A Personalized Framework for Trust Assessment

The number of computational trust models has been increasing quickly in recent years yet their applications for automating trust evaluation are still limited. The main obstacle is the difficulties in selecting a suitable trust model and adapting it for particular trust modeling requirements, which varies greatly due to the subjectivity of human trust. The Personalized Trust Framework (PTF) presented in this paper aims to address this problem by providing a mechanism for human users to capture their trust evaluation process in order for it to be replicated by computers. In more details, a user can specify how he selects a trust model based on information about the subject whose trustworthiness he needs to evaluate and how that trust model is configured. This trust evaluation process is then automated by the PTF making use of the trust models flexibly plugged into the PTF by the user. By so doing, the PTF enable users reuse and personalize existing trust models to suit their requirements without having to reprogram those models

Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells

BACKGROUND: Engineered nanoparticles (NP) are being developed for inhaled drug delivery. This route is non-invasive and the major target; alveolar epithelium provides a large surface area for drug administration and absorption, without first pass metabolism. Understanding the interaction between NPs and target cells is crucial for safe and effective NP-based drug delivery. We explored the differential effect of neutral, cationic and anionic polystyrene latex NPs on the target cells of the human alveolus, using primary human alveolar macrophages (MAC) and primary human alveolar type 2 (AT2) epithelial cells and a unique human alveolar epithelial type I-like cell (TT1). We hypothesized that the bioreactivity of the NPs would relate to their surface chemistry, charge and size as well as the functional role of their interacting cells in vivo. METHODS: Amine- (ANP) and carboxyl- surface modified (CNP) and unmodified (UNP) polystyrene NPs, 50 and 100 nm in diameter, were studied. Cells were exposed to 1–100 μg/ml (1.25-125 μg/cm(2); 0 μg/ml control) NP for 4 and 24 h at 37 °C with or without the antioxidant, N-acetyl cysteine (NAC). Cells were assessed for cell viability, reactive oxygen species (ROS), oxidised glutathione (GSSG/GSH ratio), mitochondrial integrity, cell morphology and particle uptake (using electron microscopy and laser scanning confocal microscopy). RESULTS: ANP-induced cell death occurred in all cell types, inducing increased oxidative stress, mitochondrial disruption and release of cytochrome C, indicating apoptotic cell death. UNP and CNP exhibited little cytotoxicity or mitochondrial damage, although they induced ROS in AT2 and MACs. Addition of NAC reduced epithelial cell ROS, but not MAC ROS, for up to 4 h. TT1 and MAC cells internalised all NP formats, whereas only a small fraction of AT2 cells internalized ANP (not UNP or CNP). TT1 cells were the most resistant to the effects of UNP and CNP. CONCLUSION: ANP induced marked oxidative damage and cell death via apoptosis in all cell types, while UNP and CNP exhibited low cytotoxicity via oxidative stress. MAC and TT1 cell models show strong particle-internalization compared to the AT2 cell model, reflecting their cell function in vivo. The 50 nm NPs induced a higher bioreactivity in epithelial cells, whereas the 100 nm NPs show a stronger effect on phagocytic cells. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12989-015-0091-7) contains supplementary material, which is available to authorized users

Strongly coupled artificial bulk HTS grain boundaries with high critical current densities

A multi-seeding process has been developed to fabricate single Y-Ba-Cu-O (YBCO) grains containing strong artificial grain boundaries. Multi-seeding of heterogeneous YBCO grains with controlled orientation was achieved using large Sm-Ba-Cu-O (SmBCO) single crystal seeds of rod-like geometry with slots of various widths (up to 13 mm) cut into their bottom surface (i.e. parallel to the c-axis of the seed) to produce a bridge-like structure. Several YBCO grains with artificial grain boundaries were fabricated from these seed crystals and used to investigate the effect of varying the distance between the individual grain nucleation sites and the grain orientation (in-plane and out of plane) on the nature of grain boundaries. The measured local magnetic critical current density (Jc) and the magnitude of the trapped field across these artificial grain boundaries indicate that seed alignment is a key parameter in achieving strongly-coupled grain boundaries in multi-seeded grains

