8 research outputs found
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Glyceollins Trigger Anti-Proliferative Effects in Hormone-Dependent Aromatase-Inhibitor-Resistant Breast Cancer Cells through the Induction of Apoptosis
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2022
- Field of study
Aromatase inhibitors (AIs) are standard treatment for estrogen-dependent postmenopausal breast tumors; however, resistance develops leading to tumor relapse and metastasis. We previously demonstrated that glyceollin inhibits proliferation, survival, and migration of hormone-independent letrozole-resistant breast cancer. Since many AI-resistant tumors remain hormone-dependent, identifying distinctions between estrogen-receptor-positive (ER+) and ER-negative (ER-) AI-resistant tumor response to therapy is critical. We hypothesize that treating ER+ letrozole-resistant T47D breast cancer cells (T47DaromLR) with a combination of 10 μM glyceollin and 0.5 μM lapatinib (a dual EGFR/HER2 inhibitor) will decrease cell proliferation through induction of apoptosis. The T47DaromLR cells were found to overexpress HER2 and MAPK while maintaining aromatase and ER levels compared to their letrozole-sensitive (T47Darom) counterparts. In the absence of estrogen stimulation, glyceollin ± lapatinib had no effect on the proliferation of the T47Darom cells, while glyceollin treatment caused 46% reduction in the proliferation of T47DaromLR cells, which was further diminished when combined with lapatinib. While neither agent influenced cell migration, glyceollin and lapatinib reduced S and G2/M phase cell entry and exclusively induced apoptosis by 1.29-fold in the T47DaromLR cells. Taken together, these results suggest that glyceollins and lapatinib may have potential as a novel combination therapeutic approach for hormone-dependent, letrozole-resistant tumors.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Role of allelopathy in hay-scented fern interference with black cherry regeneration
- Author
- A. Tateda
- A.D. Rovira
- B.R. Dalton
- C.H. Muller
- C.S. Tang
- D.A. Marquis
- D.A. Marquis
- E. Melin
- E.L. Rice
- F.J. Czabator
- G.A. Junk
- H.B. Tukey Jr.
- J.L. Harper
- J.P. Martin
- L. Machlis
- L. Wilkinson
- M.-C. Nilsson
- N.G. Tilghman
- R.A. Olsen
- R.C. Munter
- R.F. Fisher
- R.T. Brown
- R.W.L. Kimber
- S.B. Horsley
- S.B. Horsley
- S.B. Horsley
- S.B. Horsley
- S.B. Horsley
- S.B. Horsley
- S.B. Horsley
- S.B. Horsley
- S.L. Rose
- S.L. Stout
- W.J. Reitveld
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Long-term change in ground-layer vegetation of deciduous forests of the North Carolina Piedmont, USA
- Author
- Abrams M.D.
- Abrams M.D.
- Anderson R.C.
- Anderson R.C.
- Anderson R.C.
- Ashe W.W.
- Braun E.L.
- Brewer R.
- Christensen N.L.
- Christensen N.L.
- Christensen N.L.
- Daniels R.B.
- Davison S.E.
- Delcourt H.R.
- Dufrene M.
- Foster D.R.
- Fralish J.S.
- Frost C.C.
- Jolls C.L.
- Kartesz J.T.
- Keever C.
- Kruskal J.B.
- Lorimer C.G.
- Lorimer C.G.
- Lorimer C.G.
- Luken J.O.
- Manly B.F.J.
- Mather P.M.
- McCune B.
- McCune B.
- McDonald R.I.
- McDonald R.I.
- Mielke P.W.
- Mielke P.W.
- Oksanen L.
- Oosting H.J.
- Osborne J.S.
- Palmer M.W.
- Peet R.K.
- Peet R.K.
- Peet R.K.
- Peet R.K.
- Peterson E.B.
- Pickett S.T.A.
- Pimm S.L.
- Radford A.E.
- Roberts M.R.
- Rooney T.P.
- Strole T.A.
- Swift E.
- Tilghman N.G.
- USDA N.R.C.S.
- Waller D.M.
- White P.S.
