32 research outputs found
Investigating Predictive Factors for Online College Coursework Success Among High School Students
Get PDFThis study seeks to examine the relationship of motivation and self-regulated learning with online college course completion among dual enrolled high school students in Northwest Iowa. The purpose of this study is to determine if there is a predictive relationship between high school student self-efficacy, intrinsic value, test anxiety, cognitive strategy usage and self-regulation strategy usage and successful completion of an online college course. A predictive correlational study was performed. A convenient sample of 23 high school students from one urban Northwest Iowa school district was utilized. Students were surveyed regarding these traits using the Motivated Strategies for Learning Questionnaire (MSLQ). Once survey responses were attained, binary logistic regression modeling was used to determine the strength of predictor variables to predict the final course grade of passing or failing. The study determined there was not a significant predictive relationship between variables and successful course completion. It is suggested that further study be conducted with a larger sample
Interpreting the copolymerization of styrene with maleic anhydride and with methyl methacrylate in terms of the bootstrap model
Full text linkContribution Of Impaired Myocardial Insulin Signaling To Mitochondrial Dysfunction And Oxidative Stress In The Heart
Get PDFBackground—Diabetes-associated cardiac dysfunction is associated with mitochondrial dysfunction and oxidative stress, which may contribute to LV dysfunction. The contribution of altered myocardial insulin action, independently of associated changes in systemic metabolism is incompletely understood. The present study tested the hypothesis that perinatal loss of insulin signaling in the heart impairs mitochondrial function.
Methods and Results—In 8-week-old mice with cardiomyocyte deletion of insulin receptors (CIRKO), inotropic reserves were reduced and mitochondria manifested respiratory defects for pyruvate that was associated with proportionate reductions in catalytic subunits of pyruvate dehydrogenase. Progressive age-dependent defects in oxygen consumption and ATP synthesis with the substrates glutamate and the fatty acid derivative palmitoyl carnitine (PC) were observed. Mitochondria were also uncoupled when exposed to PC due in part to increased ROS production and oxidative stress. Although proteomic and genomic approaches revealed a reduction in subsets of genes and proteins related to oxidative phosphorylation, no reduction in maximal activities of mitochondrial electron transport chain complexes were found. However, a disproportionate reduction in TCA cycle and FA oxidation proteins in mitochondria, suggest that defects in FA and pyruvate metabolism and TCA flux may explain the mitochondrial dysfunction observed.
Conclusions—Impaired myocardial insulin signaling promotes oxidative stress and mitochondrial uncoupling, which together with reduced TCA and FA oxidative capacity impairs mitochondrial energetics. This study identifies specific contributions of impaired insulin action to mitochondrial dysfunction in the heart
