Targeting energy savings? Better on primary than final energy and less on intensity metrics

Financiado para publicación en acceso aberto: Universidade de Vigo/CISUGA eficiencia enerxética é un tema crítico nas políticas públicas, xa que é a clave para desvincular o crecemento económico e o uso da enerxía. Estes obxectivos están a ser aínda máis relevantes para abordar a crise enerxética e os novos escenarios xeopolíticos da guerra de Ucraína. Aínda que varios traballos analizaron os obxectivos de eficiencia enerxética, este traballo céntrase nos obxectivos de aforro enerxético, que representan a principal métrica de eficiencia para a Unión Europea. Este traballo enche un baleiro na literatura ao analizar os impactos económicos e ambientais da consecución de obxectivos de eficiencia enerxética mediante unha política fiscal enerxética, simulada por un modelo de equilibrio xeral computable híbrido con gran detalle tecnolóxico. Defínense seis escenarios para o aforro enerxético no consumo dos produtos enerxéticos, utilizando Portugal como caso de estudo. Os resultados relevantes para os responsables políticos dos escenarios simulados inclúen: (i) acadar obxectivos de aforro enerxético por medios alternativos, é dicir, dirixidos ao consumo de enerxía primaria ou final, proporcionar impactos heteroxéneos na eficiencia do sistema enerxético e no PIB, e algúns inesperados e indesexables nos impactos ambientais; (ii) unha fiscalidade relativamente máis baixa de todos os produtos enerxéticos produce impactos máis grandes e máis distorsionadores na xeración de electricidade que impostos máis elevados só sobre os combustibles fósiles (un resultado contraintuitivo), (iii) as políticas destinadas a reducir a enerxía primaria en lugar da enerxía final proporcionan os mellores resultados (maiores aumentos da eficiencia do sistema enerxético con impactos económicos máis suaves), o que vai en contra do principio da directiva europea sobre impostos enerxéticos pola que deben gravarse os produtos finais, independentemente dos insumos utilizados na súa produción e (iv) e os obxectivos non deben elaborarse en base a indicadores de intensidade enerxética. Polo tanto, móstrase que o tamaño dos impactos no balance entre as preocupacións económicas e ambientais depende do foco no aforro enerxético: de onde (consumo de enerxía primaria ou final) e a que (fósiles ou todos os produtos enerxéticos) sexa aplicado.Energy efficiency is a critical issue in public policies, as it is the key to decoupling economic growth and energy use. These objectives are becoming even more relevant to addressing the energy crisis and the new geopolitical scenarios delivered by the Ukraine war. Although several papers have analyzed energy efficiency goals, this paper focuses on energy savings targets, which represent the main efficiency metric for the European Union. This paper fills a gap in literature by analyzing the economic and environmental impacts of attaining energy efficiency targets through an energy fiscal policy, simulated by a hybrid computable general equilibrium model with technological detail. Six scenarios are defined for energy savings in primary/final energy consumption of fossil-fueled/all energy products, using Portugal as a case study. Relevant insights for policy makers from the simulated scenarios include: (i) achieving energy saving targets by alternative means, i.e., directed at primary or final energy consumption, provide heterogeneous impacts on the efficiency of the energy system and GDP, and some unexpected and undesirable outcomes concerning environmental impacts; (ii) a relatively lower taxation of all energy products deliver larger and more distorting impacts on electricity generation than higher taxes on fossil fuels only (a counterintuitive result), (iii) policies aiming to reduce primary energy instead of final energy provide the best outcomes (further increases in the efficiency of the energy system with smoother economic impacts), thereby pointing against the European Energy Taxation directive principle that taxation should be levied on final products, regardless of inputs used in their production and (iv) and targets should not be set up based on energy intensity indicators. Hence, it is shown that the size of the trade-off between economic and environmental concerns depends on where (primary or final energy consumption) and what (fossil or all energy products) energy savings are targeted.Fundação para a Ciência e a Tecnologia | Ref. UIDB/05037/2020Fundação para a Ciência e a Tecnologia | Ref. UIDP/05037/2020Fundação para a Ciência e a Tecnologia | Ref. UID/04085/2020Ministerio de Ciencia y Educación | Ref. PID2019-106677GB-I00Xunta de Galicia | Ref. GRC2017/063Universidade de Vigo/CISU

Genome-Wide Effects of Long-Term Divergent Selection

To understand the genetic mechanisms leading to phenotypic differentiation, it is important to identify genomic regions under selection. We scanned the genome of two chicken lines from a single trait selection experiment, where 50 generations of selection have resulted in a 9-fold difference in body weight. Analyses of nearly 60,000 SNP markers showed that the effects of selection on the genome are dramatic. The lines were fixed for alternative alleles in more than 50 regions as a result of selection. Another 10 regions displayed strong evidence for ongoing differentiation during the last 10 generations. Many more regions across the genome showed large differences in allele frequency between the lines, indicating that the phenotypic evolution in the lines in 50 generations is the result of an exploitation of standing genetic variation at 100s of loci across the genome

