Formulasi Pembuatan Teh Celup Fungsional Dengan Penambahan Adas (Foeniculum Vulgare Mill.) Sebagai Inovasi Kuliner Khas Tengger, Jawa Timur

Indonesia memiliki sepuluh tujuan destinasi atau pariwisata yang indah dan menarik, salah satunya adalah Bromo Tengger Semeru. Namun, belum adanya inovasi kuliner yang memanfaatkan komoditas asli Tengger seperti tanaman adas menjadi kekurangan tempat wisata ini. Sehingga, perlu adanya inovasi kuliner yang memanfaatkan tanaman adas menjadi produk teh celup fungsional, namun diperlukannya penelitian lanjutan dalam proses pembuatannya. Pada penelitian ini jenis teh yang digunakan yaitu teh hitam dan teh hijau yang akan dicampurkan dengan tanaman adas (batang, daun dan buah) dengan konsentrasi sebanyak 50%, 60% dan 70% dari 2,5 gram berat formulasi. Hasil dari penelitian menunjukkan bahwa kadar air yang terdapat dalam formulasi bubuk teh hitam 50% : bubuk adas 50% sebesar 14,67% dan formulasi bubuk teh hijau 30% : bubuk adas 70% sebesar 12,42%. Pada analisis uji organoleptik berdasarkan parameter warna, aroma dan rasa secara berturut ditemukan hasil rerata pada formulasi bubuk teh hitam 50% : viii bubuk adas 50% sebesar 3,60, 4,00 dan 3,80, sedangkan pada formulasi bubuk teh hijau 30% : bubuk adas 70% 3,80 untuk warna, 3,90 untuk aroma dan 3,90 untuk rasa. Pada uji tingkat kesukaan konsumen didapatkan hasil berdasarkan parameter warna, aroma dan rasa secara berturut untuk formulasi bubuk teh hitam 50% : bubuk adas 50% dan bubuk teh hijau 30% : bubuk adas 70% sebesar 82,86%, 75,24%, 74,76% dan 71,91%, 64,29%, 73,81%. Pada uji aktivitas antioksidan menggunakan metode DPPH ditemukan hasil pada formulasi bubuk teh hitam 50% : bubuk adas 50% sebesar 7,70 ± 0,05% b/b dan formulasi bubuk teh hijau 30% : bubuk adas 70% sebesar 16,06 ± 0,8% b/b

Predictors of Outcomes in 900 Alveolar Bone Grafts

Background: Significant discrepancies exist in the reported variables influencing alveolar bone graft outcomes. The purpose of this study was to evaluate graft success and identify outcome predictors in a large patient cohort using an objective cone beam computed tomography assessment tool. Methods: Consecutive patients with cleft lip/palate who underwent alveolar bone grafting by 1 surgeon were included. Predictor variables were age at graft, oronasal fistula, canine position, concurrent premaxillary osteotomy, size of cleft, presence of bony palatal bridge, history of failed graft, location of primary repair, and surgeon experience. The outcome variable was graft success, determined using a cone beam computed tomography assessment tool and defined as a score of 3 or 4 (out of 4) in the following domains: vertical bone level, labiopalatal thickness, and nasal piriform symmetry. Results: The sample included 900 alveolar cleft sites (median graft age, 9.9 years). The success rate was 94.6%. Presence of an erupted canine, large cleft defect, or premaxillary osteotomy were independent predictors of graft failure; presence of a bony palatal bridge was associated with graft success (P &lt; 0.05). Conclusions: Presence of an erupted canine, large bony defect, or premaxillary osteotomy increase the risk of failure, and a bony palatal bridge portends success. Age 12 years or older, visible oronasal fistula, history of failed graft, primary cleft repaired at outside institution, and surgeon experience were associated with higher graft failure, but were not independent predictors when controlling for covariates. Surgeons should be aware that these factors in combination increase the odds of graft failure. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III.</p

A Systematic Review on Water Hyacinth (Eichhornia crassipes) as a Biosorbent of Cadmium

