Syringoma: A Clinicopathologic and Immunohistologic Study and Results of Treatment

The purpose of our study was to describe clinical and histopathological features of sixty one patients with histological diagnosis of syringoma over four year period in our dermatology clinic in Korea. Female:male ratio was 6.6:1 with onset of age during 2nd and 3rd decades in more than half of the patients in our study. The most frequently involved site was eyelids (43 cases, 70.5%) and the most common color of lesion was skin-color (30 cases, 49.2%). In 34 cases, characteristic tad-pole appearances (55.7%) were observed. Basal hyperpigmentation was observed more frequently in brown-colored lesion (p = 0.005). Fibrosis was observed more frequently in erythematous lesion (p = 0.033). Keratin cyst was observed less frequently in genital involved group (p = 0.006). We also performed immunohistochemical stain for the presence of progesterone receptor (PR) and estrogen receptor (ER) in fifty six cases with negative results

Progesterone receptor-positive eruptive syringoma associated with diabetes

Syringoma is a benign eccrine tumor that generally forms asymptomatic papules on facial skin. Eruptive forms of the tumor are uncommon and of uncertain cause. We report a case in which eruptive syringoma with clear cell morphology was found to express progesterone receptors, suggesting the possibility of hormonal control of the tumor