Isotopic composition of gadolinium and neutron-capture effects in some meteorites

The isotopic composition of Gd in one chondrite, two achondrites, and the silicate inclusions of two iron meteorites has been determined. When corrected for mass discrimination, Gd in all samples except the Norton County achondrite shows the same relative isotopic abundances as terrestrial Gd. These results set an upper limit of 3×10^(15) neutrons per cm^2 on a differential integrated thermal neutron irradiation of the earth and these meteorites. Neutron-capture effects are present in Gd extracted from the Norton County achondrite. These most probably have been produced by secondary neutrons during the exceptionally long cosmic ray exposure of this large stone meteorite. The isotopic anomalies correspond to an integrated thermal neutron flux of (6.3±0.9)×10^(15) neutrons per cm^2. The percent abundances of terrestrial Gd found in our work for Gd^(160), Gd^(158), Gd^(157), Gd^(156), Gd^(155), Gd^(154), and Gd^(152) are 21.863, 24.835, 15.652, 20.466, 14.800, 2.1809, and 0.2029, respectively. Because of the higher precision, these abundances should replace the currently accepted values

Spitzer observations of the Hyades: Circumstellar debris disks at 625 Myr of age

We use the Spitzer Space Telescope to search for infrared excess at 24, 70, and 160 micron due to debris disks around a sample of 45 FGK-type members of the Hyades cluster. We supplement our observations with archival 24 and 70 micron Spitzer data of an additional 22 FGK-type and 11 A-type Hyades members in order to provide robust statistics on the incidence of debris disks at 625 Myr of age an era corresponding to the late heavy bombardment in the Solar System. We find that none of the 67 FGK-type stars in our sample show evidence for a debris disk, while 2 out of the 11 A-type stars do so. This difference in debris disk detection rate is likely to be due to a sensitivity bias in favor of early-type stars. The fractional disk luminosity, L_dust/L*, of the disks around the two A-type stars is ~4.0E-5, a level that is below the sensitivity of our observations toward the FGK-type stars. However, our sensitivity limits for FGK-type stars are able to exclude, at the 2-sigma level, frequencies higher than 12% and 5% of disks with L_dust/L* > 1.0E-4 and L_dust/L* > 5.0E-4, respectively. We also use our sensitivity limits and debris disk models to constrain the maximum mass of dust, as a function of distance from the stars, that could remain undetected around our targets.Comment: 33 pages, 11 figures, accepted by Ap

Isotopic analyses of barium in meteorites and in terrestrial samples

Isotopic composition and concentration of barium in six stone meteorites and the silicate inclusions of two iron meteorites and three terrestrial samples were measured by use of a ‘double spike’ isotopic dilution technique in order to correct for laboratory fractionation. Any differences between the abundances of the isotopes in meteoritic and terrestrial Ba were found to be less than 0.1% for all isotopes. The per cent abundances of Ba found in our work for Ba^(138), Ba^(137), Ba^(136), Ba^(135), Ba^(134), Ba^(132), and Ba^(130) are 71.699, 11.232, 7.853, 6.592, 2.417, 0.1012, and 0.1058, respectively. Because of the higher precision, these abundances should replace the currently accepted values. These results show the variations in the Ba isotopes reported by S. Umemoto (1962) to be unsubstantiated

Results of a Phase 1 Multicentre Investigation of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery

BACKGROUND: Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing for steady-state DEX plasma levels; and (iv) validate the PK model and dosing. METHODS: We included 122 neonates and infants (0-180 days) with D-transposition of the great arteries, ventricular septal defect, or tetralogy of Fallot. Dose escalation was used to generate NONMEM® PK modelling, and then validation was performed to achieve low (200-300 pg ml RESULTS: Five of 122 subjects had adverse safety outcomes (4.1%; 95% confidence interval [CI], 1.8-9.2%). Two had junctional rhythm, two had second-/third-degree atrioventricular block, and one had hypotension. Clearance (CL) immediately postoperative and CL on CPB were reduced by approximately 50% and 95%, respectively, compared with pre-CPB CL. DEX clearance after CPB was 1240 ml min CONCLUSIONS: When used with a careful dosing strategy, DEX results in low incidence and severity of adverse safety events in infants undergoing cardiac surgery with cardiopulmonary bypass. This validated PK model should assist clinicians in selecting appropriate dosing. The results of this phase 1 trial provide preliminary data for a phase 3 trial of DEX neuroprotection

TOI-3785 b: A Low-Density Neptune Orbiting an M2-Dwarf Star

Using both ground-based transit photometry and high-precision radial velocity (RV) spectroscopy, we confirm the planetary nature of TOI-3785 b. This transiting Neptune orbits an M2-Dwarf star with a period of ~4.67 days, a planetary radius of 5.14 +/- 0.16 Earth Radii, a mass of 14.95 +4.10, -3.92 Earth Masses, and a density of 0.61 +0.18, -0.17 g/cm^3. TOI-3785 b belongs to a rare population of Neptunes (4 Earth Radii < Rp < 7 Earth Radii) orbiting cooler, smaller M-dwarf host stars, of which only ~10 have been confirmed. By increasing the number of confirmed planets, TOI-3785 b offers an opportunity to compare similar planets across varying planetary and stellar parameter spaces. Moreover, with a high transmission spectroscopy metric (TSM) of ~150 combined with a relatively cool equilibrium temperature of 582 +/- 16 K and an inactive host star, TOI-3785 b is one of the more promising low-density M-dwarf Neptune targets for atmospheric follow-up. Future investigation into atmospheric mass loss rates of TOI-3785 b may yield new insights into the atmospheric evolution of these low-mass gas planets around M-dwarfs.Comment: 22 pages, 6 figures, 6 tables, Submitted to A