Acesso a Tratamento Endovascular para Acidente Vascular Cerebral Isquémico em Portugal

Introduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular treatment in mainland Portugal and its administrative districts. Material and methods: A retrospective national multicentric cohort study was conducted, including all ischemic stroke patients treated with endovascular treatment in mainland Portugal over two years (July 2015 to June 2017). All endovascular treatment centers contributed to an anonymized database. Demographic, stroke-related and procedure-related variables were collected. Crude endovascular treatment rates were calculated per 100 000 inhabitants for mainland Portugal, and each district and endovascular treatment standardized ratios (indirect age-sex standardization) were also calculated. Patient time metrics were computed as the median time between stroke onset, first-door, and puncture. Results: A total of 1625 endovascular treatment procedures were registered. The endovascular treatment rate was 8.27/100 000 inhabitants/year. We found regional heterogeneity in endovascular treatment rates (1.58 to 16.53/100 000/year), with higher rates in districts closer to endovascular treatment centers. When analyzed by district, the median time from stroke onset to puncture ranged from 212 to 432 minutes, reflecting regional heterogeneity. Discussion: Overall endovascular treatment rates and procedural times in Portugal are comparable to other international registries. We found geographic heterogeneity, with lower endovascular treatment rates and longer onset-to-puncture time in southern and inner regions. Conclusion: The overall national rate of EVT in the first two years after the organization of EVT-capable centers is one of the highest among European countries, however, significant regional disparities were documented. Moreover, stroke-onset-to-first-door times and in-hospital procedural times in the EVT centers were comparable to those reported in the randomized controlled trials performed in high-volume tertiary hospitals.info:eu-repo/semantics/publishedVersio

Purging Deleterious Mutations under Self Fertilization: Paradoxical Recovery in Fitness with Increasing Mutation Rate in Caenorhabditis elegans

Background: The accumulation of deleterious mutations can drastically reduce population mean fitness. Self-fertilization is thought to be an effective means of purging deleterious mutations. However, widespread linkage disequilibrium generated and maintained by self-fertilization is predicted to reduce the efficacy of purging when mutations are present at multiple loci. Methodology/Principal Findings: We tested the ability of self-fertilizing populations to purge deleterious mutations at multiple loci by exposing obligately self-fertilizing populations of Caenorhabditis elegans to a range of elevated mutation rates and found that mutations accumulated, as evidenced by a reduction in mean fitness, in each population. Therefore, purging in obligate selfing populations is overwhelmed by an increase in mutation rate. Surprisingly, we also found that obligate and predominantly self-fertilizing populations exposed to very high mutation rates exhibited consistently greater fitness than those subject to lesser increases in mutation rate, which contradicts the assumption that increases in mutation rate are negatively correlated with fitness. The high levels of genetic linkage inherent in self-fertilization could drive this fitness increase. Conclusions: Compensatory mutations can be more frequent under high mutation rates and may alleviate a portion of the fitness lost due to the accumulation of deleterious mutations through epistatic interactions with deleterious mutations. Th

Role of Pleiotropy in the Evolution of a Cryptic Developmental Variation in Caenorhabditis elegans

Using vulval phenotypes in Caenorhabditis elegans, the authors show that cryptic genetic variation can evolve through selection for pleiotropic effects that alter fitness, and identify a cryptic variant that has conferred enhanced fitness on domesticated worms under laboratory conditions

Sjögren's Syndrome or Multiple Sclerosis? A dilemma in clinical practice

The authors present a clinical case of a male, 53-years old with a multiple sclerosis like syndrome, progressive, with 3 years of evolution. The patient also referred dry eye and inflammatory arthralgias, the complementary workup was according with Sjögren's Syndrome. The central nervous system involvement of Sjögren's Syndrome and the difficulty of differential diagnosis with neurological diseases such as Multiple sclerosis is discusse

Immediate effects of hypnosis, mindfulness meditation, and prayer on cold pressor outcomes: A four-arm parallel experimental study

