Central and local government and the provision of municipal medicine, 1919-39

This article examines the relationship between central and local government - and specifically the County Boroughs - in interwar England and Wales with respect to the provision of municipal health services. It is argued that this relationship was complex, with different local authorities being compliant to a greater or lesser degree with the aspirations of the Ministry of Health. The latter, it is further suggested, started off its life as a relatively dynamic, well-run and farsighted part of central government, but for a range of reasons lost authority and influence as the interwar era progressed. This was not helped by the limited powers the Ministry held. The local authorities, meanwhile, differed widely in their aspirations for municipally-provided health care. Some were reluctant to do much, others had ambitions somewhat in advance of those of the Ministry of Health. What did unite local authorities was their collective desire to preserve the longstanding tradition of a high degree of local independence. As is also shown, specifically local factors and personnel - for example the political dynamics of the council or the standing of the Medical Officer of Health - could significantly shape a County Borough's approach to health care. The article thus contributes to the history of English and Welsh local government and, especially, to the relatively neglected period in the history of the health services which falls between the demise of the Poor Law and the coming of the National Health Service

Ecotourism and Economic Growth in the Galapagos: An Island Economy-wide Analysis

This paper raises questions about the compatibility of "ecotourism and conservation in the unique environment of the Galapagos Islands. It updates a 1999 economy-wide analysis that predicted that increases in tourism would result in rapid economic as well as demographic growth on the islands. The following six years witnessed sharp growth in tourism; a restructuring of tourism around larger cruise ships and new, larger hotels; and rapid population growth. Our findings indicate that total income (that is, the gross domestic product) of the Galapagos increased by an estimated 78% between 1999 and 2005, placing Galapagos among the fastest growing economies in the world. Tourism continues to be far and away the major driver of economic growth; however, new injections of all sorts of spending, including by government, commercial fishing, and conservation agencies, have had a multiplier effect on income in the Galapagos economy, and as a result, on population growth, via uncontrolled immigration that is theoretically prohibited by the Special Law of the Galapagos to prevent ecological harm to the islands. Further, immigration has diminished the effect of economic growth on household income, creating political pressure to find even more economic development options for Galapagos residents, including commercial fishing. The linkage between economic growth, led by tourism or any other sector, and environmental protection of the Galapagos should be taken seriously when designing and implementing economic development and conservation programs.Resource /Energy Economics and Policy,

Effects of secondary metal carbonate addition on the porous character of resorcinol-formaldehyde xerogels

A deeper understanding of the chemistry and physics of growth, aggregation and gelation processes involved in the formation of xerogels is key to providing greater control of the porous characteristics of such materials, increasing the range of applications for which they may be utilised. Time-resolved dynamic light scattering has been used to study the formation of resorcinol-formaldehyde gels in the presence of combinations of Group I (Na and Cs) and Group II (Ca and Ba) metal carbonates. It was found that the combined catalyst composition, including species and times of addition, is crucial in determining the end properties of the xerogels, via its effect on growth of clusters involved in formation of the gel network. Combination materials have textural characteristics within the full gamut offered by each catalyst alone; however, in addition, combination materials which retain the small pores associated with sodium carbonate catalysed xerogels exhibit a narrowing of the pore size distribution, providing an increased pore volume within an application-specific range of pore sizes. We also show evidence of pore size tunability while maintaining ionic strength, which significantly increases the potential of such systems for biological applications

Mechanics of musculoskeletal repair devices

This paper applies the mechanics of engineering science and materials to the understanding of clinical devices used in Orthopaedics and Trauma. The rigidity of devices is described to be a function of material stiffness and its geometry relative to the loading axes. Structures are more rigid under loads that are applied along their long axes and are more flexible under bending and torsion, which increases with length. This may be applied to an individual plate, screw or bone and to the entire construct. Increasing the thickness of a plate greatly increases rigidity as a third power relationship exists between these variables. Similarly, increasing the diameter of a rod increases its rigidity by a fourth power relationship. A hollow cylindrical cross-section, as found in long bones, provides the most effective rigidity to weight ratio when complex stresses are applied. This paper provides examples to reinforce basic structural mechanics applied to medical devices

