In-Chain Tunneling Through Charge-Density Wave Nanoconstrictions and Break-Junctions

We have fabricated longitudinal nanoconstrictions in the charge-density wave conductor (CDW) NbSe$_{3}$ using a focused ion beam and using a mechanically controlled break-junction technique. Conductance peaks are observed below the T$_{P1}$$=145$K and T$_{P2}$$=59$K CDW transitions, which correspond closely with previous values of the full CDW gaps $2\Delta_{1}$ and $2\Delta_{2}$ obtained from photo-emission. These results can be explained by assuming CDW-CDW tunneling in the presence of an energy gap corrugation $\epsilon_{2}$ comparable to $\Delta_{2}$, which eliminates expected peak at $\Delta_{1}+\Delta_{2}$. The nanometer length-scales our experiments imply indicate that an alternative explanation based on tunneling through back-to-back CDW-normal junctions is unlikely.Comment: 5 pages, 3 figures, submitted to physical review letter

Theranostic Potential of Oncolytic Vaccinia Virus

Biological cancer therapies, such as oncolytic, or replication-selective viruses have advantages over traditional therapeutics as they can employ multiple different mechanisms to target and destroy cancers (including direct cell lysis, immune activation and vascular collapse). This has led to their rapid recent clinical development. However this also makes their pre-clinical and clinical study complex, as many parameters may affect their therapeutic potential and so defining reason for treatment failure or approaches that might enhance their therapeutic activity can be complicated. The ability to non-invasively image viral gene expression in vivo both in pre-clinical models and during clinical testing will considerably enhance the speed of oncolytic virus development as well as increasing the level and type of useful data produced from these studies. Further, subsequent to future clinical approval, imaging of reporter gene expression might be used to evaluate the likelihood of response to oncolytic viral therapy prior to changes in tumor burden. Here different reporter genes used in conjunction with oncolytic viral therapy are described, along with the imaging modalities used to measure their expression, while their applications both in pre-clinical and clinical testing are discussed. Possible future applications for reporter gene expression from oncolytic viruses in the phenotyping of tumors and the personalizing of treatment regimens are also discussed

Relativistic Stellar Pulsations With Near-Zone Boundary Conditions

A new method is presented here for evaluating approximately the pulsation modes of relativistic stellar models. This approximation relies on the fact that gravitational radiation influences these modes only on timescales that are much longer than the basic hydrodynamic timescale of the system. This makes it possible to impose the boundary conditions on the gravitational potentials at the surface of the star rather than in the asymptotic wave zone of the gravitational field. This approximation is tested here by predicting the frequencies of the outgoing non-radial hydrodynamic modes of non-rotating stars. The real parts of the frequencies are determined with an accuracy that is better than our knowledge of the exact frequencies (about 0.01%) except in the most relativistic models where it decreases to about 0.1%. The imaginary parts of the frequencies are determined with an accuracy of approximately M/R, where M is the mass and R is the radius of the star in question.Comment: 10 pages (REVTeX 3.1), 5 figs., 1 table, fixed minor typos, published in Phys. Rev. D 56, 2118 (1997

High Resolution Ionization of Ultracold Neutral Plasmas

Collective effects, such as waves and instabilities, are integral to our understanding of most plasma phenomena. We have been able to study these in ultracold neutral plasmas by shaping the initial density distribution through spatial modulation of the ionizing laser intensity. We describe a relay imaging system for the photoionization beam that allows us to create higher resolution features and its application to extend the observation of ion acoustic waves to shorter wavelengths. We also describe the formation of sculpted density profiles to create fast expansion of plasma into vacuum and streaming plasmas

What is the maximum rate at which entropy of a string can increase?

According to Susskind, a string falling toward a black hole spreads exponentially over the stretched horizon due to repulsive interactions of the string bits. In this paper such a string is modeled as a self-avoiding walk and the string entropy is found. It is shown that the rate at which information/entropy contained in the string spreads is the maximum rate allowed by quantum theory. The maximum rate at which the black hole entropy can increase when a string falls into a black hole is also discussed.Comment: 11 pages, no figures; formulas (18), (20) are corrected (the quantum constant is added), a point concerning a relation between the Hawking and Hagedorn temperatures is corrected, conclusions unchanged; accepted by Physical Review D for publicatio

Minimum Length from Quantum Mechanics and Classical General Relativity

We derive fundamental limits on measurements of position, arising from quantum mechanics and classical general relativity. First, we show that any primitive probe or target used in an experiment must be larger than the Planck length, $l_P$. This suggests a Planck-size {\it minimum ball} of uncertainty in any measurement. Next, we study interferometers (such as LIGO) whose precision is much finer than the size of any individual components and hence are not obviously limited by the minimum ball. Nevertheless, we deduce a fundamental limit on their accuracy of order $l_P$. Our results imply a {\it device independent} limit on possible position measurements.Comment: 8 pages, latex, to appear in the Physical Review Letter