- Wilcove D.S.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Transcriptional Regulation of the α-fetoprotein Gene by SWI/SNF Chromatin Remodeling Complex
- Author
- B. Bois-Joyeux
- C. Muchardt
- C. Muchardt
- C.J. Fryer
- D-E. Zhang
- D-E. Zhang
- D-E. Zhang
- D. Bernier
- D.J. Murphy
- E. Kowenz-Leutz
- E. Soutoglou
- E. Soutoglou
- E.R. Groupp
- F.D. Urnov
- G.J. Narlikar
- H. Chiba
- H. Ichinose
- H. Thomassin
- Hidenori Kaneoka
- J. Vacher
- J.A. Armstrong
- J.A. Martens
- J.J. Hayes
- K. Watanabe
- K.E. Neely
- Katsuhide Miyake
- L. Semenkova
- M. Coisy
- M. Lorenzo
- M.F. Decristofaro
- M.H. Feuerman
- M.S. Li
- Masamichi Kamihira
- Mikio Takahashi
- N.L. Lazarevich
- R. Eckner
- R. Hamamoto
- R. Hamamoto
- R.E. Kingston
- R.P. Kwok
- S.K. Yoshinaga
- S.L. Berger
- S.M. Tilghman
- Shinji Iijima
- T. Dohda
- T. Dohda
- T.A. Pedersen
- T.M. Ramesh
- Takeaki Dohda
- Y. Inayoshi
- Y. Inayoshi
- Y. Osawa
- Y. Zhang
- Yoshitaka Sato
- Yujin Inayoshi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Toxicology study with microRNA
- Author
- A.M. Dudley
- A.S. Yoo
- B. Siddeek
- B. Zhang
- B.K. Elamin
- B.N. Davis-Dusenbery
- B.P. Lewis
- C. Chen
- C. Lema
- C.J. Creighton
- C.J. Marsit
- C.L. Yauk
- D. Betel
- D. Li
- D.A. Román
- D.R. Bentley
- E. McNeill
- E.K. Ng
- E.L. Marczylo
- F. Bazzoni
- F. Schembri
- G.Y. Li
- H. Geekiyanage
- H. Wang
- J. Kim
- J. Krol
- J. Mattes
- J. Shendure
- J.E. Rager
- J.K. Rieger
- K. Beezhold
- K.D. Taganov
- M. Avissar-Whiting
- M. Fabbri
- M. Margulies
- M. Shibata
- M. Åkerblom
- M.D. Waters
- M.E. Ezzie
- M.K. Song
- M.K. Song
- M.M. Perry
- M.P. Waalkes
- N. Ali
- N.J. Buckley
- N.S. Wickramasinghe
- P.B. Tchounwou
- P.J. Cock
- P.S. Mitchell
- P.T. Nelson
- P.Y. Hsu
- R. Shi
- R. Shizu
- S. Kawano
- S. Lall
- S. Motameny
- S. Paul
- S. Takagi
- S.L. Tilghman
- S.M. Lehmann
- S.S. Hébert
- T. Nolan
- T. Sato
- T. Yokoi
- V. Ambros
- V. Benes
- V. Bollati
- W. Hu
- W. Kim
- W. Zhu
- W.J. Lukiw
- X. Liu
- Y. Jiang
- Y. Teng
- Y. Yamamoto
- Y.R. An
- Y.R. An
- Z. Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A fine-structure deletion map of human chromosome 11p: Analysis of J1 series hybrids
- Author
- A. Koufos
- A. Koufos
- A.J. Ping
- A.R. Mitchell
- B. Kluve-Beckerman
- B. Nikinmaa
- B.F. Haynes
- B.U. Zabel
- C. Jones
- C. Jones
- C. Jones
- C. Jones
- C. Jones
- C. Shih
- C. Turleau
- C.B. Bridges
- C.C. Morton
- C.E. Rogler
- C.J. Barnstable
- C.M. Boone
- D. Barker
- D. Ish-Horowicz
- D. Przepiorka
- D. Tuan
- D.A. Compton
- D.E. Lea
- D.J. Porteous
- D.L. Lindsley
- D.L. Williams
- D.S. Gerhard
- D.S. Gerhard
- E.A. Shima
- E.H.Y. Chu
- E.H.Y. Chu
- E.R. Fearon
- F. Sherman
- F.D. Ledley
- F.T. Kao
- F.T. Kao
- F.T. Kao
- G. Casey
- G. Klein
- G. Stenman
- G. Vergnaud
- G.A.P. Bruns
- H. Donis-Keller
- H. Yoo-Warren
- H.E. Grenett
- J. Bill
