148 research outputs found
Selective Enzymatic Oxidation of Silanes to Silanols
Compared to the biological world's rich chemistry for functionalizing carbon, enzymatic transformations of the heavier homologue silicon are rare. We report that a wildâtype cytochrome P450 monooxygenase (P450_(BM3) from Bacillus megaterium, CYP102A1) has promiscuous activity for oxidation of hydrosilanes to give silanols. Directed evolution was applied to enhance this nonânative activity and create a highly efficient catalyst for selective silane oxidation under mild conditions with oxygen as the terminal oxidant. The evolved enzyme leaves CâH bonds present in the silane substrates untouched, and this biotransformation does not lead to disiloxane formation, a common problem in silanol syntheses. Computational studies reveal that catalysis proceeds through hydrogen atom abstraction followed by radical rebound, as observed in the native CâH hydroxylation mechanism of the P450 enzyme. This enzymatic silane oxidation extends nature's impressive catalytic repertoire
Tin(IV) chalcogenide complexes:single source precursors for SnS, SnSe and SnTe nanoparticle synthesis
A family of tin(IV) bis(hexamethylsilylamide) complexes 2â9 have been synthesized by reaction of [Sn{N(SiMe3)2}2] (1) with the diphenyl dichalcogenanes Ph2E2 (E = S, Se, Te), the radical species TEMPO, or the group 16 elements to form the complexes [(PhE)2Sn{N(SiMe3)2}2] (2â4) and [(TEMPO)2Sn{N(SiMe3)2}2] (5), and [{(Me3Si)2N}2Sn(”2-E)]2 (6â9) (E = S, 2 & 6; E = Se 3 & 7; E = Te, 4 & 9, E = O2, 9). The isolated tin complexes were characterized by elemental analysis, NMR spectroscopy, and the molecular structures of the complexes were determined by single crystal X-ray diffraction. Thermogravimetric analysis showed complexes 2â4 and 6â8 all to have residual masses close to those expected for the formation of the corresponding âSnEâ systems. Complexes 2â4 and 6â8 were also assessed for their utility in the formation of nanoparticles. The materials obtained were characterized by powder X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and energy-dispersive X-ray analysis (EDX). Analysis showed formation of SnSe and SnTe from complexes 3â4 and 6â7, respectively
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