A simple and efficient method for predicting protein-protein binding sites.

In this work, we propose a strategy for predicting binding sites by exploiting the characteristic of core and rim regions of binding sites mentioned above, while using simple and well-know pattern recognition techniques.X-meeting 2007

Hubble Space Telescope Imaging in the Chandra Deep Field South: III. Quantitative Morphology of the 1Ms Chandra Counterparts and Comparison with the Field Population

We present quantitative morphological analyses of 37 HST/WFPC2 counterparts of X-ray sources in the 1 Ms Chandra Deep Field-South (CDFS). We investigate: 1) 1-D surface brightness profiles via isophotal ellipse fitting; 2) 2-D, PSF- convolved, bulge+disk+nucleus profile-fitting; 3) asymmetry and concentration indices compared with all ~3000 sources in our three WFPC2 fields; and 4) near- neighbor analyses comparing local environments of X-ray sources versus the field control sample. Significant nuclear point-source optical components appear in roughly half of the resolved HST/WFPC2 counterparts, showing a narrow range of F_X/F_{opt,nuc} consistent with the several HST-unresolved X-ray sources (putative type-1 AGN) in our fields. We infer roughly half of the HST/WFPC2 counterparts host unobscured AGN, which suggests no steep decline in the type-1/type-2 ratio out to the redshifts z~0.5-1 typical of our sources. The concentration indices of the CDFS counterparts are clearly larger on average than those of the field distribution, at 5-sigma, suggesting that the strong correlation between central black hole mass and host galaxy properties (including concentration index) observed in nearby galaxies is already evident by z~0.5-1. By contrast, the asymmetry index distribution of the 21 resolved CDFS sources at I<23 is indistinguishable from the I<23 field. Moreover, the frequency of I<23 near neighbors around the CDFS counterparts is not significantly different from the field sample. These results, combined with previous similar findings for local samples, suggest that recent merger/ interaction history is not a good indicator of AGN activity over a substantial range of look-back time.Comment: 30 pages, incl. 8 figures; accepted for publication in the Astrophysical Journa

Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals

A lack of balance between energy intake and expenditure due to overeating or reduced physical activity does not seem to explain entirely the obesity epidemic we are facing, and further factors are therefore being evaluated. Nickel (Ni) is a ubiquitous heavy metal implied in several health conditions. Regarding this, the European Food Safety Authority has recently released an alert on the possible deleterious effects of dietary Ni on human health given the current levels of Ni dietary intake in some countries. Pre-clinical studies have also suggested its role as an endocrine disruptor and have linked its exposure to energy metabolism and glucose homeostasis dysregulation. Ni allergy is common in the general population, but preliminary data suggest it being even more widespread among overweight patients. OBJECTIVES: The aim of this study has been to evaluate the presence of Ni allergy and its association with the metabolic and endocrine profile in overweight and obese individuals. METHODS: We have evaluated 1128 consecutive overweight and obese outpatients. 784 were suspected of being allergic to Ni and 666 were assessed for it. Presence of Ni allergy and correlation with body mass index (BMI), body composition, metabolic parameters and hormonal levels were evaluated. RESULTS: We report that Ni allergy is more frequent in presence of weight excess and is associated with worse metabolic parameters and impaired Growth Hormone secretion. CONCLUSIONS: We confirm that Ni allergy is more common in obese patients, and we report for the first time its association with worse metabolic parameters and impaired function of the GH-IGF1 axis in human subjects

Temporal coherence of ultrashort high-order harmonic pulses

We have studied the temporal coherence of high-order harmonics (up to the 15th order) produced by focusing 100 fs laser pulses into an argon gas jet. We measure the visibility of the interference fringes, produced when two spatially separated harmonic sources interfere in the far field, as a function of the time delay between the two sources. In general, we find long coherence times, comparable to the expected pulse durations of the harmonics. For some of the harmonics, the interference pattern exhibits two regions, with significantly different coherence times. These results are interpreted in terms of different electronic trajectories contributing to harmonic generation. © 1998 American Physical Society

Dust observations of Comet 9P/Tempel 1 at the time of the Deep Impact

On 4 July 2005 at 05:52 UT, the impactor of NASA's Deep Impact (DI) mission crashed into comet 9P/Tempel 1 with a velocity of about 10 km/s. The material ejected by the impact expanded into the normal coma, produced by ordinary cometary activity. The characteristics of the non-impact coma and cloud produced by the impact were studied by observations in the visible wavelengths and in the near-IR. The scattering characteristics of the "normal" coma of solid particles were studied by comparing images in various spectral regions, from the UV to the near-IR. For the non-impact coma, a proxy of the dust production has been measured in various spectral regions. The presence of sublimating grains has been detected. Their lifetime was found to be about 11 hours. Regarding the cloud produced by the impact, the total geometric cross section multiplied by the albedo was measured as a function of the color and time. The projected velocity appeared to obey a Gaussian distribution with the average velocity of the order of 115 m/s. By comparing the observations taken about 3 hours after the impact, we have found a strong decrease in the cross section in J filter, while that in Ks remained almost constant. This is interpreted as the result of sublimation of grains dominated by particles of sizes of the order of some microns.Comment: Accepted by A&

The Nature of Blue Cores in Spheroids: a Possible Connection with AGN and Star Formation

