Influence of the composition and viscosity of volcanic ashes on their adhesion within gas turbine aeroengines

This paper presents experimental investigations into adhesion characteristics of four types of (Icelandic) volcanic ash (VA). Firstly, powder (∼5–50 μm) was injected into a modified vacuum plasma spray set-up and the fractional mass of particles that adhered to a substrate was measured. Secondly, large (∼6 mm), dense pellets of each ash were heated and projected at a substrate, with their impact response monitored via high speed photography. The four ashes fall into two groups of two, one with high Si content (>20%) and the other containing less Si, but higher levels of lower valence cations (such as Ca, Mg & Fe). The glass transition temperatures were all relatively low (∼650–750 °C), favouring particle adhesion on surfaces in gas turbines. All of the ashes tended to adhere, especially with higher gas temperatures and impingement velocities. However, this tendency was much greater for the two ashes with high levels of the lower valence cations. The high speed photography confirmed that this was due to these two ashes having much lower viscosities (at high strain rates). This behaviour could not have been predicted solely on the basis of Tg or glass content values. However, these cations act as “network-modifiers” in silica-based glasses, effecting sharp reductions in melt viscosity, so inferences about the danger of specific VA may be possible from simple compositional analysis. In any event, it's clearly important for VA being generated during any particular eruption to be sampled (presumably by drones) and analysed, rather than relying solely on remote measurement of atmospheric ash levels.This work forms part of a research programme funded by EPSRC (EP/K027530/1). In conjunction with this project, a consortium of partners has been set up under the PROVIDA ("PROtection against Volcanic ash Induced Damage in Aeroengines") banner and information about its operation is available at http://www.ccg.msm.cam.ac.uk/initiatives/provida. The invaluable assistance of Kevin Roberts (Materials Department in Cambridge) with operation of the plasma spray facility is gratefully acknowledged. The authors are also grateful to Mr. Max Burley, of the Materials Science Department in Cambridge, for helpful contributions to the high speed photography and gas gun work, and to Dr. Margaret Hartley, of the University of Manchester, for kindly collecting the ashes during field trips to Iceland (funded by EasyJet) and also for extensive and valuable discussions related to the science of the specific eruptions concerned, and more generally concerning the complex relationships between geological and rheological characteristics of volcanic magma and ash. In compliance with EPSRC requirements, raw data in the form of selected video files are available at www.ccg.msm.cam.ac.uk/publications/resources, and are also accessible via the University repository at http://www.data.cam.ac.uk/repository.This is the final version of the article. It first appeared from Elsevier via https://doi.org/10.1016/j.actamat.2016.02.01

Influence of the composition and viscosity of volcanic ashes on their adhesion within gas turbine aeroengines

AbstractThis paper presents experimental investigations into adhesion characteristics of four types of (Icelandic) volcanic ash (VA). Firstly, powder (∼5–50 μm) was injected into a modified vacuum plasma spray set-up and the fractional mass of particles that adhered to a substrate was measured. Secondly, large (∼6 mm), dense pellets of each ash were heated and projected at a substrate, with their impact response monitored via high speed photography. The four ashes fall into two groups of two, one with high Si content (>20%) and the other containing less Si, but higher levels of lower valence cations (such as Ca, Mg & Fe). The glass transition temperatures were all relatively low (∼650–750 °C), favouring particle adhesion on surfaces in gas turbines. All of the ashes tended to adhere, especially with higher gas temperatures and impingement velocities. However, this tendency was much greater for the two ashes with high levels of the lower valence cations. The high speed photography confirmed that this was due to these two ashes having much lower viscosities (at high strain rates). This behaviour could not have been predicted solely on the basis of Tg or glass content values. However, these cations act as “network-modifiers” in silica-based glasses, effecting sharp reductions in melt viscosity, so inferences about the danger of specific VA may be possible from simple compositional analysis. In any event, it's clearly important for VA being generated during any particular eruption to be sampled (presumably by drones) and analysed, rather than relying solely on remote measurement of atmospheric ash levels

Knowledge and attitudes of primary healthcare patients regarding population-based screening for colorectal cancer

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to assess the extent of knowledge of primary health care (PHC) patients about colorectal cancer (CRC), their attitudes toward population-based screening for this disease and gender differences in these respects.</p> <p>Methods</p> <p>A questionnaire-based survey of PHC patients in the Balearic Islands and some districts of the metropolitan area of Barcelona was conducted. Individuals between 50 and 69 years of age with no history of CRC were interviewed at their PHC centers.</p> <p>Results</p> <p>We analyzed the results of 625 questionnaires, 58% of which were completed by women. Most patients believed that cancer diagnosis before symptom onset improved the chance of survival. More women than men knew the main symptoms of CRC. A total of 88.8% of patients reported that they would perform the fecal occult blood test (FOBT) for CRC screening if so requested by PHC doctors or nurses. If the FOBT was positive and a colonoscopy was offered, 84.9% of participants indicated that they would undergo the procedure, and no significant difference by gender was apparent. Fear of having cancer was the main reason for performance of an FOBT, and also for not performing the FOBT, especially in women. Fear of pain was the main reason for not wishing to undergo colonoscopy. Factors associated with reluctance to perform the FOBT were: <b><it>(i) </it></b>the idea that that many forms of cancer can be prevented by exercise and, <b><it>(ii) </it></b>a reluctance to undergo colonoscopy if an FOBT was positive. Factors associated with reluctance to undergo colonoscopy were: <b><it>(i) </it></b>residence in Barcelona, <b><it>(ii) </it></b>ignorance of the fact that early diagnosis of CRC is associated with better prognosis, <b><it>(iii) </it></b>no previous history of colonoscopy, and <b><it>(iv) </it></b>no intention to perform the FOBT for CRC screening.</p> <p>Conclusion</p> <p>We identified gaps in knowledge about CRC and prevention thereof in PHC patients from the Balearic Islands and the Barcelona region of Spain. If fears about CRC screening, and CRC per se, are addressed, and if it is emphasized that CRC is preventable, participation in CRC screening programs may improve.</p

