457 research outputs found
Depositing boron on Cu(111): Borophene or boride?
Large-area single-crystal surface structures were successfully prepared on
Cu(111) substrate with boron deposition, which is critical for prospective
applications. However, the proposed borophene structures do not match the
scanning tunneling microscopy (STM) results very well, while the proposed
copper boride is at odds with the traditional knowledge that ordered
copper-rich borides normally do not exist due to small difference in
electronegativity and large difference in atomic size. To clarify the
controversy and elucidate the formation mechanism of the unexpected copper
boride, we conducted systematic STM, X-ray photoelectron spectroscopy and
angle-resolved photoemission spectroscopy investigations, confirming the
synthesis of two-dimensional copper boride rather than borophene on Cu(111)
after boron deposition under ultrahigh vacuum. First-principles calculations
with defective surface models further indicate that boron atoms tend to react
with Cu atoms near terrace edges or defects, which in turn shapes the
intermediate structures of copper boride and leads to the formation of stable
Cu-B monolayer via large-scale surface reconstruction eventually.Comment: 15 pages, 4 figure
Hyperprogressive disease in non-small cell lung cancer after PD-1/PD-L1 inhibitors immunotherapy: underlying killer
Immune checkpoint inhibitors (ICIs) target the negative regulatory pathway of T cells and effectively reactive the anti-tumor immune function of T cells by blocking the key pathway of the immune escape mechanism of the tumorāPD-1/PD-L1, and fundamentally changing the prospect of immunotherapy for non-small cell lung cancer patients. However, such promising immunotherapy is overshadowed by Hyperprogressive Disease, a response pattern associated with unwanted accelerated tumor growth and characterized by poor prognosis in a fraction of treated patients. This review comprehensively provides an overview of Hyperprogressive Disease in immune checkpoint inhibitor-based immunotherapy for non-small cell lung cancer including its definition, biomarkers, mechanisms, and treatment. A better understanding of the black side of immune checkpoint inhibitors therapy will provide a more profound insight into the pros and cons of immunotherapy
Enhancing the 3D printing fidelity of vat photopolymerization with machine learning-driven boundary prediction
Like many pixel-based additive manufacturing (AM) techniques, digital light processing (DLP) based vat pho-topolymerization faces the challenge that the square pixel based processing strategy can lead to zigzag edges especially when feature sizes come close to single-pixel levels. Introducing greyscale pixels has been a strategy to smoothen such edges, but it is a challenging task to understand which of the many permutations of projected pix-els would give the optimal 3D printing performance. To address this challenge, a novel data acquisition strategy based on machine learning (ML) principles is proposed, and a training routine is implemented to reproduce the smallest shape of an intended 3D printed object. Through this approach, a chessboard patterning strategy is developed along with an automated data refining and augmentation workflow, demonstrating its efficiency and effectiveness by reducing the deviation by around 30%
The LAMOST Complete Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap I. The Spectroscopic Redshift Catalog
We present a spectroscopic redshift catalog from the LAMOST Complete
Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap
(SGC), which is designed to observe all sources (Galactic and extra-galactic)
by using repeating observations with a limiting magnitude of in
two fields. The project is mainly focusing on the completeness of
LAMOST ExtraGAlactic Surveys (LEGAS) in the SGC, the deficiencies of source
selection methods and the basic performance parameters of LAMOST telescope. In
both fields, more than 95% of galaxies have been observed. A post-processing
has been applied to LAMOST 1D spectrum to remove the majority of remaining sky
background residuals. More than 10,000 spectra have been visually inspected to
measure the redshift by using combinations of different emission/absorption
features with uncertainty of . In total, there are 1528
redshifts (623 absorption and 905 emission line galaxies) in Field A and 1570
redshifts (569 absorption and 1001 emission line galaxies) in Field B have been
measured. The results show that it is possible to derive redshift from low SNR
galaxies with our post-processing and visual inspection. Our analysis also
