Polyarthrite Rhumatoïde au Niger : Etats des Lieux

 Objectif : Faire l’état des lieux sur les aspects épidémiologiques, cliniques, paracliniques et thérapeutiques de la polyarthrite rhumatoïde au Niger. Méthodes : Cette revue des données de la littérature sur la polyarthrite rhumatoïde au Niger a été réalisée en utilisant les bases de données MEDLINE (via PUBMED) et de google scholar. Les critères d’inclusion comprenaient des études publiées chez des adultes de plus de 18 ans ayant reçu un diagnostic de polyarthrite rhumatoïde. L’extraction des données a été réalisée grâce à un formulaires préétablis. Résultats : La recherche dans la littérature a identifié 5 articles. Finalement, quatre articles ont été inclus pour la revue. La fréquence de la polyarthrite rhumatoïde a été rapportée dans trois études, celle-ci variait de 1,24% à 3,7%. Le genre féminin représentait 79 (79,79%) des patients. L’âge moyen globale était de 43,41 ans. Le délai moyen avant le diagnostic était de 53,2 mois. La polyarthrite rhumatoïde a été diagnostiqué en utilisant les critères ACR 1987 et les critères ACR/EULAR 2010. Tous les patients avaient consulté pour une polyarthrite. Le coup de vent cubital était retrouvé chez 27 (27,27%) patients. Les nodules rhumatoïdes ont été retrouvé chez 12 (12,12%) patients. Les facteurs rhumatoïdes étaient positifs chez 56 (56,56%) patients. Les anticorps anti peptides cycliques citrullinés étaient positif chez 7 (7,07%) patients. Le méthotrexate était le traitement de fond chez 67 (67,67%) patients et l’hydroxychloroquine chez 43 (43,43%) patients. Conclusion : Le diagnostic de la polyarthrite est tardif au Niger. La création d’un registre national des patients ayant une polyarthrite rhumatoïde permettra un meilleur suivi des patients.   Objective: To review the epidemiologic, clinical, paraclinical and therapeutic aspects of rheumatoid arthritis in Niger. Methods: This review of literature on rheumatoid arthritis in Niger was conducted using MEDLINE (via PUBMED) and google scholar databases. Inclusion criteria included studies published in adults over 18 years of age with a diagnosis of rheumatoid arthritis. Data extraction was done using a pre-designed form. Results: The literature search identified 5 articles. Four articles were finally included in the review. The frequency of rheumatoid arthritis was reported in three studies and ranged from 1.24% to 3.7%. Females accounted for 79 (79.79%) of the patients. The mean age was 43.41 years. The mean time to diagnosis was 53.2 months. Rheumatoid arthritis was diagnosed according to ACR 1987 and ACR/EULAR 2010 criteria. All patients had a history of polyarthritis. Ulnar involvement was found in 27 (27.27%) patients. Rheumatoid nodules were found in 12 (12.12%) patients. Rheumatoid factors were positive in 56 (56.56%) patients. Anti-cyclic citrullinated peptide antibodies were positive in 7 (7.07%) patients. Methotrexate was the background treatment in 67 (67.67%) patients and hydroxychloroquine in 43 (43.43%) patients. Conclusion: Polyarthritis is diagnosed late in Niger. The creation of a national registry of rheumatoid arthritis patients will allow better follow-up of patients