Effects of Cocaine-Kindling on the Expression of NMDA Receptors and Glutamate Levels in Mouse Brain

In the present study we examined the effects of cocaine seizure kindling on the expression of NMDA receptors and levels of extracellular glutamate in mouse brain. Quantitative autoradiography did not reveal any changes in binding of [3H] MK-801 to NMDA receptors in several brain regions. Likewise, in situ hybridization and Western blotting revealed no alteration in expression of the NMDA receptor subunits, NR1 and NR2B. Basal overflow of glutamate in the ventral hippocampus determined by microdialysis in freely moving animals also did not differ between cocaine-kindled and control groups. Perfusion with the selective excitatory amino acid transporter inhibitor, pyrrolidine-2,4-dicarboxylic acid (tPDC, 0.6 mM), increased glutamate overflow confirming transport inhibition. Importantly, KCl-evoked glutamate overflow under tPDC perfusion was significantly higher in cocaine-kindled mice than in control mice. These data suggest that enhancement of depolarization stimulated glutamate release may be one of the mechanisms underlying the development of increased seizure susceptibility after cocaine kindling

Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level

<p>Abstract</p> <p>Background</p> <p>Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins. Its brain immunoreactivity is located in neurons and neuronal processes. PKCI/HINT1 gene knockout (KO) mice display hyper-locomotion in response to D-amphetamine which is considered a positive symptom of schizophrenia in animal models. <it>Postmortem </it>studies identified PKCI/HINT1 as a candidate molecule for schizophrenia and bipolar disorder. We investigated the hypothesis that the PKCI/HINT1 gene may play an important role in regulating mood function in the CNS. We submitted PKCI/HINT1 KO mice and their wild type (WT) littermates to behavioral tests used to study anti-depressant, anxiety like behaviors, and goal-oriented behavior. Additionally, as many mood disorders coincide with modifications of hypothalamic-pituitary-adrenal (HPA) axis function, we assessed the HPA activity through measurement of plasma corticosterone levels.</p> <p>Results</p> <p>Compared to the WT controls, KO mice exhibited less immobility in the forced swim (FST) and the tail suspension (TST) tests. Activity in the TST tended to be attenuated by acute treatment with valproate at 300 mg/kg in KO mice. The PKCI/HINT1 KO mice presented less thigmotaxis in the Morris water maze and spent progressively more time in the lit compartment in the light/dark test. In a place navigation task, KO mice exhibited enhanced acquisition and retention. Furthermore, the afternoon basal plasma corticosterone level in PKCI/HINT1 KO mice was significantly higher than in the WT.</p> <p>Conclusion</p> <p>PKCI/HINT1 KO mice displayed a phenotype of behavioral and endocrine features which indicate changes of mood function, including anxiolytic-like and anti-depressant like behaviors, in conjunction with an elevated corticosterone level in plasma. These results suggest that the PKCI/HINT 1 gene could be important for the mood regulation function in the CNS.</p

The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts

BACKGROUND: Colon and intestinal crypts serve as an important model system for adult stem cell proliferation and differentiation. We develop a spatial stochastic model to study the rate of somatic evolution in a normal crypt, focusing on the production of two-hit mutants that inactivate a tumor suppressor gene. We investigate the effect of cell division pattern along the crypt on mutant production, assuming that the division rate of each cell depends on its location. RESULTS: We find that higher probability of division at the bottom of the crypt, where the stem cells are located, leads to a higher rate of double-hit mutant production. The optimal case for delaying mutations occurs when most of the cell divisions happen at the top of the crypt. We further consider an optimization problem where the “evolutionary” penalty for double-hit mutant generation is complemented with a “functional” penalty that assures that fully differentiated cells at the top of the crypt cannot divide. CONCLUSION: The trade-off between the two types of objectives leads to the selection of an intermediate division pattern, where the cells in the middle of the crypt divide with the highest rate. This matches the pattern of cell divisions obtained experimentally in murine crypts. REVIEWERS: This article was reviewed by David Axelrod (nominated by an Editorial Board member, Marek Kimmel), Yang Kuang and Anna Marciniak-Czochra. For the full reviews, please go to the Reviewers’ comments section. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13062-016-0141-6) contains supplementary material, which is available to authorized users