Influence of the biologically active dietary supplement Floravit® on the skin and hair structure in sable (Martes zibellina)

It is important to search for new highly effective multicomponent compounds that are able to influence several of animals’ homeostasis systems simultaneously to improve the physiological adaptation of fur animals to different conditions of nutrition. This is the function of the feed additive Floravit® – a natural bioregulator. The compound is a combination of biologically active ingredients produced by the mycelial fungus Fusarium sambucinum. Studied was the effect of Floravit® on the structure of the skin and hair in adult female sable (Martes zibellina). The scientific and economic experiment was conducted at the JSC “Plemzavod Pushkinskyi” in the Moscow Region during the period of winter fur formation in October-November. The study of the morphological structure of the hair and skin cover was carried out in the chine, side and rump topographical areas. The structure of the guard hairs in the main topographical areas was examined on a scanning electron microscope. The experiment showed that administration of Floravit® per os to adult female sable at a dose of 1.0 ml per head per day throughout the period of winter pelt formation in October-November has an influence on the morphological structure of all the categories of hair on all topographic pelt areas. Animals in the test group exposed to Floravit® exhibited an increase in guide hair length on the chine and side, when compared to controls, by 4.1 mm (p < 0.001) and by 2.8 mm (p < 0.01), respectively. The length of guard hair on the chine, side and rump increased by 8.1, 7.8 and 7.8 mm (p < 0.001), respectively. An increase in down hair length was recorded in all areas of the pelt, when compared to controls, by 13.0, 4.5 and 6.3 mm (p < 0.001). An increase in dermal thickness was recorded in the chine area by 0.7 mm (p < 0.001). The specified changed in the skin and hair structure in sable adult females after using Floravit® have shown a positive influence on the quality of hair cover. As a result, bioregulator Floravit® takes part in the adaptation process of the sable organism to external factors

Genome sequences of Acholeplasma laidlawii strains differing in sensitivity to ciprofloxacin

© 2017 Medvedeva et al. Acholeplasma laidlawii is a well-suited model for study of the molecular basis of the adaptation of mollicutes to environmental conditions. Here we present the whole-genome sequences of four strains of A. laidlawii with differential sensitivity to ciprofloxacin

Effects of doping and epitaxy on optical behavior of NaNbO3 films

Cube-on-cube epitaxy of perovskite sub-cell of Pr-doped and undoped NaNbO3 is obtained in 130-nm-thick films on top of (La0.18Sr0.82)(Al0.59Ta0.41)O3 (001) substrates. Experimental studies show that the edge of optical absorption red-shifts and some interband transitions change in the films compared to crystals. Bright red luminescence is achieved at room-temperature under ultraviolet excitation in the Pr-doped film. An interband mechanism of luminescence excitation is detected in the film, which is in contrast to the intervalence charge transfer mechanism in the crystal. The results are discussed in terms of epitaxially induced changes of crystal symmetry and ferroelectric polarization in the films. It is suggested that the band structure and interband transitions in NaNbO3and the transition probabilities in the Pr ions can be significantly modified by these changes.Peer reviewe

A study of alcohol consumption by persons of working to grow in Sverdlovsk region

The results of the study of alcohol consumption by workers of working age of the Sverdlovsk region will reveal the main motives of alcohol consumption, the age interval of initiation to alcohol and their awareness of the dangers of alcoholismРезультаты исследования потребления алкоголя работниками трудоспособного возраста Свердловской области позволят выявить основные мотивы употребления алкоголя, возрастной интервал приобщения к алкоголю и информированности их о вреде алкоголизации

Genomic and proteomic profiles of Acholeplasma laidlawii strains differing in sensitivity to ciprofloxacin

© 2016, Pleiades Publishing, Ltd.As a result of comparative analysis of complete genomes as well as cell and vesicular proteomes of A. laidlawii strains differing in sensitivity to ciprofloxacin, it was first shown that the mycoplasma resistance to the antibiotic is associated with the reorganization of genomic and proteomic profiles, which concerns many genes and proteins involved in fundamental cellular processes and realization of bacterial virulence

Intellectual resource for professional culture formation of a high school student-future specialist for modern production

© 2016, Econjournals. All rights reserved.The relevance of the study is reasoned by the rapid changing of requirements of society and labor market to the professional culture of personality - A future specialist as the actor of active lifestyle, competent, creative, intellectually developed professional. To achieve these requirements an important role should be given to the intellectual resources in the process of formation of university students 2019; professional culture: Knowledge; competence; personal qualities, advanced requirements of the labor market; critical thinking; ability to formulate the problem, propose a hypothesis to solve problems, to carry out generalizations and to formulate reasoned conclusions, to apply the results obtained to solve emerging problems, etc. Therefore this paper is aimed at the scientific justification of the structure and content of the intellectual resources in the formation of high school students 2019; professional culture and the development of practically-oriented algorithms for their implementation. The leading research method is the method of modeling of the structure and content of intellectual resource in the process of university students’ professional culture formation. The article reveals theoretical and methodological foundations of cultural competence approach to the design and implementation of the structure and content of an intellectual resource in the process of university students 2019; professional culture formation ([1] Concept - explication of notions, the evolution of scientific approaches; [2]the structure and content of the professional culture innovation discourse of the notion, culture forming content, technology; [3] the structure and content of the intellectual resources of the professional culture - categories, objectives, content, criteria). Paper submissions are recommended for managers and high school teachers, students of high professional education staff 2019;s qualification development and retraining centers, young scientists, post-graduates and undergraduates

