Genome-edited zebrafish model of ABCC8 loss-of-function disease

ATP-sensitive potassium channel (

On the precision of the theoretical predictions for pi pi scattering

In a recent paper, Pelaez and Yndurain evaluate some of the low energy observables of pi pi scattering and obtain flat disagreement with our earlier results. The authors work with unsubtracted dispersion relations, so that their results are very sensitive to the poorly known high energy behaviour of the scattering amplitude. They claim that the asymptotic representation we used is incorrect and propose an alternative one. We repeat their calculations on the basis of the standard, subtracted fixed-t dispersion relations, using their asymptotics. The outcome fully confirms our earlier findings. Moreover, we show that the Regge parametrization proposed by these authors for the region above 1.4 GeV violates crossing symmetry: Their ansatz is not consistent with the behaviour observed at low energies.Comment: Added more material, mostly in Sects. 7, 8 and 9, in support of the same conclusions. Latex, 28 pages, 3 figure

Quantum Tunneling Effect in Oscillating Friedmann Cosmology

It is shown that the tunneling effect in quantum cosmology is possible not only at the very beginning or the very end of the evolution, but also at the moment of maximum expansion of the universe. A positive curvature expanding Friedmann universe changes its state of evolution spontaneously and completely, {\it without} any changes in the matter content, avoiding recollapse, and falling into oscillations between the nonzero values of the scale factor. On the other hand, an oscillating nonsingular universe can tunnel spontaneously to a recollapsing regime. The probability of such kind of tunneling is given explicitly. It is inversely related to the amount of nonrelativistic matter (dust), and grows from a certain fixed value to unity if the negative cosmological constant approaches zero.Comment: 18 pages Latex + 2 figures available by fax upon reques

Fomin's conception of quantum cosmogenesis

The main aim of this paper is to extend the early approach to quantum cosmogenesis provided by Fomin. His approach was developed independently to the well-known Tryon description of the creation of the closed universe as a process of quantum fluctuation of vacuum. We apply the Fomin concept to derive the cosmological observables. We argue that Fomin's idea from his 1973 work, in contrast to Tryon's one has impact on the current Universe models and the proposed extension of his theory now can be tested by distant supernovae SNIa. Fomin's idea of the creation of the Universe is based on the intersection of two fundamental theories: general relativity and quantum field theory with the contemporary cosmological models with dark energy. As a result of comparison with contemporary approaches concerning dark energy, we found out that Fomin's idea appears in the context of the present acceleration of the Universe explanation: cosmological models with decaying vacuum. Contemporary it appears in the form of Ricci scalar dark energy connected with the holographic principle. We show also that the Fomin model admits the bounce instead of the initial singularity. We demonstrate that the Fomin model of cosmogenesis can be falsified and using SNIa data the values of model parameters is in agreement with observations.Comment: 12 pages, 4 figures; (v2) 22 pages, references added, figures improved; (v3) rewritten using revtex4; (v4) minor changes; (v5) improved formulas and extended statistical analysi

Prediction of Evapotranspiration in a Mediterranean Region Using Basic Meteorological Variables

A critical need for farmers, particularly those in arid and semiarid areas is to have a reliable, accurate and reasonably accessible means of estimating the evapotranspiration rates of their crops to optimize their irrigation requirements. Evapotranspiration is a crucial process because of its influence on the precipitation that is returned to the atmosphere. The calculation of this variable often starts from the estimation of reference evapotranspiration, for which a variety of methods have been developed. However, these methods are very complex either theoretically and/or because of the large amount of parameters on which they are based, which makes the development of a simple and reliable methodology for the prediction of this variable important. This research combined three concepts such as cluster analysis, multiple linear regression (MLR), and Voronoi diagrams to achieve that end. Cluster analysis divided the study area into groups based on its weather characteristics, whose locations were then delimited by drawing the Voronoi regions associated with them. Regression equations were built to predict daily reference evapotranspiration in each cluster using basic climate variables produced in forecasts made by meteorological agencies. Finally, the Voronoi diagrams were used again to regionalize the crop coefficients and calculate evapotranspiration from the values of reference evapotranspiration derived from the regression models. These operations were applied to the Valencian region (Spain), a Mediterranean area which is partly semiarid and for which evapotranspiration is a critical issue. The results demonstrated the usefulness and accuracy of the methodology to predict the water demands of crops and hence enable farmers to plan their irrigation needs.This paper was possible thanks to the research project RHIVU (Ref. BIA2012-32463), financed by the Spanish Ministry of Economy and Competitiveness with funds from the State General Budget (PGE) and the European Regional Development Fund (ERDF). The authors also wish to express their gratitude to the Spanish Ministry of Agriculture, Food and Environment (MAGRAMA) for providing the data necessary to develop this study

Quantum Pair Creation of Soliton Domain Walls

A large body of experimental evidence suggests that the decay of the false vacuum, accompanied by quantum pair creation of soliton domain walls, can occur in a variety of condensed matter systems. Examples include nucleation of charge soliton pairs in density waves [eg. J. H. Miller, Jr. et al., Phys. Rev. Lett. 84, 1555 (2000)] and flux soliton pairs in long Josephon junctions. Recently, Dias and Lemos [J. Math. Phys. 42, 3292 (2001)] have argued that the mass $m$ of the soliton should be interpreted as a line density and a surface density, respectively, for (2+1)-D and (3+1)-D systems in the expression for the pair production rate. As the transverse dimensions are increased and the total mass (energy) becomes large, thermal activation becomes suppressed, so quantum processes can dominate even at relatively high temperatures. This paper will discuss both experimental evidence and theoretical arguments for the existence of high-temperature collective quantum phenomena

Can the Universe Create Itself?

The question of first-cause has troubled philosophers and cosmologists alike. Now that it is apparent that our universe began in a Big Bang explosion, the question of what happened before the Big Bang arises. Inflation seems like a very promising answer, but as Borde and Vilenkin have shown, the inflationary state preceding the Big Bang must have had a beginning also. Ultimately, the difficult question seems to be how to make something out of nothing. This paper explores the idea that this is the wrong question --- that that is not how the Universe got here. Instead, we explore the idea of whether there is anything in the laws of physics that would prevent the Universe from creating itself. Because spacetimes can be curved and multiply connected, general relativity allows for the possibility of closed timelike curves (CTCs). Thus, tracing backwards in time through the original inflationary state we may eventually encounter a region of CTCs giving no first-cause. This region of CTCs, may well be over by now (being bounded toward the future by a Cauchy horizon). We illustrate that such models --- with CTCs --- are not necessarily inconsistent by demonstrating self-consistent vacuums for Misner space and a multiply connected de Sitter space in which the renormalized energy-momentum tensor does not diverge as one approaches the Cauchy horizon and solves Einstein's equations. We show such a Universe can be classically stable and self-consistent if and only if the potentials are retarded, giving a natural explanation of the arrow of time. Some specific scenarios (out of many possible ones) for this type of model are described. For example: an inflationary universe gives rise to baby universes, one of which turns out to be itself. Interestingly, the laws of physics may allow the Universe to be its own mother.Comment: 48 pages, 8 figure