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Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma.
Central neurocytoma (CN) typically presents as an intraventricular mass causing obstructive hydrocephalus. The first line of treatment is surgical resection with adjuvant conventional radiotherapy. Stereotactic radiosurgery (SRS) was proposed as an alternative therapy for CN because of its lower risk profile. The objective of this systematic analysis is to assess the efficacy of SRS for CN. A systematic analysis for CN treated with SRS was conducted in PubMed. Baseline patient characteristics and outcomes data were extracted. Heterogeneity and publication bias were also assessed. Univariate and multivariate linear regressions were used to test for correlations to the primary outcome: local control (LC). The estimated cumulative rate of LC was 92.2% (95% confidence interval: 86.5-95.7%, p<0.001). Mean follow-up time was 62.4 months (range 3-149 months). Heterogeneity and publication bias were insignificant. The univariate linear regression models for both mean tumor volume and mean dose were significantly correlated with improved LC (p<0.001). Our data suggests that SRS may be an effective and safe therapy for CN. However, the rarity of CN still limits the efficacy of a quantitative analysis. Future multi-institutional, randomized trials of CN patients should be considered to further elucidate this therapy
Universal Loss Dynamics in a Unitary Bose Gas
The low temperature unitary Bose gas is a fundamental paradigm in few-body
and many-body physics, attracting wide theoretical and experimental interest.
Here we first present a theoretical model that describes the dynamic
competition between two-body evaporation and three-body re-combination in a
harmonically trapped unitary atomic gas above the condensation temperature. We
identify a universal magic trap depth where, within some parameter range,
evaporative cooling is balanced by recombination heating and the gas
temperature stays constant. Our model is developed for the usual
three-dimensional evaporation regime as well as the 2D evaporation case.
Experiments performed with unitary 133 Cs and 7 Li atoms fully support our
predictions and enable quantitative measurements of the 3-body recombination
rate in the low temperature domain. In particular, we measure for the first
time the Efimov inelasticity parameter * = 0.098(7) for the 47.8-G
d-wave Feshbach resonance in 133 Cs. Combined 133 Cs and 7 Li experimental data
allow investigations of loss dynamics over two orders of magnitude in
temperature and four orders of magnitude in three-body loss. We confirm the 1/T
2 temperature universality law up to the constant *
Non-Markovian dynamics of a nanomechanical resonator measured by a quantum point contact
We study the dynamics of a nanomechanical resonator (NMR) subject to a
measurement by a low transparency quantum point contact (QPC) or tunnel
junction in the non-Markovian domain. We derive the non-Markovian
number-resolved (conditional) and unconditional master equations valid to
second order in the tunneling Hamiltonian without making the rotating-wave
approximation and the Markovian approximation, generally made for systems in
quantum optics. Our non-Markovian master equation reduces, in appropriate
limits, to various Markovian versions of master equations in the literature. We
find considerable difference in dynamics between the non-Markovian cases and
its Markovian counterparts. We also calculate the time-dependent transport
current through the QPC which contains information about the measured NMR
system. We find an extra transient current term proportional to the expectation
value of the symmetrized product of the position and momentum operators of the
NMR. This extra current term, with a coefficient coming from the combination of
the imaginary parts of the QPC reservoir correlation functions, has a
substantial contribution to the total transient current in the non-Markovian
case, but was generally ignored in the studies of the same problem in the
literature. Considering the contribution of this extra term, we show that a
significantly qualitative and quantitative difference in the total transient
current between the non-Markovian and the Markovian wide-band-limit cases can
be observed. Thus, it may serve as a witness or signature of the non-Markovian
features in the coupled NMR-QPC system.Comment: Accepted for publication in Physical Review B (20 pages, 13 figures
Fabrication of blue top-emitting organic light-emitting devices with highly saturated color