Comments on the black hole information problem

String theory provides numerous examples of duality between gravitational theories and unitary gauge theories. To resolve the black hole information paradox in this setting, it is necessary to better understand how unitarity is implemented on the gravity side. We argue that unitarity is restored by nonlocal effects whose initial magnitude is suppressed by the exponential of the Bekenstein-Hawking entropy. Time-slicings for which effective field theory is valid are obtained by demanding the mutual back-reaction of quanta be small. The resulting bounds imply that nonlocal effects do not lead to observable violations of causality or conflict with the equivalence principle for infalling observers, yet implement information retrieval for observers who stay outside the black hole.Comment: 18 pages, 2 figures, revtex, v2 figure added and some improvements to presentatio

Gravitational waves from relativistic neutron star mergers with nonzero-temperature equations of state

We analyze the gravitational wave (GW) emission from our recently published set of relativistic neutron star (NS) merger simulations and determine characteristic signal features that allow one to link GW measurements to the properties of the merging binary stars. We find that the distinct peak in the GW energy spectrum that is associated with the formation of a hypermassive merger remnant has a frequency that depends strongly on the properties of the nuclear equation of state (EoS) and on the total mass of the binary system, whereas the mass ratio and the NS spins have a weak influence. If the total mass can be determined from the inspiral chirp signal, the peak frequency of the postmerger signal is a sensitive indicator of the EoS.Comment: 5 pages, 4 figures, revised version accepted for publication in PR

Viewing the Shadow of the Black Hole at the Galactic Center

In recent years, the evidence for the existence of an ultra-compact concentration of dark mass associated with the radio source Sgr A* in the Galactic Center has become very strong. However, an unambiguous proof that this object is indeed a black hole is still lacking. A defining characteristic of a black hole is the event horizon. To a distant observer, the event horizon casts a relatively large ``shadow'' with an apparent diameter of ~10 gravitational radii due to bending of light by the black hole, nearly independent of the black hole spin or orientation. The predicted size (~30 micro-arcseconds) of this shadow for Sgr A* approaches the resolution of current radio-interferometers. If the black hole is maximally spinning and viewed edge-on, then the shadow will be offset by ~8 micro-arcseconds from the center of mass, and will be slightly flattened on one side. Taking into account scatter-broadening of the image in the interstellar medium and the finite achievable telescope resolution, we show that the shadow of Sgr A* may be observable with very long-baseline interferometry at sub-millimeter wavelengths, assuming that the accretion flow is optically thin in this region of the spectrum. Hence, there exists a realistic expectation of imaging the event horizon of a black hole within the next few years.Comment: 5 pages, 1 figure (color), (AAS)Tex, to appear in The Astrophysical Journal Letters, Vol. 528, L13 (Jan 1, 2000 issue); also available at http://www.mpifr-bonn.mpg.de/staff/hfalcke/publications.html#bhimag

Tidal Stabilization of Rigidly Rotating, Fully Relativistic Neutron Stars

It is shown analytically that an external tidal gravitational field increases the secular stability of a fully general relativistic, rigidly rotating neutron star that is near marginal stability, protecting it against gravitational collapse. This stabilization is shown to result from the simple fact that the energy $\delta M(Q,R)$ required to raise a tide on such a star, divided by the square of the tide's quadrupole moment $Q$, is a decreasing function of the star's radius $R$, $(d/dR)[\delta M(Q,R)/Q^2]<0$ (where, as $R$ changes, the star's structure is changed in accord with the star's fundamental mode of radial oscillation). If $(d/dR)[\delta M(Q,R)/Q^2]$ were positive, the tidal coupling would destabilize the star. As an application, a rigidly rotating, marginally secularly stable neutron star in an inspiraling binary system will be protected against secular collapse, and against dynamical collapse, by tidal interaction with its companion. The ``local-asymptotic-rest-frame'' tools used in the analysis are somewhat unusual and may be powerful in other studies of neutron stars and black holes interacting with an external environment. As a byproduct of the analysis, in an appendix the influence of tidal interactions on mass-energy conservation is elucidated.Comment: Revtex, 10 pages, 2 figures; accepted for publication in Physical Review D. Revisions: Appendix rewritten to clarify how, in Newtonian gravitation theory, ambiguity in localization of energy makes interaction energy ambiguous but leaves work done on star by tidal gravity unambiguous. New footnote 1 and Refs. [11] and [19