Antimicrobial resistance in mollicutes: Known and newly emerging mechanisms

© FEMS 2018. All rights reserved. This review is devoted to the mechanisms of antibiotic resistance in mollicutes (class Bacilli, subclass Mollicutes), the smallest self-replicating bacteria, that can cause diseases in plants, animals and humans, and also contaminate cell cultures and vaccine preparations. Research in this area has been mainly based on the ubiquitous mollicute and the main contaminant of cell cultures, Acholeplasma laidlawii. The omics technologies applied to this and other bacteria have yielded a complex picture of responses to antimicrobials, including their removal from the cell, the acquisition of antibiotic resistance genes and mutations that potentially allow global reprogramming of many cellular processes. This review provides a brief summary of well-known resistance mechanisms that have been demonstrated in several mollicutes species and, in more detail, novel mechanisms revealed in A. laidlawii, including the least explored vesicle-mediated transfer of short RNAs with a regulatory potency. We hope that this review highlights new avenues for further studies on antimicrobial resistance in these bacteria for both a basic science and an application perspective of infection control and management in clinical and research/production settings

Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target

This study demonstrated that extracellular membrane vesicles are involved with the development of resistance to fluoroquinolones by mycoplasmas (class Mollicutes). This study assessed the differences in susceptibility to ciprofloxacin among strains of Acholeplasma laidlawii PG8. The mechanisms of mycoplasma resistance to antibiotics may be associated with a mutation in a gene related to the target of quinolones, which could modulate the vesiculation level. A. laidlawii extracellular vesicles mediated the export of the nucleotide sequences of the antibiotic target gene as well as the traffic of ciprofloxacin. These results may facilitate the development of effective approaches to control mycoplasma infections, as well as the contamination of cell cultures and vaccine preparations. © 2014 Elena S. Medvedeva et al

Бабезиоз у человека (лекция)

Babesiosis is a natural focal infectious disease caused by protozoa of the genus Babesia, transmitted transmissibly and characterized by fever, intoxication, progressive hemolytic anemia, and often severe course in immunocompromised patients. The clinical picture of babesiosis is nonspecific. The disease should be suspected in patients with unexplained fever who have been in endemic areas for 2 months or have received a blood transfusion within 6 months. Diagnosis of babesiosis is difficult; depends on the qualifications of the doctor and the number of parasites in the blood. The aim of the work is to summarize the available information about the etiology, epidemiology, pathogenesis, clinic, diagnosis, etiotropic therapy and prevention of babesiosis in humans. A review of domestic and foreign literature over the past 30 years, including Internet resources, has been carried out.Бабезиоз — природно-очаговое инфекционное заболевание, вызываемое простейшими рода Babesia, передающееся трансмиссивным путем и характеризующееся лихорадкой, интоксикацией, прогрессирующей гемолитической анемией и часто тяжелым течением у пациентов с иммунодефицитными состояниями. Клиническая картина бабезиоза неспецифична. Заболевание следует заподозрить у пациентов с необъяснимой лихорадкой, которые находились в эндемичных районах в течение 2 месяцев или получили переливание крови в течение 6 месяцев. Диагностика бабезиоза сложна; зависит от квалификации врача и от количества паразитов в крови. Целью работы является обобщение имеющихся сведений об этиологии, эпидемиологии, патогенезе, клинике, диагностике, этиотропной терапии и профилактике бабезиоза у человека. Проведен обзор отечественной и зарубежной литературы за последние 30 лет, в том числе Интернет-ресурсов

Assessment of early childhood health based on the results of preventive medical examinations

The article presents the results of preventive examinations of minors born in 2016-2017, the study period was the age from 1 month to 3 years. The work includes 300 registration forms No. 030-PO / u-12 "Card for preventive medical examination of a minor" of children attached to territorial polyclinics No. 1, No. 2 of the GAUZ SO DGKB No. 9 of the Zheleznodorozhny district of Yekaterinburg. A comprehensive assessment of the health status of children revealed that in all age periods there is a tendency to increase the number of children I group of health in combination with a slow decline in the fullness of the II group of health by 3 yearsВ статье представлены результаты профилактических осмотров несовершеннолетних 2016-2017 года рождения, периодом исследования стал возраст от 1 месяца до 3-х лет. В работу включено 300 учетных форм № 030-ПО/у-12 «Карта профилактического медицинского осмотра несовершеннолетнего» детей, прикрепленных к территориальным поликлиникам № 1, № 2 ГАУЗ СО ДГКБ №9 Железнодорожного района г. Екатеринбурга. Оценка состояния здоровья детей выявила, что во всех возрастных периодах отмечается тенденция к увеличению количества детей̆I группы здоровья в сочетании с медленным снижением наполняемости II группы здоровья к 3 года