Intraoperative high resolution duplex imaging during carotid endarterectomy: Which abnormalities require surgical correction?

Objectives:This study evaluates high resolution, duplex ultrasound imaging for quality control of carotid endarterectomy in order to determine which technical factors were linked to residual stenosis and to define duplex criteria for reexploration.Design, material and methods:A consecutive series of 100 patients undergoing carotid endarterectomy were evaluated. Duplex imaging was performed prior to wound closure and repeated at 6–8 weeks postoperatively. Stenoses were classified as non-significant, moderate or severe based on duplex criteria. Intimal flaps, shelves, kinks, clamp damage and fronds were identified by ultrasound imaging.Results:Five moderate stenoses were noted in the proximal endarterectomy site (PES), and at follow-up three had resolved. Adherent fronds were detected in 83% of vessels and resolved in all but three cases. At the distal endarterectomy site there were 10 severe and 12 moderate stenoses. Intimal flaps were associated with an increased incidence of residual stenosis (p = 0.010).Conclusions:We conclude that severe stenoses with an intimal flap should be corrected immediately. Further data is required to establish the significance of kinks. Residual intimal flaps in the PES appear to remodel. The role of completion duplex may lie in the modification of surgical technique to eradicate anatomical and haemodynamic imperfections

Optimized profiles for improved confinement and stability in the DIII-D tokamak

Simultaneous achievement of high energy confinement, {tau}{sub E}, and high plasma beta, {beta}, leads to an economically attractive compact tokamak fusion reactor. High confinement enhancement, H = {tau}{sub E}/{tau}{sub E-ITER89P} = 4, and high normalized beta {beta}{sub N} = {beta}/(I/aB) = 6%-m-T/MA, have been obtained in DIII-D experimental discharges. These improved confinement and/or improved stability limits are observed in several DIII-D high performance operational regimes: VH-mode, high {ell}{sub i} H-mode, second stable core, and high beta poloidal. The authors have identified several important features of the improved performance in these discharges: details of the plasma shape, toroidal rotation or ExB flow profile, q profile and current density profile, and pressure profile. From the improved physics understanding of these enhanced performance regimes, they have developed operational scenarios which maintain the essential features of the improved confinement and which increase the stability limits using localized current profile control. The stability limit is increased by modifying the interior safety factor profile to be nonmonotonic with high central q, while maintaining the edge current density consistent with the improved transport regimes and the high edge bootstrap current. They have calculated high beta equilibria with {beta}{sub N} = 6.5, stable to ideal n = 1 kinks and stable to ideal ballooning modes. The safety factor at the 95% flux surface is 6, the central q value is 3.9 and the minimum in q is 2.6. The current density profile is maintained by the natural profile of the bootstrap current, and a modest amount of electron cyclotron current drive

Correlation functions of small-scale fluctuations of the interplanetary magnetic field

The Interplanetary Magnetic Field shows complex spatial and temporal variations. Single spacecraft measurements reveal only a one dimensional section of this rich four dimensional phenomenon. Multi-point measurements of the four Cluster spacecraft provide a unique tool to study the spatiotemporal structure of the field. Using Cluster data we determined three dimensional correlation functions of the fluctuations. By means of the correlation function one can describe and measure field variations. Our results can be used to verify theoretical predictions, to understand the formation and nature of solar wind turbulence. We found that the correlation length varies over almost six orders of magnitude. The IMF turbulence shows significant anisotropy with two distinct populations. In certain time intervals the ratio of the three axes of the correlation ellipse is 1/2.2/6 while in the remaining time we found extremely high correlation along one axis. We found favoured directions in the orientation of the correlation ellipsoids.Comment: accepted to Solar Physics on June 14, 2010. 10 pages, 8 figure

A Generalized Fluctuation-Dissipation Theorem for Nonlinear Response Functions

A nonlinear generalization of the Fluctuation-Dissipation Theorem (FDT) for the n-point Green functions and the amputated 1PI vertex functions at finite temperature is derived in the framework of the Closed Time Path formalism. We verify that this generalized FDT coincides with known results for n=2 and 3. New explicit relations among the 4-point nonlinear response and correlation (fluctuation) functions are presented.Comment: 34 pages, Revte

Thermal and Chemical Equilibration in Relativistic Heavy Ion Collisions

We investigate the thermalization and the chemical equilibration of a parton plasma created from Au+Au collision at LHC and RHIC energies starting from the early moment when the particle momentum distributions in the central region become for the first time isotropic due to longitudinal cooling. Using the relaxation time approximation for the collision terms in the Boltzmann equations for gluons and for quarks and the real collision terms constructed from the simplest QCD interactions, we show that the collision times have the right behaviour for equilibration. The magnitude of the quark (antiquark) collision time remains bigger than the gluon collision time throughout the lifetime of the plasma so that gluons are equilibrating faster than quarks both chemically and kinetically. That is we have a two-stage equilibration scenario as has been pointed out already by Shuryak sometimes ago. Full kinetic equilibration is however slow and chemical equilibration cannot be completed before the onset of the deconfinement phase transition assumed to be at $T_c=200$ MeV. By comparing the collision entropy density rates of the different processes, we show explicitly that inelastic processes, and \emph{not} elastic processes as is commonly assumed, are dominant in the equilibration of the plasma and that gluon branching leads the other processes in entropy generation. We also show that, within perturbative QCD, processes with higher power in \alpha_s need not be less important for the purpose of equilibration than those with lower power. The state of equilibration of the system has also a role to play. We compare our results with those of the parton cascade model.Comment: 17 pages, revtex+psfig style with 14 embedded postscript figures, to appear in Phys. Rev.

