261 research outputs found
Extracting synaptic conductances from single membrane potential traces
In awake animals, the activity of the cerebral cortex is highly complex, with
neurons firing irregularly with apparent Poisson statistics. One way to
characterize this complexity is to take advantage of the high interconnectivity
of cerebral cortex and use intracellular recordings of cortical neurons, which
contain information about the activity of thousands of other cortical neurons.
Identifying the membrane potential (Vm) to a stochastic process enables the
extraction of important statistical signatures of this complex synaptic
activity. Typically, one estimates the total synaptic conductances (excitatory
and inhibitory) but this type of estimation requires at least two Vm levels and
therefore cannot be applied to single Vm traces. We propose here a method to
extract excitatory and inhibitory conductances (mean and variance) from single
Vm traces. This "VmT method" estimates conductance parameters using maximum
likelihood criteria, under the assumption are that synaptic conductances are
described by Gaussian stochastic processes and are integrated by a passive
leaky membrane. The method is illustrated using models and is tested on
guinea-pig visual cortex neurons in vitro using dynamic-clamp experiments. The
VmT method holds promises for extracting conductances from single-trial
measurements, which has a high potential for in vivo applications.Comment: Neuroscience (in press
Spectral functions of isoscalar scalar and isovector electromagnetic form factors of the nucleon at two-loop order
We calculate the imaginary parts of the isoscalar scalar and isovector
electromagnetic form factors of the nucleon up to two-loop order in chiral
perturbation theory. Particular attention is paid on the correct behavior of Im
and Im at the two-pion threshold
in connection with the non-relativistic 1/M-expansion. We recover the
well-known strong enhancement near threshold originating from the nearby
anomalous singularity at . In the
case of the scalar spectral function Im one finds a significant
improvement in comparison to the lowest order one-loop result. Higher order
-rescattering effects are however still necessary to close a remaining
20%-gap to the empirical scalar spectral function. The isovector electric and
magnetic spectral functions Im get additionally enhanced near
threshold by the two-pion-loop contributions. After supplementing their
two-loop results by a phenomenological -meson exchange term one can
reproduce the empirical isovector electric and magnetic spectral functions
fairly well.Comment: 10 pages, 6 figures, submitted to Physical Review
Generation of photovoltage in graphene on a femtosecond time scale through efficient carrier heating
Graphene is a promising material for ultrafast and broadband photodetection.
Earlier studies addressed the general operation of graphene-based
photo-thermoelectric devices, and the switching speed, which is limited by the
charge carrier cooling time, on the order of picoseconds. However, the
generation of the photovoltage could occur at a much faster time scale, as it
is associated with the carrier heating time. Here, we measure the photovoltage
generation time and find it to be faster than 50 femtoseconds. As a
proof-of-principle application of this ultrafast photodetector, we use graphene
to directly measure, electrically, the pulse duration of a sub-50 femtosecond
laser pulse. The observation that carrier heating is ultrafast suggests that
energy from absorbed photons can be efficiently transferred to carrier heat. To
study this, we examine the spectral response and find a constant spectral
responsivity between 500 and 1500 nm. This is consistent with efficient
electron heating. These results are promising for ultrafast femtosecond and
broadband photodetector applications.Comment: 6 pages, 4 figure
Lowest Q^2 Measurement of the gamma*p -> Delta Reaction: Probing the Pionic Contribution
To determine nonspherical angular momentum amplitudes in hadrons at long
ranges (low Q^2), data were taken for the p(\vec{e},e'p)\pi^0 reaction in the
Delta region at Q^2=0.060 (GeV/c)^2 utilizing the magnetic spectrometers of the
A1 Collaboration at MAMI. The results for the dominant transition magnetic
dipole amplitude and the quadrupole to dipole ratios at W=1232 MeV are:
M_{1+}^{3/2} = (40.33 +/- 0.63_{stat+syst} +/- 0.61_{model})
(10^{-3}/m_{\pi^+}),Re(E_{1+}^{3/2}/M_{1+}^{3/2}) = (-2.28 +/- 0.29_{stat+syst}
+/- 0.20_{model})%, and Re(S_{1+}^{3/2}/M_{1+}^{3/2}) = (-4.81 +/-
0.27_{stat+syst} +/- 0.26_{model})%. These disagree with predictions of
constituent quark models but are in reasonable agreement with lattice
calculations with non-linear (chiral) pion mass extrapolations, with chiral
effective field theory, and with dynamical models with pion cloud effects.
These results confirm the dominance, and general Q^2 variation, of the pionic
contribution at large distances.Comment: 6 pages, 3 figures, 1 tabl
A measurement of the axial form factor of the nucleon by the p(e,e'pi+)n reaction at W=1125 MeV
The reaction p(e,e'pi+)n was measured at the Mainz Microtron MAMI at an
invariant mass of W=1125 MeV and four-momentum transfers of Q^2=0.117, 0.195
and 0.273 (GeV/c)^2. For each value of Q^2, a Rosenbluth separation of the
transverse and longitudinal cross sections was performed. An effective
Lagrangian model was used to extract the `axial mass' from experimental data.