Abstract Blue top-emitting organic light-emitting devices (TOLEDs) with highly saturated color were developed by microcavity effect. The device structure studied was glass/reflective silver/indium-tin oxide (ITO)/organic electroluminescent stack/semi-transparent cathode (calcium/silver). By changing the thicknesses of ITO and organic layers in the microcavity structure device doped with p-bis(p-N, Ndi-phenyl-aminostyryl)benzene (DSA-ph), highly saturated color with Commission Internationale de L'Eclairage chromaticity coordinates (CIE x;y ) of (0.14, 0.08) was obtained
A Flexible Proximity Sensor Fully Fabricated by Inkjet Printing
A flexible proximity sensor fully fabricated by inkjet printing is proposed in this paper. The flexible proximity sensor is composed of a ZnO layer sandwiched in between a flexible aluminum sheet and a web-shaped top electrode layer. The flexible aluminum sheet serves as the bottom electrode. The material of the top electrode layer is nano silver. Both the ZnO and top electrode layers are deposited by inkjet printing. The fully inkjet printing process possesses the advantages of direct patterning and low-cost. It does not require photolithography and etching processes since the pattern is directly printed on the flexible aluminum sheet. The prototype demonstrates that the presented flexible sensor is sensitive to the human body. It may be applied to proximity sensing or thermal eradiation sensing
Genome maps across 26 human populations reveal population-specific patterns of structural variation.
Large structural variants (SVs) in the human genome are difficult to detect and study by conventional sequencing technologies. With long-range genome analysis platforms, such as optical mapping, one can identify large SVs (>2 kb) across the genome in one experiment. Analyzing optical genome maps of 154 individuals from the 26 populations sequenced in the 1000 Genomes Project, we find that phylogenetic population patterns of large SVs are similar to those of single nucleotide variations in 86% of the human genome, while ~2% of the genome has high structural complexity. We are able to characterize SVs in many intractable regions of the genome, including segmental duplications and subtelomeric, pericentromeric, and acrocentric areas. In addition, we discover ~60 Mb of non-redundant genome content missing in the reference genome sequence assembly. Our results highlight the need for a comprehensive set of alternate haplotypes from different populations to represent SV patterns in the genome
Spatially Resolved Chemistry in Nearby Galaxies I. The Center of IC 342
We have imaged emission from the millimeter lines of eight molecules--C2H,
C34S, N2H+, CH3OH, HNCO, HNC, HC3N, and SO--in the central half kpc of the
nearby spiral galaxy IC 342. The 5" (~50 pc) resolution images were made with
OVRO. Using these maps we obtain a picture of the chemistry within the nuclear
region on the sizescales of individual GMCs. Bright emission is detected from
all but SO. There are marked differences in morphology for the different
molecules. A principal component analysis is performed to quantify similarities
and differences among the images. This analysis reveals that while all
molecules are to zeroth order correlated, that is, they are all found in dense
molecular clouds, there are three distinct groups of molecules distinguished by
the location of their emission within the nuclear region. N2H+, C18O, HNC and
HCN are widespread and bright, good overall tracers of dense molecular gas. C2H
and C34S, tracers of PDR chemistry, originate exclusively from the central
50-100 pc region, where radiation fields are high. The third group of
molecules, CH3OH and HNCO, correlates well with the expected locations of
bar-induced orbital shocks. The good correlation of HNCO with the established
shock tracer molecule CH3OH is evidence that this molecule, whose chemistry has
been uncertain, is indeed produced by processing of grains. HC3N is observed to
correlate tightly with 3mm continuum emission, demonstrating that the young
starbursts are the sites of the warmest and densest molecular gas. We compare
our HNC images with the HCN images of Downes et al. (1992) to produce the first
high resolution, extragalactic HCN/HNC map: the HNC/HCN ratio is near unity
across the nucleus and the correlation of both of these gas tracers with the
star formation is excellent. (Abridged).Comment: 54 pages including 10 figures and 8 tables. Accepted for publication
in Ap
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