329 research outputs found
Temperature dependent refractive index of silicon and germanium
Silicon and germanium are perhaps the two most well-understood semiconductor
materials in the context of solid state device technologies and more recently
micromachining and nanotechnology. Meanwhile, these two materials are also
important in the field of infrared lens design. Optical instruments designed
for the wavelength range where these two materials are transmissive achieve
best performance when cooled to cryogenic temperatures to enhance signal from
the scene over instrument background radiation. In order to enable high quality
lens designs using silicon and germanium at cryogenic temperatures, we have
measured the absolute refractive index of multiple prisms of these two
materials using the Cryogenic, High-Accuracy Refraction Measuring System
(CHARMS) at NASA Goddard Space Flight Center, as a function of both wavelength
and temperature. For silicon, we report absolute refractive index and
thermo-optic coefficient (dn/dT) at temperatures ranging from 20 to 300 K at
wavelengths from 1.1 to 5.6 microns, while for germanium, we cover temperatures
ranging from 20 to 300 K and wavelengths from 1.9 to 5.5 microns. We compare
our measurements with others in the literature and provide
temperature-dependent Sellmeier coefficients based on our data to allow
accurate interpolation of index to other wavelengths and temperatures. Citing
the wide variety of values for the refractive indices of these two materials
found in the literature, we reiterate the importance of measuring the
refractive index of a sample from the same batch of raw material from which
final optical components are cut when absolute accuracy greater than +/-5 x
10^-3 is desired.Comment: 10 pages, 8 figures, to be published in the Proc. of SPIE 6273
(Orlando
Temperature-dependent Refractive Index of CaF2 and Infrasil 301
In order to enable high quality lens designs using calcium fluoride (CaF2) and Heraeus Infrasil 301 (Infrasil) for cryogenic operating temperatures, we have measured the absolute refractive index of these two materials as a function of both wavelength and temperature using the Cryogenic, High-Accuracy Refraction Measuring System (CHARMS) at NASA's Goddard Space Flight Center. For CaF2, we report absolute refractive index and thermo-optic coefficient (dn/dT) at temperatures ranging from 25 to 300 K at wavelengths from 0.4 to 5.6 pm, while for Infrasil, we cover temperatures ranging from 35 to 300 K and wavelengths from 0.4 to 3.6 pm. For CaF2, we compare our index measurements to measurements of other investigators. For Infrasil, we compare our measurements to the mate~al manufacturer's data at room temperature and to cryogenic measurements for fused silica from previous investigations including one of our own. Finally, we provide temperature-dependent Sellmeier coefficients based on our measured data to allow accurate interpolation of index to other wavelengths and temperatures
Cryogenic Temperature-dependent Refractive Index Measurements of N-BK7, BaLKN3, and SF15 for NOTES PDI
In order to enable high quality lens designs using N-BK7, BaLKN3, and SF15 at cryogenic temperatures, we have measured the absolute refractive index of prisms of these three materials using the Cryogenic, High-Accuracy Refraction Measuring System (CHARMS) at NASA's Goddard Space Flight Center, as a function of both wavelength and temperature. For N-BK7, we report absolute refractive index and thermo-optic coefficient (dn/dT) at temperatures ranging from 50 to 300 K at wavelengths from 0.45 to 2.7 micrometers; for BaLKN3 we cover temperatures ranging from 40 to 300 K and wavelengths from 0.4 to 2.6 micrometers; for SF15 we cover temperatures ranging from 50 to 300 K and wavelengths from 0.45 to 2.6 micrometers. We compare our measurements with others in the literature and provide temperature-dependent Sellmeier coefficients based on our data to allow accurate interpolation of index to other wavelengths and temperatures. While we generally find good agreement (plus or minus 2 x 10(exp -4) for N-BK7, less than 1 x 10(exp -4) for the other materials) at room temperature between our measured values and those provided by the vendor, there is some variation between the datasheets provided with the prisms we measured and the catalog values published by the vendor. This underlines the importance of measuring the absolute refractive index of the material when precise knowledge of the refractive index is required
NCLB technology and a rural school: A case study
The requirements of the No Child Left Behind Act of 2001 (NCLB) have presented special challenges and opportunities for rural schools (Reeves, 2003). Researchers have suggested that one way rural schools may be able to overcome these challenges is through an increase in the level of technology integration in their school (Collins &
Dewees, 2001). This case study reports on one school’s attempt to use grant resources funded through NCLB to integrate specific instructional technologies to facilitate increased student achievement. Through interviews and observations, the roles, attitudes, and difficulties of teachers and administrators in implementing a technology initiative in a rural middle school were observed, examined and discussed. Emerging themes included issues related to teacher
ownership of the technology, teacher feelings of power and participation, differing goals of teachers and
administrators, technical difficulties, school wide support, and changes in school culture
NCLB Technology and a Rural School: A Case Study
The requirements of the No Child Left Behind Act of 2001 (NCLB) have presented special challenges and opportunities for rural schools (Reeves, 2003). Researchers have suggested that one way rural schools may be able to overcome these challenges is through an increase in the level of technology integration in their school (Collins & Dewees, 2001). This case study reports on one school’s attempt to use grant resources funded through NCLB to integrate specific instructional technologies to facilitate increased student achievement. Through interviews and observations, the roles, attitudes, and difficulties of teachers and administrators in implementing a technology initiative in a rural middle school were observed, examined and discussed. Emerging themes included issues related to teacher ownership of the technology, teacher feelings of power and participation, differing goals of teachers and administrators, technical difficulties, school wide support, and changes in school culture
