Modelling allocation with transport/conversion processes.

A shoot:root carbon:nitrogen allocation model, based on the two processes of transport and chemical conversion, is described and explored. The view is proposed that all allocation models, whether built for the purposes of theoretical investigation or practical application, should start with this irreducible framework. In the present implementation, the processes operate according to: for substrate sources, dependence on shoot and root sizes, with possible product inhibition; for transport, movement down a substrate concentration gradient; for substrate sinks or utilization, linear bisubstrate kinetics. The dynamic and equilibrium properties of the model are explored. Failure of this approach to allocation will indicate to the modeller that additional mechanisms to control the processes are needed, and the mode of failure will indicate the type of mechanisms required. Additional mechanisms are discussed which may involve hormones or teleonomic (goal-seeking) controls, and may be added to the irreducible framework. However, these additions should not replace the irreducible framework of transport and chemical conversion, because they do not in reality. Modifications to the basic model to reflect some possibilities such as ontogenesis with the transition from exponential growth towards a steady state or with the scaling of within-plant transport resistances, the influence of hormones, and active transport, are described

Warm Dust and Spatially Variable PAH Emission in the Dwarf Starburst Galaxy NGC 1705

We present Spitzer observations of the dwarf starburst galaxy NGC 1705 obtained as part of SINGS. The galaxy morphology is very different shortward and longward of ~5 microns: short-wavelength imaging shows an underlying red stellar population, with the central super star cluster (SSC) dominating the luminosity; longer-wavelength data reveals warm dust emission arising from two off-nuclear regions offset by ~250 pc from the SSC. These regions show little extinction at optical wavelengths. The galaxy has a relatively low global dust mass (~2E5 solar masses, implying a global dust-to-gas mass ratio ~2--4 times lower than the Milky Way average). The off-nuclear dust emission appears to be powered by photons from the same stellar population responsible for the excitation of the observed H Alpha emission; these photons are unassociated with the SSC (though a contribution from embedded sources to the IR luminosity of the off-nuclear regions cannot be ruled out). Low-resolution IRS spectroscopy shows moderate-strength PAH emission in the 11.3 micron band in the eastern peak; no PAH emission is detected in the SSC or the western dust emission complex. There is significant diffuse 8 micron emission after scaling and subtracting shorter wavelength data; the spatially variable PAH emission strengths revealed by the IRS data suggest caution in the interpretation of diffuse 8 micron emission as arising from PAH carriers alone. The metallicity of NGC 1705 falls at the transition level of 35% solar found by Engelbracht and collaborators; the fact that a system at this metallicity shows spatially variable PAH emission demonstrates the complexity of interpreting diffuse 8 micron emission. A radio continuum non-detection, NGC 1705 deviates significantly from the canonical far-IR vs. radio correlation. (Abridged)Comment: ApJ, in press; please retrieve full-resolution version from http://www.astro.wesleyan.edu/~cannon/pubs.htm

The Nature of Infrared Emission in the Local Group Dwarf Galaxy NGC 6822 As Revealed by Spitzer

We present Spitzer imaging of the metal-deficient (Z ~30% Z_sun) Local Group dwarf galaxy NGC 6822. On spatial scales of ~130 pc, we study the nature of IR, H alpha, HI, and radio continuum emission. Nebular emission strength correlates with IR surface brightness; however, roughly half of the IR emission is associated with diffuse regions not luminous at H alpha (as found in previous studies). The global ratio of dust to HI gas in the ISM, while uncertain at the factor of ~2 level, is ~25 times lower than the global values derived for spiral galaxies using similar modeling techniques; localized ratios of dust to HI gas are about a factor of five higher than the global value in NGC 6822. There are strong variations (factors of ~10) in the relative ratios of H alpha and IR flux throughout the central disk; the low dust content of NGC 6822 is likely responsible for the different H alpha/IR ratios compared to those found in more metal-rich environments. The H alpha and IR emission is associated with high-column density (> ~1E21 cm^-2) neutral gas. Increases in IR surface brightness appear to be affected by both increased radiation field strength and increased local gas density. Individual regions and the galaxy as a whole fall within the observed scatter of recent high-resolution studies of the radio-far IR correlation in nearby spiral galaxies; this is likely the result of depleted radio and far-IR emission strengths in the ISM of this dwarf galaxy.Comment: ApJ, in press; please retrieve full-resolution version from http://www.astro.wesleyan.edu/~cannon/pubs.htm

