Nucleation of small silicon carbide dust clusters in AGB stars

Silicon carbide (SiC) grains are a major dust component in carbon-rich AGB stars. The formation pathways of these grains are, however, not fully understood.\ We calculate ground states and energetically low-lying structures of (SiC)$_n$, $n=1,16$ clusters by means of simulated annealing (SA) and Monte Carlo simulations of seed structures and subsequent quantum-mechanical calculations on the density functional level of theory. We derive the infrared (IR) spectra of these clusters and compare the IR signatures to observational and laboratory data.\ According to energetic considerations, we evaluate the viability of SiC cluster growth at several densities and temperatures, characterising various locations and evolutionary states in circumstellar envelopes.\ We discover new, energetically low-lying structures for Si$_{4}$C$_{4}$, Si$_{5}$C$_{5}$, Si$_{15}$C$_{15}$ and Si$_{16}$C$_{16}$, and new ground states for Si$_{10}$C$_{10}$ and Si$_{15}$C$_{15}$. The clusters with carbon-segregated substructures tend to be more stable by 4-9 eV than their bulk-like isomers with alternating Si-C bonds. However, we find ground states with cage ("bucky"-like) geometries for Si$_{12}$C$_{12}$ and Si$_{16}$C$_{16}$ and low-lying, stable cage structures for n $\ge$ 12. The latter findings indicate thus a regime of clusters sizes that differs from small clusters as well as from large-scale crystals. Thus, and owing to their stability and geometry, the latter clusters may mark a transition from a quantum-confined cluster regime to crystalline, solid bulk-material. The calculated vibrational IR spectra of the ground-state SiC clusters shows significant emission. They include the 10-13 $\mu$m wavelength range and the 11.3 $\mu$m feature inferred from laboratory measurements and observations, respectively, though the overall intensities are rather low.Comment: 16 pages, 25 figures, 3 tables, accepted for publication in Ap

Challenging the paradigm of singularity excision in gravitational collapse

A paradigm deeply rooted in modern numerical relativity calculations prescribes the removal of those regions of the computational domain where a physical singularity may develop. We here challenge this paradigm by performing three-dimensional simulations of the collapse of uniformly rotating stars to black holes without excision. We show that this choice, combined with suitable gauge conditions and the use of minute numerical dissipation, improves dramatically the long-term stability of the evolutions. In turn, this allows for the calculation of the waveforms well beyond what previously possible, providing information on the black-hole ringing and setting a new mark on the present knowledge of the gravitational-wave emission from the stellar collapse to a rotating black hole.Comment: 4 pages, 4 figures, accepted for publication on Phys. Rev. Let

Redox control of multidrug resistance and Its possible modulation by antioxidants

Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours. There is overwhelming evidence that molecular events leading to MDR are regulated by redox mechanisms. For example, chemotherapeutics which overrun the first obstacle of redox-regulated cellular uptake channels (MDR1, MDR2, and MDR3) induce a concerted action of phase I/II metabolic enzymes with a temporal redox-regulated axis. This results in rapid metabolic transformation and elimination of a toxin. This metabolic axis is tightly interconnected with the inducible Nrf2-linked pathway, a key switch-on mechanism for upregulation of endogenous antioxidant enzymes and detoxifying systems. As a result, chemotherapeutics and cytotoxic by-products of their metabolism (ROS, hydroperoxides, and aldehydes) are inactivated and MDR occurs. On the other hand, tumour cells are capable of mounting an adaptive antioxidant response against ROS produced by chemotherapeutics and host immune cells. The multiple redox-dependent mechanisms involved in MDR prompted suggesting redox-active drugs (antioxidants and prooxidants) or inhibitors of inducible antioxidant defence as a novel approach to diminish MDR. Pitfalls and progress in this direction are discussed

Quasi-periodic Oscillations in the X-ray Light Curves from Relativistic Tori

We use a relativistic ray-tracing code to analyze the X-ray emission from a pressure-supported oscillating relativistic torus around a black hole. We show that a strong correlation exists between the {\it intrinsic} frequencies of the torus normal modes and the {\it extrinsic} frequencies seen in the observed light curve power spectrum. This correlation demonstrates the feasibility of the oscillating-torus model to explain the multiple peaks seen in black hole high-frequency quasi-periodic oscillations. Using an optically thin, monochromatic emission model, we also determine how a relativistically broadened emission line and the amplitude of the X-ray modulations are dependent on the observer's inclination angle and on the torus oscillation amplitudes. Observations of these features can provide important information about the torus as well as the black hole.Comment: 4 pages, 3 figures, submitted to ApJ

Exact and heuristic allocation of multi-kernel applications to multi-FPGA platforms

FPGA-based accelerators demonstrated high energy efficiency compared to GPUs and CPUs. However, single FPGA designs may not achieve sufficient task parallelism. In this work, we optimize the mapping of high-performance multi-kernel applications, like Convolutional Neural Networks, to multi-FPGA platforms. First, we formulate the system level optimization problem, choosing within a huge design space the parallelism and number of compute units for each kernel in the pipeline. Then we solve it using a combination of Geometric Programming, producing the optimum performance solution given resource and DRAM bandwidth constraints, and a heuristic allocator of the compute units on the FPGA cluster.Peer ReviewedPostprint (author's final draft

Light-addressable liquid crystal polymer dispersed liquid crystal

Scattering-free liquid crystal polymer-dispersed liquid crystal polymer (LCPDLC) films are fabricated by combining a room temperature polymerizable liquid crystal (LC) monomer with a mesogenic photosensitive LC. The morphological and photosensitive properties of the system are analysed with polarized optical microscopy and high resolution scanning and transmission electron microscopy. A two-phase morphology comprised of oriented fibril-like polymeric structures interwoven with nanoscale domains of phase separated LC exists. The nanoscale of the structures enables an absence of scattering which allows imaging through the LCPDLC sample without optical distortion. The use of a mesogenic monomer enables much smaller phase separated domains as compared to nonmesogenic systems. All-optical experiments show that the transmitted intensity, measured through parallel polarizers, can be modulated by the low power density radiation (31 mW/cm2) of a suitable wavelength (532 nm). The reversible and repeatable transmission change is due to the photoinduced trans-cis photoisomerization process. The birefringence variation (0.01) obtained by optically pumping the LCPDLC films allow their use as an alloptical phase modulato

The Spread of Opinions and Proportional Voting

Election results are determined by numerous social factors that affect the formation of opinion of the voters, including the network of interactions between them and the dynamics of opinion influence. In this work we study the result of proportional elections using an opinion dynamics model similar to simple opinion spreading over a complex network. Erdos-Renyi, Barabasi-Albert, regular lattices and randomly augmented lattices are considered as models of the underlying social networks. The model reproduces the power law behavior of number of candidates with a given number of votes found in real elections with the correct slope, a cutoff for larger number of votes and a plateau for small number of votes. It is found that the small world property of the underlying network is fundamental for the emergence of the power law regime.Comment: 10 pages, 7 figure