Ectoparasites and Other Arthropod Associates of the Hairy-tailed Mole, \u3ci\u3eParascalops Breweri\u3c/i\u3e

A total of 33 taxa of ectoparasites and other associates was taken on seven individuals of the Hairy-tailed Mole, Parascalops breweri, from New York and New England. The most abundant form was the glycyphagid mite, Labidophorus nearcticus

Ectoparasites and Other Arthropod Associates of Some Voles and Shrews From the Catskill Mountains of New York

Reported here from the Catskill Mountains of New York are 30 ectoparasites and other associates from 39 smoky shrews, Sorex fumeus, 17 from 11 masked shrews, Sorex cinereus, 11 from eight long-tailed shrews, Sorex dispar, and 31 from 44 rock voles, Microtus chrotorrhinus

Artificial Intelligence and IT Professionals

How will continuing developments in artificial intelligence (AI) and machine learning influence IT professionals? This article approaches this question by identifying the factors that influence the demand for software developers and IT professionals, describing how these factors relate to AI, and articulating the likely impact on IT professionals

Audiovisual Metadata Platform Pilot Development (AMPPD), Final Project Report

This report documents the experience and findings of the Audiovisual Metadata Platform Pilot Development (AMPPD) project, which has worked to enable more efficient generation of metadata to support discovery and use of digitized and born-digital audio and moving image collections. The AMPPD project was carried out by partners Indiana University Libraries, AVP, University of Texas at Austin, and New York Public Library between 2018-2021

Explorations, Vol. 6, No. 2

Cover: Untitled #13, Series 2, chalk on paper, by Ronald Ghiz, Associate Professor of Art at the University of Maine. Articles include: Editorial Overview: in this issue, by Carole J. Bombard Save the Planet . . . please, by Nick Houtman Research and Public Service Recognizing Leadership, Pioneering, and Productivity, Herb Hidu and Stephen Norton Private Assistance for Maine’s Hungry, by William H. Whitaker and Jean M. Andrews The Ugly Faces of Hunger Explaining the Iranian Revolution, by Henry Munson, Jr. Biological Clocks: timing is everything—and everywhere, by Jamie Watler Love of Glory and the Common Good: Periclean Democracy and Athenian Tyranny in Thucydides, by Michael Palmer Tools of the Trade: Technology Usage and Financial Performance in Small Business, by Diane J. Garsombke and Thomas W. Garsombk

Cucurbit materials from Peru

15 p. : ill. ; 24 cm.Includes bibliographical references (p. 15).The archaeological background. Utilization of gourds. Containers. Fish-net floats. Discs. Scoops or ladles. Decorative techniques. Repair of broken gourds. Material associated with early ceramics / Junius B. Bird -- Botanical identification and significance / Thomas W. Whitaker

Detection of Early Myocardial Dysfunction by Imaging Biomarkers in Cancer Patients Undergoing Photon Beam vs. Proton Beam Radiotherapy: A Prospective Study

1. Background: We sought to determine acute and subacute changes in cardiac function after proton beam (PBT) and photon beam (PhT) radiotherapy (RT) using conventional and two-dimensional speckle tracking echocardiography (2D-STE) in patients with malignant breast and thoracic tumors. 2. Methods: Between March 2016 and March 2017, 70 patients with breast or thoracic cancer were prospectively enrolled and underwent transthoracic echocardiography with comprehensive strain analysis at pretreatment, mid-treatment, end of treatment, and 3 months after RT. 3. Results: PBT was used to treat 44 patients; PhT 26 patients. Mean ± SD age was 55 ± 12 years; most patients (93%) were women. The median (interquartile range) of the mean heart dose was lower in the PBT than the PhT group (47 [27-79] vs. 217 [120-596] cGy, respectively; p \u3c 0.001). Ejection fraction did not change in either group. Only the PhT group had reduced systolic tissue Doppler velocities at 3 months. 2D-STE showed changes in endocardial and epicardial longitudinal, radial, and circumferential early diastolic strain rate (SRe) in patients undergoing PhT (global longitudinal SRe, pretreatment vs. end of treatment (p = 0.04); global circumferential SRe, pretreatment vs. at 3-month follow-up (p = 0.003); global radial SRe, pretreatment vs. at 3-month follow-up (p = 0.02) for endocardial values). Epicardial strain values decreased significantly only in patients treated with PhT. Patients in the PhT group had a significant decrease in epicardial global longitudinal systolic strain rate (GLSRs) (epicardial GLSRs, at baseline vs. at end of treatment [p = 0.009]) and in GCSRe and GRSRe (epicardial GCSRe, at baseline vs. at 3-month follow-up (p = 0.02); epicardial GRSRe, at baseline vs. at 3-month follow-up (p = 0.03)) during treatment and follow-up. No changes on 2D-STE were detected in the PBT group. 4. Conclusions: Patients who underwent PhT but not PBT had reduced tissue Doppler velocities and SRe values during follow-up, suggesting early myocardial relaxation abnormalities. PBT shows promise as a cardiac-sparing RT technology

Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen

Hantaviruses are a group of emerging pathogens capable of causing severe disease upon zoonotic transmission to humans. The mature hantavirus surface presents higher-order tetrameric assemblies of two glycoproteins, Gn and Gc, which are responsible for negotiating host cell entry and constitute key therapeutic targets. Here, we demonstrate that recombinantly derived Gn from Hantaan virus (HTNV) elicits a neutralizing antibody response (serum dilution that inhibits 50% infection [ID50], 1:200 to 1:850) in an animal model. Using antigen-specific B cell sorting, we isolated monoclonal antibodies (mAbs) exhibiting neutralizing and non-neutralizing activity, termed mAb HTN-Gn1 and mAb nn-ITN-Gn2, respectively. Crystallographic analysis reveals that these mAbs target spatially distinct epitopes at disparate sites of the N-terminal region of the HTNV Gn ectodomain. Epitope mapping onto a model of the higher order (Gn-Gc)(4) spike supports the immune accessibility of the mAb HTN-Gn1 epitope, a hypothesis confirmed by electron cryo-tomography of the antibody with virus-like particles. These data define natively exposed regions of the hantaviral Gn that can be targeted in immunogen design. IMPORTANCE The spillover of pathogenic hantaviruses from rodent reservoirs into the human population poses a continued threat to human health. Here, we show that a recombinant form of the Hantaan virus (HTNV) surface-displayed glycoprotein, Gn, elicits a neutralizing antibody response in rabbits. We isolated a neutralizing (HTN-Gn1) and a non-neutralizing (nn-ITN-Gn2) monoclonal antibody and provide the first molecular-level insights into how the Gn glycoprotein may be targeted by the antibody-mediated immune response. These findings may guide rational vaccine design approaches focused on targeting the hantavirus glycoprotein envelope.Peer reviewe