Le programme "Walk with a Future Doc" permet aux étudiants en médecine canadiens de promouvoir l'activité physique et l'éducation en santé dans les communautés locales

Implication Statement Medical student-led walk and talk programs, such as Walk with a Future Doc (WWAFD), provide a means for the medical community and community at-large to interact in a non-clinical setting. This environment can increase attendance accountability, enhance patient-provider relationships, and allow medical professionals to be leading examples of healthy, active living. We demonstrate the positive interest for this program, rationale of participants for joining, and the feasibility of its setup. As one of the only WWAFD programs in Canada, we encourage other medical schools to implement this program to promote continuity of hands-on, community-engaged learning amongst their students.Énoncé des implications de la recherche Les programmes de marche et de discussion menés par les étudiants en médecine, tels que Walk with a Future Doc (WWAFD), permettent à la communauté médicale et à la communauté dans son ensemble d'interagir dans un cadre non clinique. Cet environnement peut accroître la responsabilité face à l'assiduité, améliorer les relations patient-fournisseur et permettre aux professionnels de la santé d'être des exemples de vie saine et active. Nous démontrons l'intérêt positif de ce programme, les raisons pour lesquelles les participants y adhèrent et la faisabilité de sa mise en place. Comme il s'agit de l'un des seuls programmes WWAFD au Canada, nous encourageons les autres facultés de médecine à mettre en œuvre ce programme pour promouvoir la continuité de l'apprentissage pratique et engagé au sein de la communauté parmi leurs étudiants

A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis.

Endometriosis is found in 5-15% of women of reproductive age and is more frequent in relatives of women with the disease. Activation of KRAS results in de novo endometriosis in mice, however, activating KRAS mutations have not been identified in women. We screened 150 women with endometriosis for a polymorphism in a let-7 microRNA (miRNA) binding site in the 3'-UTR of KRAS and detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. KRAS mRNA and protein expression were increased in cultured endometrial stromal cells of women with the KRAS variant. Increased KRAS protein was due to altered miRNA binding as demonstrated in reporter assays. Endometrial stromal cells from women with the KRAS variant showed increased proliferation and invasion. In a murine model, endometrial xenografts containing the KRAS variant demonstrated increased proliferation and decreased progesterone receptor levels. These findings suggest that an inherited polymorphism of a let-7 miRNA binding site in KRAS leads to abnormal endometrial growth and endometriosis. The LCS6 polymorphism is the first described genetic marker of endometriosis risk

Accurate and Efficient Expression Evaluation and Linear Algebra

We survey and unify recent results on the existence of accurate algorithms for evaluating multivariate polynomials, and more generally for accurate numerical linear algebra with structured matrices. By "accurate" we mean that the computed answer has relative error less than 1, i.e., has some correct leading digits. We also address efficiency, by which we mean algorithms that run in polynomial time in the size of the input. Our results will depend strongly on the model of arithmetic: Most of our results will use the so-called Traditional Model (TM). We give a set of necessary and sufficient conditions to decide whether a high accuracy algorithm exists in the TM, and describe progress toward a decision procedure that will take any problem and provide either a high accuracy algorithm or a proof that none exists. When no accurate algorithm exists in the TM, it is natural to extend the set of available accurate operations by a library of additional operations, such as $x+y+z$, dot products, or indeed any enumerable set which could then be used to build further accurate algorithms. We show how our accurate algorithms and decision procedure for finding them extend to this case. Finally, we address other models of arithmetic, and the relationship between (im)possibility in the TM and (in)efficient algorithms operating on numbers represented as bit strings.Comment: 49 pages, 6 figures, 1 tabl

Isolated pulmonary vasculitis associated with nilotinib use: A case report.

