54 research outputs found
Protease-Sensitive Conformers in Broad Spectrum of Distinct PrPSc Structures in Sporadic Creutzfeldt-Jakob Disease Are Indicator of Progression Rate
- Author
- A Aguzzi
- A Bellon
- AF Hill
- AM Thackray
- B Caughey
- B Oesch
- BW Caughey
- Chae Kim
- CJ Gibbs Jr
- CL Masters
- D Peretz
- D Peretz
- David Westaway
- DC Gajdusek
- DW Colby
- E Uro-Coste
- EM Choi
- G Legname
- G Puoti
- G Schoch
- G Zanusso
- GC Telling
- GC Telling
- GG Kovacs
- GR Mallucci
- H Wille
- I Cali
- J Collinge
- J Collinge
- J Li
- J Safar
- J Safar
- J Safar
- Janis Blevins
- JD Wadsworth
- JD Wadsworth
- JDF Wadsworth
- JG Safar
- JG Safar
- JG Safar
- JG Safar
- JI Kim
- Jiri G. Safar
- K-M Pan
- L Monari
- L Pirisinu
- M Glatzel
- M Jones
- M Jones
- M Pocchiari
- M Polymenidou
- M Tanaka
- MA Pastrana
- Man-Sun Sy
- Mark Cohen
- MD Geschwind
- MT Bishop
- MW Head
- NJ Cobb
- P Gambetti
- P Gambetti
- P Parchi
- P Parchi
- P Parchi
- P Parchi
- P Tremblay
- R Morales
- RA Bessen
- RJ Kascsak
- S Cronier
- S Notari
- S Notari
- S Tzaban
- SB Prusiner
- SB Prusiner
- SB Prusiner
- SJ Collins
- Tracy Haldiman
- V Lewis
- W Swietnicki
- Wei Chen
- WQ Zou
- YP Choi
- YP Choi
- Yvonne Cohen
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The origin, range, and structure of prions causing the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD), are largely unknown. To investigate the molecular mechanism responsible for the broad phenotypic variability of sCJD, we analyzed the conformational characteristics of protease-sensitive and protease-resistant fractions of the pathogenic prion protein (PrPSc) using novel conformational methods derived from a conformation-dependent immunoassay (CDI). In 46 brains of patients homozygous for polymorphisms in the PRNP gene and exhibiting either Type 1 or Type 2 western blot pattern of the PrPSc, we identified an extensive array of PrPSc structures that differ in protease sensitivity, display of critical domains, and conformational stability. Surprisingly, in sCJD cases homozygous for methionine or valine at codon 129 of the PRNP gene, the concentration and stability of protease-sensitive conformers of PrPSc correlated with progression rate of the disease. These data indicate that sCJD brains exhibit a wide spectrum of PrPSc structural states, and accordingly argue for a broad spectrum of prion strains coding for different phenotypes. The link between disease duration, levels, and stability of protease-sensitive conformers of PrPSc suggests that these conformers play an important role in the pathogenesis of sCJD
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
- Author
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- Adamali H
- Adeloye D
- Adeyemi O
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- Ainsworth M
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- Singh SJ
- Singh SJ
- Sissons D
- Skeemer J
- Slack K
- Smith A
- Smith D
- Smith J
- Smith L
- Smith N
- Smith N
- Smith S
- Soares M
- Solano TS
- Solly R
- Solstice AR
- Soulsby T
- Southern D
- Sowter D
- Spears M
- Spencer LG
- Speranza F
- Stadon L
- Stanel S
- Steeds R
- Steeds R
- Steele N
- Steiner M
- Stensel D
- Stephens G
- Stephenson L
- Stern M
- Stewart I
- Stimpson R
- Stockdale S
- Stockley J
- Stoker W
- Stone R
- Storrar W
- Storrie A
- Storton K
- Stringer E
- Strong-Sheldrake S
- Stroud N
- Subbe C
- Sudlow C
- Sudlow CL
- Suleiman Z
- Summers C
- Summersgill C
- Sutherland D
- Sykes DL
- Sykes R
- Talbot N
- Tan AL
- Tan AL
