Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II)

A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer’s law within the concentration range 8.5-70 mg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 mg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu2MPT2Cl2) have been reported

Electrochemical Investigation and DNA-Binding Studies of Valacyclovir-Copper(II) Complex

WOS: 000312984600006The synthesis and the electrochemical characterization of copper(II) complex containing one molecule of antiviral drug, valacyclovir (VAL), is reported. In addition to characterization, the electrochemical properties of the copper(II) complex of VAL ([Cu(VAL)Cl2]) were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The redox properties of the metal complex was reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed. Also, the interaction of copper complex of VAL- with calf thymus double-stranded DNA was studied spectrophotometrically (UV-vis) and electrochemically by using CV at glassy carbon working electrode. Additionally, the cytotoxicity activity of complex has been investigated against the bovine herpes virus type I.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109T020]; KSUKing Saud UniversityKahramanmaras Sutcu Imam University [2009/3-10]The authors wish to thank TUBITAK (Project No: 109T020) and KSU (Project No: 2009/3-10) for the financial support