Phase transition from a gel to a fluid phase of cubic symmetry in dimyristoylphosphatidylcholine/myristic acid (1:2, mol/mol) bilayers.

Aqueous dispersions (pH 4.0) of a 2:1 (mol/mol) mixture of myristic acid with dimyristoylphosphatidylcholine undergo a sharp transition at 45–47°C from a lamellar gel phase to a fluid phase which is optically isotropic. This fluid phase gives rise to 31P-NMR spectra, and 2H-NMR spectra of the chain-deuterated components, which are also isotropic. X-ray diffraction studies of the fluid phase at 49°C, reveal reflections with spacings in the ratio √2: (√3): √4: √6: √8, accompanied by a strong diffuse scatter. These reflections index on a cubic lattice of primitive space group Pn3 or Pn3m, or possibly the body-centered group Im3m, with a lattice constant of 21.2 nm. The dimensions of the phase are consistent with a structure composed of two systems of tetrahedrally (octahedrally) oriented inverted lipid cylinders, found for other cubic lipid phases with Pn3m (Im3m) symmetry. At higher temperatures the cubic phase gradually converts, with increasing temperature, to a coexisting inverted hexagonal phase

TEMPO2, a new pulsar timing package. I: Overview

Contemporary pulsar timing experiments have reached a sensitivity level where systematic errors introduced by existing analysis procedures are limiting the achievable science. We have developed tempo2, a new pulsar timing package that contains propagation and other relevant effects implemented at the 1ns level of precision (a factor of ~100 more precise than previously obtainable). In contrast with earlier timing packages, tempo2 is compliant with the general relativistic framework of the IAU 1991 and 2000 resolutions and hence uses the International Celestial Reference System, Barycentric Coordinate Time and up-to-date precession, nutation and polar motion models. Tempo2 provides a generic and extensible set of tools to aid in the analysis and visualisation of pulsar timing data. We provide an overview of the timing model, its accuracy and differences relative to earlier work. We also present a new scheme for predictive use of the timing model that removes existing processing artifacts by properly modelling the frequency dependence of pulse phase.Comment: Accepted by MNRA

Replication Timing: A Fingerprint for Cell Identity and Pluripotency

Many types of epigenetic profiling have been used to classify stem cells, stages of cellular differentiation, and cancer subtypes. Existing methods focus on local chromatin features such as DNA methylation and histone modifications that require extensive analysis for genome-wide coverage. Replication timing has emerged as a highly stable cell type-specific epigenetic feature that is regulated at the megabase-level and is easily and comprehensively analyzed genome-wide. Here, we describe a cell classification method using 67 individual replication profiles from 34 mouse and human cell lines and stem cell-derived tissues, including new data for mesendoderm, definitive endoderm, mesoderm and smooth muscle. Using a Monte-Carlo approach for selecting features of replication profiles conserved in each cell type, we identify “replication timing fingerprints” unique to each cell type and apply a k nearest neighbor approach to predict known and unknown cell types. Our method correctly classifies 67/67 independent replication-timing profiles, including those derived from closely related intermediate stages. We also apply this method to derive fingerprints for pluripotency in human and mouse cells. Interestingly, the mouse pluripotency fingerprint overlaps almost completely with previously identified genomic segments that switch from early to late replication as pluripotency is lost. Thereafter, replication timing and transcription within these regions become difficult to reprogram back to pluripotency, suggesting these regions highlight an epigenetic barrier to reprogramming. In addition, the major histone cluster Hist1 consistently becomes later replicating in committed cell types, and several histone H1 genes in this cluster are downregulated during differentiation, suggesting a possible instrument for the chromatin compaction observed during differentiation. Finally, we demonstrate that unknown samples can be classified independently using site-specific PCR against fingerprint regions. In sum, replication fingerprints provide a comprehensive means for cell characterization and are a promising tool for identifying regions with cell type-specific organization

The Parallax, Mass and Age of the PSR J2145-0750 binary system

We present results of timing measurements of the binary millisecond pulsar PSR J2145-0750. Combining timing data obtained with the Effelsberg and Lovell radio telescopes we measure a significant timing parallax of 2.0(6) mas placing the system at 500 pc distance to the solar system. The detected secular change of the projected semi-major axis of the orbit $\dot x=1.8(6)\times 10^{-14}$ lt-s s$^{-1}$, where $x=(a_{\rm p}\sin i)/c$, is caused by the proper motion of the system. With this measurement we can constrain the orbital inclination angle to i<61\degr, with a median likelihood value of 46\degr which is consistent with results from polarimetric studies of the pulsar magnetosphere. This constraint together with the non-detection of Shapiro delay rules out certain combinations of the companion mass, $m_2$, and the inclination, $i$. For typical neutron star masses and using optical observations of the carbon/oxygen-core white dwarf we derive a mass range for the companion of $0.7 M_\odot\leq m_2\leq 1.0 M_\odot$. We apply evolutionary white dwarf cooling models to revisit the cooling age of the companion. Our analysis reveals that the companion has an effective temperature of $T_{\rm eff}=5750\pm600$ K and a cooling age of $\tau_{\rm cool}=3.6(2)$ Gyr, which is roughly a factor of three lower than the pulsar's characteristic age of 10.4 Gyr. The cooling age implies an initial spin period of $P_0=13.0(5)$ ms, which is very close to the current period.Comment: 11 pages, 5 figures, accepted for publication in A&