We find a value of M_A=(1.077+-0.039) GeV which is (0.051+-0.044) GeV larger
than the axial mass known from neutrino scattering experiments. This is
consistent with recent calculations in chiral perturbation theory.Comment: 14 pages, 5 figures, uses elsart.cl
A Comprehensive Workflow for General-Purpose Neural Modeling with Highly Configurable Neuromorphic Hardware Systems
In this paper we present a methodological framework that meets novel
requirements emerging from upcoming types of accelerated and highly
configurable neuromorphic hardware systems. We describe in detail a device with
45 million programmable and dynamic synapses that is currently under
development, and we sketch the conceptual challenges that arise from taking
this platform into operation. More specifically, we aim at the establishment of
this neuromorphic system as a flexible and neuroscientifically valuable
modeling tool that can be used by non-hardware-experts. We consider various
functional aspects to be crucial for this purpose, and we introduce a
consistent workflow with detailed descriptions of all involved modules that
implement the suggested steps: The integration of the hardware interface into
the simulator-independent model description language PyNN; a fully automated
translation between the PyNN domain and appropriate hardware configurations; an
executable specification of the future neuromorphic system that can be
seamlessly integrated into this biology-to-hardware mapping process as a test
bench for all software layers and possible hardware design modifications; an
evaluation scheme that deploys models from a dedicated benchmark library,
compares the results generated by virtual or prototype hardware devices with
reference software simulations and analyzes the differences. The integration of
these components into one hardware-software workflow provides an ecosystem for
ongoing preparative studies that support the hardware design process and
represents the basis for the maturity of the model-to-hardware mapping
software. The functionality and flexibility of the latter is proven with a
variety of experimental results
The first determination of Generalized Polarizabilities of the proton by a Virtual Compton Scattering experiment
Absolute differential cross sections for the reaction (e+p -> e+p+gamma) have
been measured at a four-momentum transfer with virtuality Q^2=0.33 GeV^2 and
polarization \epsilon = 0.62 in the range 33.6 to 111.5 MeV/c for the momentum
of the outgoing photon in the photon-proton center of mass frame. The
experiment has been performed with the high resolution spectrometers at the
Mainz Microtron MAMI. From the photon angular distributions, two structure
functions which are a linear combination of the generalized polarizabilities
have been determined for the first time.Comment: 4 pages, 3 figure
Effective electro-optical modulation with high extinction ratio by a graphene-silicon microring resonator
Graphene opens up for novel optoelectronic applications thanks to its high
carrier mobility, ultra-large absorption bandwidth, and extremely fast material
response. In particular, the opportunity to control optoelectronic properties
through tuning of Fermi level enables electro-optical modulation,
optical-optical switching, and other optoelectronics applications. However,
achieving a high modulation depth remains a challenge because of the modest
graphene-light interaction in the graphene-silicon devices, typically,
utilizing only a monolayer or few layers of graphene. Here, we comprehensively
study the interaction between graphene and a microring resonator, and its
influence on the optical modulation depth. We demonstrate graphene-silicon
microring devices showing a high modulation depth of 12.5 dB with a relatively
low bias voltage of 8.8 V. On-off electro-optical switching with an extinction
ratio of 3.8 dB is successfully demonstrated by applying a square-waveform with
a 4 V peak-to-peak voltage.Comment: 12 pages, including 7 figure
Measurement of the Transverse-Longitudinal Cross Sections in the p (e,e'p)pi0 Reaction in the Delta Region
Accurate measurements of the p(e,e?p)pi0 reaction were performed at
Q^2=0.127(GeV/c)^2 in the Delta resonance energy region. The experiments at the
MIT-Bates Linear Accelerator used an 820 MeV polarized electron beam with the
out of plane magnetic spectrometer system (OOPS). In this paper we report the
first simultaneous determination of both the TL and TL? (``fifth" or polarized)
cross sections at low Q^{2} where the pion cloud contribution dominates the
quadrupole amplitudes (E2 and C2). The real and imaginary parts of the
transverse-longitudinal cross section provide both a sensitive determination of
the Coulomb quadrupole amplitude and a test of reaction calculations.
Comparisons with model calculations are presented. The empirical MAID
calculation gives the best overall agreement with this accurate data. The
parameters of this model for the values of the resonant multipoles are
|M_{1+}(I=3/2)|= (40.9 \pm 0.3)10^{-3}/m_pi, CMR= C2/M1= -6.5 \pm 0.3%,
EMR=E2/M1=-2.2 \pm 0.9%, where the errors are due to the experimental
uncertainties.Comment: 10 pages, 3 figures, minor corrections and addition
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