- Tarusan L
- Tavoukjian V
- Taylor A
- Taylor C
- Taylor J
- Taylor JP
- Te A
- Tedd H
- Tee CJ
- Teixeira J
- Tench H
- Terry S
- Thackray-Nocera S
- Thaivalappil F
- Thamu B
- Thickett D
- Thomas AK
- Thomas C
- Thomas D
- Thomas D
- Thomas DC
- Thomas DC
- Thomas S
- Thomas-Woods T
- Thompson AAR
- Thompson AAR
- Thompson AAR
- Thompson AAR
- Thompson AR
- Thompson T
- Thornton T
- Thorpe M
- Thorpe M
- Thwaites R
- Thwaites RS
- Tilley J
- Tinker N
- Tiongson GF
- Tobin M
- Tomlinson J
- Tong C
- Toshner M
- Toshner M
- Toshner M
- Toshner M
- Toshner M
- Touyz R
- Treibel T
- Tripp KA
- Tunnicliffe E
- Tunnicliffe EM
- Turnbull A
- Turner E
- Turner K
- Turner S
- Turner V
- Turney S
- Turtle L
- Turtle L
- Turton H
- Ugoji J
- Ugwuoke R
- Upthegrove R
- Valabhji J
- Venson B
- Ventura M
- Vere J
- Vickers C
- Vinson B
- Vogiatzis I
- Wade E
- Wade P
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wain LV
- Wainwright T
- Wajero LO
- Walder S
- Walker S
- Walker S
- Walker S
- Walker S
- Wall E
- Wallis T
- Walmsley S
- Walsh JA
- Walsh S
- Warburton L
- Ward TJC
- Warwick K
- Wassall H
- Waterson S
- Watson E
- Watson J
- Watson L
- Webster M
- Welch C
- Welch H
- Welsh B
- Wessely S
- West S
- Weston H
- Wheeler H
- White S
- Whitehead V
- Whitney J
- Whittaker S
- Whittam B
- Whitworth V
- Wight A
- Wild JM
- Wild JM
- Wild JM
- Wild JM
- Wilkins M
- Wilkinson D
- Wilkinson D
- Williams B
- Williams J
- Williams N
- Williams N
- Williams N
- Williams-Howard SA
- Willicombe M
- Willis G
- Willoughby J
- Wilson A
- Wilson D
- Wilson D
- Wilson I
- Window N
- Witham M
- Witham M
- Wolf-Roberts R
- Wood C
- Woodhead F
- Woods J
- Wootton DG
- Wootton DG
- Wootton DG
- Wootton DG
- Wormleighton J
- Worsley J
- Wraith D
- Wright C
- Wright L
- Wright S
- Wyles J
- Wynn E
- Wynter I
- Xie C
- Xu M
- Xu M
- Yasmin N
- Yasmin S
- Yates T
- Yates T
- Yip KP
- Young A
- Young B
- Young S
- Yousuf A
- Zawia A
- Zeidan L
- Zhao B
- Zheng B
- Zongo O
- Publication venue
- Oxford University Press (OUP)
- Publication date
- 18/12/2023
- Field of study
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls
- Author
- Abel K
- Adamali H
- Adeloye D
- Adeyemi O
- Adrego R
- Aguilar Jimenez LA
- Ahmad Haider N
- Ahmad S
- Ahmed R
- Ahwireng N
- Ainsworth M
- Al-Sheklly B
- Alamoudi A
- Ali M
- Aljaroof M
- All AM
- Allan L
- Allen RJ
- Allerton L
- Allsop L
- Almeida P
- Altmann D
- Alvarez Corral M
- Amoils S
- Anderson D
- Antoniades C
- Arbane G
- Arias A
- Armour C
- Armstrong L
- Armstrong N
- Arnold D
- Arnold H
- Ashish A
- Ashworth A
- Ashworth M
- Aslani S
- Assefa-Kebede H
- Atkin C
- Atkin P
- Aul R
- Aung H
- Austin L
- Avram C
- Ayoub A
- Babores M
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie JK
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Banerjee A
- Bang B
- Barker RE
- Barman L
- Barratt S
- Barrett F
- Basire D
- Basu N
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes H
- Beadsworth M
- Beckett P
- Beggs M
- Begum M
- Beirne P
- Bell D
- Bell R
- Bennett K
- Beranova E
- Bermperi A
- Berridge A
- Berry C
- Betts S
- Bevan E
- Bhui K
- Bingham M
- Birchall K
- Bishop L
- Bisnauthsing K
- Blaikely J
- Bloss A
- Bolger A
- Bolton CE
- Bonnington J
- Botkai A
- Bourne C
- Bourne M
- Bramham K
- Brear L
- Breen G
- Breeze J
- Briggs A
- Bright E
- Brightling CE
- Brightling CE
- Brill S
- Brindle K
- Broad L
- Broadley A
- Brookes C
- Broome M
- Brown A
- Brown CW
- Brown J
- Brown JS
- Brown JS
- Brown M
- Brown V
- Brugha T
- Brunskill N