- J. Bill
- J. Feder
- J. Kapuscinski
- J. Mallet
- J.F. Gusella
- J.F. Gusella
- J.H. Fisher
- J.J. Wasmuth
- J.J. Yunis
- J.M. Murray
- J.M. Ordovas
- J.M. Rommens
- J.R. Kidd
- J.W. Moore
- J.W.M. Hoppener
- K. Lange
- K.L. O'Malley
- K.O.J. Simola
- L.B. Russell
- L.L. Deaver
- L.M. Davis
- L.M. Davis
- L.M. Kunkel
- M. Jeanpierre
- M. Litt
- M. Nabholz
- M. Oda
- M. Waziri
- M.E. Harper
- M.E. Kamarck
- M.J. Pettenati
- M.J. Siciliano
- M.M. Elkind
- M.N. Woodroofe
- M.W. Hentze
- M.W. Taylor
- P. Lalley
- P. Lichter
- P. Wuthier
- P.C. Watkins
- P.L. Faust
- P.N. Goodfellow
- R. White
- R.E. Magenis
- R.G. Worton
- R.V. Lebo
- S. Benzer
- S. Qin
- S.D. Kittur
- S.J. Goss
- S.L. Mansour
- S.M. Tilghman
- S.P. Craig
- S.T. Reeders
- T. Boehm
- T. Glaser
- T. Glaser
- T. Glaser
- T. Holm
- T.A. Donlon
- T.G. Lugo
- T.J. Vasicek
- T.L. Yang-Feng
- T.M. Glaser
- T.T. Puck
- V. Heyningen van
- W.H. Lewis
- W.J. Rettig
- W.K. Cavenee
- W.T. Schroeder
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Paraganglioma and Pheochromocytoma
- Author
- A. Arnold
- A. Bauer
- A. Behmel
- A. Blanes
- A. Cascón
- A. Cascón
- A. Cascón
- A. Cascón
- A. Cascón
- A. Cascón
- A. Elbehti-Green
- A. Garcia
- A. Garcia-Escudero
- A. Gursoy
- A. Hering
- A. Machens
- A. Perren
- A. Subramanian
- A. Valavanis
- A. Velasco
- A.-P. Gimenez-Roqueplo
- A.-P. Gimenez-Roqueplo
- A.-P. Gimenez-Roqueplo
- A.E. Petropoulos
- A.G. Mey van der
- A.G. Mey van der
- A.J. Kroll
- A.J. Roncoroni
- A.L. Young
- A.M. McNichol
- A.M. McNicol
- A.M. Moreno
- A.M. Sawka
- A.M. Sawka
- A.N. Mhatre
- A.S. Colwell
- A.S. Tischler
- A.S. Tischler
- A.S. Tischler
- B. Bausch
- B. Bausch
- B. Bausch
- B. Gunawan
- B. Leube
- B. Parfait
- B.A. Ackrell
- B.A.J. Ponder
- B.A.J. Ponder
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.E. Baysal
- B.M. Evers
- B.S. Mandavilli
- B.U. Bender
- C. August
- C. Bauters
- C. Beldjord
- C. Boltze
- C. Eng
- C. Eng
- C. Eng
- C. Eng
- C. Eng
- C. Eng
- C. Fottner
- C. Gonzalez
- C. Jarbo
- C. Jimenez
- C. Pawlu
- C. Proye
- C. Segouffin-Cariou
- C. Suarez
- C. Williamson
- C. Yan
- C.A. Carrasco
- C.A. Friedrich
- C.A. Koch
- C.A. Koch
- C.A. Koch
- C.A. Moran
- C.A. Nurse
- C.D. Liapis
- C.G. Perry
- C.G.P. Mathew
- C.M. McDonnell
- C.R. Lancaster
- C.S. Gujrathi
- C.T. Carman
- C.W. Pugh
- D. Astuti
- D. Astuti
- D. Astuti
- D. Astuti
- D. Astuti
- D. Califano
- D. Erickson
- D. Gupta
- D. Hanahan
- D. Heath
- D. Heath
- D. Katechis
- D. Soffer
- D.E. Benn
- D.E. Benn
- D.E. Benn
- D.E. Benn
- D.E. Benn
- D.G. Balatsouras
- D.G. Wang
- D.G.R. Evans
- D.H. Gutmann
- D.H. Gutmann
- D.J. Gross
- D.J. Marsh
- D.K. Jordan
- D.M. Parry
- D.R. Green
- D.W. Kennedy
- E. Edström
- E. Edström Elder
- E. Edström Elder
- E. Edström Elder
- E. Edström Elder
- E. Gottlieb
- E. Harst van der
- E. Harst van der