Design of a Novel Antenna Array Beamformer Using Neural Networks Trained by Modified Adaptive Dispersion Invasive Weed Optimization Based Data

A new antenna array beamformer based on neural networks (NNs) is presented. The NN training is performed by using optimized data sets extracted by a novel Invasive Weed Optimization (IWO) variant called Modified Adaptive Dispersion IWO (MADIWO). The trained NN is utilized as an adaptive beamformer that makes a uniform linear antenna array steer the main lobe towards a desired signal, place respective nulls towards several interference signals and suppress the side lobe level (SLL). Initially, the NN structure is selected by training several NNs of various structures using MADIWO based data and by making a comparison among the NNs in terms of training performance. The selected NN structure is then used to construct an adaptive beamformer, which is compared to MADIWO based and ADIWO based beamformers, regarding the SLL as well as the ability to properly steer the main lobe and the nulls. The comparison is made considering several sets of random cases with different numbers of interference signals and different power levels of additive zero-mean Gaussian noise. The comparative results exhibit the advantages of the proposed beamformer

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.

Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits. More recently, there has been considerable interest in compounds, such as positive and negative allosteric modulators (PAMs and NAMs), that are able to modulate nAChR function by binding to distinct allosteric sites. Here we examined a series of compounds differing only in methyl substitution of a single aromatic ring. This series of compounds includes a previously described α7-selective allosteric agonist, cis-cis-4-p-tolyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4MP-TQS), together with all other possible combinations of methyl substitution at a phenyl ring (18 additional compounds). Studies conducted with this series of compounds have revealed five distinct pharmacological effects on α7 nAChRs. These five effects can be summarized as: 1) nondesensitizing activation (allosteric agonists), 2) potentiation associated with minimal effects on receptor desensitization (type I PAMs), 3) potentiation associated with reduced desensitization (type II PAMs), 4) noncompetitive antagonism (NAMs), and 5) compounds that have no effect on orthosteric agonist responses but block allosteric modulation (silent allosteric modulators (SAMs)). Several lines of experimental evidence are consistent with all of these compounds acting at a common, transmembrane allosteric site. Notably, all of these chemically similar compounds that have been classified as nondesensitizing allosteric agonists or as nondesensitizing (type II) PAMs are cis-cis-diastereoisomers, whereas all of the NAMs, SAMs, and type I PAMs are cis-trans-diastereoisomers. Our data illustrate the remarkable pharmacological diversity of allosteric modulators acting on nAChRs

Complexity-generating hydration reactions via gold-catalyzed addition of boronic acids to alkynes

Boronic acids can serve as organic soluble substitutes for water molecules in the metal-catalyzed hydration of alkynes. The Au-catalyzed addition of boronic acids to alkynes provides an alternative method for enolate generation, which proceeds under exceptionally mild conditions. The resulting enolates can be trapped by aldehydes present in the reaction mixture, giving aldol products that can be isolated as cyclic borate esters. These compounds are versatile synthetic intermediates that can be elaborated into a variety of products by transformation of the boron moiety. The Au-catalyzed reaction of boronic acids with propargylic alcohols results in efficient Meyer–Schuster rearrangement to the corresponding enones. The rearrangement of tertiary alcohols gives (E)-enones with moderate to good selectivity, and the addition of a boronic acid to the reaction appears to enhance the level of geometrical control. The rearrangement of primary alcohols to terminal enones also occurs readily in the presence of catalytic Au(I) and a boronic acid, and the resulting terminal enones can be reacted with nucleophiles in one-pot procedures to give a variety of β-substituted ketones

Analogical cognition and understanding a word

Gentner describes a notion of ‘analogical cognition’ that could play a significant role in elucidating what is involved in understanding a word. Gentner’s work has not, though, had much or any impact in linguistics or the philosophy of language. I explain key features of Gentner’s notion, and I argue that it explains how word understanding can be stable, specific, and shared, and how words can contribute to cognition as opposed to just being a means of conveying thoughts