Water hyacinth has gained a noteworthy reputation as the worst invasive macrophyte for its alarming proliferation rates, threatening transportation and irrigation systems and ecosystem biodiversity. Sustainable efforts have found the plant to demonstrate efficiency in sequestering toxic heavy metals such as cadmium from marine environments. Cadmium presence in water, primarily caused by anthropogenic sources, poses public health risks due to its toxicity. Consequently, studies on the applications of Eichhornia crassipes and the removal of cadmium have become active research areas in recent decades. This review presents literature related to the Cd sorption capacity of water hyacinth biosorbents. The effects and optimization of parameters including treatment, temperature, pH, initial sorbate and sorbent concentration have been explored in classical and competitive adsorption models. Investigations on kinetics, equilibrium, and desorption studies have also been conducted. From the gathered literature, water hyacinth biosorbents show potential for industrial-scale applications, but its metal recovery and utilization in multi-metal and continuous sorption may require further evaluation

ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KETEPATAN WAKTU PENYAMPAIAN LAPORAN KEUANGAN PERUSAHAAN MANUFAKTUR DI BURSA EFEK INDONESIA

The financial statements provided by each company are an important source of information in the investment business, the regulations set by BAPEPAM number : KEP-431/BL/2012 which states that companies must submit financial reports no later than four months after the end of the year.This study aims to determine the variable profitability, liquidity, company size on the timeliness of financial statement submission. The data used are secondary data in the form of annual reports for the period of 2015-2019 listed on the Indonesia Stock Exchange and the sampling technique using purposive sampling method. Based on the sample criteria, there were 14 samples. The analytical method used in this study is logistic regression and The results of the study were tested using the SPSS version 25 application. The results of this study indicate that partially profitability, liquidity and company size or simultaneously did not significantly influence the timeliness of financial statement submission

Immunomodulation and T Helper TH1/TH2 Response Polarization by CeO2 and TiO2 Nanoparticles

Immunomodulation by nanoparticles, especially as related to the biochemical properties of these unique materials, has scarcely been explored. In an in vitro model of human immunity, we demonstrate two catalytic nanoparticles, TiO2 (oxidant) and CeO2 (antioxidant), have nearly opposite effects on human dendritic cells and T helper (T-H) cells. For example, whereas TiO2 nanoparticles potentiated DC maturation that led towards T(H)1-biased responses, treatment with antioxidant CeO2 nanoparticles induced APCs to secrete the anti-inflammatory cytokine, IL-10, and induce a T(H)2-dominated T cell profile. In subsequent studies, we demonstrate these results are likely explained by the disparate capacities of the nanoparticles to modulate ROS, since TiO2, but not CeO2 NPs, induced inflammatory responses through an ROS/inflammasome/IL-1 beta pathway. This novel capacity of metallic NPs to regulate innate and adaptive immunity in profoundly different directions via their ability to modulate dendritic cell function has strong implications for human health since unintentional exposure to these materials is common in modern societies

Long-term prognostic value of quantitative myocardial perfusion in patients with chest pain and normal coronary arteries

BACKGROUND: Patients with chest pain and no obstructive coronary artery disease have shown a high incidence of major adverse cardiovascular events (MACE). We evaluated the role of absolute myocardial perfusion quantification in predicting all-cause mortality and MACE during long-term follow-up in this group of patients. METHODS: We studied 79 patients who underwent Nitrogen-13 ammonia PET for quantification of global myocardial blood flow (MBF) and myocardial flow reserve (MFR) due to suspected impaired myocardial perfusion. Patients with coronary artery disease (i.e., > 30% stenosis in one or more coronary arteries) were excluded. We assessed all-cause mortality and MACE. MACE was defined as the composite incidence of death, myocardial infarction (MI), or hospitalization due to heart failure. RESULTS: Median follow-up was 8 (IQR: 3-14) years. Univariate Cox regression showed that only MFR (P = 0.01) was a predictor of all-cause mortality. Univariate Cox regression analysis showed that both MFR and Stress MBF were predictors of the composite endpoint of MACE (P < 0.001 and P = 0.01, respectively). CONCLUSION: Quantitative assessment of myocardial perfusion may predict all-cause mortality and MACE in patients with chest pain and normal coronary arteries in the long-term follow-up