1,562 research outputs found
Les résultats des grandes banques internationales depuis le début de 2006.
Soutenue jusqu’au premier semestre 2007 par un environnement extrêmement favorable, la tendance à la progression des résultats des grandes banques internationales a connu un coup d’arrêt avec les turbulences financières de cet été, dont les conséquences à moyen/long terme sur la rentabilité du secteur restent à surveiller.produit net bancaire, produit net d’intermédiation, marge d’intérêt, charges d’exploitation, coefficient net d’exploitation, risque de crédit, résultat net, coefficient de rentabilité, ratio de solvabilité, restructurations bancaires.
Picosecond fluctuating protein energy landscape mapped by pressure–temperature molecular dynamics simulation
Microscopic statistical pressure fluctuations can, in principle, lead to corresponding fluctuations in the shape of a protein energy landscape. To examine this, nanosecond molecular dynamics simulations of lysozyme are performed covering a range of temperatures and pressures. The well known dynamical transition with temperature is found to be pressure-independent, indicating that the effective energy barriers separating conformational substates are not significantly influenced by pressure. In contrast, vibrations within substates stiffen with pressure, due to increased curvature of the local harmonic potential in which the atoms vibrate. The application of pressure is also shown to selectively increase the damping of the anharmonic, low-frequency collective modes in the protein, leaving the more local modes relatively unaffected. The critical damping frequency, i.e., the frequency at which energy is most efficiently dissipated, increases linearly with pressure. The results suggest that an invariant description of protein energy landscapes should be subsumed by a fluctuating picture and that this may have repercussions in, for example, mechanisms of energy dissipation accompanying functional, structural, and chemical relaxation
Alternating evolutionary pressure in a genetic algorithm facilitates protein model selection
<p>Abstract</p> <p>Background</p> <p>Automatic protein modelling pipelines are becoming ever more accurate; this has come hand in hand with an increasingly complicated interplay between all components involved. Nevertheless, there are still potential improvements to be made in template selection, refinement and protein model selection.</p> <p>Results</p> <p>In the context of an automatic modelling pipeline, we analysed each step separately, revealing several non-intuitive trends and explored a new strategy for protein conformation sampling using Genetic Algorithms (GA). We apply the concept of alternating evolutionary pressure (AEP), i.e. intermediate rounds within the GA runs where unrestrained, linear growth of the model populations is allowed.</p> <p>Conclusion</p> <p>This approach improves the overall performance of the GA by allowing models to overcome local energy barriers. AEP enabled the selection of the best models in 40% of all targets; compared to 25% for a normal GA.</p
Electronic Instability in a Zero-Gap Semiconductor: The Charge-DensityWave in (TaSe4)(2)I
We report a comprehensive study of the paradigmatic quasi-1D compound (TaSe4)(2)I performed by means of angle-resolved photoemission spectroscopy (ARPES) and first-principles electronic structure calculations. We find it to be a zero-gap semiconductor in the nondistorted structure, with non-negligible interchain coupling. Theory and experiment support a Peierls-like scenario for the charge-density wave formation below T-CDW = 263 K, where the incommensurability is a direct consequence of the finite interchain coupling. The formation of small polarons, strongly suggested by the ARPES data, explains the puzzling semiconductor-to-semiconductor transition observed in transport at T-CDW.open114sciescopu
Corticobulbar tract changes as predictors of dysarthria in childhood brain injury.
To identify corticobulbar tract changes that may predict chronic dysarthria in young people who have sustained a traumatic brain injury (TBI) in childhood using diffusion MRI tractography
Acetabular fracture: Long-term follow-up and factors associated with secondary implantation of total hip arthroplasty
SummaryHypothesisThe present study sought to determine long-term outcome in acetabular fracture and the factors associated with secondary implantation of a total hip arthroplasty and/or with poor functional results.Material and methodsSeventy-two patients admitted between 2000 and 2005 were followed up for a maximum 11years (mean, 6.8years): 16 females, 56 males; mean age at injury, 41.6years (median, 40years). There were 45 simple acetabular fractures, 27 complex fractures and 27 dislocations. Late complications were: osteoarthritis (n=29), osteonecrosis of the femoral head (ONFH: n=8) and heterotopic ossification (n=2).Results and discussionTwenty-five total hip arthroplasties (THA) were performed, with a mean time to surgery of 3.7years. Associated factors for THA were: VAS (P<0.0001), PMA (P<0.0001), osteoarthritis (P<0.0001), ONFH (P<0.0002), initial dislocation (P=0.0002), no functional treatment (P=0.0014), surgical treatment (P=0.0065), initial traction (P=0.0068), anterior and posterior congruency defect (P=0.0072 and P<0.0001), and initial intra-articular foreign body (P=0.045). Factors associated with poor or bad functional results were the same, plus: etiology (P=0.0021), BMI (P=0.03) and posterior wall fracture (P=0.0325).Level of evidence4; retrospective study
Giant ambipolar Rashba effect in a semiconductor: BiTeI
We observe a giant spin-orbit splitting in bulk and surface states of the
non-centrosymmetric semiconductor BiTeI. We show that the Fermi level can be
placed in the valence or in the conduction band by controlling the surface
termination. In both cases it intersects spin-polarized bands, in the
corresponding surface depletion and accumulation layers. The momentum splitting
of these bands is not affected by adsorbate-induced changes in the surface
potential. These findings demonstrate that two properties crucial for enabling
semiconductor-based spin electronics -- a large, robust spin splitting and
ambipolar conduction -- are present in this material.Comment: 4 pages, 3 figure
Glass transition in biomolecules and the liquid-liquid critical point of water
Using molecular dynamics simulations, we investigate the relation between the
dynamic transitions of biomolecules (lysozyme and DNA) and the dynamic and
thermodynamic properties of hydration water. We find that the dynamic
transition of the macromolecules, sometimes called a ``protein glass
transition'', occurs at the temperature of dynamic crossover in the diffusivity
of hydration water, and also coincides with the maxima of the isobaric specific
heat and the temperature derivative of the orientational order parameter.
We relate these findings to the hypothesis of a liquid-liquid critical point in
water. Our simulations are consistent with the possibility that the protein
glass transition results from crossing the Widom line, which is defined as the
locus of correlation length maxima emanating from the hypothesized second
critical point of water.Comment: 10 Pages, 12 figure
Evaluating 35 Methods to Generate Structural Connectomes Using Pairwise Classification
There is no consensus on how to construct structural brain networks from
diffusion MRI. How variations in pre-processing steps affect network
reliability and its ability to distinguish subjects remains opaque. In this
work, we address this issue by comparing 35 structural connectome-building
pipelines. We vary diffusion reconstruction models, tractography algorithms and
parcellations. Next, we classify structural connectome pairs as either
belonging to the same individual or not. Connectome weights and eight
topological derivative measures form our feature set. For experiments, we use
three test-retest datasets from the Consortium for Reliability and
Reproducibility (CoRR) comprised of a total of 105 individuals. We also compare
pairwise classification results to a commonly used parametric test-retest
measure, Intraclass Correlation Coefficient (ICC).Comment: Accepted for MICCAI 2017, 8 pages, 3 figure
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