- Buch M
- Buckley P
- Bularga A
- Bullmore E
- Burden L
- Burdett T
- Burn D
- Burns A
- Burns G
- Busby J
- Butcher R
- Butt A
- Byrne S
- Cairns P
- Calder PC
- Calvelo E
- Carborn H
- Card B
- Carr C
- Carr L
- Carson G
- Carter P
- Casey A
- Cassar M
- Cavanagh J
- Chablani M
- Chalder T
- Chalmers JD
- Chalmers JD
- Chambers RC
- Chan F
- Channon KM
- Chapman K
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen J
- Cheng Y
- Chetham L
- Childs C
- Chilvers ER
- Chinoy H
- Chiribiri A
- Chong-James K
- Choudhury G
- Choudhury N
- Chowienczyk P
- Christie C
- Chrystal M
- Clark C
- Clark D
- Clarke J
- Clohisey S
- Coakley G
- Coburn Z
- Coetzee S
- Cole J
- Coleman C
- Conneh F
- Connell D
- Connolly B
- Connor L
- Cook A
- Cooper B
- Cooper J
- Cooper S
- Copeland D
- Cosier T
- Coulding M
- Coupland C
- Cox E
- Craig T
- Crisp P
- Cristiano D
- Crooks MG
- Cross A
- Cruz I
- Cullinan P
- Cuthbertson D
- D-C. Man W
- Daines L
- Daines L
- Dalton M
- Daly P
- Daniels A
- Dark P
- Dasgin J
- David A
- David C
- Davies E
- Davies F
- Davies G
- Davies GA
- Davies K
- Davies MJ
- Dawson J
- Daynes E
- De Soyza A
- De Soyza A
- Deakin B
- Deans A
- Deas C
- Deery J
- Defres S
- Dell A
- Dempsey K
- Denneny E
- Dennis J
- Dewar A
- Dharmagunawardena R
- Diar-Bakerly N
- Dickens C
- Dipper A
- Diver S
- Diwanji SN
- Dixon M
- Djukanovic R
- Dobson H
- Dobson SL
- Docherty AB
- Docherty AB
- Donaldson A
- Dong T
- Dormand N
- Dougherty A
- Dowling R
- Drain S
- Draxlbauer K
- Drury HJC
- Drury K
- Dulawan P
- Dunleavy A
- Dunn S
- Dupont C
- Earley J
- Easom N
- Echevarria C
- Echevarria C
- Edwards S
- Edwardson C
- El-Taweel H
- Elliott A
- Elliott K
- Ellis Y
- Elmer A
- Elneima O
- Elneima O
- Evans D
- Evans H
- Evans J
- Evans R
- Evans RA
- Evans RA
- Evans RI
- Evans T
- Evenden C
- Evison L
- Fabbri L
- Fairbairn S
- Fairman A
- Fallon K
- Faluyi D
- Favager C
- Fayzan T
- Featherstone J
- Felton T
- Finch J
- Finney S
- Finnigan J
- Finnigan L
- Fisher H
- Fletcher S
- Flockton R
- Flynn M
- Foot H
- Foote D
- Ford A
- Forton D
- Fraile E
- Francis C
- Francis R
- Francis S
- Frankel A
- Fraser E
- Free R
- French N
- Fu X
- Fuld J
- Furniss J
- Garner L
- Gautam N
- Geddes JR
- George J
- George P
- Gibbons M
- Gill M
- Gilmour L
- Gleeson F
- Glossop J
- Glover S
- Goodman N
- Goodwin C
- Gooptu B
- Gordon H
- Gorsuch T
- Greatorex M
- Greenhaff PL
- Greenhalf W
- Greenhalgh A
- Greening NJ
- Greening NJ
- Greenwood J
- Gregory H
- Gregory R
- Grieve D
- Griffin D
- Griffiths L
- Guerdette A-M
- Guio BG
- Gummadi M
- Gupta A
- Gurram S
- Guthrie E
- Guy Z
- Hadley K
- Haggar A
- Hainey K
- Hairsine B
- Haldar P
- Hall I
- Hall L
- Halling-Brown M
- Hamil R
- Hancock A
- Hancock K
- Hanley KP
- Hanley NA
- Haq S
- Hardwick HE
- Hardy E
- Hardy T
- Hargadon B
- Harrington K
- Harris E
- Harris VC
- Harris VC
- Harrison EM
- Harrison EM
- Harrison P
- Hart N
- Harvey A
- Harvey M
- Harvie M
- Haslam L
- Havinden-Williams M
- Hawkes J
- Hawkings N
- Haworth J
- Hayday A
- Haynes M
- Hazeldine J
- Hazelton T
- Heaney LG
- Heaney LG
- Heeley C
- Heeney JL
- Heightman M
- Heller S
- Henderson M
- Henson HH
- Hesselden L
- Hewitt M
- Highett V
- Hillman T
- Hiwot T
- Ho L-P
- Ho LP
- Hoare A
- Hoare M
- Hockridge J
- Hogarth P
- Holbourn A
- Holden S
- Holdsworth L
- Holgate D
- Holland M
- Holloway L
- Holmes K
- Holmes M
- Holroyd-Hind B
- Holt L
- Hormis A
- Horsley A
- Horsley A
- Hosseini A
- Hotopf M
- Houchen-Wolloff L
- Houchen-Wolloff L
- Howard K
- Howard LS