- E. Harst van der
- E. Modigliani
- E. Shin
- E. Temes
- E.-M. Duerr
- E.C. Mariman
- E.C.M. Mariman
- E.E. Lack
- E.E. Lack
- E.E. Lack
- E.F. Hensen
- E.L. Bravo
- E.L. Held
- E.L. Sabban
- E.M. Schothorst van
- E.M. Schothorst van
- E.M. Schothorst van
- E.R. Maher
- E.R. Maher
- E.R. Maher
- E.R. Maher
- E.R. Woodward
- F. Chen
- F. Hes
- F. Latif
- F. Lumachi
- F. Mantero
- F. Schiavi
- F. Sköldberg
- F. Weber
- F. Zorlu
- F.F. Telischi
- F.G. Zak
- F.H. Nederveen van
- F.H. Nederveen van
- F.J. Hes
- F.J. Pomares
- F.M. Baars van
- F.M. Brouwers
- F.M. Brouwers
- for the European-American Paraganglioma Study Group
- G. Bernini
- G. Eisenhoer
- G. Eisenhofer
- G. Eisenhofer
- G. Eisenhofer
- G. Eisenhofer
- G. Eisenhofer
- G. Eisenhofer
- G. Eisenhofer
- G. Eisenhofer
- G. Eisenhofer
- G. Kroemer
- G. Opocher
- G. Opocher
- G. Sanso
- G.A. Kaltsas
- G.L. Semenza
- G.L. Semenza
- G.P. Bernini
- H. Brauch
- H. Brauch
- H. Dannenberg
- H. Dannenberg
- H. Dannenberg
- H. Dannenberg
- H. Dannenberg
- H. Dannenberg
- H. Dannenberg
- H. Dekken Van
- H. Donis-Keller
- H. Hir Le
- H. Hir Le
- H. Hir Le
- H. Hirawake
- H. Hirawake
- H. John
- H. Le Hir
- H. Murakami
- H. Ohji
- H. Satake
- H. Yan
- H.-J. Decker
- H.C. Kang
- H.D. Appelman
- H.D. Schroder
- H.E. Harst van der
- H.J.-H. Decker
- H.J.L.M. Timmers
- H.J.L.M. Timmers
- H.M. Brown
- H.P.H. Neumann
- H.P.H. Neumann
- H.P.H. Neumann
- H.P.H. Neumann
- H.P.H. Neumann
- H.S. Jeong
- I. Dalainas
- I. Ilias
- I. Ilias
- I.E. Scheffler
- J. Arias-Stella
- J. Arias-Stella
- J. Bertherat
- J. Bryant
- J. Favier
- J. Favier
- J. Gijtenbeek
- J. Gospeth
- J. Guillemot
- J. Jeffery
- J. Keith
- J. Koreth
- J. Lima
- J. Masuoka
- J. Milunsky
- J. Mundschenk
- J. Mundschenk
- J. Pozo
- J. Walter
- J. Zedenius
- J.-J. Briére
- J.-P. Bayley
- J.-P. Bayley
- J.-S. Kim
- J.A. Carney
- J.A. Carney
- J.A. Plaza
- J.C. Jensen
- J.C. Oosterwijk
- J.C. Reubi
- J.E. Farr
- J.F. Moley
- J.F. Powers
- J.F. Powers
- J.I. Lew
- J.I. Piruat
- J.J. Schuringa
- J.J.S. Treanor
- J.L. Hegarty
- J.M. Dionne
- J.M. Milunsky
- J.R. Hansford
- J.R. Howe
- J.S. Carew
- J.W. Lenders
- J.W. Pritchett
- J.W.M. Lenders
- K. Aström
- K. Ejeskär
- K. Isobe
- K. Isobe
- K. Iwai
- K. Nathanson
- K. Ogawa
- K. Pacak
- K. Pacak
- K. Pacak
- K. Pacak
- K. Riemann
- K. Salame
- K. Salmenkivi
- K. Salmenkivi
- K. Takahashi
- K. Takaya
- K. Takaya
- K. Tory
- K.K. Herfarth
- K.L. Brain
- K.Y. Lam
- L. Amar
- L. Amar
- L. Bernardi
- L. Boccon-Gibod
- L. Grumolato
- L. Hederstedt
- L. Matyakhina
- L. Nguyen
- L. Pacheco-Ojeda
- L. Ravagnan
- L. Renard
- L. Simi
- L. Yon
- L.C. Pang
- L.D. Thompson
- L.D.R. Thompson
- L.J. Helman
- L.M. DeAngelis
- L.M. Mulligan
- L.M. Mulligan
- L.M. Mulligan
- L.M. Mulligan
- L.R. Cavalli
- M. Aarts
- M. Bar
- M. Bolland
- M. Fassnacht
- M. Kiechle-Schwarz
