diagnóstico predominante de acuerdo con el CIE-10 fue la artritis reumatoide seropositiva con 59.8% (IC 95%: 54.8-64.8%) y se encontró el factor reumatoide positivo alto en un 78.3% (IC 95%: 74.1%-82.5%); el tratamiento predominante fue con terapia combinada al diagnóstico en un 97.6%, (IC 95%: 96.0-99.1%). La duración del tratamiento fue > 10 años en el 34.1% (IC 95%: 29.2-38.8%). Conclusión: este trabajo ha descrito el perfil epidemiológico del paciente con artritis reumatoide en diferentes dimensiones

Creación y organización de un modelo administrativo para el sistema cooperativo en la ciudad de Cali

Tesis (Ingeniero Industrial)-- Corporación Universitaria Autónoma de Occidente, 1990PregradoIngeniero(a) Industria

6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors

et al.6-Hydroxydopamine (6-OHDA) is a neurotoxin that generates an experimental model of Parkinson's disease in rodents and is commonly employed to induce a lesion in dopaminergic pathways. The characterization of those molecular mechanisms linked to 6-OHDA-induced early toxicity is needed to better understand the cellular events further leading to neurodegeneration. The present work explored how 6-OHDA triggers early downstream signaling pathways that activate neurotoxicity in the rat striatum. Mitochondrial function, caspases-dependent apoptosis, kinases signaling (Akt, ERK 1/2, SAP/JNK and p38) and crosstalk between nuclear factor kappa B (NF-κB) and nuclear factor-erythroid-2-related factor 2 (Nrf2) were evaluated at early times post-lesion. We found that 6-OHDA initiates cell damage via mitochondrial complex I inhibition, cytochrome c and apoptosis-inducing factor (AIF) release, as well as activation of caspases 9 and 3 to induce apoptosis, kinase signaling modulation and NF-κB-mediated inflammatory responses, accompanied by inhibition of antioxidant systems regulated by the Nrf2 pathway. Our results suggest that kinases SAP/JNK and p38 up-regulation may play a role in the early stages of 6-OHDA toxicity to trigger intrinsic pathways for apoptosis and enhanced NF-κB activation. In turn, these cellular events inhibit the activation of cytoprotective mechanisms, thereby leading to a condition of general damage. © 2012 Elsevier Ireland Ltd.This work was supported in part by PAPIIT/UNAM (IN201910) and CONACyT (129838 J.P.-C.) and (168356 MO-I). J.C. Tobón-Velasco is scholarship holder from CONACyT-Mexico (239757, 46497), and gratefully acknowledges Santander Bank for the fellowship and scholarship student exchange. J.H. Limón-Pacheco is grant-fellowship from CONACYT 129838- J.P.-C.Peer Reviewe

S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: Involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades

Pharmacological activation at the basal ganglia of the transcription factor Nrf2, guardian of redox homeostasis, holds a strong promise for the slow progression of Parkinson's disease (PD). However, a potent Nrf2 activator in the brain still must be found. In this study, we have investigated the potential use of the antioxidant compound S-allyl cysteine (SAC) in the activation of Nrf2 in 6-hydoxydopamine (6-OHDA)-intoxicated rats. In the rat striatum, SAC by itself promoted the Nrf2 dissociation of Keap-1, its nuclear translocation, the subsequent association with small MafK protein, and further binding of the Nrf2/MafK complex to ARE sequence, as well as the up-regulation of Nrf2-dependent genes encoding the antioxidant enzymes HO-1, NQO-1, GR, and SOD-1. In vivo and in vitro experiments to identify signaling pathways activated by SAC pointed to Akt as the most likely kinase participating in Nrf2 activation by SAC. In PC12 cells, SAC stimulated the activation of Akt and ERK1/2 and inhibited JNK1/2/3 activation. In the rat striatum, the SAC-induced activation of Nrf2 is likely to contribute to inhibit the toxic effects of 6-OHDA evidenced by phase 2 antioxidant enzymes up-regulation, glutathione recovery, and attenuation of reactive oxygen species (ROS), nitric oxide (NO), and lipid peroxides formation. These early protective effects correlated with the long-term preservation of the cellular redox status, the striatal dopamine (DA) and tyrosine hydroxylase (TH) levels, and the improvement of motor skills. Therefore, this study indicates that, in addition to direct scavenging actions, the activation of Nrf2 by SAC might confer neuroprotective responses through the modulation of kinase signaling pathways in rodent models of PD, and suggests that this antioxidant molecule may have a therapeutic value in this human pathology. © 2012 Elsevier Inc. All rights reserved.This work was supported in part by PAPIIT/UNAM (IN201910) and CONACyT (129838) (J.P.-C.), PAPIIT/UNAM (IN222909) (M.M.-S.), and SAF2010-17822 from the Spanish Ministry of Science and Innovation. Julio Cesar Tobón-Velasco is scholarship holder from CONACyT-Mexico (239757).Peer Reviewe

