The Sourcerer's Apprentice

This assignment considers the use of the apprenticeship model of teaching in academic subject areas. This has been investigated by various authors since 1989. I will consider the various flavors of the techniques presented and some of the practical implications of these. I will draw from our experience running several courses where students undertake business like projects within a protective environment

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma

Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma. Additional drugs include leukotriene-receptor antagonists, slow-release theophylline and the long-acting muscarinic antagonist (LAMA) tiotropium (approved in 2015). There is a need for more effective therapies, as many patients continue to have poorly controlled asthma. Areas covered: New and developing long-acting non-adrenoreceptor synthetic drugs for the treatment of symptomatic chronic asthma despite treatment with an ICS alone or combined with a LABA. Data was reviewed from studies published up until November 2016. Expert opinion: Tiotropium improves lung function and has a modest effect in reducing exacerbations when added to ICS alone or ICS and LABA. The LAMAs umeclidinium and glycopyrronium are under development in fixed dose combination with ICS and LABA. Novel small molecule drugs, such as CRTH2 receptor antagonists, PDE4 inhibitors, protein kinase inhibitors and nonsteroidal glucocorticoid receptor agonists and ‘off-label’ use of licensed drugs, such as macrolides and statins are under investigation for asthma, although their effectiveness in clinical practice is not established. To better achieve the goal of developing effective novel small molecule drugs for asthma will require greater understanding of mechanisms of disease and the different phenotypes and endotypes of asthma

Does age of onset of asthma influence the effect of cigarette smoking on lung function?

No abstract available

Professionalism In The First Year Of A Software Engineering Curriculum

Professionalism is an important part of any subject of study where graduates subsequently move into a professional career following their degree course. Most professional bodies therefore require accredited degree programmes to include this topic in the curriculum. The British Computer Society gives guidelines to institutions in the UK. These guidelines have been followed in the construction of the current Software Engineering Curriculum in the Department Of computer Science at the University of Sheffield. However it is unclear how effective the current form of presentation is. This report seeks to investigate this and look to possible ways of improving the presentation, particularly in the first year. I conclude that the most important factor in teaching professionalism; is the professionalism of the teachers. Students seem to learn these skills best by example, and therefore the greatest improvements are likely to be found by implementing common standards for teaching practice across the syllabus

Applying XP Ideas Formally: The Story Card and Extreme X-Machines

By gathering requirements on story cards extreme programming (XP) makes requirements collection easy. However it is less clear how the story cards are translated into a �finished product. We propose that a formal specification method based on X-Machines can be used to direct this transition. Extreme X-Machines �t in to the XP method well, without large overheads in design and maintenance. We also investigate how such machines adapt to change in the story cards and propose how this could be further enhanced

Du Quoin strives to diversify beyond state fair

Economic development ; Federal Reserve District, 8th ; Illinois

Factory closings shock community into opening wallets for economic development

Federal Reserve District, 8th ; Manufactures ; Arkansas

Alton comes to grip with industrial decline

Illinois ; Federal Reserve District, 8th ; Economic development