Tritium supply and use: a key issue for the development of nuclear fusion energy

Full power operation of the International Thermonuclear Experimental Reactor (ITER) has been delayed and will now begin in 2035. Delays to the ITER schedule may affect the availability of tritium for subsequent fusion devices, as the global CANDU-type fission reactor fleet begins to phase out over the coming decades. This study provides an up to date account of future tritium availability by incorporating recent uncertainties over the life extension of the global CANDU fleet, as well as considering the potential impact of tritium demand by other fusion efforts. Despite the delays, our projections suggest that CANDU tritium remains sufficient to support the full operation of ITER. However, whether there is tritium available for a DEMO reactor following ITER is largely uncertain, and is subject to numerous uncontrollable externalities. Further tritium demand may come from any number of private sector “compact fusion” start-ups which have emerged in recent years, all of which aim to accelerate the development of fusion energy. If the associated technical challenges can be overcome, compact fusion programmes have the opportunity to use tritium over the next two decades whilst it is readily available, and before full power DT operation on ITER starts in 2035. Assuming a similar level of performance is achievable, a compact fusion development programme, using smaller reactors operating at lower fusion power, would require smaller quantities of tritium than the ITER programme, leaving sufficient tritium available for multiple concepts to be developed concurrently. The development of concurrent fusion concepts increases the chances of success, as it spreads the risk of failure. Additionally, if full tritium breeding capability is not expected to be demonstrated in DEMO until after 2050, an opportunity exists for compact fusion programmes to incorporate tritium breeding technology in nearer-term devices. DD start-up, which avoids the need for external tritium for reactor start-up, is dependent upon full tritium breeding capability, and may be essential for large-scale commercial roll-out of fusion energy. As such, from the standpoint of availability and use of external tritium, a compact route to fusion energy may be more advantageous, as it avoids longer-term complications and uncertainties in the future supply of tritium

Big-pharmaceuticalisation:Clinical trials and contract research organisations in India

The World Trade Organisation's Trade Related Intellectual Property Rights [TRIPS] agreement aimed to harmonise intellectual property rights and patent protection globally. In India, the signing of this agreement resulted in a sharp increase in clinical trials since 2005. The Indian government, along with larger Indian pharmaceutical companies, believed that they could change existing commercial research cultures through the promotion of basic research as well as attracting international clinical trials, and thus create an international level, innovation-based drug industry. The effects of the growth of these outsourced and off-shored clinical trials on local commercial knowledge production in India are still unclear. What has been the impact of the increasing scale and commercialisation of clinical research on corporate science in India? In this paper we describe Big-pharmaceuticalisation in India, whereby the local pharmaceutical industry is moving from generic manufacturing to innovative research. Using conceptual frameworks of pharmaceuticalisation and innovation, this paper analyses data from research conducted in 2010-2012 and describes how Contract Research Organisations (CROs) enable outsourcing of randomised control trials to India. Focussing on twenty-five semi-structured interviews CRO staff, we chart the changes in Indian pharmaceutical industry, and implications for local research cultures. We use Big-pharmaceuticalisation to extend the notion of pharmaceuticalisation to describe the spread of pharmaceutical research globally and illustrate how TRIPS has encouraged a concentration of capital in India, with large companies gaining increasing market share and using their market power to rewrite regulations and introduce new regulatory practices in their own interest. Contract Research Organisations, with relevant, new, epistemic skills and capacities, are both manifestations of the changes in commercial research cultures, as well as the vehicles to achieve them. These changes have reinvigorated public concerns that stress not only access to new medicines but also the 'price' of innovation on research participants

Assessing the feasibility of integrating ecosystem-based with engineered water resource governance and management for water security in semi-arid landscapes: A case study in the Banas catchment, Rajasthan, India

