Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a life-saving procedure used for the treatment of selected hematological malignancies, inborn errors of metabolism, and bone marrow failures. The role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against infection. However, recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered functions. Accordingly, neutrophils are emerging as highly versatile cells that are able to acquire different, often opposite, functional capacities depending on the microenvironment and their differentiation status. Herein, we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT, from the hematopoietic stem cell (HSC) mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC infusion. We also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versus-host disease (GVHD) prophylaxis. Finally, the potential involvement of neutrophils in alloHSCT-related complications, such as transplant-associated thrombotic microangiopathy (TA-TMA), acute and chronic GVHD, and cytomegalovirus (CMV) reactivation, is also discussed. Based on the data reviewed herein, the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial role. However, much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT

eLand Governance in India: Transcending Digitization

Part 1: General E-Government and Open GovernmentInternational audienceLand governance is a complex issue to be addressed in many countries including India. All three branches of the government viz. judiciary, executive and legislature have tried to address the issue in various forms but have failed to achieve the outcomes of development. The failure, or limited success can be attributed to their narrow vision of or focus on the problem. The objectives of land governance have changed over time. With the advent of digitization, land administration has become more efficient and transparent, aiding the managerial process of land records and registration. However, the outcomes of economic, social, human, and cultural development, have been given paltry importance. In this paper we present the cases of Bhoomi and KAVERI, two initiatives to computerize land records and registration in the state of Karnataka, India. We present an ontological framework to envision the big picture in eLand governance. We argue that in achieving the desired outcome, we must see the problem in its entirety without losing focus on its key aspects. Regarding eland Governance, policy instruments, eGovernance, and land governance must work in tandem

A Unified Definition of a Smart City

Part 1: Smart Governance, Government and CitiesInternational audienceThere is some consensus among researchers that the first urban civilization labeled a ‘city’ was Sumer in the period 3,500–3,000 BC. The meaning of the word, however, has evolved with the advancement of technology. Adjectives such as digital, intelligent, and smart have been prefixed to ‘city’, to reflect the evolution. In this study, we pose the question: What makes a ‘Smart City’, as opposed to a traditional one? We review and synthesize multiple scientific studies and definitions, and present a unified definition of Smart City—a complex concept. We present the definition as an ontology which encapsulates the combinatorial complexity of the concept. It systematically and systemically synthesizes, and looks beyond, the various paths by which theory and practice contribute to the development and understanding of a smart city. The definition can be used to articulate the components of a Smart City using structured natural English. It serves as a multi-disciplinary lens to study the topic drawing upon concepts from Urban Design, Information Technology, Public Policy, and the Social Sciences. It can be used to systematically map the state-of-the-research and the state-of-the-practice on Smart Cities, discover the gaps in each and between the two, and formulate a strategy to bridge the gaps