- M. Killert
- M. Kino
- M. Kirchhoff
- M. Maier-Woelfle
- M. Miettinen
- M. Miettinen
- M. Sanicola
- M. Santoro
- M. Santoro
- M. Santoro
- M. Statuto
- M. Strauss
- M. Takahashi
- M. Takahashi
- M. Tsutsumi
- M. Wada
- M. Zanelli
- M.-A. Abbott
- M.A. Birch-Machin
- M.A. Hoffman
- M.A. Selak
- M.A. Zeiger
- M.B. Mosunjac
- M.C. Gelato
- M.F. Czyzyk-Krezeska
- M.G.E.H. Lam
- M.J. Saldana
- M.K. Pu˜ales
- M.M. Grumbach
- M.M. Ritter
- M.M. Walther
- M.M. Walther
- M.M. Walther
- M.P. Vargas
- M.R. Clarke
- M.S. Elston
- M.T. Hull
- N. Ishii
- N. Kimura
- N. Kimura
- N. Kimura
- N. Kimura
- N. Marangos
- N. Sevastos
- N. Sevastos
- N. Tanaka
- N.M. Lindor
- N.O. Atuk
- O. Beck
- O. Gimm
- O. Gimm
- O. Gimm
- O. Gimm
- O. Gimm
- O. Illiopoulos
- O. Illiopoulos
- O. Nativ
- O. Nilsson
- P. Antonitsis
- P. Deb
- P. Devilee
- P. Dundee
- P. Heutink
- P. Heutink
- P. Komminoth
- P. Patetsios
- P. Reichardt
- P. Rodien
- P. Rustin
- P. Zbaren
- P.A. Crossey
- P.A. Crossey
- P.B. Douwes Dekker
- P.B. Douwes Dekker
- P.E.M. Täschner
- P.F. Plouin
- P.H. Bikhazi
- P.H. Bikhazi
- P.H. Kann
- P.H. Maxwell
- P.H. Maxwell
- P.H. Maxwell
- P.J. Pollard
- P.J. Pollard
- P.K. Pellitteri
- P.L. Dahia
- P.L. Dahia
- P.L.M. Dahia
- P.L.M. Dahlia
- P.L.M. Dahlia
- P.S. White
- R. Caiazzo
- R. Dammann
- R. Gonzalez-Campora
- R. Paddenberg
- R. Pfragner
- R. Pfragner
- R. Pfragner
- R.C. Aguiar
- R.C.D. Herdman
- R.C.T. Aguiar
- R.E. Goldstein
- R.F. Badenhop
- R.F. Badenhop
- R.F. Pommier
- R.G. Dluhy
- R.I. Linnoila
- R.J. Gorlin
- R.M. Walsh
- R.M.W. Hofstra
- R.N. Schimke
- R.R. Krijger de
- R.R. Krijger de
- R.R. Lonser
- R.W. Jyung
- S. Blasius
- S. Bonnet
- S. Braun
- S. Casanova
- S. Frenzel
- S. Grufferman
- S. Gullu
- S. Hirano
- S. Hosoe
- S. Iyengar
- S. Jing
- S. Khosla
- S. Kytölä
- S. Lahiri
- S. Leckschat
- S. Lee
- S. Lementa
- S. Mehra
- S. Mercuri
- S. Niemann
- S. Niemann
- S. Niemann
- S. Niemann
- S. Niemann
- S. Qiao
- S. Richard
- S. Rodriguez-Cuevas
- S. Takai
- S. Takeda
- S. Valimaki
- S. Vanharanta
- S. Wakasugi
- S.-C. Lee
- S.-Y. Yang
- S.C. Clifford
- S.C. Clifford
- S.C. Cunningham
- S.C. Huang
- S.E. Tisherman
- S.G. lland
- S.K. Mithani
- S.L. Li
- S.M. Arum
- S.M. Huson
- S.M. Tilghman
- S.P. Lee
- S.R. Lin
- S.R. McWhinney
- S.R. McWhinney
- S.W. Weiss
- T. Acker
- T. Bourgeron
- T. Böhling
- T. Ishii
- T. Kamura
- T. Suzuki
- T. Yoshimoto
- T.-T. Huynh
- T.W.A. Vogel
- U. Blume-Peytavi
- U. Bockmuhl
- U. Muller
- V. Wautot
- V. Yankovskaya
- W. Maier
- W. Xu
- W.B. Kinlaw
- W.F. Young Jr.
- W.G. Kaelin
- W.G. Kaelin Jr.
- W.H. Chase
- W.H. Houtum van
- W.M. Manger
- W.M. Manger
- W.O. Lui
- W.P. Tormey
- X. Matias-Guiu
- Y. Tatekawa
- Y. Yokogoshi
- Y.-S. Yoon
- Z. Songyang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study
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