STUDIES OF SAFETY AND FUNCTIONAL AND METABOLIC EFFECTS OF NON-IONIC CONTRAST MEDIA IN CHILDREN WITH NEPHROPATHIES

A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy. After contrast media use we observed elevation of cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation were identified. The results obtained indicate that renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy. Increased serum cystatin C reflects adverse impact of contrast agents on renal function. Hypocoagulation effect requires that coagulation disorders must be excluded before use of contast media.Key words: children, contrast-induced nephropathy, renal function, cystatin C, endothelin, hemostasis. (Pediatric Pharmacology. – 2010; 7(2):78-82

STUDIES OF SAFETY AND FUNCTIONAL AND METABOLIC EFFECTS OF NON-IONIC CONTRAST MEDIA IN CHILDREN WITH NEPHROPATHIES

A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy. After contrast media use we observed elevation of cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation were identified. The results obtained indicate that renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy. Increased serum cystatin C reflects adverse impact of contrast agents on renal function. Hypocoagulation effect requires that coagulation disorders must be excluded before use of contast media.Key words: children, contrast-induced nephropathy, renal function, cystatin C, endothelin, hemostasis. (Pediatric Pharmacology. – 2010; 7(2):78-82

ИССЛЕДОВАНИЕ БЕЗОПАСНОСТИ НЕИОННЫХ РЕНТГЕНОКОНТРАСТНЫХ СРЕДСТВ И ИХ ВЛИЯНИЯ НА ФУНКЦИОНАЛЬНЫЕ И МЕТАБОЛИЧЕСКИЕ ПОКАЗАТЕЛИ У ДЕТЕЙ С НЕФРОПАТИЯМИ

A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy. After contrast media use we observed elevation of cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation were identified. The results obtained indicate that renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy. Increased serum cystatin C reflects adverse impact of contrast agents on renal function. Hypocoagulation effect requires that coagulation disorders must be excluded before use of contast media.Key words: children, contrast-induced nephropathy, renal function, cystatin C, endothelin, hemostasis. (Pediatric Pharmacology. – 2010; 7(2):78-82)Проведено исследование безопасности применения неионных рентгеноконтрастных средств в детской нефроурологии и определение их влияния на отдельные функциональные параметры почек и гомеостаза, отображающие риск развития контраст-индуцированной нефропатии. После введения рентгеноконтрастных средств обнаружены повышение уровней цистатина С, эндотелина, снижение фракционной экскреции натрия и гипокоагуляция. Полученные результаты свидетельствуют о том, что факторами риска развития контраст-индуцированной нефропатии могут быть гипоперфузия почек, вызывающая снижение фракционной экскреции натрия и повышение эндотелина. Повышение сывороточного цистатина С отображает негативное влияние контрастных препаратов на функцию почек. Гипокоагуляционный эффект рентгеноконтрастных средств требует предварительного исключения расстройств гемостаза. Ключевые слова: дети, контраст-индуцированная нефропатия, электролитный обмен, функции почек, цистатин С, эндотелин, гемостаз. (Педиатрическая фармакология. – 2010; 7(2):78-82