An association between tyrosine-kinase inhibitor therapy for chronic myeloid leukemia and vascular adverse events including peripheral arterial disease, coronary artery disease, and pulmonary hypertension has been described. We present a patient who developed isolated pulmonary artery vasculitis resulting in left pulmonary artery stenosis, in addition to left coronary artery stenosis while on nilotinib. While monitoring for cardiovascular events is important, clinicians should also recognize possible drug-induced vasculitis during chronic nilotinib therapy

Faculty Empowering Faculty: SoTL Leaders Catalyzing Institutional and Cultural Change

Faculty are increasingly interested in engaging in the scholarship of teaching and learning (SoTL) across disciplines, necessitating educational development support. While many institutions utilize one-time workshops and faculty communities offering professional development funding, the case study presented in this article takes a different approach. The aim of the Engaged Teacher-Scholar (ETS) program is to support faculty growth in a process of becoming ETS leaders across the university campus. ETS leaders advance an individual SoTL research project and are trained to develop a plan for and offer professional development events to their department, college, and university related to SoTL. The article presents an overview of the program’s objectives, organization, and outcomes over four years of implementation. The article concludes with implications for implementation at other institutions

Performance of Different Carbon Electrode Materials: Insights into Stability and Degradation under Real Vanadium Redox Flow Battery Operating Conditions

This work focuses on the performance and stability of selected commercial carbon electrode materials before and after heat-treatment in an operating all-vanadium redox flow battery (VRB). Heat treatment results in improved cell performance for all tested materials, with SGL 39 AA carbon papers and SIGRACELL GFD4.6 EA carbon felt showing the best performance. Further investigation of these two materials by in situ reference electrode measurements reveal improvements after heat-treatment that originate mainly from the negative electrode or V2+/V3+ side of the cell. Upon extended cycling, carbon felt is found to be stable. Carbon papers however, show significant performance losses originating from the negative electrode side. The potential limit during charging and the exposure to very negative potentials appears to be a critical issue at the negative electrode in the VRB. Analysis of both materials after cycling by scanning electron microscopy, Raman spectroscopy and X-ray photoelectron spectroscopy reveal significant differences in their surface chemistry, structure and morphology. These differences give valuable insights into the behavior and degradation of different carbon materials used in VRBs.ISSN:0013-4651ISSN:1945-711

Concert recording 2012-11-05

[Track 01]. Danse macabre / Camille Saint-Saens -- [Track 02]. Mazurka / Francis Poulenc -- [Track 03]. Now sleeps the crimson petal / Roger Quilter -- [Track 04]. O cessate di piagarmi / Alessandro Scarlatti -- [Track 05]. Widmung / Robert Schumann -- [Track 06]. Pique dame. Pauline\u27s aria / Peter IIlyich Tchaikovsky -- [Track 07]. Don Giovanni. Deh vieni alla finestra / Wolfgang Amadeus Mozart -- [Track 08]. Manon. Epouse quelque brave fille / Jules Massenet -- Die tote Stadt. Tanzlied des pierrot / Erick Wolfgang Korngold -- [Track 09]. Die Forelle / Franz Schubert -- [Track 10]. Ici-bas / Gabriel Faure -- [Track 11]. Un ballo in maschera. Saper vorreste / Guiseppe Verdi -- [Track 12]. Il Floriodo. Per pieta / Alessandro Stradella -- [Track 13]. Mein schoner stern/ Robert Schumann -- [Track 14]. Fleur jetee / Gabriel Faure -- [Track 15]. A view from the bridge. New York lights / William Bolcom -- [Track 16]. Les nuits d\u27ete. Vilanelle / Hector Berlioz -- [Track 17]. Ständchen / Joseph Marx -- Will there really be a morning? / Andre Previn -- The trees on the mountain / Carlisle Floyd

Dynamic Contrast Enhanced MRI Can Monitor the Very Early Inflammatory Treatment Response upon Intra-Articular Steroid Injection in the Knee Joint: A Case Report with Review of the Literature

Dynamic contrast-enhanced MRI in inflammatory arthritis, especially in conjunction with computer-aided analysis using appropriate dedicated software, seems to be a highly sensitive tool for monitoring the early inflammatory treatment response in patients with rheumatoid arthritis. This paper gives a review of the current knowledge of the emerging technique. The potential of the technique is demonstrated and discussed in the context of a case report following the early effect of an intra-articular steroid injection in a patient with rheumatoid arthritis flare in the knee

Advanced qEEG analyses discriminate between dementia subtypes

Acknowledgement This study is part of the academic postgraduate research of Masha Burelo, financed through the postgraduate fellowship program of the National Council of Science and Technology (CONACYT, by its Spanish acronym) of Mexico.Peer reviewe