NEPHROPROTECTIVE ROLE OF ZINC AGAINST THE AMMONIUM SULFATE TOXICITY IN MALE ALBINO RATS

Objective: Intention of the present study is to investigate the protective role of zinc against ammonium sulfate (AS) toxicity in renal tissue by evaluating certain biochemical activities of albino rats. Methods: Rats were divided into four groups, namely control, ammonia, zinc, and ammonia + zinc. Rats were exposed to AS (18.3 mg/kg body weight) or zinc chloride (4 mg/kg body weight) or both through intraperitoneally for 7-day experimentation with 24-h time interval. Results: AS-administered rats showed significant increased levels of ammonia, urea, glutamine, glutamine synthetase, free amino acids, and lactate dehydrogenase and decreased levels of total proteins, pyruvate, succinate dehydrogenases, malate dehydrogenase, and biochemical activities when compared with control. Supplementation of zinc mitigated AS-induced oxidative stress and restored all the biochemical parameter activities. Zinc administered to normal rats did not exhibit any significant changes in any of the parameters studied. Conclusion: From the study, it concluded that zinc cotreatment with AS has effectively recovered the mitochondrial enzyme activities and ammonia metabolic biochemical parameters in renal tissue of rat treated with AS

Unravelling a trichloroacetic acid-catalyzed cascade access to benzo[f]chromeno[2,3-h]quinoxalinoporphyrins

A facile one-pot four-component synthetic methodology is evolved to construct novel copper(II) benzo[f]chromeno[2,3-h]quinoxalinoporphyrins in good yields via a sequential reaction of copper(II) 2,3-diamino-5,10,15,20-tetraarylporphyrins, 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes, and dimedone in the presence of a catalytic amount of trichloroacetic acid in chloroform at 65 °C. Further, the newly prepared copper(II) porphyrins were transformed to the corresponding free base and zinc(II) benzo[f]chromeno[2,3-h]quinoxalinoporphyrins under standard demetallation and zinc insertion conditions. The absorption and emission properties of the obtained porphyrins were investigated by using UV–visible and fluorescence spectroscopy. The preliminary photophysical results revealed a significant red-shift in their absorption and emission spectra as compared to the meso-tetrakis(4-methylphenyl)porphyrins due to the extended π-conjugation

bowtie-json-schema/bowtie: v2023.11.24

<p><!-- Release notes generated using configuration in .github/release.yml at v2023.11.24 --></p> <p><strong>Full Changelog</strong>: https://github.com/bowtie-json-schema/bowtie/compare/v2023.11.23...v2023.11.24</p&gt

bowtie-json-schema/bowtie: v2023.11.12

<p><!-- Release notes generated using configuration in .github/release.yml at v2023.11.12 --></p> <p><strong>Full Changelog</strong>: https://github.com/bowtie-json-schema/bowtie/compare/v2023.11.11...v2023.11.12</p&gt

bowtie-json-schema/bowtie: v2023.11.23

<p><!-- Release notes generated using configuration in .github/release.yml at v2023.11.23 --></p> <p><strong>Full Changelog</strong>: https://github.com/bowtie-json-schema/bowtie/compare/v2023.11.22...v2023.11.23</p&gt

bowtie-json-schema/bowtie: v2023.11.15

<p><!-- Release notes generated using configuration in .github/release.yml at v2023.11.15 --></p> <p><strong>Full Changelog</strong>: https://github.com/bowtie-json-schema/bowtie/compare/v2023.11.14...v2023.11.15</p&gt

bowtie-json-schema/bowtie: v2023.11.18

<p><!-- Release notes generated using configuration in .github/release.yml at v2023.11.18 --></p> <p><strong>Full Changelog</strong>: https://github.com/bowtie-json-schema/bowtie/compare/v2023.11.17...v2023.11.18</p&gt

bowtie-json-schema/bowtie: v2023.09.15

What's Changed try fixing fork GH deployment by @harrel56 in https://github.com/bowtie-json-schema/bowtie/pull/465 Reduce JVM images size by @harrel56 in https://github.com/bowtie-json-schema/bowtie/pull/464 Full Changelog: https://github.com/bowtie-json-schema/bowtie/compare/v2023.09.14...v2023.09.1

bowtie-json-schema/bowtie: v2023.11.2

<p><!-- Release notes generated using configuration in .github/release.yml at v2023.11.2 --></p> <p><strong>Full Changelog</strong>: https://github.com/bowtie-json-schema/bowtie/compare/v2023.11.1...v2023.11.2</p&gt

bowtie-json-schema/bowtie: v2023.09.18

Full Changelog: https://github.com/bowtie-json-schema/bowtie/compare/v2023.09.17...v2023.09.1