Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Magnetohydrodynamic Stirrer Liquid Metal with a Non-Sinusoidal Currents

The article compared the induction MHD stirrer liquid metals with sinusoidal and non-sinusoidal periodic currents. On the basis of numerical simulation software product ANSYS, define differential and integral electromagnetic characteristics magnetohydrodynamic stirrer with two-phase and three-phase windings. It is shown that under certain conditions the inductor and the frequency of the supply current, magnetohydrodynamic stirrers with non-sinusoidal currents are more efficient and less energy-intensive than the magnetohydrodynamic stirrers with sinusoidal currents.В статье проведено сравнение индукционных магнитогидродинамических перемешивателей жидких металлов с синусоидальными и несинусоидальными периодическими токами. На основе численного моделирования с использованием программного продукта ANSYS определены дифференциальные и интегральные электромагнитные характеристики магнитогидродинамических перемешивателей с двухфазной и трехфазной обмотками. Показано, что при определенных параметрах индуктора и частоты питающего тока магнитогидродинамические перемешиватели с несинусоидальными токами являются более эффективными и менее энергоемкими, чем с синусоидальными

Magnetohydrodynamic Stirrer Liquid Metal with a Non-Sinusoidal Currents

The article compared the induction MHD stirrer liquid metals with sinusoidal and non-sinusoidal periodic currents. On the basis of numerical simulation software product ANSYS, define differential and integral electromagnetic characteristics magnetohydrodynamic stirrer with two-phase and three-phase windings. It is shown that under certain conditions the inductor and the frequency of the supply current, magnetohydrodynamic stirrers with non-sinusoidal currents are more efficient and less energy-intensive than the magnetohydrodynamic stirrers with sinusoidal currents.В статье проведено сравнение индукционных магнитогидродинамических перемешивателей жидких металлов с синусоидальными и несинусоидальными периодическими токами. На основе численного моделирования с использованием программного продукта ANSYS определены дифференциальные и интегральные электромагнитные характеристики магнитогидродинамических перемешивателей с двухфазной и трехфазной обмотками. Показано, что при определенных параметрах индуктора и частоты питающего тока магнитогидродинамические перемешиватели с несинусоидальными токами являются более эффективными и менее энергоемкими, чем с синусоидальными

Electromagnetic form-factors of odd-A rotational nuclei

We present a systematic study of single-particle and collective transverse current multipoles in the ground-state band of odd-A axially symmetric deformed nuclei. We analyze the interplay between single-particle and collective contributions to the total transverse form factors for elastic and inelastic scattering in a number of nuclei (169Tm, 177-179Hf, 239Pu), which exemplify different possibilities of ground state K-bands (1/2+, 7/2-, 9/2+) and of odd-Z or odd-N character. We also discuss the dependence of form factors and static moments on the mean field used to generate the ground-state wave function. The dominant contribution is found to come from the odd nucleon, except in the low momentum transfer region (q<1fm-1) where the core is manifest trough its interference with the single-particle amplitude.Peer reviewe