Polyarthrite Rhumatoïde au Niger : États des Lieux

Objectif : faire une revue des données de la littérature sur les aspects épidémiologiques, cliniques, paracliniques et thérapeutiques de la polyarthrite rhumatoïde au Niger. Méthodes : Cette revue des données de la littérature sur la polyarthrite rhumatoïde au Niger a été réalisée en utilisant les bases de données MEDLINE (via PUBMED) et de Google Scholar. Les critères d’inclusion comprenaient des études publiées chez des adultes de plus de 18 ans ayant reçu un diagnostic de polyarthrite rhumatoïde. L’extraction des données a été réalisée grâce à un formulaire préétabli. Résultats : La recherche dans la littérature a identifié 5 articles. Finalement, quatre articles ont été inclus pour la revue. La fréquence de la polyarthrite rhumatoïde a été rapportée dans trois études, celle-ci variait de 1,24% à 3,7%. Le genre féminin représentait 79 (79,79%) des patients. L’âge moyen globale était de 43,41 ans. Le délai moyen avant le diagnostic était de 53,2 mois. La polyarthrite rhumatoïde a été diagnostiqué en utilisant les critères ACR 1987 et les critères ACR/EULAR 2010. Tous les patients avaient consulté pour une polyarthrite. Le coup de vent cubital était retrouvé chez 27 (27,27%) patients. Les nodules rhumatoïdes ont été retrouvé chez 12 (12,12%) patients. Les facteurs rhumatoïdes étaient positifs chez 56 (56,56%) patients. Les anticorps anti peptides cycliques citrullinés étaient positif chez 7 (7,07%) patients. Le méthotrexate était le traitement de fond chez 67 (67,67%) patients et l’hydroxychloroquine chez 43 (43,43%) patients. Conclusion : Le diagnostic de la polyarthrite est tardif au Niger. La création d’un registre national des patients ayant une polyarthrite rhumatoïde permettra un meilleur suivi des patients.   Objective: To review the epidemiologic, clinical, paraclinical and therapeutic aspects of rheumatoid arthritis in Niger. Methods: This review of literature on rheumatoid arthritis in Niger was conducted using MEDLINE (via PUBMED) and Google Scholar databases. Inclusion criteria included studies published in adults over 18 years of age with a diagnosis of rheumatoid arthritis. Data extraction was done using a pre-designed form. Results: The literature search identified 5 articles. Four articles were finally included in the review. The frequency of rheumatoid arthritis was reported in three studies and ranged from 1.24% to 3.7%. Females accounted for 79 (79.79%) of the patients. The mean age was 43.41 years. The mean time to diagnosis was 53.2 months. Rheumatoid arthritis was diagnosed according to ACR 1987 and ACR/EULAR 2010 criteria. All patients had a history of polyarthritis. Ulnar gale was found in 27 (27.27%) patients. Rheumatoid nodules were found in 12 (12.12%) patients. Rheumatoid factors were positive in 56 (56.56%) patients. Anti-cyclic citrullinated peptide antibodies were positive in 7 (7.07%) patients. Methotrexate was the background treatment in 67 (67.67%) patients and hydroxychloroquine in 43 (43.43%) patients. Conclusion: Polyarthritis is diagnosed late in Niger. The creation of a national registry of rheumatoid arthritis patients will allow better follow-up of patients

Polyarthrite Rhumatoïde au Niger : Etats des Lieux

 Objectif : Faire l’état des lieux sur les aspects épidémiologiques, cliniques, paracliniques et thérapeutiques de la polyarthrite rhumatoïde au Niger. Méthodes : Cette revue des données de la littérature sur la polyarthrite rhumatoïde au Niger a été réalisée en utilisant les bases de données MEDLINE (via PUBMED) et de google scholar. Les critères d’inclusion comprenaient des études publiées chez des adultes de plus de 18 ans ayant reçu un diagnostic de polyarthrite rhumatoïde. L’extraction des données a été réalisée grâce à un formulaires préétablis. Résultats : La recherche dans la littérature a identifié 5 articles. Finalement, quatre articles ont été inclus pour la revue. La fréquence de la polyarthrite rhumatoïde a été rapportée dans trois études, celle-ci variait de 1,24% à 3,7%. Le genre féminin représentait 79 (79,79%) des patients. L’âge moyen globale était de 43,41 ans. Le délai moyen avant le diagnostic était de 53,2 mois. La polyarthrite rhumatoïde a été diagnostiqué en utilisant les critères ACR 1987 et les critères ACR/EULAR 2010. Tous les patients avaient consulté pour une polyarthrite. Le coup de vent cubital était retrouvé chez 27 (27,27%) patients. Les nodules rhumatoïdes ont été retrouvé chez 12 (12,12%) patients. Les facteurs rhumatoïdes étaient positifs chez 56 (56,56%) patients. Les anticorps anti peptides cycliques citrullinés étaient positif chez 7 (7,07%) patients. Le méthotrexate était le traitement de fond chez 67 (67,67%) patients et l’hydroxychloroquine chez 43 (43,43%) patients. Conclusion : Le diagnostic de la polyarthrite est tardif au Niger. La création d’un registre national des patients ayant une polyarthrite rhumatoïde permettra un meilleur suivi des patients.   Objective: To review the epidemiologic, clinical, paraclinical and therapeutic aspects of rheumatoid arthritis in Niger. Methods: This review of literature on rheumatoid arthritis in Niger was conducted using MEDLINE (via PUBMED) and google scholar databases. Inclusion criteria included studies published in adults over 18 years of age with a diagnosis of rheumatoid arthritis. Data extraction was done using a pre-designed form. Results: The literature search identified 5 articles. Four articles were finally included in the review. The frequency of rheumatoid arthritis was reported in three studies and ranged from 1.24% to 3.7%. Females accounted for 79 (79.79%) of the patients. The mean age was 43.41 years. The mean time to diagnosis was 53.2 months. Rheumatoid arthritis was diagnosed according to ACR 1987 and ACR/EULAR 2010 criteria. All patients had a history of polyarthritis. Ulnar involvement was found in 27 (27.27%) patients. Rheumatoid nodules were found in 12 (12.12%) patients. Rheumatoid factors were positive in 56 (56.56%) patients. Anti-cyclic citrullinated peptide antibodies were positive in 7 (7.07%) patients. Methotrexate was the background treatment in 67 (67.67%) patients and hydroxychloroquine in 43 (43.43%) patients. Conclusion: Polyarthritis is diagnosed late in Niger. The creation of a national registry of rheumatoid arthritis patients will allow better follow-up of patients