Much of the developing world and areas of the developed world suffer water vulnerability. Engineering solutions enable technically efficient extraction and diversion of water towards areas of demand but, without rebalancing resource regeneration, can generate multiple adverse ecological and human consequences. The Banas River, Rajasthan (India), has been extensively developed for water diversion, particularly from the Bisalpur Dam from which water is appropriated by powerful urban constituencies dispossessing local people. Coincidentally, abandonment of traditional management, including groundwater recharge practices, is leading to increasingly receding and contaminated groundwater. This creates linked vulnerabilities for rural communities, irrigation schemes, urban users, dependent ecosystems and the multiple ecosystem services that they provide, compounded by climate change and population growth. This paper addresses vulnerabilities created by fragmented policy measures between rural development, urban and irrigation water supply and downstream consequences for people and wildlife. Perpetuating narrowly technocentric approaches to resource exploitation is likely only to compound emerging problems. Alternatively, restoration or innovation of groundwater recharge practices, particularly in the upper catchment, can represent a proven, ecosystem-based approach to resource regeneration with linked beneficial socio-ecological benefits. Hybridising an ecosystem-based approach with engineered methods can simultaneously increase the security of rural livelihoods, piped urban and irrigation supplies, and the vitality of river ecosystems and their services to beneficiaries. A renewed policy focus on local-scale water recharge practices balancing water extraction technologies is consistent with emerging Rajasthani policies, particularly Jal Swavlamban Abhiyan (‘water self-reliance mission’). Policy reform emphasising recharge can contribute to water security and yield socio-economic outcomes through a systemic understanding of how the water system functions, and by connecting goals and budgets across multiple, currently fragmented policy areas. The underpinning principles of this necessary paradigm shift are proven and have wider geographic relevance, though context-specific research is required to underpin robust policy and practical implementation

Towards a radical re-appropriation: gender, development and Neoliberal Feminism

Tracing a complex trajectory from ‘liberal’ to ‘neoliberal’ feminism in development, this article argues that approaches to gender which are currently being promoted within neoliberal development frameworks, while often characterized as ‘instrumentalizing’ gender equality, in fact rely upon, extend and deepen gendered inequalities in order to sustain and strengthen processes of global capital accumulation in several ways. This is explored through development discourses and practices relating to microfinance, reproductive rights and adolescent girls. Drawing on examples from India, the article goes on to reflect on experiences of collective movements in which the assumptions underpinning this ‘Gender Equality as Smart Economics’ approach are challenged. Finally, it highlights several concepts associated with Marxist, Black, Post-colonial and Queer feminisms and underlines their importance to projects seeking to critically redefine development, arguing for a radical re-appropriation of gender in this context

Genomic-based-breeding tools for tropical maize improvement

Maize has traditionally been the main staple diet in the Southern Asia and Sub-Saharan Africa and widely grown by millions of resource poor small scale farmers. Approximately, 35.4 million hectares are sown to tropical maize, constituting around 59% of the developing worlds. Tropical maize encounters tremendous challenges besides poor agro-climatic situations with average yields recorded <3 tones/hectare that is far less than the average of developed countries. On the contrary to poor yields, the demand for maize as food, feed, and fuel is continuously increasing in these regions. Heterosis breeding introduced in early 90 s improved maize yields significantly, but genetic gains is still a mirage, particularly for crop growing under marginal environments. Application of molecular markers has accelerated the pace of maize breeding to some extent. The availability of array of sequencing and genotyping technologies offers unrivalled service to improve precision in maize-breeding programs through modern approaches such as genomic selection, genome-wide association studies, bulk segregant analysis-based sequencing approaches, etc. Superior alleles underlying complex traits can easily be identified and introgressed efficiently using these sequence-based approaches. Integration of genomic tools and techniques with advanced genetic resources such as nested association mapping and backcross nested association mapping could certainly address the genetic issues in maize improvement programs in developing countries. Huge diversity in tropical maize and its inherent capacity for doubled haploid technology offers advantage to apply the next generation genomic tools for accelerating production in marginal environments of tropical and subtropical world. Precision in phenotyping is the key for success of any molecular-breeding approach. This article reviews genomic technologies and their application to improve agronomic traits in tropical maize breeding has been reviewed in detail

Prof. C V Raman with the Apparatus [Raman Spectrograph]

Picture showing Prof. C V Raman with Spctrograp

Reporting of the Raman Research Institute in Hindu, 1958

Reporting in Hindu on Raman Research Institute by S. Ramaseshan in 195