We investigate the physical nature of blue cores in early-type galaxies through the first multi-wavelength analysis of a serendipitously discovered field blue-nucleated spheroid in the background of the deep ACS/WFC griz multicolor observations of the cluster Abell 1689. The resolved g-r, r-i and i-z color maps reveal a prominent blue core identifying this galaxy as a ``typical'' case study, exhibiting variations of 0.5-1.0 mag in color between the center and the outer regions, opposite to the expectations of reddened metallicity induced gradients in passively evolved ellipticals. From a Magellan-Clay spectrum we secure the galaxy redshift at $z=0.624$. We find a strong X-ray source coincident with the spheroid galaxy. Spectral features and a high X-ray luminosity indicate the presence of an AGN in the galaxy. However, a comparison of the X-ray luminosity to a sample derived from the Chandra Deep Field South displays Lx to be comparable to Type I/QSO galaxies while the optical flux is consistent with a normal star-forming galaxy. We conclude that the galaxy's non-thermal component dominates at high-energy wavelengths while we associate the spheroid blue light with the stellar spectrum of normal star-forming galaxies. We argue about a probable association between the presence of blue cores in spheroids and AGN activity.Comment: Accepted for publication in the Astrophysical Journal. 6 pages, 3 figures. Full resolution images available at http://acs.pha.jhu.edu/~felipe/e-print

A Puzzling X-Ray Source Found in the chandra Deep Field South

In this letter we report the detection of an extremely strong X-ray emission line in the 940ks chandra ACIS-I spectrum of CXO CDFS J033225.3-274219. The source was identified as a Type1 AGN at redshift of z = 1.617, with 2.0 -- 10.0 keV rest frame X-ray luminosity of ~ 10^44 ergs s^-1. The emission line was detected at 6.2^{+0.2}_{-0.1} keV, with an equivalent width (EW) of 4.4^{+3.2}_{-1.4} keV, both quantities referring to the observed frame. In the rest frame, the line is at 16.2^{+0.4}_{-0.3} keV with an EW of 11.5^{+8.3}_{-3.7} keV. An X-ray emission line at similar energy (~ 17 keV, rest frame) in QSO PKS 2149-306 was discovered before using ASCA data. We reject the possibility that the line is due to a statistical or instrumental artifact. The line is most likely due to blueshifted Fe-K emission from an relativistic outflow, probably an inner X-ray jet, with velocities of the order of ~ 0.6-0.7c. Other possible explanations are also discussed

HST Imaging in the Chandra Deep Field South: II. WFPC2 Observations of an X-Ray Flux-Limited Sample from the 1 Msec Chandra Catalog

We present HST/WFPC2 observations of a well-defined sample of 40 X-ray sources with X-ray fluxes above the detection threshold of the full 1 Msec Chandra Deep Field South (CDFS). The sensitivity and spatial resolution of our HST observations are sufficient to detect the optical counterparts of 37 of the X-ray sources, yielding information on their morphologies and environments. In this paper we extend the results obtained in our previous study on the 300 ks CDFS X-ray data (Schreier et al. 2001, Paper I). Specifically, we show that the optical counterparts to the X-ray sources are divided into two distinct populations: 1) an optically faint group with relatively blue colors, similar to the faint blue field galaxy population, and 2) an optically brighter group, including resolved galaxies with average colors significantly redder than the corresponding bright field galaxy population. The brighter objects comprise a wide range of types, including early and late type galaxies, starbursts, and AGN. By contrast, we show that the faint blue X-ray population are most consistent with being predominantly Type 2 AGN of low to moderate luminosity, located at higher redshifts (z ~ 1 - 2). This conclusion is supported by luminosity function models of the various classes of objects. Hence, the combination of deep X-ray data with the high spatial resolution of HST are for the first time allowing us to probe the faint end of the AGN luminosity function at cosmologically interesting redshifts.Comment: AASTEX-Latex, 25 pages, 4 postscript figures, 9 jpg figures. Accepted by the Astrophysical Journal. Full-size postscript images and figures, included in the preprint, are available from: http://www.stsci.edu/~koekemoe/papers/cdfs-hst

GIANO-TNG spectroscopy of red supergiants in the young star cluster RSGC3

The Scutum complex in the inner disk of the Galaxy has a number of young star clusters dominated by red supergiants that are heavily obscured by dust extinction and observable only at infrared wavelengths. These clusters are important tracers of the recent star formation and chemical enrichment history in the inner Galaxy. During the technical commissioning and as a first science verification of the GIANO spectrograph at the Telescopio Nazionale Galileo, we secured high-resolution (R=50,000) near-infrared spectra of five red supergiants in the young Scutum cluster RSGC3. Taking advantage of the full YJHK spectral coverage of GIANO in a single exposure, we were able to measure several tens of atomic and molecular lines that were suitable for determining chemical abundances. By means of spectral synthesis and line equivalent width measurements, we obtained abundances of Fe and iron-peak elements such as Ni, Cr, and Cu, alpha (O, Mg, Si, Ca, Ti), other light elements (C, N, F, Na, Al, and Sc), and some s-process elements (Y, Sr). We found average half-solar iron abundances and solar-scaled [X/Fe] abundance patterns for most of the elements, consistent with a thin-disk chemistry. We found depletion of [C/Fe] and enhancement of [N/Fe], consistent with standard CN burning, and low 12C/13C abundance ratios (between 9 and 11), which require extra-mixing processes in the stellar interiors during the post-main sequence evolution. We also found local standard of rest V(LSR)=106 km/s and heliocentric V(HEL)=90 km/s radial velocities with a dispersion of 2.3 km/s. The inferred radial velocities, abundances, and abundance patterns of RSGC3 are very similar to those previously measured in the other two young clusters of the Scutum complex, RSGC1 and RSGC2, suggesting a common kinematics and chemistry within the Scutum complex