Children's understanding of inherited resemblance: The case of two parents. [IF 1.0]

Four-, 6-, and 10-year-old children were tested in a forced-choice procedure about their beliefs on the inheritance of physical characteristics. They were presented with pictures of two biological parents, and then asked to select the most likely descendant out of three alternatives: a father look-alike, a mother look-alike, and an alternative representing the combined influence of both parents. In several question pairs, additional information was given about the parent-child relationship that was clearly irrelevant to the principles of heredity to examine the extent to which domain confusions were likely to occur. The majority of the 10-year-olds consistently preferred the alternative in which the combined influence of both parents was shown and domain confusions hardly ever occurred. Four- and 6-year-olds, in contrast, were still influenced by information from alien domains, although even their reasoning about inheritance seemed to be theory-like. Overall, the results suggest that with age, children develop a more restricted and better-defined conception of the principles of heredity, in which the combined influence of both parents is acknowledged

Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity

BACKGROUND: Epigenetic mechanisms such as chromatin accessibility impact transcription factor binding to DNA and transcriptional specificity. The androgen receptor (AR), a master regulator of the male phenotype and prostate cancer pathogenesis, acts primarily through ligand-activated transcription of target genes. Although several determinants of AR transcriptional specificity have been elucidated, our understanding of the interplay between chromatin accessibility and AR function remains incomplete. RESULTS: We used deep sequencing to assess chromatin structure via DNase I hypersensitivity and mRNA abundance, and paired these datasets with three independent AR ChIP-seq datasets. Our analysis revealed qualitative and quantitative differences in chromatin accessibility that corresponded to both AR binding and an enrichment of motifs for potential collaborating factors, one of which was identified as SP1. These quantitative differences were significantly associated with AR-regulated mRNA transcription across the genome. Base-pair resolution of the DNase I cleavage profile revealed three distinct footprinting patterns associated with the AR-DNA interaction, suggesting multiple modes of AR interaction with the genome. CONCLUSIONS: In contrast with other DNA-binding factors, AR binding to the genome does not only target regions that are accessible to DNase I cleavage prior to hormone induction. AR binding is invariably associated with an increase in chromatin accessibility and, consequently, changes in gene expression. Furthermore, we present the first in vivo evidence that a significant fraction of AR binds only to half of the full AR DNA motif. These findings indicate a dynamic quantitative relationship between chromatin structure and AR-DNA binding that impacts AR transcriptional specificity

The effects of an experimental programme to support students’ autonomy on the overt behaviours of physical education teachers

Although the benefits of autonomy supportive behaviours are now well established in the literature, very few studies have attempted to train teachers to offer a greater autonomy support to their students. In fact, none of these studies has been carried out in physical education (PE). The purpose of this study is to test the effects of an autonomy-supportive training on overt behaviours of teaching among PE teachers. The experimental group included two PE teachers who were first educated on the benefits of an autonomy supportive style and then followed an individualised guidance programme during the 8 lessons of a teaching cycle. Their behaviours were observed and rated along 3 categories (i.e., autonomy supportive, neutral and controlling) and were subsequently compared to those of three teachers who formed the control condition. The results showed that teachers in the experimental group used more autonomy supportive and neutral behaviours than those in the control group, but no difference emerged in relation to controlling behaviours. We discuss the implications for schools of our findings

Signals for Lorentz Violation in Electrodynamics

An investigation is performed of the Lorentz-violating electrodynamics extracted from the renormalizable sector of the general Lorentz- and CPT-violating standard-model extension. Among the unconventional properties of radiation arising from Lorentz violation is birefringence of the vacuum. Limits on the dispersion of light produced by galactic and extragalactic objects provide bounds of 3 x 10^{-16} on certain coefficients for Lorentz violation in the photon sector. The comparative spectral polarimetry of light from cosmologically distant sources yields stringent constraints of 2 x 10^{-32}. All remaining coefficients in the photon sector are measurable in high-sensitivity tests involving cavity-stabilized oscillators. Experimental configurations in Earth- and space-based laboratories are considered that involve optical or microwave cavities and that could be implemented using existing technology.Comment: 23 pages REVTe

Solar Wind Turbulence and the Role of Ion Instabilities

International audienc