The privilege of induction avoidance and calcineurin inhibitors withdrawal in 2 haplotype HLA matched white kidney transplantation

BACKGROUND: White recipients of 2-haplotype HLA-matched living kidney transplants are perceived to be of low immunologic risk. Little is known about the safety of induction avoidance and calcineurin inhibitor withdrawal in these patients. METHODS: We reviewed our experience at a single center and compared it to Organ Procurement and Transplantation Network (OPTN) registry data and only included 2-haplotype HLA-matched white living kidney transplants recipients between 2000 and 2013. RESULTS: There were 56 recipients in a single center (where no induction was given) and 2976 recipients in the OPTN. Among the OPTN recipients, 1285 received no induction, 903 basiliximab, 608 thymoglobulin, and 180 alemtuzumab. First-year acute rejection rates were similar after induction-free transplantation among the center and induced groups nationally. Compared with induction-free transplantation in the national data, there was no decrease in graft failure risk over 13 years with use of basiliximab (adjusted hazard ratio [aHR], 0.86; confidence interval [CI], 0.68-1.08), Thymoglobulin (aHR, 0.92; CI, 0.7-1.21) or alemtuzumab (aHR, 1.18; CI, 0.72-1.93). Among induction-free recipients at the center, calcineurin inhibitor withdrawal at 1 year (n = 27) did not significantly impact graft failure risk (HR,1.62; CI, 0.38-6.89). CONCLUSIONS: This study may serve as a foundation for further studies to provide personalized, tailored, immunosuppression for this very low-risk population of kidney transplant patients

: Familias populares e institução escolar : entre autonomia e heteronomia

Version française de "Familias populares e institução escolar : entre autonomia e heteronomia", Educação e Pesquisa, 2010, vol. 36, n°espcial, p. 65-76International audienceL'article se propose d'analyser quelques problèmes théoriques dans l'étude des relations entre familles populaires et école, problèmes qui sont ceux que rencontre la sociologie dans l'étude des classes populaires et de leurs relations avec le monde dominant et les institutions. Il explore la possibilité de dépasser l'alternative entre une perspective strictement légitimiste qui tend à réduire les classes populaires et leurs pratiques au rapport de domination qui les aliène (hétéronomie) et la perspective relativiste qui les envisage dans une altérité radicale (autonomie) en occultant les rapports sociaux de domination. Il insiste sur l'ambivalence des logiques et des pratiques des familles populaire

Active video games: An opportunity for enhanced learning and positive health effects?

Active video games are an emerging genre of electronic games that provide engaging exercise experiences by combining physical exertion with interactive game play. As such they have attracted increased interest from health promotion professionals to reduce sedentary behavior, increase physical activity, and improve health outcomes such as body composition. However their potential for enhancing the educational experience has not been extensively explored. This paper provides a brief overview of active video game research to date and outlines opportunities for future research. Specifically, we highlight the need to develop a conceptual framework to better understand the determinants, mediators, moderators, and consequences of active video gaming and integrate learning and health outcomes. We propose that active video games can be a key part of a wider “digital” supportive environment where education and health researchers and professionals work with, rather than against, video game technologies to promote learning and health

Fake

Fakes, forgery, counterfeits, hoaxes, bullshit, frauds, knock offs—such terms speak, ostensibly, to the inverse of truth or the obverse of authenticity and sincerity. But what does the modern human obsession with fabrications and frauds tell us about ourselves? And what can anthropology tell us about this obsession? This timely book is the product of the first Annual Debate of Anthropological Keywords, a collaborative project between HAU, the American Ethnological Society, and L’Homme, held each year at the American Anthropological Association Meetings. The aim of the debate is reflect critically on keywords and terms that play a pivotal and timely role in discussions of different cultures and societies, and of the relations between them. This book, with multiple authors, explodes open our common sense notions of “novelty,” “originality,” and “truth,” questioning how cultures where deception and mistrust flourish seem to produce effective, albeit opaque, forms of sociality

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. Comparative metabolomics and lipidomics demonstrated that acetate is used as a nutritional source by cancer cells in an ACSS2-dependent manner, and supplied a significant fraction of the carbon within the fatty acid and phospholipid pools. ACSS2 expression is upregulated under metabolically stressed conditions and ACSS2 silencing reduced the growth of tumor xenografts. ACSS2 exhibits copy-number gain in human breast tumors, and ACSS2 expression correlates with disease progression. These results signify a critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment

Dispatching Vehicles in a Mega Container Terminal

Port Authority of Singapore partialResearch was supported in part by the Port of Singapore Authority (PSA).</p

Implementation of National Action Plans on Noncommunicable Diseases, Bhutan, Cambodia, Indonesia, Philippines, Sri Lanka, Thailand and Viet Nam

By 2016, Member States of the World Health Organization (WHO) had developed and implemented national action plans on noncommunicable diseases in line with the Global action plan for the prevention and control of noncommunicable diseases (2013–2020). In 2018, we assessed the implementation status of the recommended best-buy noncommunicable diseases interventions in seven Asian countries: Bhutan, Cambodia, Indonesia, Philippines, Sri Lanka, Thailand and Viet Nam. We gathered data from a range of published reports and directly from health ministries. We included interventions that addressed the use of tobacco and alcohol, inadequate physical activity and high salt intake, as well as health-systems responses, and we identified gaps and proposed solutions. In 2018, progress was uneven across countries. Implementation gaps were largely due to inadequate funding; limited institutional capacity (despite designated noncommunicable diseases units); inadequate action across different sectors within and outside the health system; and a lack of standardized monitoring and evaluation mechanisms to inform policies. To address implementation gaps, governments need to invest more in effective interventions such as the WHO-recommended best-buy interventions, improve action across different sectors, and enhance capacity in monitoring and evaluation and in research. Learning from the Framework Convention on Tobacco Control, the WHO and international partners should develop a standardized, comprehensive monitoring tool on alcohol, salt and unhealthy food consumption, physical activity and health-systems response