Elliptic curves, modular forms, and sums of Hurwitz class numbers
Let H(N) denote the Hurwitz class number. It is known that if is a prime,
then {equation*} \sum_{|r|<2\sqrt p}H(4p-r^2) = 2p. {equation*} In this paper,
we investigate the behavior of this sum with the additional condition . Three different methods will be explored for determining the values
of such sums. First, we will count isomorphism classes of elliptic curves over
finite fields. Second, we will express the sums as coefficients of modular
forms. Third, we will manipulate the Eichler-Selberg trace for ula for Hecke
operators to obtain Hurwitz class number relations. The cases and 4 are
treated in full. Partial results, as well as several conjectures, are given for
and 7.Comment: Preprint of an old pape
Analysis of Electrodeposited Nickel-Iron Alloy Film Composition Using Particle-Induced X-Ray Emission
The elemental composition of electrodeposited NiFe thin films was analyzed with particle-induced X-ray emission (PIXE). The thin films were electrodeposited on polycrystalline Au substrates from a 100mM NiSO4, 10 mM FeSO4, 0.5M H3BO3, and 1M Na2SO4 solution. PIXE spectra of these films were analyzed to obtain relative amounts of Ni and Fe as a function of deposition potential and deposition time. The results show that PIXE can measure the total deposited metal in a sample over at least four orders of magnitude with similar fractional uncertainties. The technique is also sensitive enough to observe the variations in alloy composition due to sample nonuniformity or variations in deposition parameters
Localization of muscarinic M3 receptor protein and M3 receptor binding in rat brain
A family of receptor subtypes, defined either by molecular (ml-m5) or pharmacological (M1-M4) analysis, mediates muscarinic cholinergic neurotransmission in brain. The distribution and functions of the m3 receptor protein in brain and its relation to M3 ligand binding sites are poorly understood. To better characterize the native brain receptors, subtype-specific antibodies reactive with the putative third inner loops were used: (i) to measure the abundance of m3 protein and its regional distribution in rat brain by immunoprecipitation; (ii) to determine the cellular and subcellular distribution of m3 protein by light microscopic immunocytochemistry; and (iii) to compare the distribution of m3 immunoreactivity with the autoradiographic distribution of M3 binding sites labeled by [3H]4-diphenylacetoxy-N-methyl pipericline methioxide in the presence of antagonists selective for the other receptor binding sites. The m3 protein, measured by immunoprecipitation, accounted for 5-10% of total solubilized receptors in all brain regions studied. Immunocytochemistry also revealed a widespread distribution of m3-like immunoreactivity, and localized the subtype to discrete neuronal populations and distinct subcellular compartments. The distribution of m3 protein was consistent with the messenger RNA expression, and like M3 binding sites, the protein was enriched in limbic cortical regions, striatum, hippocompus, anterior thalamic nuclei, superior colliculus and pontine nuclei. However, m3 immunoreactivity and M3 binding were differentially localized in regions and lamina of cortex and hippocompus.The results confirm the presence of m3 protein in brain, its low abundance compared to other muscarinic receptor subtypes, and provide the first immunocytochemical map of its precise localization. The distribution of m3 suggests that it mediates a wide variety of cholinergic processes in brain, inclucling possible roles in learning and memory, motor function and behavioral state control. However, since the distribution of the molecularly-defined receptor protein is distinct from the pharmacologically-defined M3 binding site, investigations of the functions of m3 in brain must await development of more selective ligands or use of non-pharmacological approaches.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31207/1/0000109.pd
Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor – a pharmacokinetic study
Solvent facilitated perfusion (SFP) has been proposed as a technique to increase the delivery of chemotherapeutic agents to tumors. SFP entails direct injection of the agent into the tumor in a water-miscible organic solvent, and because the solvent moves easily through both aqueous solutions and cellular membranes it drives the penetration of the solubilized anticancer agent throughout the tumor. To test this hypothesis, we compared the pharmacokinetics (PK) of 14 C-labeled 1,3-bis-chlorethyl-1-nitrosourea (BCNU) in intra-cerebral 9L rat gliomas after intravenous (IV) infusion in 90% saline –10% ethanol or direct intratumoral (IT) injection of 14 C-BCNU in 100% ethanol (DTI-015). Treatment with DTI-015 yielded a peak radioactive count (Cmax) for the 14 C label that was 100–1000 fold higher in the tumor than in all other tissues in addition to a concentration in the tumor that was 100-fold higher than that achieved following IV infusion of 14 C-BCNU. Pathologic and auto-radiographic analysis of tissue sections following IT injection of 14 C-BCNU in ethanol into either tumor or normal rat brain revealed both an enhanced local volume of distribution and an increased concentration of BCNU delivered to tumor compared to non-tumor bearing brain. To investigate the mechanism behind the SFP of BCNU to the tumor both dynamic contrast and perfusion MRI were performed on 9L tumors before and after treatment and demonstrated a decrease in tumor perfusion following IT injection of DTI-015. Finally, initial PK of patient blood samples following administration of DTI-015 into relapsed high-grade glioma indicated a 20-fold decrease in systemic exposure to BCNU compared to IV infusion of BCNU providing further evidence for the enhanced therapeutic ratio observed for DTI-015.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45396/1/11060_2004_Article_5675.pd
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