Purpose: Previous research supports the usefulness of hypnosis (HYP), mindfulness meditation (MM), and prayer as pain self -management strategies in adults with chronic pain. However, their effects on acute pain have been less researched, and no previous head-to-head study compared the immediate effects of these three approaches on pain-related outcomes. This study compared the immediate effects of HYP, MM, and Christian prayer (CP) on pain intensity, pain tolerance, and stress as assessed by heart rate variability (HRV). Participants and Methods: A total of 232 healthy adults were randomly assigned to, and completed, a single 20-minute session of MM, SH, CP, or an attention control (CN), and underwent two cycles (one pre- and one post-intervention) of Cold Pressor Arm Wrap (CPAW). Sessions were audio-delivered. Participants responded to pre- and post-intervention pain intensity measurements. Pain tolerance (sec) was assessed during the CPAW cycles. HRV was assessed at baseline, and at pre- and post-intervention CPAW cycles. The study protocol was pre-registered at the ClinicalTrials.gov registry (NCT04491630). Results: Small within-group decreases in pain intensity and small increases in pain tolerance were found for HYP and MM from the pre- to the post-intervention. Small within-group improvements in the LH/HF ratio were also found for HYP. The exploratory between-group pairwise comparisons revealed a medium effect size effects of HYP on pain tolerance relative to the control condition. The effects of CP were positive, but small and not statistically significant. Only small to medium, though non-significant, Time × Group interaction effects were found. Conclusion: Study results suggest that single short-term HYP and MM sessions, but not biblical-based CP, may be useful for acute pain self-management, with HYP being the slightly superior option. Future research should compare the effects of different types of prayer and examine the predictors and moderators of these pain approaches’ effects on pain-related outcomesFundação para a Ciência e Tecnologia - FCTinfo:eu-repo/semantics/publishedVersio

Bronze Age sea salt production in Northwestern Iberia

The neo-glaciation, characterized by a cooling and a decrease in humidity, despite the existence of several episodes of slight climatic improvement, which occurred between the middle of the 4th and the end of the 2nd millennia BCE in the Iberian Northwest, is a well-known reality. The effects of this climate change on the Atlantic coast are also known. It was found that the coastline would be more to the west and irregular than it currently is, with numerous lagoons and different types of wetlands favourable to salt extraction. In this region the earliest evidences of sea salt exploitation are the removable sinks, excavated in slabs of schist. One of these was discovered in a camp-size found at Praia de Carreço in Viana do Castelo, dated by the thermoluminescence of the end of the 3rd, beginning of the 2nd millennium BCE, a period that, in regional terms, is considered from the end of the Chalcolithic to the Early Bronze Age. Due to the geographic distribution of this type of sinks in the north coast, the exploitation of salt during the Bronze Age would have been a relevant activity. Other archaeological evidence of sea salt exploration during the first half of the 2nd millennium BCE comes from the Areias Altas site in Oporto. At this locus, remains of poorly preserved, fragile and fragmented ceramic vessels have been found morphologically similar to those found in other prehistoric salt extraction contexts in western and eastern Europe (Fig. 1). These are containers used for the evaporation of salt water through the brine process, or as moulds for salt. On the northwest coast, in areas with an abundance of granite outcrops or other rocks other than shale, there are also innumerable rock sinks. These were performed by percussion, probably with stone hammers, and polished with rolled pebbles. Some of them are currently on the coastline. By their manufacturing conditions they can also begging in the Bronze Age. In the rare excavations carried out in its environs, still unpublished, they were find network weights, on rolled pebbles, whose chronology dates back at least to the 2nd millennium BCE, in moments of the Middle Bronze Age. Extraction of sea salt may explain, at least in part, the intensity of settlement during the Bronze Age at the edge of the shoreline

The genomic basis of Red Queen dynamics during rapid reciprocal host–pathogen coevolution

Pathogens are omnipresent and by definition detrimental to their hosts. Pathogens thus exert high selection on their hosts, which, if adapting, can exert similar levels of selection on the pathogen, resulting in ongoing cycles of reciprocal adaptation between the antagonists. Such coevolutionary interactions have a central influence on the evolution of organisms. Surprisingly, we still know little about the exact selection dynamics and the genome regions involved. Our study uses a controlled experimental approach with an animal host to dissect coevolutionary selection. We find that distinct selective processes underlie rapid coadaptation in the two antagonists, including antagonistic frequency-dependent selection on toxin gene copy number in the pathogen, while the host response is likely influenced by changes in multiple genome regions.Red Queen dynamics, involving coevolutionary interactions between species, are ubiquitous, shaping the evolution of diverse biological systems. To date, information on the underlying selection dynamics and the involved genome regions is mainly available for bacteria–}phage systems or only one of the antagonists of a eukaryotic host{–}pathogen interaction. We add to our understanding of these important coevolutionary interactions using an experimental host{–pathogen model, which includes the nematode Caenorhabditis elegans and its pathogen Bacillus thuringiensis. We combined experimental evolution with time-shift experiments, in which a focal host or pathogen is tested against a coevolved antagonist from the past, present, or future, followed by genomic analysis. We show that (i) coevolution occurs rapidly within few generations, (ii) temporal coadaptation at the phenotypic level is found in parallel across replicate populations, consistent with antagonistic frequency-dependent selection, (iii) genomic changes in the pathogen match the phenotypic pattern and include copy number variations of a toxin-encoding plasmid, and (iv) host genomic changes do not match the phenotypic pattern and likely involve selective responses at more than one locus. By exploring the dynamics of coevolution at the phenotypic and genomic level for both host and pathogen simultaneously, our findings demonstrate a more complex model of the Red Queen, consisting of distinct selective processes acting on the two antagonists during rapid and reciprocal coadaptation