Respiratory symptoms in older people and their association with mortality.

BACKGROUND: A study was undertaken to assess the prevalence of reported respiratory symptoms in a population aged over 75 years and their association with mortality. METHODS: A total of 14 458 people aged 75 years and over participating in a trial of health screening of older people in general practice answered questions on three respiratory symptoms: cough, sputum production, and wheeze. The association of symptoms with mortality was examined for all cause and respiratory causes of death taking account of potential confounders. RESULTS: Coughing up phlegm in winter mornings had a prevalence of 27.0% (95% confidence interval (CI) 26.8 to 27.2). Those with this symptom had an adjusted hazard ratio for all cause mortality of 1.35 (95% CI 1.21 to 1.50), p<0.001 and for respiratory specific mortality of 2.01 (95% CI 1.66 to 2.41), p<0.001. Phlegm at any time of the day in winter had a prevalence of 16.5% (95% CI 16.3 to 16.7) with hazard ratios for all cause and respiratory specific mortality of 1.28 (95% CI 1.15 to 1.42) and 2.28 (95% CI 1.92 to 2.70), p<0.001. Wheeze or whistling from the chest had a prevalence of 14.3% (95% CI 14.1 to 14.5) with hazard ratios of 1.45 (95% CI 1.31 to 1.61) and 2.86 (95% CI 2.45 to 3.35), p<0.001. CONCLUSIONS: The prevalence of respiratory symptoms is widespread among elderly people and their presence is a strong predictor of mortality

The monitoring of environmental conditions within corporate collections at Keyworth and Murchison House : 2004

This report presents the environment data gathered during the calendar year 2004 in the storerooms for the British Geological Survey’s Corporate Collections Archives. The report follows the pattern laid down in the first in the series, released in 2004, The Monitoring of Environmental Conditions within Corporate Collections at Keyworth and Murchison House 2002-03, with comparisons made between data collected in pervious years to assess the benefits or otherwise of modifications to either working practices or the fabric of the building. The data are discussed in chapters 2 and 3 where they are also illustrated in graphical format. A full copy of the data is contained on the accompanying compact disk, together with an Adobe Acrobat format version of this report. We will discuss the factors that affect the temperature and humidity of the storerooms, including the duration and number of workers present in the room, heating cycles of the building and external influences such as variations in the weather, from temperature and precipitation to the direction of the wind. Alterations to working practices and improvements in the fabric of the stores over the period of reporting will also be discussed. Possible future modifications are identified, however these are made in a controlled manner to allow changes in the environment to be assessed

Case studies to enhance online student evaluation: Bond University – Surveying students online to improve learning and teaching

One of the most sensible ways of improving learning and teaching is to ask the students for feedback. At the end of each teaching period (i.e. semester or term) all universities and many schools survey their students. Usually these surveys are managed online. Questions ask for student perceptions about teaching, assessment and workload. The survey administrators report four common problems

Index-driven XML data integration to support functional genomics

We identify a new type of data integration problem that arises in functional genomics research in the context of large-scale experiments involving arrays, 2-dimensional protein gels and mass-spectrometry. We explore the current practice of data analysis that involves repeated web queries iterating over long lists of gene or protein names. We postulate a new approach to solve this problem, applicable to data sets stored in XML format. We propose to discover data redundancies using an XML index we construct and to remove them from the results returned by the query. We combine XML indexing with queries carried out on top of relational tables. We believe our approach could support semi-automated data integration such as that required in the interpretation of large-scale biological experiments

Methamphetamine Induces Striatal Cell Death Followed by the Generation of New Cells and a Second Round of Cell Death in Mice

Our laboratory has been investigating the impact of a neurotoxic exposure to methamphetamine (METH) on cellular components of the striatum post-synaptic to the dopaminergic terminals. A systemic bolus injection of METH (30 mg/kg, ip) induces the production of new cells in the striatum during a period lasting from 24-48 hours after METH. The newly generated cells arise from dormant striatal progenitors and not from the subventricular zone. The newly generated cells display glial phenotypes and begin to die 24 hours after birth, or 2.5 days post-METH. The protracted phase of cell death lasts for at least three months post-METH at which time the bulk of the newly generated cells have disappeared. The METH-induced production of new cells is associated with enlarged striatal volume (up to 50% larger than controls in some animals). As the newly generated cells die over a period of three months, the enlarged striatal volume normalizes. In conclusion, a neurotoxic dose of METH induces the generation of new cells in the striatum associated with enlarged striatal volume. The new cells die over three months post-METH and the enlarged striatal volume returns to control levels. This observation is significant because studies involving METH users show striatal enlargement and the normalization of striatal volume in METH users who have been abstinent for up to 20 months

Tensile rotary power transmission model development for airborne wind energy systems

Rotary airborne wind energy (AWE) systems are a family of AWE devices that utilise networked kites to form rotors. One such device is the Daisy Kite developed by Windswept and Interesting. The Daisy Kite uses a novel tensile rotary power transmission (TRPT) to transfer power generated at the flying rotor down to the ground. Two dynamic models have been developed and compared; one with simple spring-disc representation, and one with multi-spring representation that can take account of more degrees of freedom. Simulation results show that the angular velocity responses of the two TRPT models are more closely correlated in higher wind speeds when the system shows stiffer torsional behaviour. Another interesting point is the observation of two equilibrium states, when the spring-disc TRPT model is coupled with NREL's AeroDyn. Given the computational efficiency of the simpler model and the high correlation of the results between the two models, the simple model can be used for more demanding simulations

‘We haven’t got here just on our own. It’s a conversation’. Jo Littler interviews Carol Tulloch.

Carol Tulloch is an author, curator, maker and academic, and Professor of Dress, Diaspora and Transnationalism at the University of the Arts in London. She grew up in Doncaster in the North of England and studied BA Fashion and Textile Design at Ravensbourne College Design and Communication, and MA History of Design at the Royal College of Art and Victoria and Albert Museum. She is known for her innovative work on heritage, personal archives, style narratives and auto/biography, and her books include Black Style (2004) and The Birth of Cool: Style Narratives of the African Diaspora (2016). She has curated and co-curated a wide range of exhibitions, including Grow Up! Advice and the Teenage Girl (The Women’s Library, 2002); The March of the Women: Suffragettes and the State (National Archives, 2003); Picture This: Representations of Black People in Product Promotion (Archives and Museum of Black Heritage, 2002); Black British Style (V&A, 2004); and Rock Against Racism (Autograph, 2015). In this interview, conducted online in summer 2021, she talks to Jo Littler about her work and the contexts and cultures it emerged out of

The trypanosome alternative oxidase:a potential drug target?

New drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely ineffective therapies currently used. The trypanosome alternative oxidase (TAO) is an essential and unique mitochondrial protein in these parasites and is absent from mammalian mitochondria, making it an attractive drug target. The structure and function of the protein are now well characterized, with several inhibitors reported in the literature which show potential as clinical drug candidates. In this review we provide an update on the functional activity and structural aspects of TAO. We then discuss TAO inhibitors reported to date, problems encountered with in vivo testing of these compounds, and discuss the future of TAO as a therapeutic target.PostprintPeer reviewe