Cardiac arrhythmia analysis used in the system of electrocardiosignal transmission to the supervision center

In the paper, we consider an algorithm for analyzing a person's heart condition. This algorithm is intended for systems of wireless electrocardiosignal transfer to the supervision and analysis center. Such systems are very useful when it is necessary to promptly estimate condition and operation work of the heart. Thus, more thorough analysis can be carried out later.These systems can be successfully used in medicine of accidents (ministry of emergency rescue) while evaluating condition of vehicle drivers, of sportsmen during training, of people at home.It is especially important to detect various kinds of cardiac arrhythmias at early stages. In our work, we have developed the block diagram of algorithm detecting the basic kinds of cardiac arrhythmias using logical formulae

Development of algorithm for transmission of electrocardiogram and its parameters

One of important problems in modern medicine is monitoring of parameters of an electrocardiogram. This can help to detect cardiovascular diseases. If patient has a cardiovascular disease, then it is important to monitor his state outside a hospital. In this paper we describe the developed algorithm of transmission of electrocardiogram and its parameters. The algorithm takes into account the properties of wireless technologies of transmission and can be used in portable devices intended for electrocardiogram registration and monitoring

LONG-TERM THERAPY WITH INDAPAMIDE IN ELDERLY AND SENILE PATIENTS WITH HYPERTENSION: CARDIORENOPROTECTIVE EFFECTS AND INFLUENCE ON QUALITY OF LIFE

Aim. To estimate cardiorenoprotective effect of 12-month therapy by indapamide in elderly and senile patients with arterial hypertension (HT) and its influence on quality of life.Material and methods. 40 elderly and senile patients with HT were examined. 70% of patients received monotherapy by indapamide 2,5 mg once daily and 30% of patients were treated with indapamide and lisinopril combination. Duration of observation was 12 months. Ambulatory blood pressure (BP) monitoring, echocardiography, plasma lipid profile, glycemia and uricemia levels and potassium serum level was evaluated initially and after 12 months of therapy. Glomerular filtration rate and albuminuria as well as patient quality of life also was evaluated.Results. Target BP level was reached in all patients during 12 month therapy. Reduction of average 24-hour, day and night BP, BP load, rate of morning BP rising was observed. Negative influence on BP variability was not found. Improvement of daily BP profile also was found. The indapamide reduced left ventricle mass, improved renal function, vessel resistance and quality of life. Negative influence of long-term therapy with indapamide on lipid, glucose, purine metabolism and serum potassium level was not observed.Conclusion. Indapamide is an effective antihypertensive drug for long-term treatment of elderly and senile patients with HT of 1-2 degree

LONG-TERM THERAPY WITH INDAPAMIDE IN ELDERLY AND SENILE PATIENTS WITH HYPERTENSION: CARDIORENOPROTECTIVE EFFECTS AND INFLUENCE ON QUALITY OF LIFE

Aim. To estimate cardiorenoprotective effect of 12-month therapy by indapamide in elderly and senile patients with arterial hypertension (HT) and its influence on quality of life.Material and methods. 40 elderly and senile patients with HT were examined. 70% of patients received monotherapy by indapamide 2,5 mg once daily and 30% of patients were treated with indapamide and lisinopril combination. Duration of observation was 12 months. Ambulatory blood pressure (BP) monitoring, echocardiography, plasma lipid profile, glycemia and uricemia levels and potassium serum level was evaluated initially and after 12 months of therapy. Glomerular filtration rate and albuminuria as well as patient quality of life also was evaluated.Results. Target BP level was reached in all patients during 12 month therapy. Reduction of average 24-hour, day and night BP, BP load, rate of morning BP rising was observed. Negative influence on BP variability was not found. Improvement of daily BP profile also was found. The indapamide reduced left ventricle mass, improved renal function, vessel resistance and quality of life. Negative influence of long-term therapy with indapamide on lipid, glucose, purine metabolism and serum potassium level was not observed.Conclusion. Indapamide is an effective antihypertensive drug for long-term treatment of elderly and senile patients with HT of 1-2 degree.</p

Molecular-Genetic and Epidemiologic Examination of Personnel Subjected to Occupational Irradiation

It is given an evaluation of the genetic polymorphisms (Hp, Tf, Gc; 6-PGD, EsD, ACP, PGM1, microsatellite loci CSF1PO и F13AO1, detoxicating genes GSTT1, GSTM1 and GSTP1), individual radiosensitivity (by the criterion of ribosome gene fragments) and DNA-damage rate (Comet-assay) in two cohorts comprised by VNIIEF personnel subjected chronically to gamma-neutron ionizing radiation and to β-radiation of Tritium in comparison with the effects in non-irradiated cohort. There are discussed data on the influence of the occupational irradiation, age and genotype on the rate of structural genome damage, as well as on the activity of the human repair system activity and health status