Warm Dust and Spatially Variable Polycyclic Aromatic Hydrocarbon Emission in the Dwarf Starburst Galaxy NGC 1705

We present Spitzer observations of the nearby dwarf starburst galaxy NGC 1705 obtained as part of the Spitzer Infrared Nearby Galaxies Survey. The galaxy morphology is very different shortward and longward of ~5 μm: optical and short-wavelength IRAC imaging shows an underlying red stellar population, with the central super star cluster (SSC) dominating the luminosity; longer wavelength IRAC and MIPS imaging reveals warm dust emission arising from two off-nuclear regions that are offset by ~250 pc from the SSC and that dominate the far-IR flux of the system. These regions show little extinction at optical wavelengths. The galaxy has a relatively low global dust mass (~2 × 10^5 M_☉, implying a global dust-to-gas mass ratio ~2-4 times lower than the Milky Way average, roughly consistent with the metallicity decrease). The off-nuclear dust emission appears to be powered by photons from the same stellar population responsible for the excitation of the observed Hα emission; these photons are unassociated with the SSC (although a contribution from embedded sources to the IR luminosity of the off-nuclear regions cannot be ruled out). Low-resolution IRS spectroscopy shows moderate-strength PAH emission in the 11.3 μm band in the more luminous eastern peak; no PAH emission is detected in the SSC or the western dust emission complex. There is significant diffuse emission in the IRAC 8 μm band after starlight has been removed by scaling shorter wavelength data; the fact that IRS spectroscopy shows spatially variable PAH emission strengths compared to the local continuum within this diffuse gas suggests caution in the interpretation of IRAC diffuse 8 μm emission as arising from PAH carriers alone. The nebular metallicity of NGC 1705 falls at the transition level of ~0.35 Z_☉ found by Engelbracht and collaborators, below which PAH emission is difficult to detect; the fact that a system at this metallicity shows spatially variable PAH emission demonstrates the complexity of interpreting diffuse 8 μm emission in galaxies. NGC 1705 deviates significantly from the canonical far-infrared versus radio correlation, having significant far-infrared emission but no detected radio continuum

Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND)

Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident end-stage kidney disease (ESKD) have DKD. Independent of glycemic control, DKD aggregates in families and has higher incidence rates in African, Mexican, and American Indian ancestral groups relative to European populations. The Family Investigation of Nephropathy and Diabetes (FIND) performed a genome-wide association study (GWAS) contrasting 6,197 unrelated individuals with advanced DKD with healthy and diabetic individuals lacking nephropathy of European American, African American, Mexican American, or American Indian ancestry. A large-scale replication and trans-ethnic meta-analysis included 7,539 additional European American, African American and American Indian DKD cases and non-nephropathy controls. Within ethnic group meta-analysis of discovery GWAS and replication set results identified genome-wide significant evidence for association between DKD and rs12523822 on chromosome 6q25.2 in American Indians (P = 5.74x10-9). The strongest signal of association in the trans-ethnic meta-analysis was with a SNP in strong linkage disequilibrium with rs12523822 (rs955333; P = 1.31x10-8), with directionally consistent results across ethnic groups. These 6q25.2 SNPs are located between the SCAF8 and CNKSR3 genes, a region with DKD relevant changes in gene expression and an eQTL with IPCEF1, a gene co-translated with CNKSR3. Several other SNPs demonstrated suggestive evidence of association with DKD, within and across populations. These data identify a novel DKD susceptibility locus with consistent directions of effect across diverse ancestral groups and provide insight into the genetic architecture of DKD

An open-ended logistic-based growth function: analytical solutions and the power-law logistic model

An open-ended form of the logistic equation was recently proposed, using a model comprising two differential equations [Thornley, J.H.M., France, J., 2005. An open-ended logistic-based growth function. Ecol. Model. 184, 257–261]. The equations represent the two processes of growth and development, and are coupled. In this note, an analytical solution is developed for constant parameters. The solution can be expressed as a targetted single-differential-equation model, the θ-logistic or power-law logistic model, which is a well-known empirical growth equation in ecology and elsewhere. The analysis may facilitate mechanistic interpretation and application of the power-law logistic model as well as the original open two-differential-equation model