Environmental and genetic factors associated with Solanesol accumulation in potato leaves

Solanesol is a high value 45-carbon, unsaturated, all-trans-nonaprenol isoprenoid. Recently solanesol has received particular attention because of its utility, both in its own right and as a precursor in the production of numerous compounds used in the treatment of disease states. Solanesol is found mainly in solanaceous crops such as potato, tomato, tobacco and pepper where it accumulates in the foliage. There is considerable potential to explore the extraction of solanesol from these sources as a valuable co-product. In this study we have characterised the genetic variation in leaf solanesol content in a biparental, segregating diploid potato population. We demonstrate that potato leaf solanesol content is genetically controlled and identify several quantitative trait loci associated with leaf solanesol content. Transient over-expression of genes from the methylerythritol 4-phosphate (MEP) and mevalonic acid (MVA) pathways, either singly or in combination, resulted in enhanced accumulation of solanesol in leaves of Nicotiana benthamiana, providing insights for genetically engineering the pathway. We also demonstrate that in potato, leaf solanesol content is enhanced by up to six-fold on exposure to moderately elevated temperature and show corresponding changes in expression patterns of MEP and MVA genes. Our combined approaches offer new insights into solanesol accumulation and strategies for developing a bio-refinery approach to potato production

Miniature nitro and peroxide vapor sensors using nanoporous thin films

With the increased and continuous threat of terrorist attacks in public areas, new sensors are required to safeguard the public from home-made explosive devices. Current commercial sensors for explosive vapors are high-cost, bulky equipment not amenable to mass production, thus limiting their widespread deployment within society. We are conducting research on polymer-based microsensors that can overcome these limitations. Our devices offer an approach to the realization of low-cost sensors that can readily be placed as a network of electronic sentinels that can be permanently located in areas of public access. The polymers are chemically tailored to have a high affinity for nitro and peroxide vapors and are grown electrochemically on microelectrodes. Novel nanoporous polymer-based sensors are demonstrated with a detection level of 200 ppb of nitro vapors. In addition, a prototype reversible sensor for peroxide vapors is demonstrated to low ppm concentrations

Fate of the Organophosphate Insecticide, Chlorpyrifos, in Leaves, Soil, and Air Following Application

A field study was conducted to further our understanding about the fate and transport of the organophosphate insecticide, chlorpyrifos, and its degradation product, chlorpyrifos oxon. Leaf, soil and air sampling was conducted for 21 days after chlorpyrifos application to a field of purple tansy (Phacelia tanacetifolia). Air samples were collected using a high-volume air sampler (HVAS) and seven battery-operated medium-volume active air samplers placed around the field and on a 500-m transect extending away from the field. Chlorpyrifos was detected every day of the sampling period in all matrices, with concentrations decreasing rapidly after application. Chlorpyrifos oxon was only detected in air samples collected with the HVAS during the first three days after application. Wind direction played a significant role in controlling the measured air concentrations in near-field samples. The SCREEN3 model and chlorpyrifos’ Characteristic Travel Distance (CTD) were used to predict modelled chlorpyrifos concentrations in air along the transect. The concentration trend predicted by the SCREEN3 model was similar to that of measured concentrations whereas CTD-modelled concentrations decreased at a significantly slower rate, indicating that downwind chlorpyrifos concentrations in air were primarily controlled by air dispersion. The SCREEN3-predicted chlorpyrifos concentrations were \u3e5 times higher than measured concentrations, indicating that simple approaches for calculating accurate pesticide volatilization fluxes from agricultural fields are still needed. Finally, we found that measured concentrations in air on Days 0–2 at locations up to 500 m from the field were at levels considered concerning for human health