About the results of the online conference “Sports psychology in the intercultural space”

The article is presented an analysis of the results of the international online conference. The article is described the format of the conference and examined the topics of presentations by leading foreign and Russian sports psychologists.В статье представлен анализ результатов проведения международной онлайн-конференции. Дается характеристика формата проведения конференции и анализ тем выступлений ведущих зарубежных и российских спортивных психологов

Девочки чаще учатся на спортивных сборах по сравнению с мальчиками: роль тренера в гендерном разделении двух карьерных путей спортсменов

Рукопись поступила в редакцию: 21.01.2022.Received: 21.01.2022.В статье даются результаты исследования о роли тренера в мотивации спортсменов на построение двух карьер, а также их взглядов на двойную карьеру девушек и юношей. Результаты показали, что учащиеся-спортсмены в старших классах спортивных школ часто воспринимали созданный тренером мотивационный климат как нацеленный на достижение спортивного результата. Опрошенные спортсмены объяснили, что такой подход не мотивировал их на учебный процесс, а скорее обесценивал их образовательные цели. Выявлено, что тренеры, хотя и подчеркивали важность получения спортсменами среднего образования, не могли обосновать, как данные идеи включены в тренерскую практику. Тренеры согласились с тем, что те спортсмены, которые переходят в элитный спорт, должны сосредоточиться на развитии своей спортивной карьеры, при этом требования элитного спорта и высшего образования часто считались как несовместимые. Результаты показали, что стили коучинга играют важную роль в поддержке мотивации спортсменов к достижению целей двух карьер.The article presents the results of a study on the role of a coach in motivating athletes to build two careers, as well as their coaches’ views on the dual careers of girls and boys. The results have showed that student-athletes in high school of sports schools often perceived the motivational climate created by the coach as a process aimed at achieving sports results. The interviewed athletes explained that this approach did not motivate them to the learning process, and moreover, devalued their educational goals. It was revealed that although the coaches emphasized the importance of receiving secondary education for athletes, they could not justify how these ideas were included in coaching practice. The coaches have agreed that those athletes who switch to elite sports should focus on developing their sports career, while the requirements of elite sports and higher education were often considered incompatible. The results have showed that coaching styles play an important role in supporting the motivation of athletes to achieve the goals of two careers

Подростки-спортсмены строят двойную карьеру и благополучие в условиях двойного карьерного роста: роль факторов окружающей среды

Рукопись поступила в редакцию: 20.12.2021.Received: 20.12.2021.Цель исследования заключалась в изучении карьерного роста и благополучия спортсменов-подростков в условиях двойного карьерного роста. В исследовании выявлены особенности адаптивности к карьере в старших классах спортивной школы. В статье представлены данные относительно того, в какой степени самооценка и пол связаны с адаптивностью к двойной карьере, определены профили адаптации к карьере спортсменов-подростков, выявлены как ожидания студентов-спортсменов в зависимости от их успехов в спорте и учебе и соответствующие ожидания их родителей связаны с их профилями адаптации к карьере. Получены новые данные относительно того, как организационная культура спортивной школы влияет на построение карьеры спортсменов-подростков.The purpose of the scientific research was to study the career growth and well-being of adolescent athletes in conditions of dual career growth. The study revealed the features of adaptability to a career in high school of sports school. The article presents data on the extent to which self-esteem and gender are associated with adaptability to a dual career, the profiles of adaptation to the career of adolescent athletes have been defined, it is also revealed how the expectations of student-athletes depending on their success in sports and studies and the corresponding expectations of their parents are associated with their profiles of adaptation to a career. The new data on how the organizational culture of a sports school affects the career development of teenage athletes have been obtained

Состояния настроения студентов-спортсменов: профили развития, предпосылки и последствия

Рукопись поступила в редакцию: 14.01.2022.Received: 14.01.2022.Цель исследования заключается в получении информации о психическом здоровье молодых финских спортсменов старшего школьного возраста с точки зрения профилей состояний настроения. Было описано шесть разных профилей. Общий показатель настроения был выше у женщин, чем у мужчин. Энергетический индекс был самым высоким у мужчин в индивидуальных видах спорта и самым низким у мужчин в командных видах спорта. У женщин в индивидуальных видах спорта он был ниже, чем у мужчин в индивидуальных видах спорта, и выше в командных видах спорта, чем у мужчин. Он был выше у женщин в индивидуальных видах спорта, чем у женщин в командных видах спорта.The aim of the study is to obtain information about the mental health of young Finnish athletes of high school age in terms of mood state profiles. Six different profiles were described. The overall mood score of women was higher than of men. The energy index was the highest for the men in individual sports and the lowest one was for the men in team sports. For the women in individual sports, it was lower than for men in individual sports. For the women in team sports it was higher than for men in team sports. The energy index was higher for women in individual sports than for women in team sports