- Howell A
- Hufton E
- Hughes AD
- Hughes J
- Hughes R
- Humphries A
- Huneke N
- Hurditch E
- Hurst J
- Hurst JR
- Husain M
- Hussell T
- Hutchinson J
- Ibrahim W
- Ilyas F
- Ingham J
- Ingram L
- Ionita D
- Isaacs K
- Ismail K
- Jackson T
- Jacob J
- James WY
- Jang W
- Jarman C
- Jarrold I
- Jarvis H
- Jastrub R
- Jayaraman B
- Jenkins RG
- Jezzard P
- Jiwa K
- Johnson C
- Johnson S
- Johnston D
- Jolley CJ
- Jones D
- Jones G
- Jones H
- Jones I
- Jones L
- Jones MG
- Jones S
- Jose S
- Kabir T
- Kaltsakas G
- Kamwa V
- Kanellakis N
- Kausar Z
- Keenan N
- Kelly S
- Kemp G
- Kerr S
- Kerslake H
- Key AL
- Khan F
- Khunti K
- Kilroy S
- King B
- King C
- Kingham L
- Kirk J
- Kitterick P
- Klenerman P
- Knibbs L
- Knight S
- Knighton A
- Kon O
- Kon S
- Kon SS
- Koprowska S
- Korszun A
- Koychev I
- Kurasz C
- Kurupati P
- Laing C
- Lamlum H
- Landers G
- Langenberg C
- Lasserson D
- Lavelle-Langham L
- Lawrie A
- Lawson C
- Layton A
- Lea A
- Leavy OC
- Leavy OC
- Lee D
- Lee E
- Lee J-H
- Leitch K
- Lenagh R
- Lewis D
- Lewis J
- Lewis KE
- Lewis V
- Lewis-Burke N
- Li X
- Light T
- Lightstone L
- Lilaonitkul W
- Lim L
- Linford S
- Lingford-Hughes A
- Lipman M
- Liyanage K
- Lloyd A
- Logan S
- Lomas D
- Lone N
- Lone NI
- Loosley R
- Lord JM
- Lota H
- Lovegrove W
- Lucey A
- Lukaschuk E
- Lye A
- Lynch C
- MacDonald S
- MacGowan G
- Macharia I
- Mackie J
- Macliver L
- Madathil S
- Madzamba G
- Magee N
- Magtoto MM
- Mairs N
- Majeed N
- Major E
- Malein F
- Malim M
- Mallison G
- Mandal S
- Mangion K
- Manisty C
- Manley R
- March K
- Marciniak S
- Marino P
- Mariveles M
- Marks M
- Marks M
- Marouzet E
- Marsh S
- Marshall B
- Marshall M
- Martin J
- Martineau A
- Martineau A
- Martinez LM
- Maskell N
- Matila D
- Matimba-Mupaya W
- Matthews L
- Mbuyisa A
- McAdoo S
- McAllister-Williams H
- McArdle A
- McArdle P
- McAulay D
- McAuley HJC
- McCall JW
- McCann GP
- McCormick J
- McCormick W
- McCourt P
- McGarvey L
- McGee C
- Mcgee K
- McGinness J
- McGlynn K
- McGovern A
- McGuinness H
- McInnes IB
- McIntosh J
- McIvor E
- McIvor K
- McLeavey L
- McMahon A
- McMahon MJ
- McMorrow L
- Mcnally T
- McNarry M
- McNeill J
- McQueen A
- McShane H
- Mears C
- Megson C
- Megson S
- Mehta P
- Meiring J
- Melling L
- Mencias M
- Menzies D
- Merida Morillas M
- Michael A
- Miller C
- Milligan L
- Mills C
- Mills G
- Mills NL
- Milner L
- Misra S
- Mitchell J
- Mohamed A
- Mohamed N
- Mohammed S
- Molyneaux PL
- Monteiro W
- Moriera S
- Morley A
- Morrison L
- Morriss R
- Morrow A
- Moss AJ
- Moss P
- Motohashi K
- Msimanga N
- Mukaetova-Ladinska E
- Munawar U
- Murira J
- Nanda U
- Nassa H
- Nasseri M
- Neal A
- Needham R
- Neill P
- Neubauer S
- Newby DE
- Newell H
- Newman J
- Newman T
- Newton-Cox A
- Nicholson T
- Nicoll D
- Nikolaidis A
- Nolan CM
- Noonan MJ
- Norman C
- Novotny P
- Nunag J
- Nwafor L
- Nwanguma U
- Nyaboko J
- O'Brien C
- O'Brien L
- O'Donnell K
- O'Regan D
- Odell N
- Ogg G
- Olaosebikan O
- Oliver C
- Omar Z
- Openshaw PJM
- Orriss-Dib L
- Osborne L
- Osbourne R
- Ostermann M
- Overton C
- Owen J
- Oxton J
- Pack J
- Pacpaco E
- Paddick S
- Painter S
- Pakzad A
- Palmer S
- Papineni P
- Paques K
- Paradowski K
- Pareek M
- Parekh D
- Parfrey H
- Pariante C
- Parker S
- Parkes M
- Parmar J
- Patale S
- Patel B
- Patel M
- Patel S
- Pattenadk D
- Pavlides M
- Payne S
- Pearce L
- Pearl JE
- Peckham D
- Pendlebury J
- Peng Y
- Pennington C
- Peralta I
- Perkins E
- Peterkin Z
- Peto T
- Petousi N
- Petrie J
- Pfeffer P
- Pfeffer PE
- Phipps J