Myalgia‐induced discovery of rhabdomyolysis complicating generalized varicella in an immunocompetent patient: Case report and review of the literature

Key clinical message In a rare occurrence, primary varicella infection led to rhabdomyolysis in a 24‐year‐old with no medical history. Presenting with rash, fever, and weakness, he developed diffuse myalgia at 72 h. Elevated muscle enzymes confirmed rhabdomyolysis secondary to varicella zoster virus (VZV) infection. Treatment with acyclovir and hydration resulted in significant improvement within a month. Abstract Primary varicella infection is rarely complicated by rhabdomyolysis. In this study, we describe a case of rhabdomyolysis complicating a VZV infection in a black subject. The patient was a 24‐year‐old black African with no particular medical history and was immunocompetent. He presented with an acute onset of generalized rash, fever, and generalized weakness. Physical examination revealed vesicular lesions typical of chickenpox. Antipyretic treatment combined with acyclovir was instituted in hospital. At the 72nd hour, diffuse myalgia developed. Muscle enzyme tests revealed CPK elevated to 40 times the upper limit of normal, LDH elevated to 2 times the upper limit of normal, ASAT and ALAT elevated to 7 times the upper limit of normal, and 2.5 times the upper limit of normal, respectively. We accepted the diagnosis of rhabdomyolysis secondary to VZV infection. The patient was given saline hydration and showed clinical and biological improvement 1 month later. A patient presenting with muscular symptoms during a VZV infection should be considered for rhabdomyolysis

Covid‐19‐related right hip monoarthritis: A case report and literature review

Key Clinical Message This article presents the case of a young patient with severe acute left hip pain who tested positive for COVID‐19. The diagnostic approach and management are presented, followed by a review of the literature. This 11‐year‐old student was admitted for acute left hip pain of abrupt onset, inflammatory, evolving for 24 h in a febrile context with no change in general condition. The initial workup revealed a hyperleukocytosis in the blood count, CRP 198.52 mg/L, and a 95 mm SV. The pelvic X‐ray was unremarkable, and the hip ultrasound showed synovial hypertrophy, with no effusion on Doppler examination. The situation worsened 24 h later with the onset of acute respiratory distress syndrome. The chest X‐ray showed bilateral alveolar interstitial lung disease, and the CT scan showed hyperdensity and crazy paving. The COVID‐19 RDT test on a nasopharyngeal sample came back positive, as did the RT‐PCR. Death occurred a few hours later in acute respiratory distress. Our case is consistent with what has been reported in the literature, but requires further study on an international scale to better define the phenotype of the disease

Epidemiology and diagnosis of gout in sub-saharan Africa: a scoping review

Abstract Background The episodic nature of gout and diagnostic uncertainty in the absence of microcrystal evidence make it particularly difficult to estimate the frequency of gout. Our aim was to review the literature on the epidemiological and diagnostic aspects of gout in sub-Saharan Africa. Methods This literature review was conducted using the MEDLINE database (via PUBMED), Google Scholar, and conference abstracts. The selection process was based on reading the titles first, then the abstracts, and then the full texts once the articles had been selected. Studies were included in this review if they presented original findings on the epidemiological and/or diagnostic aspects of gout in sub-Saharan Africa. Two groups of two investigators independently reviewed the studies. The results were analysed descriptively. Results The literature search identified 131 articles and 22 conference abstracts. Nineteen articles were included in our review. Twelve studies were retrospective, five were cross-sectional, one was prospective, and one was both retrospective and cross-sectional. The duration of the studies ranged from 1 to 15 years, and the sample size ranged from 15 to 511 patients, for a total of 2557 patients. Gout was quite common, with a maximum frequency of 11.87%. Fourteen articles diagnosed gout via criteria, including 9 studies totaling 1174 patients via the 1977 ACR criteria. Gout tophi were reported in 15 articles involving 464 patients. Of these studies, seven looked for monosodium urate crystals in 317 (43.85%) of 723 patients. Among the 317 patients, monosodium urate crystals were detected in 263 (82.97%) patients. Eleven studies reported mean uricemia values ranging from 452.09 µmol/L to 642.44 µmol/L, with a mean of 510.63 µmol/L. Conclusions This review revealed that all the studies conducted in sub-Saharan Africa were intrahospital studies, and the majority were retrospective. Consequently, there is a clear need for population-based studies