Impacto de la gestión de calidad en la estructura organizativa y en la innovación de la industria azucarera colombiana

El estudio analiza el posible impacto de la gestión de calidad en la estructura organizativa y en la innovación en tres ingenios azucareros colombianos. Se creó un instrumento para recolectar información que fue diligenciado por algunos colaboradores. Los resultados indican que los ingenios presentan estructuras organizativas formalizadas y una menor especialización horizontal, haciendo énfasis en la formación del personal. No se podría afirmar que implementar un sistema de gestión de calidad genera cambios en la estructura, los niveles jerárquicos, descentralización vertical y en los dispositivos de enlace laterales. Tampoco se evidencia una diferencia significativa en la innovación de los tres ingenios

Creación y organización de un modelo administrativo para el sistema cooperativo en la ciudad de Cali

Tesis (Ingeniero Industrial)-- Corporación Universitaria Autónoma de Occidente, 199

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

The transcription factor NF-E2-related factor 2 (Nrf2) is a master regulator of a genetic program, termed the phase 2 response, that controls redox homeostasis and participates in multiple aspects of physiology and pathology. Nrf2 protein stability is regulated by two E3 ubiquitin ligase adaptors, Keap1 and β-TrCP, the latter of which was only recently reported. Here, two-dimensional (2D) gel electrophoresis and site-directed mutagenesis allowed us to identify two serines of Nrf2 that are phosphorylated by glycogen synthase kinase 3β (GSK-3β) in the sequence DSGISL. Nuclear magnetic resonance studies defined key residues of this phosphosequence involved in docking to the WD40 propeller of β-TrCP, through electrostatic and hydrophobic interactions. We also identified three arginine residues of β-TrCP that participate in Nrf2 docking. Intraperitoneal injection of the GSK-3 inhibitor SB216763 led to increased Nrf2 and heme oxygenase-1 levels in liver and hippocampus. Moreover, mice with hippocampal absence of GSK-3β exhibited increased levels of Nrf2 and phase 2 gene products, reduced glutathione, and decreased levels of carbonylated proteins and malondialdehyde. This study establishes the structural parameters of the interaction of Nrf2 with the GSK-3/β-TrCP axis and its functional relevance in the regulation of Nrf2 by the signaling pathways that impinge on GSK-3.This work was supported by MICINN grant SAF2010-18722 from the Spanish Ministry of Science and Innovation. Patricia Rada is contracted under the Formación de Profesorado Universitario program of the Spanish Ministry of Science and Innovation. We acknowledge funding and infrastructural support from EEC 7th Framework Program, KU Leuven Research Fund, and KU Leuven Research & Development.Peer reviewe

El sistema acusatorio y los preacuerdos

Los códigos de procedimiento penal que precedieron al actual, es decir, a la Ley 906 de 2004, han mostrado una significativa evolución en materia de medidas alternativas para la solución de conflictos, pero, habida cuenta de que el modelo que orientó la expedición de los estatutos anteriores fue el inquisitivo o el formal acusatorio, en su normativa no se encuentran instituciones equivalentes a los preacuerdos cuyo desarrollo es propio de los sistemas acusatorios. Dentro de un sistema penal acusatorio, los mecanismos de solución alternativa de conflictos permiten hacer más ágil el trámite del proceso penal, por cuanto la sentencia proferida después de haberse agotado la totalidad de las etapas procesales no es la única forma de terminación del proceso, sino que se admiten otras formas que podrían denominarse anormales o atípicas por permitir una conclusión precoz de la actividad procesal