ANTIPROLIFERATIVE EFFECT OF ALCOHOLIC EXTRACTS OF SOME GABONESE MEDICINAL PLANTS ON HUMAN COLONIC CANCER CELLS

Extracts from Piptadeniastrum africanum Brenan (Mimosaceae), Petersianthus macrocarpus (Breauv) L. (Lecydaceae), Cissus debilis Planch (Vitaceae) and Dieffenbachia seguine Jacq. (Araceae) were tested in vitro for their antiproliferative activity on human colon cancer cell line (CaCo-2). The highest antiproliferative activities were obtained with the alcoholic extracts of the roots of Piptadeniastrum africanum (G-PAR), the leaves of Petersianthus macrocarpus (G-PMF) and the stem of Cissus debilis (G-CDL), with 50% inhibition concentrations (IC50) of 15 µg/ml, 17 µg/ml and 25 µg/ml respectively. Only one extract (leaves of Dieffenbachia seguine (G-DSF)) exhibited weak antiproliferative activity with 50% inhibition concentration (IC50) higher than 50 µg/ml

An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology

© 2017 Elsevier B.V. All rights reserved.Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary healthcare. The aim of this review was to collect and present the scientific evidence for the use of medicinal plants that are in currect by Gabonese traditional healers to manage diabetes or hyperglycaemia based here on the pharmacological and toxicological profiles of plants with anti-diabetic activity. There are presented in order to promote their therapeutic value, ensure a safer use by population and provide some bases for further study on high potential plants reviewed. Materials and methods: Ethnobotanical studies were sourced using databases such as Online Wiley library, Pubmed, Google Scholar, PROTA, books and unpublished data including Ph.D. and Master thesis, African and Asian journals. Keywords including ‘Diabetes’ ‘Gabon’ ‘Toxicity’ ‘Constituents’ ‘hyperglycaemia’ were used. Results: A total of 69 plants currently used in Gabon with potential anti-diabetic activity have been identified in the literature, all of which have been used in in vivo or in vitro studies. Most of the plants have been studied in human or animal models for their ability to reduce blood glucose, stimulate insulin secretion or inhibit carbohydrates enzymes. Active substances have been identified in 12 out of 69 plants outlined in this review, these include Allium cepa and Tabernanthe iboga. Only eight plants have their active substances tested for anti-diabetic activity and are suitables for further investigation. Toxicological data is scarce and is dose-related to the functional parameters of major organs such as kidney and liver. Conclusion: An in-depth understanding on the pharmacology and toxicology of Gabonese anti-diabetic plants is lacking yet there is a great scope for new treatments. With further research, the use of Gabonese anti-diabetic plants is important to ensure the safety of the diabetic patients in Gabon.Peer reviewedFinal Accepted Versio

The Antiplasmodial Agents Of The Stem Bark Of Entandrophragma Angolense (Meliaceae).

In the search of active principles from the stem bark of Entandrophragma angolense , we submitted the compounds isolated from the dichloromethane – methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7α- obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC50s of 2 and 5.4 μg/ml respectively. Other compounds were moderately active

An estimation approach for the influential–imitator diffusion

International audienc

Antimalarial activity in crude extracts of some Cameroonian medicinal plants

Fifteen crude extracts from the stem bark and seeds of four medicinal plants, viz: Entandrophragma angolense, Picralima nitida, Schumanniophyton magnificum and Thomandersia hensii were tested in vitro for their antimalarial activity against the chloroquine-resistant Plasmodium falciparum W2 strain. The results showed that the extracts of these plants possessed some antimalarial activity, the methanol extract of Picralima nitida demonstrating the highest activity in vitro. Further isolation and identification of some active compounds from these plants will justify their common use in traditional medicine for the treatment of malaria or fever in Cameroon.Keywords: Entandrophragma angolense; Picralima nitida; Schumanniophyton magnificum; Thomandersia hensii; Plasmodium falciparum; Antimalarial activity The African Journal of Traditional, Complementary and Alternative Medicines Vol. 4 (1) 2007: pp. 107-11

Comparative study of the anti-oxidant activity of the total polyphenols extracted from Hibiscus Sabdariffa L., Glycine max L. Merr., yellow tea and red wine through reaction with DPPH free radicals

The present study is part of the evaluation of extracts of Glycine max L. Merr and Hibiscus L. Sabdariffa as antioxidants. A comparative study was performed with extracts of yellow tea and commercial red wine, two foods known for their antioxidant activity. The method applied is free radical scavenging using the 1,1-diphenyl-2-picrylhydrazyl (DPPH°). The antioxidant properties were identified and measured by the determining the anti-radical activity reducing index, expressed in percentage % RSA (Radical Scavenger Activity), and by the determination of the colouring intensity (IC50). All results are compared to those of ascorbic acid as reference antioxidant. The results indicate the following order for the antioxidant power of the extracts tested. % RSA (tea) > % RSA (Glycine max) % > RSA (red wine) % > RSA (Sabdariffa Hibiscus), and colouring intensities (IC50) ranging from 4.62 μM (ascorbic acid) to 1.10 μM (Hibiscus sabdariffa) correlated with their chemical structure and the content of phenolic compounds

In Vitro anti-malarial activity of limonoids from two meliacious plants

Four limonoids, atomasin A 1, atomasin B 2, entilin A 3 and entilin B 4 from Entandrophragma candollei and Entandrophragma utile (Meliaceae) were tested for in vitro antimalarial activity against Plasmodium falciparum chloroquine–resistant W2 strain. Three limonoids (1, 3, 4) were moderately active with IC50 values between 11.6 and 28.2 µg/mL. atomasin B was devoid of activity. The in vitro activities of the compounds were further analysed using fresh isolates of P. falciparum among which three were chloroquine–resistant. The comparison of the mean IC50 values of atomasin A and entilin B did show any significant difference between chloroquine-resistant and –sensitive isolates. Keywords: Plasmodium falciparum; Antimalarial activity; Meliaceae; Limonoids; Entandrophragma candollei; Entandrophragma utile. West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 39-4