indicates that up to 1/4 of the input targets for a typical extra-galactic
spectroscopic survey might be unreliable. The multi-wavelength data analysis
shows that the majority of mid-infrared-detected absorption (91.3%) and
emission line galaxies (93.3%) can be well separated by an empirical criterion
of . Meanwhile, a fainter sequence paralleled to the main population
of galaxies has been witnessed both in / and /
diagrams, which could be the population of luminous dwarf galaxies but
contaminated by the edge-on/highly inclined galaxies ().Comment: 19 pages, 14 figures, 2 MRT, accepted by ApJ
Duration of Antibody Responses after Severe Acute Respiratory Syndrome
Among 176 patients who had had severe acute respiratory syndrome (SARS), SARS-specific antibodies were maintained for an average of 2 years, and significant reduction of immunoglobulin Gāpositive percentage and titers occurred in the third year. Thus, SARS patients might be susceptible to reinfection >3 years after initial exposure
Time-reversal symmetry breaking driven topological phase transition in EuB
The interplay between time-reversal symmetry (TRS) and band topology plays a
crucial role in topological states of quantum matter. In
time-reversal-invariant (TRI) systems, the inversion of spin-degenerate bands
with opposite parity leads to nontrivial topological states, such as
topological insulators and Dirac semimetals. When the TRS is broken, the
exchange field induces spin splitting of the bands. The inversion of a pair of
spin-splitting subbands can generate more exotic topological states, such as
quantum anomalous Hall insulators and magnetic Weyl semimetals. So far, such
topological phase transitions driven by the TRS breaking have not been
visualized. In this work, using angle-resolved photoemission spectroscopy, we
have demonstrated that the TRS breaking induces a band inversion of a pair of
spin-splitting subbands at the TRI points of Brillouin zone in EuB, when a
long-range ferromagnetic order is developed. The dramatic changes in the
electronic structure result in a topological phase transition from a TRI
ordinary insulator state to a TRS-broken topological semimetal (TSM) state.
Remarkably, the magnetic TSM state has an ideal electronic structure, in which
the band crossings are located at the Fermi level without any interference from
other bands. Our findings not only reveal the topological phase transition
driven by the TRS breaking, but also provide an excellent platform to explore
novel physical behavior in the magnetic topological states of quantum matter.Comment: 22 pages, 7 figures, accepted by Phys. Rev.
Global intron retention mediated gene regulation during CD4+ T cell activation.
T cell activation is a well-established model for studying cellular responses to exogenous stimulation. Using strand-specific RNA-seq, we observed that intron retention is prevalent in polyadenylated transcripts in resting CD4(+) T cells and is significantly reduced upon T cell activation. Several lines of evidence suggest that intron-retained transcripts are less stable than fully spliced transcripts. Strikingly, the decrease in intron retention (IR) levels correlate with the increase in steady-state mRNA levels. Further, the majority of the genes upregulated in activated T cells are accompanied by a significant reduction in IR. Of these 1583 genes, 185 genes are predominantly regulated at the IR level, and highly enriched in the proteasome pathway, which is essential for proper T cell proliferation and cytokine release. These observations were corroborated in both human and mouse CD4(+) T cells. Our study revealed a novel post-transcriptional regulatory mechanism that may potentially contribute to coordinated and/or quick cellular responses to extracellular stimuli such as an acute infection
Measurements of J/psi Decays into 2(pi+pi-)eta and 3(pi+pi-)eta
Based on a sample of 5.8X 10^7 J/psi events taken with the BESII detector,
the branching fractions of J/psi--> 2(pi+pi-)eta and J/psi-->3(pi+pi-)eta are
measured for the first time to be (2.26+-0.08+-0.27)X10^{-3} and
(7.24+-0.96+-1.11)X10^{-4}, respectively.Comment: 11 pages, 6 figure
BESII Detector Simulation
A Monte Carlo program based on Geant3 has been developed for BESII detector
simulation. The organization of the program is outlined, and the digitization
procedure for simulating the response of various sub-detectors is described.
Comparisons with data show that the performance of the program is generally
satisfactory.Comment: 17 pages, 14 figures, uses elsart.cls, to be submitted to NIM
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