- Pimm J
- Pius R
- Plant H
- Plein S
- Plekhanova T
- Plowright M
- Poinasamy K
- Poinasamy K
- Polgar O
- Poll L
- Porter J
- Porter JC
- Portukhay S
- Powell N
- Prabhu A
- Pratt J
- Price A
- Price C
- Price D
- Price L
- Prickett A
- Propescu J
- Prosper S
- Pugmire S
- Quaid S
- Quigley J
- Quint J
- Quint JK
- Qureshi H
- Qureshi IN
- Radhakrishnan K
- Rahman NM
- Ralser M
- Raman B
- Raman B
- Ramos A
- Ramos H
- Rangeley J
- Rangelov B
- Ratcliffe L
- Ravencroft P
- Reddington A
- Reddy A
- Reddy R
- Redfearn H
- Redwood D
- Reed A
- Rees M
- Rees T
- Regan K
- Reynolds W
- Ribeiro C
- Richards A
- Richardson E
- Richardson M
- Richardson M
- Rivera-Ortega P
- Roberts K
- Robertson E
- Robinson E
- Robinson L
- Roche L
- Roddis C
- Rodger J
- Ross A
- Ross G
- Rossdale J
- Rostron A
- Rowe A
- Rowland A
- Rowland J
- Rowland MJ
- Rowland-Jones SL
- Roy K
- Roy M
- Rudan I
- Russell E
- Russell R
- S. Kaprowska
- Saalmink G
- Sabit R
- Sage EK
- Samakomva T
- Samani N
- Sampson C
- Samuel K
- Samuel R
- Sanderson A
- Sapey E
- Saralaya D
- Sargant J
- Sarginson C
- Sass T
- Sattar N
- Saunders K
- Saunders LC
- Saunders P
- Saunders RM
- Saunders RM
- Savill H
- Saxon W
- Sayer A
- Schronce J
- Schwaeble W
- Scott JT
- Scott K
- Selby N
- Semple MG
- Sereno M
- Sereno M
- Sewell TA
- Shah A
- Shah K
- Shah P
- Shankar-Hari M
- Shankar-Hari M
- Sharma M
- Sharpe C
- Sharpe M
- Shashaa S
- Shaw A
- Shaw K
- Shaw V
- Sheikh A
- Sheikh A
- Shelton S
- Shenton L
- Shevket K
- Shikotra A
- Shikotra A
- Short J
- Siddique S
- Siddiqui S
- Sidebottom J
- Sigfrid L
- Simons G
- Simpson J
- Simpson N
- Singapuri A
- Singapuri A
- Singh C
- Singh S
- Singh SJ
- Sissons D
- Skeemer J
- Slack K
- Smith A
- Smith D
- Smith J
- Smith L
- Smith S
- Soares M
- Solano TS
- Solly R
- Solstice AR
- Soulsby T
- Southern D
- Sowter D
- Spears M
- Spencer LG
- Speranza F
- Stadon L
- Stanel S
- Steele N
- Steiner M
- Stensel D
- Stephens G
- Stephenson L
- Stern M
- Stewart I
- Stimpson R
- Stockdale S
- Stockley J
- Stoker W
- Stone R
- Storrar W
- Storrie A
- Storton K
- Stringer E
- Strong-Sheldrake S
- Stroud N
- Subbe C
- Sudlow CL
- Suleiman Z
- Summers C
- Summersgill C
- Sutherland D
- Sykes DL
- Sykes R
- Talbot N
- Tan AL
- Tarusan L
- Tavoukjian V
- Taylor A
- Taylor C
- Taylor J
- Te A
- Tedd H
- Tee CJ
- Teixeira J
- Tench H
- Terry S
- Thackray-Nocera S
- Thaivalappil F
- Thamu B
- Thickett D
- Thomas AK
- Thomas C
- Thomas DC
- Thomas S
- Thomas-Woods T
- Thompson AAR
- Thompson T
- Thornton T
- Thorpe M
- Thwaites RS
- Tilley J
- Tinker N
- Tiongson GF
- Tobin M
- Tomlinson J
- Tong C
- Toshner M
- Touyz R
- Tripp KA
- Tunnicliffe E
- Turnbull A
- Turner E
- Turner K
- Turner S
- Turner V
- Turney S
- Turtle L
- Turton H
- Ugoji J
- Ugwuoke R
- Upthegrove R
- Valabhji J
- Ventura M
- Vere J
- Vickers C
- Vinson B
- Vivaldi G
- Wade E
- Wade P
- Wain LV
- Wain LV
- Wainwright T
- Wajero LO
- Walder S
- Walker S
- Wall E
- Wallis T
- Walmsley S
- Walsh JA
- Walsh S
- Warburton L
- Ward TJC
- Warwick K
- Wassall H
- Waterson S
- Watson E
- Watson J
- Watson L
- Welch C
- Welch H
- Welsh B
- Wessely S
- West S
- Weston H
- Wheeler H
- White S
- Whitehead V
- Whitney J
- Whittaker S
- Whittam B
- Whitworth V
- Wight A
- Wild J
- Wilkins M
- Wilkinson D
- Williams B
- Williams J
- Williams N
- Williams-Howard SA
- Willicombe M
- Willis G
- Willoughby J
- Wilson A
- Wilson D
- Wilson I
- Window N
- Witham M
- Wolf-Roberts R
- Wood C
- Woodhead F
- Woods J
- Wootton DG
