Legionnaires disease in a female patient with comorbid agranulocytosis and specific epidemiological history: A case report

The case presents development of Legionella pneumonia in a patient with a concurrent heamotological disease and reflects a real-life medical situation when a patient with an infectious disease suffering from its complications, polipragmasia and self-treatment, comes to an infectionist. The article describes difficulties of diagnostics and ways of treatment as well as development of underlying and concomitant diseases. Many ways of transmission, a wide variety of clinical manifestations, complications and outcomes demand from doctors to remain alert for legionellosis and require a constant improvement of our knowledge of the disease. The aim of this article is to summarize information about Legionella, including diagnostics, clinical manifestations and treatment and to present a clinical case with a unique transmission of the pathogen. The article describes different clinical strategies for legionellosis control. © 2020, Dynasty Publishing House. All rights reserved

Infectious mononucleosis in children: Clinical and laboratory characteristics depending on the disease etiology and phase of infection

Objective. To assess the association between clinical and laboratory characteristics of infectious mononucleosis (IM) and disease etiology and phase of infection. Patients and methods. This prospective observational study was conducted at Z.A.Bashlyaeva Children's City Clinical Hospital, Moscow Healthcare Department and included 107 children with IM. Laboratory testing was performed at the Department of Virological Diagnostics, National Medical Research Center for Hematology, Ministry of Health of the Russian Federation. Results. IM is a polyetiologic disease. So far, researcher have failed to find a significant correlation between clinical manifestations of IM and its etiology and phase of infection. Patients with IM caused by primary monoinfection with Epstein–Barr virus (EBV) are at high risk of developing chronic EBV infection. Neutrophilia is a typical laboratory sign of IM during the acute phase of it. Conclusion. The improvement of IM diagnosis with a detailed evaluation of clinical and laboratory criteria, as well as risk assessment of unfavorable outcome are currently impossible without the identification of both disease etiology and phase of infection. © 2020, Dynasty Publishing House. All rights reserved

Clinical manifestations of infectious mononucleosis in primary or reactivated herpes virus infection [Клинические проявления инфекционного мононуклеоза при первичной или реактивированной герпесвирусной инфекции]

Based on the analysis of foreign and domestic literature, the article presents the features of infectious mononucleosis caused by the main pathogens from the Herpesviridae family, course of the disease at various phases of the infectious process. The article identifies clinical and laboratory manifestations characteristic of each pathogen. The authors discuss the issues related to the lack of the unified terminology for describing chronic herpes virus infection. The article discusses the causes of persistent herpes virus infections, risk factors for the adverse course and outcome of herpes virus infections. © 2020 National Academy of Pediatric Science and Innovation. All rights reserved

Клинические проявления инфекционного мононуклеоза при первичной или реактивированной герпесвирусной инфекции

Based on the analysis of foreign and domestic literature, the article presents the features of infectious mononucleosis caused by the main pathogens from the Herpesviridae family, course of the disease at various phases of the infectious process. The article identifies clinical and laboratory manifestations characteristic of each pathogen. The authors discuss the issues related to the lack of the unified terminology for describing chronic herpes virus infection. The article discusses the causes of persistent herpes virus infections, risk factors for the adverse course and outcome of herpes virus infections.На основе анализа данных зарубежной и отечественной литературы представлены особенности инфекционного мононуклеоза, вызванного основными возбудителями из семейства Herpesviridae, течения заболевания в различных фазах инфекционного процесса. Выделены клинические и лабораторные проявления инфекционного мононуклеоза, характерные для каждого из возбудителей. Выносятся на обсуждение вопросы, связанные с отсутствием единой терминологии для описания хронически протекающей герпесвирусной инфекции. Приводится обсуждение причин персистенции герпесвирусных инфекций, факторов риска неблагоприятного течения и исхода герпесвирусных инфекций

Clinical and laboratory profile of patients with COVID-19 admitted to hospital in Moscow between may and july 2020

Objective. Data of the clinical picture forms of the disease, management and diagnostic capabilities of patients with COVID-19 continue to be studied. Our study presents results from the analysis of clinical and laboratory parameters of patients with COVID-19 in the period May-June 2020, who were treated in an infectious diseases hospital in Moscow. Patients and methods. The analytical cohort included 444, 198 men, 246 women aged 18 to 95 years, who were identified with SARS-CoV-2 RNA. The severity of the disease was determined in accordance with the temporary clinical recommendations (version 6 effective April 28, 2020), NEWS. Results. The study of the clinical picture showed the variability of the spectrum of clinical manifestations of COVID-19. The most common symptoms were fever, weakness, myalgia, dry cough, shortness of breath, diarrhea. The severity of the infection was not associated with the patient's gender, but was significantly correlated with age and the presence of comorbid status, which included chronic lung diseases, obesity, diabetes mellitus, and cardiovascular diseases. Observations of patients with severe and extremely severe course revealed characteristic laboratory markers of severity. The main method of etiological diagnosis was the RT-PCR method for detecting SARS-CoV-2 RNA in the nasopharyngeal secret. To verify COVID-19, we used an additional PCR method, fecal testing for the detection of SARS-CoV-2 RNA. © 2021, Dynasty Publishing House. All rights reserved