TOI-5205b: A Jupiter transiting an M dwarf near the Convective Boundary

We present the discovery of TOI-5205b, a transiting Jovian planet orbiting a solar metallicity M4V star, which was discovered using TESS photometry and then confirmed using a combination of precise radial velocities, ground-based photometry, spectra and speckle imaging. The host star TOI-5205 sits near the eponymous `Jao gap', which is the transition region between partially and fully-convective M dwarfs. TOI-5205b has one of the highest mass ratio for M dwarf planets with a mass ratio of almost 0.3$\%$, as it orbits a host star that is just $0.392 \pm 0.015$ $M_{\odot}$. Its planetary radius is $1.03 \pm 0.03~R_J$, while the mass is $1.08 \pm 0.06~M_J$. Additionally, the large size of the planet orbiting a small star results in a transit depth of $\sim 7\%$, making it one of the deepest transits of a confirmed exoplanet orbiting a main-sequence star. The large transit depth makes TOI-5205b a compelling target to probe its atmospheric properties, as a means of tracing the potential formation pathways. While there have been radial velocity-only discoveries of giant planets around mid M dwarfs, this is the first transiting Jupiter with a mass measurement discovered around such a low-mass host star. The high mass of TOI-5205b stretches conventional theories of planet formation and disk scaling relations that cannot easily recreate the conditions required to form such planets.Comment: Submitted to ApJ. Comments are welcome. arXiv admin note: text overlap with arXiv:2203.0717

The role of planetary formation and evolution in shaping the composition of exoplanetary atmospheres

Over the last twenty years, the search for extrasolar planets revealed us the rich diversity of the outcomes of the formation and evolution of planetary systems. In order to fully understand how these extrasolar planets came to be, however, the orbital and physical data we possess are not enough, and they need to be complemented with information on the composition of the exoplanets. Ground-based and space-based observations provided the first data on the atmospheric composition of a few extrasolar planets, but a larger and more detailed sample is required before we can fully take advantage of it. The primary goal of the Exoplanet Characterization Observatory (EChO) is to fill this gap, expanding the limited data we possess by performing a systematic survey of hundreds of extrasolar planets. The full exploitation of the data that EChO and other space-based and ground-based facilities will provide in the near future, however, requires the knowledge of what are the sources and sinks of the chemical species and molecules that will be observed. Luckily, the study of the past history of the Solar System provides several indications on the effects of processes like migration, late accretion and secular impacts, and on the time they occur in the life of planetary systems. In this work we will review what is already known about the factors influencing the composition of planetary atmospheres, focusing on the case of gaseous giant planets, and what instead still need to be investigated.Comment: 26 pages, 9 figures, 1 table. Accepted for publication on Experimental Astronomy, special issue on the M3 EChO mission candidat

Standardized reporting on studies of psychiatric pharmacist interventions

Reporting interventions thoroughly and consistently in the literature allows for study reproducibility or implementation of the intervention into practice. Although there is currently no standard for describing Board-Certified Psychiatric Pharmacist (BCPP) interventions in the published literature, there are multiple checklists or guides that have been developed for reporting clinical interventions, including the template for intervention description and replication and the pharmacist patient care intervention reporting (PaCIR) checklist, that seek to improve the quality of reporting interventions in the literature. The purpose of this paper is to describe a proposed guide for reporting BCPP interventions in the literature by expanding the PaCIR checklist. Authors use a logic model developed by the American Association of Psychiatric Pharmacists to ensure all elements of the process are addressed in the expanded guide

The unusual M-dwarf Warm Jupiter TOI-1899~b: Refinement of orbital and planetary parameters

TOI-1899~b is a rare exoplanet, a temperate Warm Jupiter orbiting an M-dwarf, first discovered by \citet{Canas2020_toi1899} from a TESS single-transit event. Using new radial velocities (RVs) from the precision RV spectrographs HPF and NEID, along with additional TESS photometry and ground-based transit follow-up, we are able to derive a much more precise orbital period of $P = 29.090312_{-0.000035}^{+0.000036}$~d, along with a radius of $R_p = 0.99\pm0.03$~\unit{R_{J}}. We have also improved the constraints on planet mass, $M_p = 0.67\pm{0.04}$~\unit{M_{J}}, and eccentricity, which is consistent with a circular orbit at 2$\sigma$ ($e = 0.044_{-0.027}^{+0.029}$). TOI-1899~b occupies a unique region of parameter space as the coolest known ($T_{eq} \approx$ 380~K) Jovian-sized transiting planet around an M-dwarf; we show that it has great potential to provide clues regarding the formation and migration mechanisms of these rare gas giants through transmission spectroscopy with JWST as well as studies of tidal evolution.Comment: 19 pages, 7 figures, 3 tables, submitted to AJ (comments welcome