- Wormleighton J
- Worsley J
- Wraith D
- Wright C
- Wright L
- Wright S
- Wyles J
- Wynter I
- Xu M
- Yasmin N
- Yasmin S
- Yates T
- Yip KP
- Young A
- Young B
- Young S
- Yousuf AJ
- Zawia A
- Zeidan L
- Zhao B
- Zheng B
- Zheng B
- Zongo O
- Publication venue
- 'Elsevier BV'
- Publication date
- 27/03/2023
- Field of study
Background The risk factors for recovery from COVID-19 dyspnoea are poorly understood. We investigated determinants of recovery from dyspnoea in adults with COVID-19 and compared these to determinants of recovery from non-COVID-19 dyspnoea. Methods We used data from two prospective cohort studies: PHOSP-COVID (patients hospitalised between March 2020 and April 2021 with COVID-19) and COVIDENCE UK (community cohort studied over the same time period). PHOSP-COVID data were collected during hospitalisation and at 5-month and 1-year follow-up visits. COVIDENCE UK data were obtained through baseline and monthly online questionnaires. Dyspnoea was measured in both cohorts with the Medical Research Council Dyspnoea Scale. We used multivariable logistic regression to identify determinants associated with a reduction in dyspnoea between 5-month and 1-year follow-up. Findings We included 990 PHOSP-COVID and 3309 COVIDENCE UK participants. We observed higher odds of improvement between 5-month and 1-year follow-up among PHOSP-COVID participants who were younger (odds ratio 1.02 per year, 95% CI 1.01–1.03), male (1.54, 1.16–2.04), neither obese nor severely obese (1.82, 1.06–3.13 and 4.19, 2.14–8.19, respectively), had no pre-existing anxiety or depression (1.56, 1.09–2.22) or cardiovascular disease (1.33, 1.00–1.79), and shorter hospital admission (1.01 per day, 1.00–1.02). Similar associations were found in those recovering from non-COVID-19 dyspnoea, excluding age (and length of hospital admission). Interpretation Factors associated with dyspnoea recovery at 1-year post-discharge among patients hospitalised with COVID-19 were similar to those among community controls without COVID-19. Funding PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19. The views expressed in the publication are those of the author(s) and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health and Social Care. COVIDENCE UK is supported by the UK Research and Innovation, the National Institute for Health Research, and Barts Charity. The views expressed are those of the authors and not necessarily those of the funders
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
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- Zawia A
- Zeidan L
- Zhao B
- Zheng B
- Zongo O
- Publication venue
- Elsevier
- Publication date
- 01/04/2022
- Field of study
Background
No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the previously described recovery clusters at 5 months after hospital discharge.
Methods
The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID-19 across the UK. Recovery was assessed using patient-reported outcome measures, physical performance, and organ function at 5 months and 1 year after hospital discharge, and stratified by both patient-perceived recovery and recovery cluster. Hierarchical logistic regression modelling was performed for patient-perceived recovery at 1 year. Cluster analysis was done using the clustering large applications k-medoids approach using clinical outcomes at 5 months. Inflammatory protein profiling was analysed from plasma at the 5-month visit. This study is registered on the ISRCTN Registry, ISRCTN10980107, and recruitment is ongoing.
Findings
2320 participants discharged from hospital between March 7, 2020, and April 18, 2021, were assessed at 5 months after discharge and 807 (32·7%) participants completed both the 5-month and 1-year visits. 279 (35·6%) of these 807 patients were women and 505 (64·4%) were men, with a mean age of 58·7 (SD 12·5) years, and 224 (27·8%) had received invasive mechanical ventilation (WHO class 7–9). The proportion of patients reporting full recovery was unchanged between 5 months (501 [25·5%] of 1965) and 1 year (232 [28·9%] of 804). Factors associated with being less likely to report full recovery at 1 year were female sex (odds ratio 0·68 [95% CI 0·46–0·99]), obesity (0·50 [0·34–0·74]) and invasive mechanical ventilation (0·42 [0·23–0·76]). Cluster analysis (n=1636) corroborated the previously reported four clusters: very severe, severe, moderate with cognitive impairment, and mild, relating to the severity of physical health, mental health, and cognitive impairment at 5 months. We found increased inflammatory mediators of tissue damage and repair in both the very severe and the moderate with cognitive impairment clusters compared with the mild cluster, including IL-6 concentration, which was increased in both comparisons (n=626 participants). We found a substantial deficit in median EQ-5D-5L utility index from before COVID-19 (retrospective assessment; 0·88 [IQR 0·74–1·00]), at 5 months (0·74 [0·64–0·88]) to 1 year (0·75 [0·62–0·88]), with minimal improvements across all outcome measures at 1 year after discharge in the whole cohort and within each of the four clusters.
Interpretation
The sequelae of a hospital admission with COVID-19 were substantial 1 year after discharge across a range of health domains, with the minority in our cohort feeling fully recovered. Patient-perceived health-related quality of life was reduced at 1 year compared with before hospital admission. Systematic inflammation and obesity are potential treatable traits that warrant further investigation in clinical trials.
Funding
UK Research and Innovation and National Institute for Health Research
Prion-Seeding Activity in Cerebrospinal Fluid of Deer with Chronic Wasting Disease
- Author
- AF Hill
- Alexandra Van de Motter
- AM Thackray
- Byron Caughey
- Candace Mathiason
- CD Orrú
- CJ Sigurdson
- CJ Sigurdson
- CK Mathiason
- CK Mathiason
- CK Mathiason
- Davin Henderson
- Davis M. Seelig
- DM Henderson
- DP Keane
- DP Keane
- Edward Hoover
- ES Williams
- ES Williams
- GA Wells
- GP Saborio
- J Safar
- JG Fournier
- JG Safar
- JM Wilham
- JM Wilham
- KI O'Rourke
- KP Burnham
- Kristen Davenport
- L González
- LI McGuire
- LJ van Keulen
- MW Miller
- N Gonzalez-Montalban
- Nicholas J. Haley
- NJ Haley
- NJ Haley
- NJ Haley
- NJ Haley
- R Atarashi
- RC Angers
- RJ Monello
- Scott Carver
- SR Browning
- TA Nichols
- TD Kurt
- TR Spraker
- TR Spraker
- TR Spraker
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Closed Loop Stimulation Improves Ejection Fraction in Pediatric Patients with Pacemaker and Ventricular Dysfunction
- Author
- Balmer C
- Bardy GH
- Breur JMPJ
- Bristow MR
- Chuang ML
- Cohen MI
- Cron TA
- Drago F
- Dubin AM
- Faris OP
- Feldman AM
- Folino AF
- Gregoratos G
- Grothues F
- Horenstein MS
- Karpawich PP
- Karpawich PP
- Kertesz NJ
- Malinowski K
- Manno BV
- Manolis AG
- Masaki H
- Michaelsson M
- Michaelsson M
- Moak JP
- Moro E
- Osswald S
- Otterstad JE
- Paisana F
- Proctor EE
- Quaglione R
- Rodriguez-Cruz E
- Santini M
- Schaldach M
- Strieper M
- Swedberg K
- Tantengco MV
- Taylor AE
- Thackray SD
- Udink ten Cate FEA
- Villain E
- Wiegand UK
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Faculty development through simulation-based education in physical therapist education
- Author
- A Cheng
- A Hargreaves
- A Oleson
- A Ornstein
- AGR Kordowicz
- D Thackray
- DT Peterson
- EW Taylor
- FC Blackstock
- H Bui
- H Owen
- I Edwards
- I Pietkiewicz
- INACSL Standards Committee
- INACSL Standards Committee
- INACSL Standards Committee
- J Mezirow
- JA Smith
- JA Smith
- KA Ericsson
- KV Smith
- M Hecimovich
- M Hilliard
- M Larkin
- MJ Shoemaker
- MJ Shoemaker
- N Bagatell
- N Pataraia
- N Smith
- NJ Silberman
- P Cranton
- PR Jeffries
- R Frederick
- R Lyons
- S Boet
- S Buckley
- S Deering
- S Gough
- SA Pritchard
- SB Issenberg
- SB Merriam
- TC Clapper
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Electroweak parameters of the z0 resonance and the standard model
- Author
- Abbaneo D
- ABREU P
- Adam W
- Adami F
- ADEVA B
- Adriani O
- Adye T
- Aguilar-Benitez M
- Ajaltouni Z
- Akbari H
- Akesson T
- Albanese JP
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- Alekseev GD
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- Aloisio A
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- Anderson KJ
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- Apel WD
- Apollinari G
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- Arcelli S
- Arefev A
- Armitage JC
- Ashman JG
- Ashton P
- Asman B
- Astbury A
- Astier P
- Atwood WB
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- Augustinus A
- Axen D
- Azemoon T
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- Bardadin-Otwinowska M
- Bardin DY
- Barker GJ
- Barlow RJ
- Baroncelli A
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- Barring O
- Bartl W
- Bates MJ
- Batignani G
- Batley JR
- Battaglia M
- Baubillier M
- Bauerdick LAT
- Bay A
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- Beeston CJ
- Begalli M
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- Zalewski P
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- Zeng M
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- Zevgolatakos E
- Zhang DH
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- Zukanovich-Funchal R
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- Zuniga J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1992
- Field of study
Contains fulltext :
124399.pdf (publisher's version ) (Open Access
Expression of oncogenes in human tumours with special reference to the head and neck region
- Author
- Agnantis NJ
- Agnantis NJ
- Armitage P.
- Barbacid M
- Batsakis JG
- Berridge MJ
- Besmer P
- Birnie GD
- Birnie WM
- Bishop JM
- Brodeur GM
- Burkhardt A
- Der C
- Doolittle RF
- Erikson RL
- Ernberg I
- Evan G
- Evans RW
- Field JK
- Friedman WH
- Furth ME
- Gallick GE
- Ghosh AK
- Gibbs JB
- Goyette M
- Green GL
- Hart JR
- Harvey J.J
- Horan-Hand P
- Hunter T
- Hurley JB
- Jhanwar SC
- Kerr IB
- Kirsten WH
- Knudson AG
- Lucas RB
- Marshall CJ
- Marshall CM
- Moberger JG
- Ohuchi N
- Papageorge AG
- Paul J
- Pragnell EJ
- Rabbitts PH
- Robinson A
- Rous PJ
- Sandos E
- Santos E
- Schwab M
- Semba K
- Shih C
- Shimizu K
- Sikora K
- Slamon DJ
- Spandidos DA
- Spandidos DA
- Spandidos DA
- Spandidos DA
- Spandidos DA
- Spandidos DA
- Stenman G
- Stewart J
- Sweet RW
- Thackray AC
- Thorgeirsson UP
- Toda T
- Viola MV
- Vousden KM
- Weiss L
- Williams ARW
- Yokota J
- Publication venue
- 'Wiley'
- Publication date
- Field of study
The differential diagnosis of testicular germ cell tumors in theory and practice
- Author
- A Albertini von
- A Peyron
- A Peyron
- A Talerman
- A Talerman
- A Talerman
- AC Thackray
- AF Holstein
- AR Hochstetter von
- B Nørgaard-Pedersen
- B Nørgaard-Pedersen
- C Parkinson
- Chr Hedinger
- Chr Hedinger
- Chr Hedinger
- Chr Sigg
- CP White
- D Magner
- D Raghavan
- DJB Ashley
- EE Fraley
- F Horn
- F Nogales-Fernandez
- FJ Dixon
- FK Mostofi
- FK Mostofi
- FK Mostofi
- FK Mostofi
- FK Mostofi
- G Mikuz
- G Teilum
- G Teilum
- G Teilum
- GB Pierce
- GB Pierce
- GB Pierce
- GB Pierce
- GI Abelev
- GJ Mark
- GR Martin
- GW Willis
- H Lange
- HJ Clark
- I Damjanov
- I Sesterhenn
- IH Nüesch-Bachmann
- JG Azzopardi
- K Wurster
- L J Kleinsmith
- LC Stevens
- LE Nochomovitz
- LE Nochomovitz
- LM McManus
- M Burri
- M Dallas
- M Marin-Padilla
- M Marin-Padilla
- M Payot
- M Wilms
- MM Melicow
- MR Abell
- N Javadpour
- N Javadpour
- NB Friedman
- NB Friedman
- NE Skakkebaek
- NE Skakkebaek
- NE Skakkebaek
- NJ Brown
- NJ Brown
- NV Engelhardt
- O Meienberg
- PT Scardino
- RA Willis
- RCB Pugh
- RJ Kurman
- RW Evans
- RW Huntington
- T Ito
- T Tomoyoshi
- TB Teoh
- W Woodtli
- WK Hong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …