When I get back to my American blighty /

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Throw no stones in the well that gives you water

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Alice I\u27m In Wonderland : Since The Day That I First Met You

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Urban Struggles with Financialization

The 2008 financial crisis and its impacts on the urban landscape contributed to a proliferation of research on the financialization of urban space, particularly of housing. Today, financialization is a mainstream focus of study within geography. But while scholars have responded to earlier calls to center space and place in their research, it has only been quite recently that geographers have taken up efforts to politicize and contest the financialization of urban space. This essay assesses the emerging body of literature on urban struggles with financialization. It first draws on historical materialist perspectives to situate financialization within urban contexts, showing why there is a particular relationship between this process and urban space, and how moments of crisis reveal tensions in this relationship. Reviewing literature focused on places exposed to the most systemic housing-financial crises in 2008, the essay then explores how residents, activists, and movements have grappled with financialization. It argues that a key aspect of such struggles is the ability to make their presence felt within chains of financial intermediaries or the corporate headquarters of foreign investors. The essay also highlights how moments of crisis open space for more radical tactics that disrupt the dominant production of space and emphasize the social value of housing. It suggests ways to fruitfully expand geographic inquiry into urban struggles with financialization through focusing on the formation of political subjectivities and engaging geographies beyond the global north

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead